المؤلفون: Simon C. C. Lucas (7180415), Stephen J. Atkinson (1297362), Chun-wa Chung (1343454), Rob Davis (9204195), Laurie Gordon (1357524), Paola Grandi (1343472), James J. R. Gray (11134045), Thomas Grimes (11134048), Alexander Phillipou (8806631), Alex G. Preston (11134051), Rab K. Prinjha (449759), Inmaculada Rioja (8539), Simon Taylor (441637), Nicholas C. O. Tomkinson (7417448), Ian Wall (1697842), Robert J. Watson (1343463), James Woolven (2439757), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Evolutionary Biology, Ecology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, BD, Inhibitors Herein, GSK, BET, quaternary center, extra-terminal domain, 1000- fold-selective, inhibitor 71, vivo rat, bromodomain, suboptimal solubility, Second Bromodomain, dog pharmacokinetics, dihydrobenzofuran

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_a_Series_of_2_3-Dihydrobenzofurans_as_Highly_Potent_Second_Bromodomain_BD2_-Selective_Bromo_and_Extra-Terminal_Domain_BET_Inhibitors/14983774

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00344.s002

المؤلفون: Jonathan T. Seal (2119816), Stephen J. Atkinson (1297362), Paul Bamborough (1343466), Anna Bassil (10233082), Chun-wa Chung (1343454), James Foley (1694122), Laurie Gordon (1357524), Paola Grandi (1343472), James R. J. Gray (9105255), Lee A. Harrison (2160145), Ryan G. Kruger (2013604), Jeanne J. Matteo (2335558), Michael T. McCabe (449753), Cassie Messenger (8189169), Darren Mitchell (3834424), Alex Phillipou (8551068), Alex Preston (9105252), Rab K. Prinjha (449759), Francesco Rianjongdee (9260972), Inmaculada Rioja (8539), Simon Taylor (441637), Ian D. Wall (2525425), Robert J. Watson (1343463), James M. Woolven (2119828), Anastasia Wyce (449747), Xi-Ping Zhang (11128371), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, drug-like pan-BD 2 inhibitors, furan 24, pharmacology-driven toxicity, pyrrole fragment 6, GSK 620 2, representative example, pyridone series, chemistry efforts, safety profile, Second Bromodomain, Soluble Bromo, pyrazole 23, Extra Terminal Domain, novel class, pan-BET inhibitors, BET family, Fragment-based Scaffold Hopping

Relation: https://figshare.com/articles/dataset/Fragment-based_Scaffold_Hopping_Identification_of_Potent_Selective_and_Highly_Soluble_Bromo_and_Extra_Terminal_Domain_BET_Second_Bromodomain_BD2_Inhibitors/14977137

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00365.s001

المؤلفون: Simon C. C. Lucas (7180415), Stephen J. Atkinson (1297362), Chun-wa Chung (1343454), Rob Davis (9204195), Laurie Gordon (1357524), Paola Grandi (1343472), James J. R. Gray (11134045), Thomas Grimes (11134048), Alexander Phillipou (8806631), Alex G. Preston (11134051), Rab K. Prinjha (449759), Inmaculada Rioja (8539), Simon Taylor (441637), Nicholas C. O. Tomkinson (7417448), Ian Wall (1697842), Robert J. Watson (1343463), James Woolven (2439757), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Evolutionary Biology, Ecology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, BD, Inhibitors Herein, GSK, BET, quaternary center, extra-terminal domain, 1000- fold-selective, inhibitor 71, vivo rat, bromodomain, suboptimal solubility, Second Bromodomain, dog pharmacokinetics, dihydrobenzofuran

Relation: https://figshare.com/articles/dataset/Optimization_of_a_Series_of_2_3-Dihydrobenzofurans_as_Highly_Potent_Second_Bromodomain_BD2_-Selective_Bromo_and_Extra-Terminal_Domain_BET_Inhibitors/14983771

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00344.s001