المؤلفون: Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä, Eemeli Moisio, Juha R. Savinainen, Jarmo T. Laitinen

المصدر: Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)

مصطلحات موضوعية: Activity-based protein profiling (ABPP), Brain cryosection, Glioblastoma multiforme (GBM), Immunohistochemistry, Serine hydrolase activity, Neutrophil serine protease (NSP), Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12575-020-00118-4; https://doaj.org/toc/1480-9222

URL الوصول: https://doaj.org/article/39a46c768cee473fbdc8573d58d1d4d5

المؤلفون: Aaltonen, Niina, Singha, Prosanta K., Jakupovic, Hermina, Wirth, Thomas, Samaranayake, Haritha, Pasonen-Seppanen, Sanna, Rilla, Kirsi, Varjosalo, Markku, Edgington-Mitchell, Laura E., Kasperkiewicz, Paulina, Drag, Marcin, Kälvälä, Sara, Moisio, Eemeli, Savinainen, Juha R., Laitinen, Jarmo T.

المساهمون: University Management, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Joint Activities, Molecular Systems Biology

مصطلحات موضوعية: Activity-based protein profiling (ABPP), Brain cryosection, Glioblastoma multiforme (GBM), Immunohistochemistry, Serine hydrolase activity, Neutrophil serine protease (NSP), TAMRA-FP probe, Tumor-associated neutrophils, INHIBITORS, DISCOVERY, PROTEASES, AUTORADIOGRAPHY, METABOLISM, PROTEOMICS, LANDSCAPE, PROBES, CELLS, ABHD6, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: J.T.L. was supported by the Finnish Academy (grant no. 278212). L.E.M. was supported by a Grimwade Fellowship from the Russell and Mab Grimwade Miegunyah Fund at The University of Melbourne and a DECRA Fellowship from the Australian Research Council (ARC, DE180100418). Drag laboratory is supported by Foundation for Polish Science and National Science Centre in Poland. PK. is the beneficiary of a L'Oreal Poland and the Polish' Ministry of Science and Higher Education scholarships.; Aaltonen , N , Singha , P K , Jakupovic , H , Wirth , T , Samaranayake , H , Pasonen-Seppanen , S , Rilla , K , Varjosalo , M , Edgington-Mitchell , L E , Kasperkiewicz , P , Drag , M , Kälvälä , S , Moisio , E , Savinainen , J R & Laitinen , J T 2020 , ' High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils ' , Biological Procedures Online , vol. 22 , no. 1 , 6 . https://doi.org/10.1186/s12575-020-00118-4; ORCID: /0000-0002-1340-9732/work/77087683; http://hdl.handle.net/10138/317397; c0c698a8-9bf4-44a0-bc12-2ed174a583e2; 000520970600001

الاتاحة: http://hdl.handle.net/10138/317397

المؤلفون: Daniel Abegg, Chao Wang, Alexander Adibekian, Brendan G. Dwyer

المصدر: ChemBioChem. 20:2212-2216

مصطلحات موضوعية: Azides, Hydrolases, Organophosphonates, 010402 general chemistry, 01 natural sciences, Biochemistry, Serine, chemistry.chemical_compound, Humans, Serine hydrolase activity, Molecular Biology, 010405 organic chemistry, Chemistry, Drug discovery, Organic Chemistry, Leaving group, Activity-based proteomics, Serine hydrolase, 0104 chemical sciences, Molecular Probes, Click chemistry, Molecular Medicine, Click Chemistry, Azide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56dd1b2ae3c46025c824560a52d0aa90
https://doi.org/10.1002/cbic.201900126

المؤلفون: Lauren R. Blankenship, Darby Herkert, Stavroula K. Hatzios, Daniel G. Dumitrescu, Matthew Howell

المصدر: Journal of Biological Chemistry. 294:9888-9900

مصطلحات موضوعية: 0301 basic medicine, Serine protease, chemistry.chemical_classification, Proteases, 030102 biochemistry & molecular biology, biology, medicine.diagnostic_test, Chemistry, Proteolysis, Subtilisin, Cell Biology, medicine.disease_cause, Biochemistry, Serine, 03 medical and health sciences, 030104 developmental biology, Enzyme, Vibrio cholerae, biology.protein, medicine, Serine hydrolase activity, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b27b4f9273cbc109041ad3726d107ac4
https://doi.org/10.1074/jbc.ra119.007745

المؤلفون: John A. Wilkins, Ying Lao, Adam Lesner, Brice Korkmaz, Peter Nickerson, Carla Guarino, Julie Ho, Mario Navarrete

المساهمون: University of Manitoba

المصدر: Clinical Proteomics

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, ABPP/activity-based protein profiling, 030232 urology & nephrology, ABHD14B/CCG1-interacting factor B, Urine, Serine, 03 medical and health sciences, 0302 clinical medicine, Proteinase 3, Medicine, Serine hydrolase activity, Molecular Biology, Subclinical infection, business.industry, Research, Activity-based proteomics, Serine hydrolase, PR3/PRTN3/myeloblastin, General Medicine, medicine.disease, Transplant rejection, Transplantation, Renal transplant, Neurotrypsin/PRSS12, 030104 developmental biology, LTF/LactotransferrinPR3, Immunology, Molecular Medicine, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d1a07e4e534763581d7659761f330c
https://hdl.handle.net/1993/34737

المؤلفون: Thomas Wirth, Eemeli Moisio, Kirsi Rilla, Paulina Kasperkiewicz, Prosanta K. Singha, Markku Varjosalo, Sanna Pasonen-Seppänen, Jarmo T. Laitinen, Sara Kälvälä, Marcin Drag, Juha R. Savinainen, Hermina Jakupović, Laura E. Edgington-Mitchell, Niina Aaltonen, Haritha Samaranayake

المساهمون: University Management, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Joint Activities, Molecular Systems Biology

المصدر: Biological Procedures
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)

مصطلحات موضوعية: 0301 basic medicine, Streptavidin, Proteases, Fluorescence-lifetime imaging microscopy, Confocal, Serine hydrolase activity, METABOLISM, Proteomics, General Biochemistry, Genetics and Molecular Biology, PROBES, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Activity-based protein profiling (ABPP), Brain cryosection, lcsh:QH301-705.5, Tumor-associated neutrophils, lcsh:R5-920, Tumor microenvironment, Glioblastoma multiforme (GBM), LANDSCAPE, Research, Neutrophil serine protease (NSP), Immunohistochemistry, Cell biology, PROTEASES, ABHD6, 030104 developmental biology, lcsh:Biology (General), chemistry, 030220 oncology & carcinogenesis, DISCOVERY, AUTORADIOGRAPHY, Proteome, CELLS, TAMRA-FP probe, PROTEOMICS, 1182 Biochemistry, cell and molecular biology, lcsh:Medicine (General), INHIBITORS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc07b4597e8c09e23c74070010b5b96d
http://hdl.handle.net/10138/317397

المؤلفون: Yanping Fu, Jiatao Xie, Tao Chen, Ting Zhou, Huizhang Zhao, Daohong Jiang, Jiasen Cheng

المصدر: Microbial Genomics. 6

مصطلحات موضوعية: Genetics, Sclerotinia sclerotiorum, ATP-binding cassette transporter, General Medicine, Biology, Secondary metabolite, biology.organism_classification, Genome, Major facilitator superfamily, Transcriptome, medicine, Serine hydrolase activity, Gene, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9abf541779fb94eccb3954a2a69e80f2
https://doi.org/10.1099/mgen.0.000345

المؤلفون: Haritha Samaranayake, Marcin Drag, Sanna Pasonen-Seppänen, Sara Kälvälä, Laura E. Edgington-Mitchell, Jarmo T. Laitinen, Eemeli Moisio, Markku Varjosalo, Prosanta K. Singha, Paulina Kasperkiewicz, Juha R. Savinainen, Hermina Jakupović, Niina Aaltonen, Kirsi Rilla, Thomas Wirth

مصطلحات موضوعية: Streptavidin, 0303 health sciences, Fluorescence-lifetime imaging microscopy, Confocal, medicine.disease, 3. Good health, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biotin, chemistry, 030220 oncology & carcinogenesis, Glioma, Proteome, medicine, Immunohistochemistry, Serine hydrolase activity, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a12dc98db7aac398bba304bd842d700

المؤلفون: Jianbin Zhang, Yang Chen, Lin Pan, Peng Liu, Cheng Wang, Jianyan Wen, Xueqiang Fan, Chaozeng Si, Jing Guo, Yiyao Cui, Zhidong Ye, Jie Kong, Feng Wang, Weiliang Sun, Qiangqiang Nie

المصدر: Frontiers in Physiology
Frontiers in Physiology, Vol 10 (2019)

مصطلحات موضوعية: 0301 basic medicine, Tunica media, Pathology, medicine.medical_specialty, Physiology, RNA-sequencing, lcsh:Physiology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Guanylate binding protein 5, Varicose veins, Medicine, Serine hydrolase activity, varicose veins, Original Research, lcsh:QP1-981, business.industry, interferon, Internal elastic lamina, Tunica intima, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, cardiovascular system, Gene co-expression network, GBP5, medicine.symptom, weight gene co-expression network analysis, business, guanylate-binding protein 5

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acf94916fc6f1de9ee06182530a1474
https://doi.org/10.3389/fphys.2019.00278

المؤلفون: Philippe V. Jutras, Friederike M. Grosse-Holz, Markus Kaiser, Renier A. L. van der Hoorn, Dominique Michaud, Farnusch Kaschani

المصدر: Plant Biotechnology Journal

مصطلحات موضوعية: Proteomics, 0106 biological sciences, 0301 basic medicine, Proteases, activity‐based protein profiling, medicine.medical_treatment, Nicotiana benthamiana, Plant Science, Protein degradation, 01 natural sciences, protease inhibitor, 03 medical and health sciences, Tobacco, papain‐like cysteine proteases, medicine, Protease Inhibitors, Serine hydrolase activity, cystatin, Research Articles, Protease, biology, Activity-based proteomics, food and beverages, biology.organism_classification, Cystatins, Cysteine protease, Recombinant Proteins, Protease inhibitor (biology), 030104 developmental biology, Biochemistry, SlCYS8, Biologie, Agronomy and Crop Science, Peptide Hydrolases, Research Article, 010606 plant biology & botany, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf5b08f4c235f67cdd73a3c3d96efa4
https://doi.org/10.1111/pbi.13092

المؤلفون: Tanos C. C. França, Jorge Estévez, Iris Mangas, Eugenio Vilanova

المصدر: Toxicology. 376:30-43

مصطلحات موضوعية: 0301 basic medicine, Protein family, Crystallography, X-Ray, Toxicology, Protein Structure, Secondary, Serine, 03 medical and health sciences, Organophosphorus Compounds, 0302 clinical medicine, Hydrolase, Animals, Cholinesterases, Humans, Pesticides, Serine hydrolase activity, chemistry.chemical_classification, biology, Chemistry, Esterases, Active site, Serine hydrolase, 030104 developmental biology, Enzyme, Lysophospholipase, Biochemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f829e8b12df485e814ada1302cedf6
https://doi.org/10.1016/j.tox.2016.06.006

المؤلفون: Congjie Zhai, Xia Jiang, Zengren Zhao, Shihao Chen, Weifang Yu, Weitao Yan, Wei Li, Guiqi Wang, Fangjian Shang

المصدر: Oncology Letters

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, proliferation, Wnt signaling pathway, Cancer, colorectal cancer, Articles, microRNA-424-5p, Biology, migration, invasion, medicine.disease, Actin cytoskeleton, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endopeptidase activity, Oncology, 030220 oncology & carcinogenesis, microRNA, medicine, Cancer research, KEGG, Serine hydrolase activity, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928cb08ff23ca7093403a9479d3d9dd2
https://doi.org/10.3892/ol.2020.11982

المؤلفون: Riley T Paulsen, Brian D. Burrell, Emily J. Kabeiseman

المصدر: Comp Biochem Physiol B Biochem Mol Biol

مصطلحات موضوعية: 0301 basic medicine, Physiology, Succinimides, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Hirudo, Leeches, Catalytic triad, Animals, Humans, Benzodioxoles, Cloning, Molecular, Enzyme Inhibitors, Serine hydrolase activity, Molecular Biology, Phylogeny, JZL184, biology, Cell Membrane, Serine hydrolase, biology.organism_classification, Endocannabinoid system, Monoacylglycerol Lipases, Monoacylglycerol lipase, HEK293 Cells, 030104 developmental biology, chemistry, Carbamates, Hirudo verbana, 030217 neurology & neurosurgery, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2241f36ae7f73be05842b761db10e644
https://doi.org/10.1016/j.cbpb.2020.110433

المؤلفون: Hans C. Bernstein, Lindsey N. Anderson, Regan F Volk, Anil K. Shukla, Aaron T. Wright, Vivian S. Lin, Samuel O. Purvine, Jordan N. Smith, Adrian J DeLeon

المصدر: Chem Res Toxicol

مصطلحات موضوعية: Computational biology, 010501 environmental sciences, VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Biokjemi: 476, Toxicology, Diagnostic tools, medicine.disease_cause, 01 natural sciences, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, VDP::Mathematics and natural science: 400::Basic biosciences: 470::Biochemistry: 476, Protein targeting, medicine, Animals, Serine hydrolase activity, 030304 developmental biology, 0105 earth and related environmental sciences, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Organophosphate, Activity-based proteomics, Brain, General Medicine, Acetylcholinesterase, Organophosphates, Enzyme, chemistry, Liver, Electrophorus, Cholinesterase Inhibitors, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64054ab41fea5c8f97cdfdc161744b8c
https://hdl.handle.net/10037/17719

المؤلفون: Qingpi Yan, Yongquan Su, Xiaojin Xu, Gang Luo, Yingxue Qin, Ruiqiang Tang, Lingmin Zhao, Lixing Huang

المصدر: Fishshellfish immunology. 89

مصطلحات موضوعية: 0301 basic medicine, RNA-Seq, Aquatic Science, Transcriptome, 03 medical and health sciences, Bacterial Proteins, RNA interference, Pseudomonas, Transcriptional regulation, Environmental Chemistry, Animals, KEGG, Serine hydrolase activity, Gene, Pseudomonas plecoglossicida, biology, 04 agricultural and veterinary sciences, General Medicine, biology.organism_classification, Molecular biology, Immunity, Innate, 030104 developmental biology, Genes, Bacterial, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Bass, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb7e5fc97bc4fbd40d9d63da24154c4
https://pubmed.ncbi.nlm.nih.gov/30974221

المؤلفون: Victor Spicer, Claudio Rigatto, Nora Choi, Julie Ho, Ravi Kumar Dwivedi, John A. Wilkins, Mario Navarrete, Peyman Ezzati, Rakesh C. Arora

المصدر: Journal of proteome research. 17(10)

مصطلحات موضوعية: 0301 basic medicine, Male, Proteomics, Hydrolases, Urinary system, 030232 urology & nephrology, Pharmacology, urologic and male genital diseases, Biochemistry, Mass Spectrometry, law.invention, 03 medical and health sciences, Intraoperative Period, 0302 clinical medicine, law, medicine, Cardiopulmonary bypass, Serine, Humans, Serine hydrolase activity, Aged, chemistry.chemical_classification, Cardiopulmonary Bypass, business.industry, Acute kidney injury, Activity-based proteomics, Serine hydrolase, General Chemistry, Acute Kidney Injury, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, 030104 developmental biology, Enzyme, chemistry, Case-Control Studies, Female, business, Tissue Kallikreins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b480eacfbb7238fb0b6a57b3070ab286
https://pubmed.ncbi.nlm.nih.gov/30192561

المؤلفون: Johannes M. F. G. Aerts, Rolf G. Boot, Marc P. Baggelaar, Roelof Ottenhoff, Bogdan I. Florea, Mario van der Stelt, André R. A. Marques, Eva J. van Rooden, Hui Deng, Annelot C. M. van Esbroeck, Herman S. Overkleeft

المساهمون: Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes

المصدر: Frontiers in Neuroscience
Frontiers in Neuroscience, 12, 440
Frontiers in neuroscience, 12(JUL):440. Frontiers Media S.A.
Frontiers in Neuroscience, Vol 12 (2018)

مصطلحات موضوعية: 0301 basic medicine, Diacylglycerol lipase, hydrolases, lcsh:RC321-571, Serine, 03 medical and health sciences, 0302 clinical medicine, Thioesterase, chemical proteomics, Fatty acid amide hydrolase, Serine hydrolase activity, endocannabinoid system, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Niemann-Pick type C, Original Research, activity-based protein profiling, biology, Chemistry, General Neuroscience, Activity-based proteomics, Serine hydrolase, Monoacylglycerol lipase, 030104 developmental biology, Biochemistry, biology.protein, 030217 neurology & neurosurgery, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09533ca9fc318ba7d9240ad32939ca4a
https://doi.org/10.3389/fnins.2018.00440

المؤلفون: Richard D. Smith, Andrew Frando, Corrie Ortega, Robert W. Brown, Christoph Grundner, Lindsey N. Anderson, Natalie C. Sadler, Aaron T. Wright

المصدر: Cell Chemical Biology. 23:290-298

مصطلحات موضوعية: 0301 basic medicine, Serine Proteinase Inhibitors, Tuberculosis, Hydrolases, Mycobacterium smegmatis, Clinical Biochemistry, Antitubercular Agents, Druggability, Proteomics, Biochemistry, Article, Mycobacterium, Serine, Mycobacterium tuberculosis, 03 medical and health sciences, Enzyme activator, Bacterial Proteins, Drug Discovery, medicine, Serine hydrolase activity, Molecular Biology, Pharmacology, Genetics, 030102 biochemistry & molecular biology, biology, Hydrolysis, Serine Endopeptidases, Nontuberculous Mycobacteria, medicine.disease, biology.organism_classification, Virology, 030104 developmental biology, Molecular Medicine, Serine Proteases, Serine O-Acetyltransferase, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2e750f16c1163b8919911741ec2fb3
https://doi.org/10.1016/j.chembiol.2016.01.003

المؤلفون: Shu Ling Fu, Ya-Hsin Hsu, Ting-Yun Huang, Lee-Chiang Lo, Chao Hsiung Lin

المصدر: Cancer Research. 75:A2-31

مصطلحات موضوعية: Cancer Research, Andrographolide, Cell, Cell migration, Monoacylglycerol lipase, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, Downregulation and upregulation, chemistry, Biochemistry, Cancer research, medicine, Serine hydrolase activity, Signal transduction, JZL184

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4deb911553cea5ff2ccb78bc1f3ff8b2
https://doi.org/10.1158/1538-7445.transcagen-a2-31

المؤلفون: John A. Wilkins, Dmitry Shamshurin, David B. Levin, Richard Sparling, Oleg V. Krokhin

المصدر: EuPA Open Proteomics, Vol 4, Iss C, Pp 18-24 (2014)

مصطلحات موضوعية: Fluorophosphonate probe, chemistry.chemical_classification, Lysis, lcsh:QH426-470, E. coli, Activity-based proteomics, Alkyne, Serine hydrolase, medicine.disease_cause, Biochemistry, Molecular biology, Cycloaddition, In situ, Serine, lcsh:Genetics, chemistry, medicine, ABPP, Serine hydrolase activity, Escherichia coli

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678111fafaf66c4941ffb1985bba121b
https://doi.org/10.1016/j.euprot.2014.04.007