المؤلفون: Ricky Lieu, Stephen Antonysamy, Zhanna Druzina, Carolyn Ho, N. Rebecca Kang, Anna Pustilnik, Jing Wang, Shane Atwell, Bostjan Kobe

المصدر: PLoS ONE, Vol 15, Iss 9 (2020)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485759/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/71c535ead04e47c7ac68c439f0278250

المؤلفون: Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b253da2b8af69b57f61a86d3221a13f9
https://doi.org/10.1158/1535-7163.22485138

المؤلفون: Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53a296e3d5b8a6d460e10e97860b5a
https://doi.org/10.1158/1535-7163.22485141.v1

المؤلفون: Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265be7461b5631c4751aa9dac9de05d6
https://doi.org/10.1158/1535-7163.c.6531795.v1

المؤلفون: Joseph D. Ho, Michelle C. Vargas, Jing Wang, Junliang Hao, Shane Atwell, James A. Monn, Sheela Ashok, Mark G. Bures, Qi Chen, Jeffery M. Schkeryantz

المصدر: Journal of Medicinal Chemistry. 61:10040-10052

مصطلحات موضوعية: 0301 basic medicine, Agonist, Chemistry, Stereochemistry, medicine.drug_class, Protein domain, Crystal structure, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Discovery, medicine, Molecular Medicine, DCPG, Homology modeling, Binding site, Selectivity, Receptor, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::33be9a640f18a032be5e1bd51cd0d5b7
https://doi.org/10.1021/acs.jmedchem.8b01120

المؤلفون: Shane Atwell, Petra Verdino, S.J. Demarest

المصدر: Current Opinion in Chemical Engineering. 19:107-123

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Bispecific antibody, Protein therapeutics, business.industry, medicine.drug_class, The Renaissance, Computational biology, Monoclonal antibody, Epitope, Immunological synapse, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, General Energy, Antigen, 030220 oncology & carcinogenesis, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7c4d376af7a96bb0b009441c8f04cfb
https://doi.org/10.1016/j.coche.2018.01.004

المؤلفون: Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow

المصدر: Journal of Medicinal Chemistry. 61:2303-2328

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Agonist, Bicyclic molecule, Stereochemistry, medicine.drug_class, Glutamate binding, Ligand (biochemistry), Small molecule, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Metabotropic receptor, Dicarboxylic acid, chemistry, Drug Discovery, medicine, Molecular Medicine, Receptor, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481

المؤلفون: Alicia Torrado, Shane Atwell, Timothy B. Durham, Njoroge F George, Timothy I. Meier, Brandon J. Margolis, Stefan Jon Thibodeaux, Yu-Hua Hui, Robert Dean Dally, Kevin Robert Fales, Kenneth Jeff Thrasher, James Lee Toth, Jing Wang, Kwame Frimpong, Susan A. Konicek, Yong Wang, Chong Si, Kenneth D. Roth, Matthew Lee, Zhipei Wu, Jefferson R. Mc Cowan, Timothy Alan Shepherd, Sandaruwan Geeganage, Harold B. Brooks

المصدر: Journal of Medicinal Chemistry. 60:9599-9616

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Purine, Ribonucleotide, Mice, Nude, Antineoplastic Agents, Triple Negative Breast Neoplasms, Thiophenes, Phosphoribosylaminoimidazolecarboxamide Formyltransferase, Mice, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Breast, Cell Proliferation, Sulfonamides, Phosphoribosylaminoimidazolecarboxamide formyltransferase, Cell growth, Cancer, medicine.disease, Oncolytic virus, 030104 developmental biology, chemistry, Biochemistry, Antifolate, Cancer research, Folic Acid Antagonists, Molecular Medicine, Female, Growth inhibition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b243bbece7ad1a8ca057dbf632832ff1
https://doi.org/10.1021/acs.jmedchem.7b01046

المؤلفون: Holly A. Bina, Bryan Edward Jones, Yan Ji, Jirong Lu, Victor J. Wroblewski, Robert J. Benschop, Qing Chai, Stacy Torgerson, Barrett Allan, James Nelson, Shane Atwell, Ningjie Hu, Chi-Kin Chow, Yu Tian, David K. Clawson, Mahmoud Ghanem, Barbra Barmettler, J.R. Fitchett, Joseph Manetta

المصدر: MAbs

مصطلحات موضوعية: Immunology, Protein Data Bank (RCSB PDB), chemical and pharmacologic phenomena, Mice, Transgenic, Antibodies, Monoclonal, Humanized, Autoimmune Diseases, 03 medical and health sciences, Mice, 0302 clinical medicine, Report, Antibodies, Bispecific, B-Cell Activating Factor, medicine, Immunology and Allergy, Animals, Humans, B-cell activating factor, B cell, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Interleukin-17, Protein engineering, Molecular biology, Amino acid, Tabalumab, Macaca fascicularis, medicine.anatomical_structure, HEK293 Cells, 030220 oncology & carcinogenesis, biology.protein, Female, Antibody, Linker, HT29 Cells, Single-Chain Antibodies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875fe1f65f13696c2fbf292fb27f362d
https://pubmed.ncbi.nlm.nih.gov/31181988

المؤلفون: Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy

المصدر: Journal of Medicinal Chemistry. 59:10974-10993

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Metabotropic glutamate receptor 5, Hydrochloride, medicine.drug_class, Stereochemistry, Antagonist, Receptor antagonist, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Dicarboxylic acid, Metabotropic receptor, chemistry, APICA, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119

المؤلفون: Qi, Chen, Joseph D, Ho, Sheela, Ashok, Michelle C, Vargas, Jing, Wang, Shane, Atwell, Mark, Bures, Jeffery M, Schkeryantz, James A, Monn, Junliang, Hao

المصدر: Journal of medicinal chemistry. 61(22)

مصطلحات موضوعية: Models, Molecular, Binding Sites, Protein Domains, Drug Design, Glycine, Humans, Ligands, Receptors, Metabotropic Glutamate, Benzoates

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::abe467531ff4115e443495ba4bed0c79
https://pubmed.ncbi.nlm.nih.gov/30365309

المؤلفون: Yilin Meng, Cen Gao, Michal Vieth, Shane Atwell, Marijane Russell, Benoît Roux, David K. Clawson

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Allosteric regulation, Computational biology, Molecular Dynamics Simulation, 01 natural sciences, Myristic Acid, Article, 03 medical and health sciences, Molecular dynamics, Protein structure, Adenosine Triphosphate, 0103 physical sciences, Physical and Theoretical Chemistry, Proto-Oncogene Proteins c-abl, ABL, 010304 chemical physics, Markov chain, Chemistry, Drug discovery, Energy landscape, Markov Chains, Computer Science Applications, Kinetics, 030104 developmental biology, Thermodynamics, Target protein, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f561d0d49719d28f107f83c9e480c8e
https://europepmc.org/articles/PMC6317529/

المؤلفون: Chi-Kin Chow, Barrett Allan, Shane Atwell, Jirong Lu, Qing Chai

المصدر: Molecular Pharmaceutics. 13:915-923

مصطلحات موضوعية: 0301 basic medicine, Work (thermodynamics), Low protein, Protein Conformation, Liquid-Liquid Extraction, Analytical chemistry, Pharmaceutical Science, Crystal structure, Flory–Huggins solution theory, Protein Engineering, 030226 pharmacology & pharmacy, law.invention, 03 medical and health sciences, Viscosity, 0302 clinical medicine, Dynamic light scattering, law, Drug Discovery, Humans, Crystallization, Chemistry, Osmolar Concentration, Antibodies, Monoclonal, Hydrogen-Ion Concentration, Pharmaceutical Solutions, 030104 developmental biology, Amino Acid Substitution, Virial coefficient, Immunoglobulin G, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefe4ed667b6be2d4cfea26817194d24
https://doi.org/10.1021/acs.molpharmaceut.5b00817

المؤلفون: Louise C. Pyle, Steve Aller, Hal A. Lewis, Wei Wang, Eric J. Sorscher, Gergely L. Lukacs, Shane Atwell, Christine E. Bear, W. Joon Chung, Annette Ehrhardt, Kryzysztof Nowotarski, Kevin L. Kirk, Cory M. Mulvihill, Jeong S. Hong, Mohabir Ramjeesingh, Sadanandan E. Velu

المصدر: Journal of Biological Chemistry. 291:1854-1865

مصطلحات موضوعية: 0301 basic medicine, Molecular Sequence Data, Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding cassette transporter, macromolecular substances, Biology, Biochemistry, Cystic fibrosis, 03 medical and health sciences, Adenosine Triphosphate, ATP hydrolysis, medicine, Humans, Amino Acid Sequence, Molecular Biology, Ion transporter, Binding Sites, musculoskeletal, neural, and ocular physiology, Hydrolysis, Cell Biology, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Protein Structure, Tertiary, Cell biology, Kinetics, Transmembrane domain, 030104 developmental biology, nervous system, Cyclic nucleotide-binding domain, Protein Structure and Folding, Chloride channel, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e67c85caf3010f2c2149f230fd0fb4
https://doi.org/10.1074/jbc.m115.704809

المؤلفون: Mark G. Bures, David Edward Tupper, Joan H. Carter, James A. Monn, David L. McKinzie, Marijane Russell, Lourdes Prieto, Steven S. Henry, Reinhard Matthew Robert, Alicia Marcos, Lesley Walton, Christopher David Beadle, Bryan G. Johnson, Brian G. Getman, John T. Catlow, Frances Lu, Xushan Wang, Lorena Taboada, S. Richard Baker, Beverly A. Heinz, Helene Rudyk, David B. Shaw, Jaime Blanco, Carlos Lamas, Steven Swanson, David K. Clawson, Junliang Hao, Carlos Montero, Teresa Man, Shane Atwell, Barry Peter Clark, Jing Wang

المصدر: Journal of Medicinal Chemistry. 58:7526-7548

مصطلحات موضوعية: Agonist, chemistry.chemical_classification, Bicyclic molecule, medicine.drug_class, Stereochemistry, Allosteric regulation, Stereoisomerism, Partial agonist, Dicarboxylic acid, Protein structure, chemistry, Biochemistry, Drug Discovery, medicine, Molecular Medicine, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::13d4b305d2ec1acea2f3d473c73251c1
https://doi.org/10.1021/acs.jmedchem.5b01124

المؤلفون: James A, Monn, Steven S, Henry, Steven M, Massey, David K, Clawson, Qi, Chen, Benjamin A, Diseroad, Rajni M, Bhardwaj, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xu-Shan, Wang, Joan H, Carter, Brian G, Getman, Kofi, Adragni, Lisa M, Broad, Helene E, Sanger, Daniel, Ursu, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie, Junliang, Hao

المصدر: Journal of medicinal chemistry. 61(6)

مصطلحات موضوعية: Male, Models, Molecular, Neurons, Molecular Structure, Phencyclidine, Motor Activity, Crystallography, X-Ray, Receptors, Metabotropic Glutamate, Rats, Molecular Docking Simulation, Rats, Sprague-Dawley, Bridged Bicyclo Compounds, Cyclic AMP, Excitatory Amino Acid Agonists, Animals, Humans, Excitatory Amino Acid Antagonists, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0b0a91b923b376e1620dd4223a841b23
https://pubmed.ncbi.nlm.nih.gov/29350927

المؤلفون: Junliang Hao, Matt R. Reinhard, Barry Peter Clark, Jaime Blanco, Concepción Pedregal, Shane Atwell, Michael P. Johnson, Paul Goldsmith, Carlos Montero, Rosa Maria A. Simmons, James A. Monn, Steven Swanson, Chuanxi Xiang, Bryan G. Johnson, Frances Lu, Lorena Taboada, Teresa Man, David K. Clawson, Marijane Russell, Lesley Walton, Steven S. Henry, Jing Wang, Beverly A. Heinz, S. Richard Baker, Helen E. Sanger, Xushan Wang, David B. Shaw, Lourdes Prieto, Mark G. Bures, Joan H. Carter, Lisa M. Broad, Kelly L. Knopp, Helene Rudyk, David L. McKinzie, David Edward Tupper, Christopher David Beadle, John T. Catlow, Carlos Lamas, Alicia Marcos

المصدر: Journal of Medicinal Chemistry. 58:1776-1794

مصطلحات موضوعية: Agonist, Chemistry, medicine.drug_class, Stereochemistry, Metabotropic glutamate receptor 5, Receptor agonist activity, Biochemistry, Metabotropic glutamate receptor, Drug Discovery, medicine, Molecular Medicine, Metabotropic glutamate receptor 1, Inverse agonist, Metabotropic glutamate receptor 2, Endogenous agonist

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::527bce29ceb86979086e1027b9d87633
https://doi.org/10.1021/jm501612y

المؤلفون: Jeffery M. Schkeryantz, Qi Chen, Joseph D. Ho, Shane Atwell, Aiping Zhang, Michelle C. Vargas, Jing Wang, James A. Monn, Junliang Hao

المصدر: Bioorganicmedicinal chemistry letters. 28(4)

مصطلحات موضوعية: 0301 basic medicine, Aminobutyrates, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Glutamic Acid, Crystallography, X-Ray, Ligands, Receptors, Metabotropic Glutamate, 01 natural sciences, Biochemistry, Recombinant Proteins, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, 030104 developmental biology, Protein Domains, Drug Discovery, Molecular Medicine, Humans, Molecular Biology, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662502c4305171f5c54aa8953f44db3f
https://pubmed.ncbi.nlm.nih.gov/29402739

المؤلفون: Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: Male, Models, Molecular, Behavior, Animal, Dose-Response Relationship, Drug, Molecular Structure, Brain, Mice, Inbred Strains, Motor Activity, Receptors, Metabotropic Glutamate, Antidepressive Agents, Mice, Structure-Activity Relationship, Cyclohexanes, Drug Discovery, Animals, Humans, Swimming

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967

المؤلفون: Josef G. Heuer, Zhanna Druzina, Shane Atwell, Derrick R. Witcher, Jeffrey S. Boyles

مصطلحات موضوعية: 0301 basic medicine, TGF alpha, Biology, Biochemistry, Epiregulin, 03 medical and health sciences, Epitopes, Immunoglobulin Fab Fragments, Mice, 0302 clinical medicine, Amphiregulin, Epidermal growth factor, Antibody Specificity, Animals, Humans, Epidermal growth factor receptor, Molecular Biology, Betacellulin, Articles, Transforming Growth Factor alpha, Molecular biology, Antibodies, Neutralizing, Cell biology, 030104 developmental biology, Epigen, 030220 oncology & carcinogenesis, biology.protein, Conformational epitope

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f782eb70387dda6f9010a3f67ea2d1
https://europepmc.org/articles/PMC5079263/