المؤلفون: Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella

المصدر: Frontiers in Oncology, Vol 12 (2023)

مصطلحات موضوعية: mutant p53, metabolism, p53-R248W, gain-of-function, NSC59984, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1094210/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/c07b755597a5468588906ab014a43c40

المؤلفون: Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8

المؤلفون: Kate Brown (393684), Lisa M. Miller Jenkins (14378181), Daniel R. Crooks (9197483), Deborah R. Surman (14378184), Sharlyn J. Mazur (1630933), Yuan Xu (161775), Bhargav S. Arimilli (10531020), Ye Yang (297214), Andrew N. Lane (446636), Teresa W-M. Fan (13529366), David S. Schrump (13582987), W. Marston Linehan (204577), R. Taylor Ripley (14378187), Ettore Appella (468966)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mutant p53, metabolism, p53-R248W, gain-of-function, NSC59984

Relation: https://figshare.com/articles/dataset/DataSheet_2_Targeting_mutant_p53-R248W_reactivates_WT_p53_function_and_alters_the_onco-metabolic_profile_docx/21863805

الاتاحة: https://doi.org/10.3389/fonc.2022.1094210.s002

المؤلفون: Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cell biology, DNA damage, Neutrophils, T-Lymphocytes, Science, Immunology, General Physics and Astronomy, Antineoplastic Agents, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Cell Line, Tumor, Conditional gene knockout, medicine, Tumor Microenvironment, Cytotoxic T cell, Animals, Humans, Lung, Cell Proliferation, Cancer, Mice, Knockout, Multidisciplinary, Molecular medicine, Melanoma, Immunity, General Chemistry, medicine.disease, Mice, Inbred C57BL, Protein Phosphatase 2C, Haematopoiesis, 030104 developmental biology, Phenotype, 030220 oncology & carcinogenesis, Cancer research, Female, Tumor Suppressor Protein p53, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8854a60cd08e290182a884440da95b
https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8

المؤلفون: Marco Robello, Hongchao Zheng, Mrinmoy Saha, Kara M. George Rosenker, Subrata Debnath, Jay Prakash Kumar, Harichandra D. Tagad, Sharlyn J. Mazur, Ettore Appella, Daniel H. Appella

المصدر: European journal of medicinal chemistry. 243

مصطلحات موضوعية: Pharmacology, Protein Phosphatase 2C, Organic Chemistry, Drug Discovery, Phosphoprotein Phosphatases, Humans, General Medicine, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Phosphorylation, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60af2fe47f5d166bd42937846431f61
https://pubmed.ncbi.nlm.nih.gov/36179402

المؤلفون: Sharlyn J. Mazur, Olga Vasalatiy, Dingyin Tao, Daniel H. Appella, Subrata Debnath, Yuhong Wang, Rebecca Eells, Harichandra D. Tagad, Mark J. Henderson, Victor Clausse, Kelly Lane, Nathan P. Coussens, Christopher A. LeClair, Zhen-Dan Shi, Martin R. Webb, Min Shen, Yuhong Fang, Lynn K. Baker, Matthew D. Hall, Hongmao Sun, Ettore Appella

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Phosphopeptides, Phosphatase, Wip1, Enzyme Activators, Peptide, Biochemistry & Proteomics, Biochemistry, phosphatase, Substrate Specificity, Serine, Small Molecule Libraries, 03 medical and health sciences, high-throughput screening (HTS), oncogene, enzyme kinetics, therapeutics, cancer, Humans, mass spectrometry (MS), Enzyme kinetics, Surface plasmon resonance, Molecular Biology, chemistry.chemical_classification, 030102 biochemistry & molecular biology, phosphorylation, Methods and Resources, Cell Biology, assay, Small molecule, High-Throughput Screening Assays, Protein Phosphatase 2C, 030104 developmental biology, Enzyme, chemistry, RapidFire, kinetics, Phosphorylation, cancer therapy, fluorescence, Tumor Suppressor Protein p53, Structural Biology & Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195e41fcef7b640fd2b44107385f675a
http://europepmc.org/articles/PMC6873202

المؤلفون: Fred Dyda, Harichandra D. Tagad, Roderico Acevedo, Dalibor Kosek, Daniel H. Appella, Subrata Debnath, Alexander Grishaev, Stewart R. Durell, Ettore Appella, Sharlyn J. Mazur

المصدر: Journal of Biological Chemistry. 293:7993-8008

مصطلحات موضوعية: Models, Molecular, Phosphopeptides, 0301 basic medicine, Protein Conformation, Stereochemistry, Metal ions in aqueous solution, Phosphatase, Sequence Homology, Crystallography, X-Ray, Biochemistry, Substrate Specificity, 03 medical and health sciences, Catalytic Domain, Hydrolase, Humans, Amino Acid Sequence, Enzyme kinetics, Molecular Biology, Binding Sites, 030102 biochemistry & molecular biology, biology, Phosphopeptide, Chemistry, Active site, Substrate (chemistry), Cell Biology, Enzyme structure, Protein Phosphatase 2C, 030104 developmental biology, Metals, Mutation, Mutagenesis, Site-Directed, biology.protein, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae54b1823e2aadabf6b20f968e2bf498
https://doi.org/10.1074/jbc.ra117.001213

المؤلفون: Subrata Debnath, Ettore Appella, Sharlyn J. Mazur, Harichandra D. Tagad, Victor Clausse, Daniel H. Appella, Mrinmoy Saha

المصدر: ChemMedChem

مصطلحات موضوعية: 0301 basic medicine, p38 mitogen-activated protein kinases, Phosphatase, Biochemistry, Article, law.invention, Serine, Structure-Activity Relationship, 03 medical and health sciences, law, Drug Discovery, Tumor Cells, Cultured, Humans, Enzyme kinetics, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Dose-Response Relationship, Drug, biology, Chemistry, Organic Chemistry, Protein Phosphatase 2C, 030104 developmental biology, MCF-7 Cells, biology.protein, Cancer research, Molecular Medicine, Suppressor, Mdm2, Function (biology), Human cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378f860218d8b8e5576e770489acc788
https://doi.org/10.1002/cmdc.201700779

المؤلفون: Matteo Rossi, Oleg N. Demidov, Carl W. Anderson, Sharlyn J. Mazur

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://nar.oxfordjournals.org/content/36/22/7168.full-text-lowres.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.598.2958; http://nar.oxfordjournals.org/content/36/22/7168.full-text-lowres.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.598.2958
http://nar.oxfordjournals.org/content/36/22/7168.full-text-lowres.pdf

المؤلفون: Lisa M. Miller Jenkins, Hiroshi Yamaguchi, Ryo Hayashi, Scott Cherry, Joseph E, Maria Miller, Er Wlodawer, Sharlyn J. Mazur, Joseph E. Tropea

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcl1.ncifcrf.gov/wlo_pubs/289.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.374.9782; http://mcl1.ncifcrf.gov/wlo_pubs/289.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.374.9782
http://mcl1.ncifcrf.gov/wlo_pubs/289.pdf

المؤلفون: Ncp -mercaptobenzamide Thioesters, Lisa M. Miller Jenkins, J. Calvin Byrd, Toshiaki Hara, Pratibha Srivastava, Sharlyn J. Mazur

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://phoenix.tuwien.ac.at/lectures/pdf_JMC/jm0492195_Zinc.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.595.6089; http://phoenix.tuwien.ac.at/lectures/pdf_JMC/jm0492195_Zinc.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.595.6089
http://phoenix.tuwien.ac.at/lectures/pdf_JMC/jm0492195_Zinc.pdf

المؤلفون: Kyle Anderson, Ettore Appella, Subrata Debnath, Elyssia S. Gallagher, Jeffrey W. Hudgens, Sharlyn J. Mazur, Stewart R. Durell, Lisa M. Miller Jenkins

المصدر: Biochemistry. 56:2676-2689

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, Protein Conformation, Stereochemistry, Inorganic chemistry, Biochemistry, Mass Spectrometry, Article, Serine, 03 medical and health sciences, Protein structure, Humans, Threonine, Binding site, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, Deuterium Exchange Measurement, Active site, Protein Phosphatase 2C, 030104 developmental biology, Deuterium, biology.protein, Hydrogen–deuterium exchange

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6549363acbe5bfe6629cd70aa4385ef
https://doi.org/10.1021/acs.biochem.6b01220

المؤلفون: Izumi Horikawa, P. Louann Cable, Sharlyn J. Mazur, Cynthia A. Afshari, J. Carl Barrett

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.molbiolcell.org/content/13/8/2585.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.145; http://www.molbiolcell.org/content/13/8/2585.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.145
http://www.molbiolcell.org/content/13/8/2585.full.pdf

المؤلفون: Daniel P. Weber, Sharlyn J. Mazur

المصدر: Journal of the American Society for Mass Spectrometry. 28:978-981

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Quantitative Biology::Biomolecules, Chemistry, Globular protein, 010401 analytical chemistry, Analytical chemistry, Functional data analysis, Thermodynamics, Mass spectrometry, 01 natural sciences, Measure (mathematics), Article, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Structural Biology, Hydrogen–deuterium exchange, Spectroscopy, Log ratio

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771a6e86f5eeb5e682d49102c2f2f717
https://doi.org/10.1007/s13361-017-1615-1

المؤلفون: VESCHI V, Zhihui Liu, Ty C Voss, Laurent Ozbun, Berkley Gryder, Chunhua Yan, Ying Hu, Anqi Ma, Jian Jin, Sharlyn J Mazur, Norris Lam, Barbara K Souza, Giuseppe Giannini, Gordon L Hager, Cheryl H Arrowsmith, Javed Khan, Ettore Appella, Carol Thiele

المساهمون: Veschi, V, Zhihui, Liu, Ty, C Vo, Laurent, Ozbun, Berkley, Gryder, Chunhua, Yan, Ying, Hu, Anqi, Ma, Jian, Jin, Sharlyn, J Mazur, Norris, Lam, Barbara, K Souza, Giuseppe, Giannini, Gordon, L Hager, Cheryl, H Arrowsmith, Javed, Khan, Ettore, Appella, Carol, Thiele

Relation: journal:CANCER RESEARCH; https://hdl.handle.net/11573/1698881

الاتاحة: https://hdl.handle.net/11573/1698881
https://doi.org/10.1158/1538-7445.AM2017-3867

المؤلفون: Ettore Appella, Sharlyn J. Mazur, Hiroyasu Sakai, Hidetsugu Fujigaki

المصدر: Cell Cycle

مصطلحات موضوعية: DNA Replication, p53, replication, senescence, DNA damage, WIP1, Phosphatase, Endogeny, DNA damage response, S Phase, Histones, Mice, Cell Cycle News & Views, Phosphoprotein Phosphatases, Animals, Phosphorylation, Molecular Biology, Cells, Cultured, Mice, Knockout, chemistry.chemical_classification, Reactive oxygen species, biology, DNA replication, Aging, Premature, ROS, Cell Biology, Molecular biology, Mice, Inbred C57BL, Oxygen, Protein Phosphatase 2C, Histone, chemistry, biology.protein, Tumor Suppressor Protein p53, Signal transduction, Reactive Oxygen Species, DNA Damage, Signal Transduction, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0935ef99823988779fc6ee55aa432a0d
https://doi.org/10.4161/cc.27920

المؤلفون: David P. Lane, Sharlyn J. Mazur, Kaori Fujita, Ettore Appella, Elsa Vera, Maria A. Blasco, Abdul M. Mondal, Sharon R. Pine, Curtis C. Harris, Izumi Horikawa, Borivoj Vojtesek, Katherine M. Morgan

المصدر: Journal of Clinical Investigation

مصطلحات موضوعية: Adult, Male, Senescence, Lung Neoplasms, Leupeptins, Endogeny, CD8-Positive T-Lymphocytes, Biology, Young Adult, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Downregulation and upregulation, Transduction, Genetic, Autophagy, Tumor Microenvironment, Humans, Protein Isoforms, Cells, Cultured, Cellular Senescence, Aged, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Cell growth, CD28, General Medicine, Middle Aged, Recombinant Proteins, Neoplasm Proteins, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Tumor progression, 030220 oncology & carcinogenesis, Proteolysis, Female, Macrolides, Tumor Suppressor Protein p53, Cell Division, CD8, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331a3046e613bd1068818ad0aa3c0d71
https://doi.org/10.1172/jci70355

المؤلفون: Kazushige Ishida, Harichandra D. Tagad, Lisa M. Miller Jenkins, Stewart R. Durell, Ettore Appella, Sharlyn J. Mazur, Subrata Debnath, Hiroyasu Sakai, Kan Tanoue

المصدر: Biochemistry. 52:5830-5843

مصطلحات موضوعية: inorganic chemicals, Phosphopeptides, Metal ions in aqueous solution, Phosphatase, Pyruvate dehydrogenase phosphatase, Biochemistry, Article, Catalysis, Catalytic Domain, Phosphoprotein Phosphatases, Humans, Magnesium, Amino Acid Sequence, Alanine, Aspartic Acid, Manganese, biology, Phosphopeptide, Chemistry, Substrate (chemistry), Active site, Isothermal titration calorimetry, Protein Phosphatase 2C, HEK293 Cells, biology.protein, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5f18a1745f6f76fb33e5a9d183ed79
https://doi.org/10.1021/bi4005649

المؤلفون: Robert Robinson, Crissy Dudgeon, Sathyavageeswaran Shreeram, Kan Tanoue, Ettore Appella, Ahmed Sayadi, Dmitry V. Bulavin, Sharlyn J. Mazur

المصدر: Cell Cycle. 12:2656-2664

مصطلحات موضوعية: Models, Molecular, DNA damage, Blotting, Western, Molecular Sequence Data, Phosphatase, Fluorescent Antibody Technique, Single-nucleotide polymorphism, Biology, medicine.disease_cause, Colony-Forming Units Assay, Evolution, Molecular, Report, Neoplasms, Genetic variation, Phosphoprotein Phosphatases, medicine, Humans, Missense mutation, Amino Acid Sequence, Molecular Biology, Genetics, Mutation, Genetic Variation, Cell Biology, Phenotype, Protein Phosphatase 2C, Mutagenesis, Site-Directed, Carcinogenesis, DNA Damage, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3509518d847e1831c86d2394ee5e520c
https://doi.org/10.4161/cc.25694

المؤلفون: Giuseppe Giannini, Ying Hu, Carol J. Thiele, Jian Jin, Zhihui Liu, Ettore Appella, Chunhua Yan, Sharlyn J. Mazur, Bárbara Kunzler Souza, Veronica Veschi, Laurent Ozbun, Javed Khan, Norris Lam, Anqi Ma, Cheryl H. Arrowsmith, Gordon L. Hager, Ty C. Voss, Berkley E. Gryder

المساهمون: Veschi V., Liu Z., Voss T.C., Ozbun L., Gryder B., Yan C., Hu Y., Ma A., Jin J., Mazur S.J., Lam N., Souza B.K., Giannini G., Hager G.L., Arrowsmith C.H., Khan J., Appella E., Thiele C.J.

مصطلحات موضوعية: p53, 0301 basic medicine, Cancer Research, Small interfering RNA, Methyltransferase, Cellular differentiation, Druggability, Biology, Article, Epigenesis, Genetic, Neuroblastoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Epigenetics, RNA, Small Interfering, Gene, Cell Proliferation, siRNA screen, Cell growth, Quinazoline, Cell Differentiation, differentiation, Histone-Lysine N-Methyltransferase, medicine.disease, SETD8, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Quinazolines, Cancer research, epigenetics, neuroblastoma, Cell Biology, Tumor Suppressor Protein p53, epigenetic, Human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774daa5664f2503097fffeaef6bbd43
http://hdl.handle.net/11573/927636