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المؤلفون: Sharan R, Srinivasan, Haoran, Huang, Wei-Chih, Chang, Joshua A, Nasburg, Hai M, Nguyen, Tim, Strassmaier, Heike, Wulff, Vikram G, Shakkottai
المصدر: Molecular pharmacology, vol 102, iss 1
Mol Pharmacolمصطلحات موضوعية: Potassium Channels, Cerebellar Ataxia, Neurodegenerative, Potassium Channels, Calcium-Activated, Mice, Rare Diseases, Animals, Spinocerebellar Ataxias, Large-Conductance Calcium-Activated Potassium Channels, Pharmacology & Pharmacy, Pharmacology, Neurosciences, Articles, Pharmacology and Pharmaceutical Sciences, Brain Disorders, Calcium-Activated, Orphan Drug, 5.1 Pharmaceuticals, Neurological, Potassium, Molecular Medicine, Ataxia, Calcium, Biochemistry and Cell Biology, Development of treatments and therapeutic interventions, Biotechnology
وصف الملف: application/pdf
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المؤلفون: Samira Abdulai-Saiku, Stanley H. Appel, Arthur P. Arnold, Lisa M. Arnold, Robert M. Arnold, Alexa Bacha, Miroslav 'Misha' Backonja, Zinzi D. Bailey, Lucinda Bateman, David R. Beers, Anna Berti, Mamta Bhatnagar, Devin K. Binder, Marina Boido, Maura Boldrini, David Borsook, Xandra O. Breakefield, Robert H. Brown, Rami Burstein, Eduardo R. Butelman, Louis R. Caplan, S. Chen, Marie-Françoise Chesselet, Stefan Clemens, Paula R. Clemens, Joseph T. Coyle, John C. DeWitt, Dena B. Dubal, Veljko Dubljević, Eva L. Feldman, Beth A. Fischer, M.C. Flux, J.S. Fortin, Angelisa Frasca, Francesca Garbarini, Thomas Gasser, Charles F. Gillespie, Michael S. Gold, Stefan M. Gold, Randi Hagerman, Regan Hamel, Craig Haney, James C. Harris, Sara Hassani, Norman J. Haughey, Vibol Heng, J. Horn, Rosana-Bristena Ionescu, Raffaele Iorio, David J. Irwin, Henry J. Kaminski, Dalia Khammash, Vikram Khurana, Charlotte Kilstrup-Nielsen, Bhumsoo Kim, Boram Kim, Marieke Klein, Nastassja Koen, Glenn T. Konopaske, Joanna A. Korecka, Birgitte Rahbek Kornum, Mary Jeanne Kreek, Krister Kristensson, Grzegorz Krzak, Linda L. Kusner, Nicoletta Landsberger, Edward B. Lee, Tong Li, Paweł P. Liberski, Christine Lochner, Christopher A. Lowry, J. John Mann, Clara Marincowitz, E.A. Mayer, E.D. Mayer, Iris Coates McCall, Louise D. McCullough, Michael J. Meaney, Claudio Melo de Gusmao, Abhishek L. Menesgere, Emmanuel Mignot, William C. Mobley, Mayra Montalvo, Alisha R. Moreland-Capuia, Marco Neppi-Modona, Alexandra M. Nicaise, Rae Nishi, Orna O'Toole, Cassia Overk, Laurie Ozelius, Matthew P. Parsons, H.B. Penticoff, Luca Peruzzotti-Jametti, Owen M. Peters, Allison Peterson, Jessica M. Phan, Sean J. Pittock, Stefano Pluchino, Thad A. Polk, Araya Puwanant, Shreya K. Rajagopal, Vijayalakshmi Ravindranath, Lynn A. Raymond, Brian Reed, Kerry J. Ressler, Diane L. Ritchie, Leah H. Rubin, Stacey A. Sakowski, Mario A. Saporta, Alena V. Savonenko, Helen E. Scharfman, Bruce K. Shapiro, Nutan Sharma, Cayce K. Shaw, Michael E. Shy, Beata Sikorska, Ethan J. Silverman, Roger P. Simon, Kristina Simonyan, Catrina Sims-Robinson, Richard Jay Smeyne, Clay Smith, Colin Smith, Sharan R. Srinivasan, Dan J. Stein, Christopher D. Stephen, Indu Subramanian, Edina Szabo, Alissa A. Thomas, Luis B. Tovar-y-Romo, Arshya Vahabzadeh, Alessandro Vercelli, Ashley Viera-Ortiz, Mitchell T. Wallin, Donna M. Werling, Thomas Wichmann, Clayton A. Wiley, David R. Williams, Cory Willis, Philip C. Wong, Vadim Yuferov, Weihua Zhao, Michael J. Zigmond, Saša A. Živković
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المؤلفون: Alain Ndayisaba, Ariana T. Pitaro, Andrew S. Willett, Kristie A. Jones, Claudio Melo de Gusmao, Abby L. Olsen, Jisoo Kim, Eero Rissanen, Jared K. Woods, Sharan R. Srinivasan, Anna Nagy, Amanda Nagy, Merlyne Mesidor, Steven Cicero, Viharkumar Patel, Derek H. Oakley, Idil Tuncali, Katherine Taglieri-Noble, Emily C. Clark, Jordan Paulson, Richard C. Krolewski, Gary P. Ho, Albert Y. Hung, Anne-Marie Wills, Michael T. Hayes, Jason P. Macmore, Luigi Warren, Pamela G. Bower, Carol B. Langer, Lawrence R. Kellerman, Christopher W. Humphreys, Bonnie I. Glanz, Elodi J. Dielubanza, Matthew P. Frosch, Roy L. Freeman, Christopher H. Gibbons, Nadia Stefanova, Tanuja Chitnis, Howard L. Weiner, Clemens R. Scherzer, Sonja W. Scholz, Dana Vuzman, Laura M. Cox, Gregor Wenning, Jeremy D. Schmahmann, Anoopum S. Gupta, Peter Novak, Geoffrey S. Young, Mel B. Feany, Tarun Singhal, Vikram Khurana
المصدر: The Cerebellum.
مصطلحات موضوعية: Neurology, Neurology (clinical)
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المؤلفون: Alain Ndayisaba, Ariana T. Pitaro, Andrew S. Willett, Kristie A. Jones, Claudio Melo de Gusmao, Abby L. Olsen, Jisoo Kim, Eero Rissanen, Jared K. Woods, Sharan R. Srinivasan, Anna Nagy, Amanda Nagy, Merlyne Mesidor, Steven Cicero, Viharkumar Patel, Derek H. Oakley, Idil Tuncali, Katherine Taglieri-Noble, Emily C. Clark, Jordan Paulson, Richard C. Krolewski, Gary P. Ho, Albert Y. Hung, Anne-Marie Wills, Michael T. Hayes, Jason P. Macmore, Luigi Warren, Pamela G. Bower, Carol B. Langer, Lawrence R. Kellerman, Christopher W. Humphreys, Bonnie I. Glanz, Elodi J. Dielubanza, Matthew P. Frosch, Roy L. Freeman, Christopher H. Gibbons, Nadia Stefanova, Tanuja Chitnis, Howard L. Weiner, Clemens R. Scherzer, Sonja W. Scholz, Dana Vuzman, Laura M. Cox, Gregor Wenning, Jeremy D. Schmahmann, Anoopum S. Gupta, Peter Novak, Geoffrey S. Young, Mel B. Feany, Tarun Singhal, Vikram Khurana
المصدر: The Cerebellum.
مصطلحات موضوعية: Neurology, Neurology (clinical)
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المؤلفون: Erik R. P. Zuiderweg, Eric Tse, Daniel R. Southworth, Chetali Jain, Jason E. Gestwicki, Sharan R. Srinivasan, Laura C. Cesa, Hao Shao, Anna K. Mapp
المصدر: The Journal of biological chemistry, vol 293, iss 7
مصطلحات موضوعية: 0301 basic medicine, Biochemistry & Molecular Biology, chemical biology, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, Medical and Health Sciences, Proto-Oncogene Mas, Biochemistry, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Breast Cancer, chaperone, Humans, HSP70 Heat-Shock Proteins, Editors' Picks, HSP90 Heat-Shock Proteins, heat shock protein 90, Molecular Biology, cancer biology, Cancer, Tumor, biology, Kinase, Chemistry, Cell Biology, Biological Sciences, Hsp90, Hsp70, Cell biology, XIAP, protein–protein interaction, 030104 developmental biology, Apoptosis, Chaperone (protein), Chemical Sciences, Cancer cell, biology.protein, Generic health relevance, Biomarkers, Biotechnology, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Sharan R. Srinivasan, Vikram G. Shakkottai
المصدر: Neurotherapeutics
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Neurology, Disease, Review, 03 medical and health sciences, 0302 clinical medicine, Drug Delivery Systems, medicine, Animals, Humans, Spinocerebellar Ataxias, Pharmacology (medical), Excitatory Amino Acid Agents, Ataxin-1, Pharmacology, Clinical Trials as Topic, business.industry, Genetic Therapy, Oligonucleotides, Antisense, medicine.disease, 030104 developmental biology, Antisense oligonucleotides, Gene Targeting, Spinocerebellar ataxia, Treatment strategy, Gait imbalance, Identification (biology), RNA Interference, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery
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المؤلفون: Atta Ahmad, Bryan M. Dunyak, Misol Ahn, Chad A. Dickey, Jennifer N. Rauch, Victoria A. Assimon, Umesh K. Jinwal, Erik R. P. Zuiderweg, Sharan R. Srinivasan, George A. Carlson, Zapporah T. Young, Xiaokai Li, Jason E. Gestwicki
المصدر: Cell chemical biology, vol 23, iss 8
مصطلحات موضوعية: 0301 basic medicine, Aging, Clinical Biochemistry, Neurodegenerative, Alzheimer's Disease, Biochemistry, 0302 clinical medicine, Models, Drug Discovery, Tumor Cells, Cultured, 2.1 Biological and endogenous factors, Normal protein, Aetiology, Cultured, Molecular Structure, biology, Protein Stability, Tumor Cells, Cell biology, Tauopathies, Proteome, Thiazolidines, Molecular Medicine, Tauopathy, Drug, Chemical biology, tau Proteins, Models, Biological, Article, Dose-Response Relationship, Structure-Activity Relationship, 03 medical and health sciences, Acquired Cognitive Impairment, medicine, Humans, Structure–activity relationship, HSP70 Heat-Shock Proteins, Benzothiazoles, Molecular Biology, Pharmacology, Dose-Response Relationship, Drug, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biological, medicine.disease, Brain Disorders, Hsp70, 030104 developmental biology, Hela Cells, Chaperone (protein), biology.protein, Dementia, Generic health relevance, 030217 neurology & neurosurgery, Homeostasis, HeLa Cells
وصف الملف: application/pdf
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المؤلفون: Min Zhuang, Sharan R. Srinivasan, Colin S. Duckett, Laura C. Cesa, Xiaokai Li, James A. Wells, Ivan Maillard, Jason E. Gestwicki, Olivier Julien, Jooho Chung, Hao Shao
المصدر: Molecular cancer research : MCR, vol 16, iss 1
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, Necroptosis, 1.1 Normal biological development and functioning, Oncology and Carcinogenesis, Breast Neoplasms, Apoptosis, Protein degradation, Article, CFLAR, Cell Line, 03 medical and health sciences, RIPK1, Jurkat Cells, Necrosis, 0302 clinical medicine, Underpinning research, Heat shock protein, Cell Line, Tumor, Breast Cancer, Humans, 2.1 Biological and endogenous factors, HSP70 Heat-Shock Proteins, Oncology & Carcinogenesis, Aetiology, Molecular Biology, Cancer, Tumor, biology, Hsp90, Cell biology, XIAP, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Receptor-Interacting Protein Serine-Threonine Kinases, Cancer research, biology.protein, MCF-7 Cells, Female, Signal Transduction, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Duxin Sun, Atta Ahmad, Xiaokai Li, Adam M. Kabza, Jamie N. Connarn, Jason E. Gestwicki, Erik R. P. Zuiderweg, Zapporah T. Young, Sharan R. Srinivasan
المصدر: ACS Medicinal Chemistry Letters. 4:1042-1047
مصطلحات موضوعية: biology, Organic Chemistry, Allosteric regulation, AKT1, Bioinformatics, Biochemistry, Hsp90, Hsp70, Proteostasis, Apoptosis, Chaperone (protein), Drug Discovery, biology.protein, Microsome
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المؤلفون: Chad A. Dickey, Jennifer N. Rauch, Umesh K. Jinwal, Jason E. Gestwicki, Sharan R. Srinivasan, Andrea D. Thompson, Yoshinari Miyata
المصدر: Chemistry & Biology. 19:1391-1399
مصطلحات موضوعية: Protein Conformation, Molecular Sequence Data, Clinical Biochemistry, HSP72 Heat-Shock Proteins, Biology, Biochemistry, Article, Serine, 03 medical and health sciences, 0302 clinical medicine, Heat shock protein, Drug Discovery, Humans, HSP70 Heat-Shock Proteins, Amino Acid Sequence, Cysteine, HSPA8, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, HSC70 Heat-Shock Proteins, Hydrogen Peroxide, General Medicine, HSPA1A, Hsp70, Cell biology, Methylene Blue, Proteostasis, Amino Acid Substitution, Chaperone (protein), Mutation, biology.protein, Molecular Medicine, Oxidation-Reduction, 030217 neurology & neurosurgery, HeLa Cells
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المؤلفون: Sharan R. Srinivasan, Xiaokai Li, Jason E. Gestwicki, Hao Shao
المصدر: Topics in Medicinal Chemistry ISBN: 9783319326054
مصطلحات موضوعية: biology, Chemistry, Chaperone (protein), Heat shock protein, Protein domain, Allosteric regulation, Cancer cell, biology.protein, Protein folding, Hsp90, Protein–protein interaction, Cell biology
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المؤلفون: Umesh K. Jinwal, Xiaokai Li, Jason E. Gestwicki, Yoshinari Miyata, Sandlin P. Seguin, Chad A. Dickey, Sharan R. Srinivasan, Duxin Sun, Hsiu Fang Lee, Zapporah T. Young, Jeffrey L. Brodsky
المصدر: ACS chemical neuroscience, vol 4, iss 6
مصطلحات موضوعية: Physiology, Pyridines, Drug Evaluation, Preclinical, Biochemistry, chemistry.chemical_compound, Mice, Cells, Cultured, Cultured, Chemistry, General Medicine, Alzheimer's disease, Preclinical, medicine.anatomical_structure, Liver, Blood-Brain Barrier, 5.1 Pharmaceuticals, Neurological, Microsomes, Liver, MCF-7 Cells, Thiazolidines, Female, Pyridinium, Development of treatments and therapeutic interventions, Cognitive Neuroscience, Cells, Central nervous system, Allosteric regulation, tau Proteins, Blood–brain barrier, Capillary Permeability, Medicinal and Biomolecular Chemistry, Rare Diseases, Pharmacokinetics, Microsomes, medicine, Animals, Humans, HSP70 Heat-Shock Proteins, Benzothiazoles, protein quality control, proteostasis, tauopathy, Neurosciences, Cell Biology, In vitro, Hsp70, Brain Disorders, Thiazoles, Proteostasis, Orphan Drug, rhodacyanines, Biophysics, Drug Evaluation, Allosteric inhibitors, microtubule-associated protein tau
وصف الملف: application/pdf
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المصدر: Molecular BioSystems. 8:2323
مصطلحات موضوعية: endocrine system, Proteome, Escherichia coli Proteins, genetic processes, Plasma protein binding, Biology, Protein Homeostasis, medicine.disease_cause, Article, medicine, HSP70 Heat-Shock Proteins, Binding site, Molecular Biology, Escherichia coli, Genetics, Binding Sites, HSP40 Heat-Shock Proteins, Folding (chemistry), Biochemistry, biological sciences, bacteria, Molecular Chaperones, Protein Binding, Biotechnology