المؤلفون: Fuhs, Dominika T., Cortés-Lara, Sara, Tait, Jessica R., Rogers, Kate E., López-Causapé, Carla, Lee, Wee Leng, Shackleford, David M., Nation, Roger L., Oliver, Antonio, Landersdorfer, Cornelia B.

المصدر: Clinical Microbiology and Infection ; volume 30, issue 10, page 1276-1283 ; ISSN 1198-743X

الاتاحة: https://doi.org/10.1016/j.cmi.2024.06.026
https://api.elsevier.com/content/article/PII:S1198743X24003069?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1198743X24003069?httpAccept=text/plain

المؤلفون: Nie, Zhe, Bonnert, Roger, Tsien, Jet, Deng, Xiaoyi, Higgs, Christopher, El Mazouni, Farah, Zhang, Xiaoyu, Li, Renzhe, Ho, Nhi, Feher, Victoria, Paulsen, Janet, Shackleford, David M., Katneni, Kasiram, Chen, Gong, Ng, Alice C. F., McInerney, Mitchell, Wang, Wen, Saunders, Jessica, Collins, Daniel, Yan, Dandan, Li, Peng, Campbell, Michael, Patil, Rahul, Ghoshal, Atanu, Mondal, Pallab, Kundu, Abhijit, Chittimalla, Rajesh, Mahadeva, Muralikumar, Kokkonda, Sreekanth, White, John, Das, Rishi, Mukherjee, Partha, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Malmstrom, Robert, Lawrenz, Morgan, Rodriguez-Granillo, Agustina, Rathod, Pradipsinh K., Tomchick, Diana R., Palmer, Michael J., Laleu, Benoît, Qin, Tian, Charman, Susan A., Phillips, Margaret A.

المساهمون: Welch Foundation, Bill and Melinda Gates Foundation, Medicines for Malaria Venture, U.S. Department of Energy, National Institutes of Health

المصدر: Journal of Medicinal Chemistry ; volume 68, issue 1, page 590-637 ; ISSN 0022-2623 1520-4804

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c02394
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c02394

المؤلفون: Nie, Zhe, Bonnert, Roger, Tsien, Jet, Deng, Xiaoyi, Higgs, Christopher, El Mazouni, Farah, Zhang, Xiaoyu, Li, Renzhe, Ho, Nhi, Feher, Victoria, Paulsen, Janet, Shackleford, David M., Katneni, Kasiram, Chen, Gong, Ng, Alice C. F., McInerney, Mitchell, Wang, Wen, Saunders, Jessica, Collins, Daniel, Yan, Dandan

المصدر: Journal of Medicinal Chemistry; 1/9/2025, Vol. 68 Issue 1, p590-637, 48p

المؤلفون: Braillard, Stéphanie, Keenan, Martine, Breese, Karen J., Heppell, Jacob, Abbott, Michael, Islam, Rafiqul, Shackleford, David M., Katneni, Kasiram, Crighton, Elly, Chen, Gong, Patil, Rahul, Lee, Given, White, Karen L., Carvalho, Sandra, Wall, Richard J., Chemi, Giulia, Zuccotto, Fabio, Gonzalez, Silvia, Marco, Maria, Deakyne, Julianna, Standing, David, Brunori, Gino, Lyon, Jonathan J., Castañeda-Casado, Pablo, Camino, Isabel, Martinez Martinez, Maria S., Zulfiqar, Bilal, Avery, Vicky M., Feijens, Pim-Bart, Van Pelt, Natascha, Matheeussen, An, Hendrickx, Sarah, Maes, Louis, Caljon, Guy, Yardley, Vanessa, Wyllie, Susan, Charman, Susan A., Chatelain, Eric

المصدر: Braillard , S , Keenan , M , Breese , K J , Heppell , J , Abbott , M , Islam , R , Shackleford , D M , Katneni , K , Crighton , E , Chen , G , Patil , R , Lee , G , White , K L , Carvalho , S , Wall , R J , Chemi , G , Zuccotto , F , Gonzalez , S , Marco , M , Deakyne , J , Standing , D , Brunori , G , Lyon , J J , Castañeda-Casado , ....

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/834df077-1345-4a01-bd6b-8f58a6c672e7
https://doi.org/10.1126/scitranslmed.adh9902
https://discovery.dundee.ac.uk/ws/files/116343034/adh9902_Article_Content_Suppl_Info_Combined_FINAL_17112023_CLEAN.pdf

المؤلفون: Francisco, Amanda F, Chen, Gong, Wang, Wen, Sykes, Melissa L, Escudié, Fanny, Scandale, Ivan, Olmo, Francisco, Shackleford, David M, Zulfiqar, Bilal, Kratz, Jadel M, Pham, Thao, Saunders, Jessica, Hu, Meiyu, Avery, Vicky M, Charman, Susan A, Kelly, John M, Chatelain, Eric

وصف الملف: text

Relation: https://researchonline.lshtm.ac.uk/id/eprint/4671151/5/Francisco-etal-2023-Preclinical-data-do-not-support-the-use-of-amiodarone-or-dronedarone-as-antiparasitic-drugs-for-Chagas-disease.pdf; Francisco, Amanda F ; Chen, Gong; Wang, Wen; Sykes, Melissa L; Escudié, Fanny; Scandale, Ivan; Olmo, Francisco; Shackleford, David M; Zulfiqar, Bilal; Kratz, Jadel M; +7 more. Pham, Thao; Saunders, Jessica; Hu, Meiyu; Avery, Vicky M; Charman, Susan A; Kelly, John M ; Chatelain, Eric; (2023) Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen. Frontiers in tropical diseases, 4. DOI: https://doi.org/10.3389/fitd.2023.1254061

الاتاحة: https://researchonline.lshtm.ac.uk/id/eprint/4671151/
https://researchonline.lshtm.ac.uk/id/eprint/4671151/5/Francisco-etal-2023-Preclinical-data-do-not-support-the-use-of-amiodarone-or-dronedarone-as-antiparasitic-drugs-for-Chagas-disease.pdf
https://www.frontiersin.org/articles/10.3389/fitd.2023.1254061/full

المؤلفون: Francisco, Amanda F., Chen, Gong, Wang, Wen, Sykes, Melissa L., Escudié, Fanny, Scandale, Ivan, Olmo, Francisco, Shackleford, David M., Zulfiqar, Bilal, Kratz, Jadel M., Pham, Thao, Saunders, Jessica, Hu, Meiyu, Avery, Vicky M., Charman, Susan A., Kelly, John M., Chatelain, Eric

المصدر: Frontiers in Tropical Diseases ; volume 4 ; ISSN 2673-7515

الاتاحة: http://dx.doi.org/10.3389/fitd.2023.1254061
https://www.frontiersin.org/articles/10.3389/fitd.2023.1254061/full

المؤلفون: Leas, Derek A., Keiser, Jennifer, Charman, Susan A., Shackleford, David M., Jones, Jeremy O., Campbell, Michael, Chen, Gong, Katneni, Kasiram, Patil, Rahul, Hu, Meiyu, Pham, Thao, Häberli, Cécile, Schulze, Thomas T., Neville, Andrew J., Wang, Xiaofang, Dong, Yuxiang, Davis, Paul H., Vennerstrom, Jonathan L.

المصدر: ACS Infectious Diseases; 11/8/2024, Vol. 10 Issue 11, p3963-3972, 10p

المؤلفون: Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Gummer, Joel P. A., Olasz, Bence, Nambiar, Shabarinath, Hope, Danika E., Casey, Thomas H., Lee, Y. C. Gary, Leslie, Connull, Nealon, Gareth, Shackleford, David M., Powell, Andrew K., Grimaldi, Marina, Balaguer, Patrick, Zemek, Rachael M., Bosco, Anthony, Piggott, Matthew J., Vrielink, Alice, Lake, Richard A., Lesterhuis, W. Joost

المصدر: Research outputs 2022 to 2026

مصطلحات موضوعية: Biological sciences, Metabolomics, Transcriptomics, Diseases, Life Sciences, Medicine and Health Sciences, Physical Sciences and Mathematics

وصف الملف: application/pdf

Relation: https://ro.ecu.edu.au/ecuworks2022-2026/45; https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=1044&context=ecuworks2022-2026

الاتاحة: https://ro.ecu.edu.au/ecuworks2022-2026/45
https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=1044&context=ecuworks2022-2026

المؤلفون: Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M, Myrand-Lapierre, Marie-Eve, O’Loughlin, Kathleen G, Shackleford, David M, de Almeida, Mariana Justino, Carrillo, Angela K, Clark, Julie A, Dennis, Adelaide SM, Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N, Fedewa, Greg, Guiguemde, W Armand, Gómez, María G, Holbrook, Gloria, Horst, Jeremy, Kim, Charles C, Liu, Jian, Lee, Marcus CS, Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J, Stein, Philip D, Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M, Fidock, David A, Gamo, Francisco-Javier, Charman, Susan A, Mirsalis, Jon C, Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E, DeRisi, Joseph L, Floyd, David M, Guy, R Kiplin

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 111(50)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Antimicrobial Resistance, Infectious Diseases, Orphan Drug, Rare Diseases, Malaria, Vector-Borne Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Antimalarials, Calcium-Transporting ATPases, Cellular Senescence, Drug Discovery, Drug Resistance, Erythrocytes, Flow Cytometry, Heterocyclic Compounds, 4 or More Rings, High-Throughput Screening Assays, Isoquinolines, Models, Molecular, Molecular Structure, Plasmodium, malaria, PfATP4, drug discovery

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6sf76049
https://escholarship.org/content/qt6sf76049/qt6sf76049.pdf

المؤلفون: Gillis, Ryan D., Botteri, Edoardo, Chang, Aeson, Ziegler, Alexandra I., Chung, Ni Chun, Pon, Cindy K., Shackleford, David M., Andreassen, Bettina K., Halls, Michelle L., Baker, Jillian G., Sloan, Erica K.

مصطلحات موضوعية: Carvedilol, Breast cancer, Metastasis, β-adrenergic, Survival

Relation: https://nottingham-repository.worktribe.com/output/5369341; European Journal of Cancer; Volume 147; Pagination 106-116

الاتاحة: https://doi.org/10.1016/j.ejca.2021.01.029
https://nottingham-repository.worktribe.com/file/5369341/1/Carvedilol%20blocks%20neural%20regulation%20of%20breast%20cancer%20progression%20in%20vivo%20and%20is%20associated%20with%20reduced%20breast%20cancer%20mortality%20in%20patients
https://nottingham-repository.worktribe.com/output/5369341

المؤلفون: Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A., Craik, David J.

المصدر: MEDICINE IN DRUG DISCOVERY ; ISSN: 2590-0986

مصطلحات موضوعية: Medicine and Health Sciences, Pharmacology (medical), Drug Discovery, Pharmacology

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/8732739; http://hdl.handle.net/1854/LU-8732739; http://dx.doi.org/10.1016/j.medidd.2021.100087; https://biblio.ugent.be/publication/8732739/file/8732741

الاتاحة: https://biblio.ugent.be/publication/8732739
http://hdl.handle.net/1854/LU-8732739
https://doi.org/10.1016/j.medidd.2021.100087
https://biblio.ugent.be/publication/8732739/file/8732741

المؤلفون: Okaniwa, Masanori, Shibata, Akira, Ochida, Atsuko, Akao, Yuichiro, White, Karen L, Shackleford, David M, Duffy, Sandra, Lucantoni, Leonardo, Dey, Sumanta, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Aguiar, Anna Caroline C, Sturm, Angelika, Crespo, Benigno, Sanz, Laura M, Churchyard, Alisje, Baum, Jake, Pereira, Dhelio B, Guido, Rafael VC, Dechering, Koen J, Wittlin, Sergio, Uhlemann, Anne-Catrin, Fidock, David A, Niles, Jacquin C, Avery, Vicky M, Charman, Susan A, Laleu, Benoît

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: ACS

وصف الملف: application/pdf

Relation: ACS Infectious Diseases; https://hdl.handle.net/1721.1/133582

الاتاحة: https://hdl.handle.net/1721.1/133582

المؤلفون: Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis CK, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Avery, Vicky M

مصطلحات موضوعية: Macromolecular and materials chemistry, Organic chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry

Relation: Journal of Medicinal Chemistry; Laleu, B; Akao, Y; Ochida, A; Duffy, S; Lucantoni, L; Shackleford, DM; Chen, G; Katneni, K; Chiu, FCK; White, KL; Chen, X; Sturm, A; Dechering, KJ; Avery, VMet al., Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials, Journal of Medicinal Chemistry, 2021; http://hdl.handle.net/10072/407383

الاتاحة: http://hdl.handle.net/10072/407383
https://doi.org/10.1021/acs.jmedchem.1c00441

المؤلفون: Priebbenow, Daniel L, Mathiew, Mitch, Shi, Da-Hua, Harjani, Jitendra R, Beveridge, Julia G, Chavchich, Marina, Edstein, Michael D, Duffy, Sandra, Avery, Vicky M, Jacobs, Robert T, Brand, Stephen, Shackleford, David M, Wang, Wen, Zhong, Longjin

مصطلحات موضوعية: Medicinal and biomolecular chemistry, Organic chemistry, Pharmacology and pharmaceutical sciences, Science & Technology, Life Sciences & Biomedicine, Chemistry, Medicinal, Pharmacology & Pharmacy

Relation: Journal of Medicinal Chemistry; Priebbenow, DL; Mathiew, M; Shi, D-H; Harjani, JR; Beveridge, JG; Chavchich, M; Edstein, MD; Duffy, S; Avery, VM; Jacobs, RT; Brand, S; Shackleford, DM; Wang, W; Zhong, L; et al., Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines, Journal of Medicinal Chemistry, 2021, 64 (7), pp. 4150-4162; http://hdl.handle.net/10072/404978

الاتاحة: http://hdl.handle.net/10072/404978
https://doi.org/10.1021/acs.jmedchem.1c00044

المؤلفون: Finkelstein, David I., Billings, Jessica L., Adlard, Paul A., Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L., Wilkins, Simon, Shackleford, David M., Charman, Susan A., Bal, Wojciech, Zawisza, Izabela A., Kurowska, Ewa, Gundlach, Andrew L., Ma, Sheri, Bush, Ashley I., Hare, Dominic J., Doble, Philip A., Crawford, Simon, Gautier, Elisabeth C. L., Parsons, Jack, Huggins, Penny, Barnham, Kevin J., Cherny, Robert A.

المصدر: Acta Neuropathologica Communications ; volume 9, issue 1 ; ISSN 2051-5960

الاتاحة: https://doi.org/10.1186/s40478-021-01258-8
https://link.springer.com/content/pdf/10.1186/s40478-021-01258-8.pdf
https://link.springer.com/article/10.1186/s40478-021-01258-8/fulltext.html

المؤلفون: Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L., Shackleford, David M., O’Loughlin, Kathleen G., Charman, Susan A., Mirsalis, Jon C., Guy, R. Kiplin

المساهمون: National Institute of Allergy and Infectious Diseases, Medicines for Malaria Venture, NHMRC, St. Jude Children's Research Hospital, American Lebanese Syrian Associated Charities

المصدر: Malaria Journal ; volume 20, issue 1 ; ISSN 1475-2875

الاتاحة: http://dx.doi.org/10.1186/s12936-021-03617-1
http://link.springer.com/content/pdf/10.1186/s12936-021-03617-1.pdf
http://link.springer.com/article/10.1186/s12936-021-03617-1/fulltext.html

المؤلفون: Shackleford, David M., Chiu, Francis C. K., Katneni, Kasiram, Blundell, Scott, McLaren, Jenna, Wang, Xiaofang, Zhou, Lin, Sriraghavan, Kamaraj, Alker, André M., Hunziker, Daniel, Scheurer, Christian, Zhao, Qingjie, Dong, Yuxiang, Möhrle, Jörg J., Abla, Nada, Matile, Hugues, Wittlin, Sergio, Vennerstrom, Jonathan L., Charman, Susan A.

المساهمون: Medicines for Malaria Venture, Nebraska Research Initiative

المصدر: ACS Infectious Diseases ; volume 7, issue 7, page 1885-1893 ; ISSN 2373-8227 2373-8227

الاتاحة: http://dx.doi.org/10.1021/acsinfecdis.1c00225
https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00225

المؤلفون: Charman, Susan A., Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C.K., Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M., White, Karen L., Almond, Lisa, Dickins, Maurice, Smith, Dennis A., Moehrle, Joerg J., Burrows, Jeremy N., Abla, Nada

المصدر: Charman , S A , Andreu , A , Barker , H , Blundell , S , Campbell , A , Campbell , M , Chen , G , Chiu , F C K , Crighton , E , Katneni , K , Morizzi , J , Patil , R , Pham , T , Ryan , E , Saunders , J , Shackleford , D M , White , K L , Almond , L , Dickins , M , Smith , D A , Moehrle , J J , Burrows , J N & Abla , N ....

مصطلحات موضوعية: Anti-malarial drugs, Biorelevant solubility, Blood to plasma partitioning, CYP inhibition, Ionization constant, Microsomal stability, Partition coefficient, Physiologically-based pharmacokinetic modelling, Protein binding

وصف الملف: application/pdf

الاتاحة: https://research.monash.edu/en/publications/2c3c60db-f68b-48e5-a7b1-1910e49c3065
https://doi.org/10.1186/s12936-019-3075-5
https://researchmgt.monash.edu/ws/files/299940182/295024887_oa.pdf
http://www.scopus.com/inward/record.url?scp=85077398282&partnerID=8YFLogxK

المؤلفون: Chang, Aeson, Chung, Ni-Chun, Lawther, Adam J., Ziegler, Alexandra I., Shackleford, David M., Sloan, Erica K., Walker, Adam K.

المصدر: Frontiers in Oncology ; volume 10 ; ISSN 2234-943X

الاتاحة: http://dx.doi.org/10.3389/fonc.2020.564965
https://www.frontiersin.org/articles/10.3389/fonc.2020.564965/full

المؤلفون: Braillard, Stéphanie, Keenan, Martine, Breese, Karen J., Heppell, Jacob, Abbott, Michael, Islam, Rafiqul, Shackleford, David M., Katneni, Kasiram, Crighton, Elly, Chen, Gong, Patil, Rahul, Lee, Given, White, Karen L., Carvalho, Sandra, Wall, Richard J., Chemi, Giulia, Zuccotto, Fabio, González, Silvia, Marco, Maria, Deakyne, Julianna

المصدر: Science Translational Medicine; 12/13/2023, Vol. 15 Issue 726, p1-15, 15p

مصطلحات موضوعية: VISCERAL leishmaniasis, CHAGAS' disease, NEGLECTED diseases, PARASITIC diseases, PARASITES