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1Academic Journal
المؤلفون: Hongtao Yu, Sebastian Ueckert, Lina Zhou, Jenny Cheng, Darren Robertson, Lars Hansen, Armando Flor, Victoria Parker, Bengt Hamrén, Anis A. Khan
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1582-1594 (2024)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2163-8306
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2Academic Journal
المؤلفون: Jane Knöchel, Linnéa Bergenholm, Eman Ibrahim, Stergios Kechagias, Sara Hansson, Mathias Liljeblad, Patrik Nasr, Björn Carlsson, Mattias Ekstedt, Sebastian Ueckert
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 2038-2049 (2023)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2163-8306
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3Academic Journal
المؤلفون: Po‐Wei Chen, Mats O. Karlsson, Sebastian Ueckert, Ari Pritchard‐Bell, Cheng‐Pang Hsu, Sandeep Dutta, Malidi Ahamadi
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1988-2000 (2023)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2163-8306
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4Academic Journal
المؤلفون: Sebastian Ueckert
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 4, Pp 205-218 (2018)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2163-8306
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5
المؤلفون: Sebastian Ueckert, Simon Buatois, Sylvie Retout, Nicolas Frey
المصدر: Statistics in Medicine. 40:2435-2451
مصطلحات موضوعية: Statistics and Probability, Dose-Response Relationship, Drug, Epidemiology, Computer science, Uncertainty, Phase (waves), Coverage probability, Contrast (statistics), Context (language use), 01 natural sciences, Confidence interval, Power (physics), 010104 statistics & probability, 03 medical and health sciences, Nonlinear system, Clinical Trials, Phase II as Topic, 0302 clinical medicine, Nonlinear Dynamics, Research Design, Sample Size, Humans, 030212 general & internal medicine, 0101 mathematics, Algorithm, Type I and type II errors
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6
المؤلفون: Sebastian Ueckert, Mats O. Karlsson
المصدر: Journal of Pharmacokinetics and Pharmacodynamics
مصطلحات موضوعية: Logarithm, Composite score, Computer science, 030226 pharmacology & pharmacy, 03 medical and health sciences, Pharmaceutical Sciences, 0302 clinical medicine, Numeric stability, Humans, Computer Simulation, Implementation, NONMEM, Pharmacology, Original Paper, Clinical Trials as Topic, Models, Statistical, Laplace transform, Farmaceutiska vetenskaper, Error function, Bounded function, Data Interpretation, Statistical, Algorithm, Monte Carlo Method, 030217 neurology & neurosurgery, Algorithms, Numerical stability, Integer (computer science)
وصف الملف: application/pdf
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7
المصدر: The AAPS Journal
مصطلحات موضوعية: Scale (ratio), composite scale data, Pharmaceutical Science, Pharmacology and Toxicology, Latent variable, Expected value, Severity of Illness Index, 030226 pharmacology & pharmacy, Standard deviation, 03 medical and health sciences, 0302 clinical medicine, Homoscedasticity, Statistics, Item response theory, Humans, Categorical variable, Mathematics, Models, Statistical, Parkinson Disease, Farmakologi och toxikologi, total score analysis, IRT-informed total score analysis, Data Interpretation, Statistical, Bounded function, bounded integer model, 030217 neurology & neurosurgery, Research Article
وصف الملف: application/pdf
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8
المؤلفون: France Mentré, Sebastian Ueckert
المساهمون: Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), This work was supported by the Innovative Medicines Initiative Joint Undertakingunder grant agreement no. 115156, resources of which are composed of nancial contri-butions from the European Unions Seventh Framework Program (FP7/2007 2013) andEFPIA companies in-kind contribution. The DDMoRe project is also supported by -nancial contribution from academic and SME partners. This work does not necessarilyrepresent the view of all DDMoRe partners.This work has also received funding from the European Unions 7th Framework Pro-gramme for research, technological development and demonstration under Grant Agree-ment no. 602552., European Project: DDMoRe, European Project: FP7/2007 2013, Comets, Emmanuelle, Drug Disease Model Resources - DDMoRe - INCOMING, European Unions Seventh Framework Program - FP7/2007 2013 - INCOMING
المصدر: Computational Statistics and Data Analysis
Computational Statistics and Data Analysis, Elsevier, 2016, ⟨10.1016/j.csda.2016.10.011⟩مصطلحات موضوعية: Statistics and Probability, Optimal design, Mathematical optimization, Computational complexity theory, Fisher information matrix, Monte Carlo method, nonlinear mixed effect models, 030226 pharmacology & pharmacy, 01 natural sciences, Generalized linear mixed model, 010104 statistics & probability, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, discrete data, Applied mathematics, optimal design, 0101 mathematics, Fisher information, Mathematics, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Applied Mathematics, Design of experiments, Random effects model, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Computational Mathematics, Computational Theory and Mathematics, generalized linear mixed model, symbols, Gaussian quadrature
وصف الملف: application/pdf
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9
المصدر: Journal of Pharmacokinetics and Pharmacodynamics
مصطلحات موضوعية: Composite score, Motor Activity, Models, Biological, Severity of Illness Index, 030226 pharmacology & pharmacy, behavioral disciplines and activities, Item response theory, Antiparkinson Agents, 03 medical and health sciences, Pharmaceutical Sciences, 0302 clinical medicine, Pharmacometrics, Statistics, Humans, Computer Simulation, Longitudinal Studies, Drug effect, Mathematics, Pharmacology, Original Paper, Disease progression, Contrast (statistics), Parkinson Disease, Farmaceutiska vetenskaper, Treatment Outcome, Information function, Simulated data, Disease Progression, Item information, Metric (unit), Drug Monitoring, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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10
المؤلفون: Mats O. Karlsson, Svetlana Freiberga, Sebastian Ueckert, Maria C. Kjellsson, Moustafa M. A. Ibrahim
المصدر: The AAPS Journal
مصطلحات موضوعية: model evaluation, Time Factors, media_common.quotation_subject, Datasets as Topic, Pharmaceutical Science, Models, Biological, 030226 pharmacology & pharmacy, Minimal model, 03 medical and health sciences, Pharmaceutical Sciences, 0302 clinical medicine, Software, Drug Development, prediction bias, Statistics, diagnostics, Homeostasis, Humans, Insulin, Glucose homeostasis, Prediction bias, media_common, Mathematics, structural model, Variables, business.industry, Inversion (meteorology), Glucose Tolerance Test, Covariance, nonlinear mixed effects models, Farmaceutiska vetenskaper, Healthy Volunteers, Nonlinear system, Glucose, Nonlinear Dynamics, 030220 oncology & carcinogenesis, Administration, Intravenous, business, conditional weighted residuals, Research Article
وصف الملف: application/pdf
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11
المؤلفون: Simon Buatois, Nicolas Frey, Sebastian Ueckert, Sylvie Retout
المساهمون: Roche Pharma Research and Early Development [Basel] ( pRED ), F. Hoffmann-La Roche [Basel], Infection, Antimicrobiens, Modélisation, Evolution ( IAME ), Université Paris 13 ( UP13 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), INSTITUT ROCHE, Faculty of pharmacy / Department of Pharmaceutical Biosciences / Division of Pharmacokinetics and drug therapy, Uppsala University, INSTITUT Roche, This work was financed by a CIFRE agreement (Conventions Industrielles de Formation par la Recherche) and was conducted under the supervision of the ANRT (Association Nationale Recherche Technologie). The CIFRE agreement is a partnership between a public laboratory and a company, here the UMR 1137 and INSTITUT ROCHE, respectively., Comets, Emmanuelle, Roche Pharma Research and Early Development [Basel] (pRED), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)
المصدر: The AAPS Journal
The AAPS Journal, 2018, 20 (3), pp.56. 〈10.1208/s12248-018-0205-x〉
AAPS Journal
AAPS Journal, American Association of Pharmaceutical Scientists, 2018, 20 (3), pp.56. ⟨10.1208/s12248-018-0205-x⟩مصطلحات موضوعية: Mixed model, model selection, Computer science, Visual Acuity, Pharmaceutical Science, Information Criteria, computer.software_genre, 030226 pharmacology & pharmacy, 01 natural sciences, nonlinear mixed effect models, dose-response relationship, Set (abstract data type), Macular Degeneration, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Humans, 0101 mathematics, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Clinical Trials as Topic, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Dose-Response Relationship, Drug, Model selection, model averaging, Function (mathematics), [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Weighting, Nonlinear system, Nonlinear Dynamics, Data mining, Akaike information criterion, computer
وصف الملف: application/pdf
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12
المؤلفون: Sebastian Ueckert, Mats O. Karlsson, Elodie L. Plan, Brian Corrigan, Andrew C. Hooker, Kaori Ito
المصدر: Pharmaceutical Research
مصطلحات موضوعية: Databases, Factual, Statistics as Topic, Pharmaceutical Science, Item response theory, nonlinear mixed effect models, Models, Biological, behavioral disciplines and activities, 030226 pharmacology & pharmacy, Pharmaceutical Sciences, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, Assessment data, Alzheimer Disease, Statistics, Atorvastatin, Humans, Medicine, Pyrroles, Pharmacology (medical), Longitudinal Studies, ADAS-cog, pharmacometrics, Pharmacology, business.industry, Organic Chemistry, item response theory, Method of analysis, Alzheimer's disease, Farmaceutiska vetenskaper, Pharmacometrics, Clinical trial, Clinical Trials, Phase III as Topic, Adas cog, Heptanoic Acids, Molecular Medicine, Cognition Disorders, business, Alzheimer’s disease, 030217 neurology & neurosurgery, Research Paper, Biotechnology, Alzheimer's Disease Neuroimaging Initiative
وصف الملف: application/pdf
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13
المصدر: Journal of Pharmacokinetics and Pharmacodynamics. 40:587-596
مصطلحات موضوعية: Pharmacology, Optimal design, Clinical Trials as Topic, Mathematical optimization, Models, Statistical, Clinical study design, Contrast (statistics), Wald test, Statistical power, Power (physics), Drug Therapy, Predictive Value of Tests, Research Design, Metric (mathematics), Statistics, Disease Progression, Humans, Computer Simulation, Statistic, Mathematics
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14
المؤلفون: Sebastian Ueckert, Nicolas Frey, Sylvie Retout, Simon Buatois
المساهمون: Comets, Emmanuelle, Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Institut ROCHE [Boulogne-Billancourt], Roche S.A.S, Department of Pharmaceutical Biosciences [Uppsala, Sweden], Uppsala University, This work was financed by F-Hoffmann- La Roche Ltd. We are grateful to the PPMI – a public-private partnership – funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including Abbvie, Inc., Eli Lilly and Company and its subsidiary company Avid Radiopharmaceuticals, Biogen Idec Inc., Bristol-MyersSquibb Company, Covance, Inc., F-Hoffmann- La Roche Ltd and its subsidiary company Genetech, Inc., GE Healthcare, Servier, GlaxoSmithKline plc., H. Lundbeck A/S, Merck & Co., Inc., Meso Scale Diagnostics, LLC., Pfizer Inc., Piramal Imaging, and UCB. for providing access to the PPMI cohort.
المصدر: Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2017, 34 (10), pp.2109-2118. ⟨10.1007/s11095-017-2216-1⟩مصطلحات موضوعية: Male, medicine.medical_specialty, Parkinson's disease, Pharmaceutical Science, Disease, Models, Biological, Severity of Illness Index, 030226 pharmacology & pharmacy, Idiopathic parkinson's disease, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Rating scale, Item response theory, medicine, Humans, Computer Simulation, Pharmacology (medical), Drug effect, pharmacometrics, Aged, Pharmacology, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], business.industry, Organic Chemistry, drug effect, item response theory, Parkinson Disease, Middle Aged, MDS-UPDRS, medicine.disease, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Pharmacometrics, Clinical trial, Disease Progression, Parkinson’s disease, Database Management Systems, Molecular Medicine, Female, business, 030217 neurology & neurosurgery, Biotechnology
وصف الملف: application/pdf
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15
المؤلفون: Mats O. Karlsson, Eric A. Strömberg, Andrew C. Hooker, Stefanie Hennig, Sebastian Ueckert, Joakim Nyberg
المصدر: Computer Methods and Programs in Biomedicine. 108:789-805
مصطلحات موضوعية: Optimal design, Mathematical optimization, Computer science, business.industry, Design of experiments, Constrained optimization, Health Informatics, Models, Theoretical, Translation (geometry), Computer Science Applications, Nonlinear system, Software, Mixed effects, business, Algorithms
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16
المؤلفون: Mats O. Karlsson, Elodie L. Plan, Sven van Dijkman, Sebastian Ueckert
المصدر: Journal of the Neurological Sciences. 381:97-98
مصطلحات موضوعية: medicine.medical_specialty, Physical medicine and rehabilitation, Neurology, business.industry, Item response theory, Multi dimensional, medicine, Healthy subjects, Neurology (clinical), business
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17
المصدر: AAPS JOURNAL, 19, 172
مصطلحات موضوعية: Disease status, medicine.medical_specialty, Item Response Theory, Pharmaceutical Science, cladribine tablets, Logistic regression, Placebo, multiple sclerosis, Severity of Illness Index, behavioral disciplines and activities, 030226 pharmacology & pharmacy, Disability Evaluation, 03 medical and health sciences, Pharmaceutical Sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Item response theory, medicine, Humans, Cladribine, disease progression model, Expanded Disability Status Scale, business.industry, Multiple sclerosis, Models, Theoretical, medicine.disease, Farmaceutiska vetenskaper, Pharmacometrics, Logistic Models, Clinical Trials, Phase III as Topic, Disease Progression, Physical therapy, business, Immunosuppressive Agents, 030217 neurology & neurosurgery, medicine.drug
وصف الملف: application/pdf
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18
المؤلفون: Sebastian, Ueckert, Mats O, Karlsson, Andrew C, Hooker
المصدر: Journal of Pharmacokinetics and Pharmacodynamics
مصطلحات موضوعية: Monte Carlo method, Original Paper, Nonlinear Dynamics, Sample Size, Power, Non-linear mixed effect models, Regression Analysis, Computer Simulation, Hypothesis test, Algorithms, NONMEM
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19
المؤلفون: Marie-Karelle Riviere, Sebastian Ueckert, France Mentré
المساهمون: HAL-UPMC, Gestionnaire, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)
المصدر: Biostatistics
Biostatistics, Oxford University Press (OUP), 2016, ⟨10.1093/biostatistics/kxw020⟩مصطلحات موضوعية: Statistics and Probability, Optimal design, Monte Carlo method, Fisher information matrix, Biostatistics, 030226 pharmacology & pharmacy, 01 natural sciences, 010104 statistics & probability, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Continuous data, Discrete data, Linearization, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Statistics, Applied mathematics, Humans, Markov Chain Monte Carlo, 0101 mathematics, Fisher information, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST], Mathematics, Models, Statistical, Markov chain, Markov chain Monte Carlo, General Medicine, Random effects model, Nonlinear mixed effect models, Markov Chains, Nonlinear Dynamics, Laplace's method, Research Design, symbols, Gaussian quadrature, Statistics, Probability and Uncertainty, Monte Carlo Method
وصف الملف: applicaton/octet-stream
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20
المصدر: Journal of pharmacokinetics and pharmacodynamics. 41(3)
مصطلحات موضوعية: Pharmacology, education.field_of_study, Models, Statistical, Computer science, Bayesian probability, Population, Imidazoles, Reproducibility of Results, Markov chain Monte Carlo, Stochastic approximation, NONMEM, symbols.namesake, Norepinephrine, Bias, Robustness (computer science), Statistics, symbols, Sympatholytics, Humans, Pharmacokinetics, Point estimation, education, Importance sampling, Algorithms, Software
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