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1Academic Journal
المؤلفون: Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
المصدر: PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
وصف الملف: electronic resource
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المؤلفون: Ramadevi Prathapam, Alexandra Frommlet, Jacob Shaul, Dita M. Rasper, Xiaoyu Shen, Alexey Ruzin, Sharadha Subramanian, Feng Wang, Micah Steffek, Bret Benton, Jason Vo, Steven Shia, Wooseok Han, Andreas O. Frank, Charles Wartchow, Patrick Lee, Xiaolei Ma, Fergal Casey, Hanne Merritt, Carl J. Balibar, Alun Bermingham, Elizabeth Ornelas, Tsuyoshi Uehara, Andreas Lingel, Chi-Min Ho, Barbara Chie-Leon, William S. Sawyer, Min-Kyu Cho, Sylvia Ma, Katherine R Prosen, Min Li, Christopher M. Rath, Gianfranco De Pascale
المصدر: Journal of the American Chemical Society. 142:4445-4455
مصطلحات موضوعية: Microbial Sensitivity Tests, Crystallography, X-Ray, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, Catalysis, Colloid and Surface Chemistry, Escherichia coli, medicine, Enzyme Inhibitors, chemistry.chemical_classification, biology, Chemistry, Drug discovery, Imidazoles, General Chemistry, biology.organism_classification, In vitro, Anti-Bacterial Agents, 0104 chemical sciences, Enzyme, Acyltransferase, Pyrazoles, Antibacterial activity, Uncompetitive inhibitor, Acyltransferases, Bacteria, Protein Binding
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المؤلفون: Sharadha Subramanian, Valery Polyakov, Giordano Caponigro, Amy Lambert, Lina Setti, Ann Van Abbema, Nicholas Keen, Matthew Burger, Mallika Singh, Emma Lees, Michael Patrick Dillon, Alice Rico, Wenlin Shao, Mohamad Hekmat-Nejad, Lesley A. Mathews Griner, Stacey Rivera, Robert J. Aversa, William R. Sellers, Victor Tamez, Joshua M. Korn, Lifeng Wan, Yan Lou, Benjamin R. Taft, Payman Amiri, Savithri Ramurthy, Richard Zang, Darrin Stuart, Jacob R. Haling, Yuji Mishina, Fang Shen, Giselle Nishiguchi, Yun Feng, John Tellew, Vesselina G. Cooke
المصدر: Cancer Research. 78:DDT01-04
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Kinase, Chemistry, MEK inhibitor, Dabrafenib, Raf Kinase Inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, medicine, Cancer research, Signal transduction, Vemurafenib, Protein kinase A, medicine.drug
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المؤلفون: Wei Shu, Sean P. Brown, Allan S. Wagman, Kirk W. Johnson, Dane Goff, Eric Fang, Vincent P. Le, Keith B. Pfister, Zhi-Jie Ni, Rustum S. Boyce, Paul A. Renhowe, Dirksen E. Bussiere, Stephen D. Harrison, Xiaohui A. Zhou, Barry Levine, David B. Ring, Cynthia M. Shafer, Savithri Ramurthy, Johanna M. Jansen, Sharadha Subramanian, Simon Ng, John M. Nuss
المصدر: Journal of Medicinal Chemistry. 60:8482-8514
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Proton Magnetic Resonance Spectroscopy, medicine.medical_treatment, CHO Cells, Crystallography, X-Ray, 01 natural sciences, Mass Spectrometry, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, GSK-3, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Enzyme Inhibitors, Glycogen synthase, Chromatography, High Pressure Liquid, biology, 010405 organic chemistry, Chemistry, Chinese hamster ovary cell, Insulin, Glycogen Synthase Kinases, biology.organism_classification, Rats, 0104 chemical sciences, Pyrimidines, 030104 developmental biology, biology.protein, Molecular Medicine, Amine gas treating, Linker
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المؤلفون: Xiaoyu Shen, William S. Sawyer, Micah Steffek, Wooseok Han, Tsuyoshi Uehara, Andreas O. Frank, Sharadha Subramanian, Alexey Ruzin, Feng Wang, Alexandra Frommlet, C. M. Baxter Rath, Hanne Merritt, Min Li, Alun Bermingham, Elizabeth Ornelas, Jason Vo, Fergal Casey, B. Chie-Leon, Andreas Lingel, Bret Benton, Xiaolei Ma, Steven Shia, Carl J. Balibar, G. de Pascale, Jacob Shaul, Patrick Lee, Dita M. Rasper, Min-Kyu Cho, Charles Wartchow, Sylvia Ma, Chi-Min Ho, Katherine R Prosen, Ramadevi Prathapam
مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, Biochemistry, Chemistry, Drug discovery, Acyltransferase, medicine, Wild type, medicine.disease_cause, Uncompetitive inhibitor, Antibacterial activity, Small molecule, Escherichia coli
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المؤلفون: Stephen Basham, Brent A. Appleton, Rama Jain, Lina Setti, Savithri Ramurthy, Paul Feucht, Jiong Lan, Anne B. Jefferson, Laura Doyle, Bob Warne, Mika Lindvall, Sharadha Subramanian, Gordana Atallah, Michelle Mathur, Abran Costales, Cynthia M. Shafer
المصدر: Bioorganicmedicinal chemistry letters. 28(19)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Ring (chemistry), Biochemistry, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Phenols, In vivo, Drug Discovery, Pyridine, Moiety, Molecule, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Hydrogen bond, Organic Chemistry, In vitro, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, Chromatography, Liquid
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المؤلفون: Anne B. Jefferson, Lina Setti, Mika Lindvall, Savithri Ramurthy, Stephen Basham, Bob Warne, Laura Doyle, Rama Jain, Brent A. Appleton, Paul Feucht, Cynthia M. Shafer, Sharadha Subramanian, Gordana Atallah, Abran Costales, Jiong Lan, Michelle Mathur
المصدر: Journal of Medicinal Chemistry. 58:6766-6783
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Pyridines, Crystallography, X-Ray, Ribosomal Protein S6 Kinases, 90-kDa, Cell Line, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Protein structure, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Chemistry, Kinase, In vitro, Pyrimidines, Biochemistry, Cell culture, Cancer cell, Pyrazoles, Molecular Medicine, Y-Box-Binding Protein 1, Signal transduction, Signal Transduction
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المؤلفون: Yan Lou, Sharadha Subramanian, Yingyun Wang, Lifeng Wan, John Tellew, Laura Tandeske, Benjamin R. Taft, Kalyani Gampa, Jacob R. Haling, Gisele Nishiguchi, Lina Setti, Alice Rico, Sylvia Ma, Payman Amiri, Mallika Singh, Huw Tanner, Brent A. Appleton, Robert J. Aversa, Sepideh Vaziri, Shenlin Huang, Johanna M. Jansen, Anne Van Abbema, Jing Yuan, Vesselina G. Cooke, Hanne Merritt, Aaron Smith, Wenlin Shao, Valery Polyakov, Fei Feng, Savithri Ramurthy, Matthew Burger, Mulugeta Mamo, Lesley A. Mathews Griner, Vijay Sethuraman, Victoriano Tamez, Michael Patrick Dillon, Emma Lees, Ina Dix, Paul A. Barsanti, Richard Zang, Darrin Stuart, Mohammad Hekmat-Nejad
المصدر: Journal of medicinal chemistry. 60(12)
مصطلحات موضوعية: 0301 basic medicine, Proto-Oncogene Proteins B-raf, Mutant, Antineoplastic Agents, medicine.disease_cause, Crystallography, X-Ray, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, 2,2'-Dipyridyl, Dogs, Drug Stability, Neoplasms, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, c-Raf, Molecular Targeted Therapy, Benzamide, Chemistry, Kinase, Drug discovery, Small molecule, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, Benzamides, ras Proteins, Molecular Medicine, raf Kinases, KRAS
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المؤلفون: Sharadha Subramanian, Anne B. Jefferson, Ida Aronchik, Cynthia M. Shafer, Paul Feucht, Gordana Atallah, Elizabeth Ornelas, Abran Costales, Bob Warne, Mika Lindvall, Michelle Mathur, Lina Setti, Brent A. Appleton, Laura Doyle, Rama Jain, Stephen Basham, Jiong Lan, Savithri Ramurthy
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1592-1596
مصطلحات موضوعية: Benzoxazoles, Binding Sites, Molecular model, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Molecular Dynamics Simulation, Benzoxazole, Crystallography, X-Ray, Ribosomal Protein S6 Kinases, 90-kDa, Biochemistry, In vitro, Protein Structure, Tertiary, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Medicine, Protein Kinase Inhibitors, Molecular Biology, Protein Binding
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المؤلفون: Aurélie Winterhalter, Sharadha Subramanian, Tiffany Tsang, Jean-Michel Florent, Stephen F. Hardy, Laura Tandeske, Armin Widmer, Arndt Meyer, Johanna M. Jansen, Charles Wartchow, S. Rieffel, Stephania Widger, Yumin Dai, Tatiana Zavorotinskaya, Savithri Ramurthy, Dove Jeffrey H, Yun Feng, Julia Klopp, Isabel Zaror, Kenneth Crawford, Alvar D. Gossert, Susan Fong, Darrin Stuart, Yuji Mishina, John Fuller, Gwynn Pardee, Andreas Lingel, Lenahan William P, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Eric Fang, Dirksen E. Bussiere, Sylvia Ma, Wolfgang Jahnke, Jan Marie Cheng, Chrystèle Henry
المصدر: PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
PLoS ONE, 12 (4)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Cell Membranes, lcsh:Medicine, medicine.disease_cause, 01 natural sciences, Biochemistry, Binding Analysis, lcsh:Science, Multidisciplinary, Drug discovery, Effector, Physics, In vitro toxicology, Assay, Chemical Reactions, Lipids, Insects, Chemistry, Physical Sciences, KRAS, Cellular Structures and Organelles, Cell Binding Assay, Research Article, Arthropoda, Chemical biology, Biophysics, Biology, Research and Analysis Methods, Cell Line, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Prenylation, Cell Line, Tumor, medicine, Animals, Humans, Vesicles, Chemical Characterization, 010405 organic chemistry, lcsh:R, Organisms, Biology and Life Sciences, Membrane Proteins, Cell Biology, Invertebrates, 0104 chemical sciences, 030104 developmental biology, Membrane protein, Liposomes, lcsh:Q
وصف الملف: application/application/pdf
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المؤلفون: Cynthia M. Shafer, Barry Levine, Paul A. Renhowe, Johanna M. Jansen, Savithri Ramurthy, Sharadha Subramanian, Abran Costales
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1678-1681
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Enzyme activator, Heterocyclic Compounds, Drug Discovery, Humans, Enzyme Inhibitors, Binding site, Molecular Biology, Cells, Cultured, Binding Sites, Molecular Structure, Chemistry, Kinase, Organic Chemistry, Raf kinase, Amides, In vitro, Enzyme Activation, Drug Design, Molecular Medicine, raf Kinases, Selectivity, V600E
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المؤلفون: Sharadha Subramanian, Song Lin, Abran Costales, Hashash Ahmad, Mina Aikawa, Leonard Sung, Johanna M. Jansen, Savithri Ramurthy, Cynthia M. Shafer, Paul A. Renhowe, Joelle Verhagen, Payman Amiri, Sylvia Ma
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3286-3289
مصطلحات موضوعية: Models, Molecular, Binding Sites, Molecular Structure, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Raf kinase, Amides, Biochemistry, In vitro, Enzyme Activation, Structure-Activity Relationship, Heterocyclic Compounds, Drug Design, Drug Discovery, Molecular Medicine, raf Kinases, Enzyme Inhibitors, Molecular Biology, Cell Proliferation
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13
المؤلفون: Pick Teresa E, Darrin Stuart, Poon Daniel J, Johanna M. Jansen, Barry Levine, Mina Aikawa, Susan Fong, Jonah Michaelian, Leonard Sung, Christopher McBride, Cynthia M. Shafer, Savithri Ramurthy, Paul A. Renhowe, Sandhya Girish, Sylvia Ma, Dove Jeffrey H, Sharadha Subramanian, Abran Costales, Payman Amiri
المصدر: Journal of Medicinal Chemistry. 51:7049-7052
مصطلحات موضوعية: Models, Molecular, Administration, Oral, Biological Availability, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Cytotoxicity, Protein Kinase Inhibitors, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Stereoisomerism, Xenograft Model Antitumor Assays, In vitro, Protein Structure, Tertiary, Enzyme, Biochemistry, Enzyme inhibitor, Drug Design, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Benzimidazoles, Female, raf Kinases
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المؤلفون: Joelle Verhagen, Brent A. Appleton, Cynthia M. Shafer, Sharadha Subramanian, Louie Alicia, Abran Costales, William R. Antonios-Mccrea, Kimberly Aardalen, Maureen Mckenna, Darrin Stuart, Paul A. Renhowe, Leonard Sung, Barry Levine, Teresa E. Williams, Timothy D. Machajewski, Savithri Ramurthy, James Chou, Daniel Poon, Christopher McBride, Payman Amiri
المصدر: ACS medicinal chemistry letters. 6(9)
مصطلحات موضوعية: MAPK/ERK pathway, Metastatic melanoma, business.industry, Kinase, Organic Chemistry, Bioinformatics, Biochemistry, Clinical trial, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, Cancer research, Medicine, business, Tyrosine kinase
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المؤلفون: Lina Setti, Robert J. Aversa, Rama Jain, George Thomas, Savithri Ramurthy, Lorena Taricani, Robert Elling, Mark Knapp, Paul A. Barsanti, Yipin Lu, Matthew Cox, Michelle Mathur, Yue Pan, Xianming Jin, Patrick J Rudewicz, Cheng Hu, Michael Patrick Dillon, Qin Yue, Sharadha Subramanian, Jiong Lan, Linda Xiao
مصطلحات موضوعية: Indole test, CYP3A4, biology, Organic Chemistry, hERG, Pharmacology, Biochemistry, chemistry.chemical_compound, chemistry, Morpholine, Drug Discovery, biology.protein, Moiety, Efflux, Aldehyde oxidase, Ion channel
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المؤلفون: Darrin Stuart, Teresa E. Williams, Daniel Poon, Savithri Ramurthy, Payman Amiri, Sharadha Subramanian, Cynthia M. Shafer, Abran Costales, Barry Levine, Joelle Verhagen, Paul A. Renhowe, Christopher McBride
المصدر: ACS medicinal chemistry letters. 5(9)
مصطلحات موضوعية: MAPK/ERK pathway, Benzimidazole, biology, Organic Chemistry, MAPK7, Biochemistry, MAP2K7, chemistry.chemical_compound, chemistry, In vivo, Mitogen-activated protein kinase, Drug Discovery, biology.protein, c-Raf, Tyrosine kinase
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المؤلفون: J. P. Chinn, Hilary Dorr, Dane Goff, L. Wang, Paul A. Renhowe, Rajinder Singh, John M. Nuss, Ronald N. Zuckermann, Sharadha Subramanian, Edward G. Brown, Manoj C. Desai
المصدر: Pure and Applied Chemistry. 69:447-452
مصطلحات موضوعية: Peptidomimetic, Chemistry, Drug discovery, General Chemical Engineering, General Chemistry, Computational biology, respiratory system, human activities, Combinatorial chemistry, Small molecule, Diversity (business)
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المؤلفون: Sharadha Subramanian, Dane Goff, Manoj C. Desai, J. P. Chinn, Edward G. Brown, Hilary Dorr, L. Wang, Ronald N. Zuckermann, John M. Nuss, Paul A. Renhowe, Rajinder Singh
المصدر: ChemInform. 28
مصطلحات موضوعية: Focus (computing), Chemistry, Drug discovery, Peptidomimetic, General Medicine, Computational biology, respiratory system, human activities, Small molecule, Diversity (business)
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المؤلفون: Alvar D. Gossert, Dove Jeffrey H, Sharadha Subramanian, Susan Fong, Bill Lenahan, Gwynn Pardee, Simona Gokhin, Andreas Lingel, Arndt Meyer, Savithri Ramurthy, Laura Tandeske, David Farley, Charles Wartchow, Tatiana Zavorotinskaya, Julia Klopp, John Fuller, Kevin Shoemaker, Eric Fang, Anke Blechschmidt, Yumin Dai, Chrystèle Henry, Isabel Zaror, Dirksen E. Bussiere, Wolfgang Jahnke, Jean-Michel Florent, C. Gregory Paris, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Johanna M. Jansen, Stephen F. Hardy, Armin Widmer, Stephania Widger, Tiffany Tsang, Paul A. Renhowe, S. Rieffel
المصدر: Molecular Cancer Research. 12:B38-B38
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Effector, Activator (genetics), Context (language use), Biology, medicine.disease_cause, Amino acid, A-site, Oncology, chemistry, Prenylation, Biochemistry, medicine, KRAS, Binding site, Molecular Biology
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المؤلفون: Joelle Verhagen, Teresa E. Williams, Payman Amiri, Paul A. Renhowe, Daniel Poon, Darrin Stuart, Christopher McBride, Sharadha Subramanian, Abran Costales, Barry Levine, Savithri Ramurthy, Cynthia M. Shafer
المصدر: ACS Medicinal Chemistry Letters. 5:1340-1340
مصطلحات موضوعية: Benzimidazole, chemistry.chemical_compound, chemistry, Biochemistry, business.industry, Organic Chemistry, Drug Discovery, Medicine, Raf kinase, Bioinformatics, business
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