المؤلفون: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

المؤلفون: Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50

المؤلفون: Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks

المصدر: Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716302996; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141

المؤلفون: Haris Jamil, Ching-Hsuen Chu, John K. Dickson, Jr., Ying Chen, Mujing Yan, Scott A. Biller, Richard E. Gregg, John R. Wetterau, David A. Gordon

المصدر: Journal of Lipid Research, Vol 39, Iss 7, Pp 1448-1454 (1998)

مصطلحات موضوعية: lipid transfer protein, protein disulfide isomerase, photoaffinity, benzophenone, HepG2 cells, McArdle RH-7777 cells, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520325268; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/16c45b43aabf402ba2850fe8686267a1

المؤلفون: Zenon Konteatis (2236249), Jeremy Travins (4810641), Stefan Gross (673951), Katya Marjon (10571777), Amelia Barnett (10571780), Everton Mandley (10571783), Brandon Nicolay (8213556), Raj Nagaraja (8413410), Yue Chen (73753), Yabo Sun (10571786), Zhixiao Liu (3719695), Jie Yu (150626), Zhixiong Ye (1370289), Fan Jiang (144211), Wentao Wei (2135263), Cheng Fang (611972), Yi Gao (112914), Peter Kalev (10571789), Marc L. Hyer (10571792), Byron DeLaBarre (673950), Lei Jin (120473), Anil K. Padyana (1833913), Lenny Dang (2035819), Joshua Murtie (4471198), Scott A. Biller (2035810), Zhihua Sui (27883), Kevin M. Marks (1277097)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Homozygous MTAP Deletion, allosteric MAT 2A inhibitors, adenosyl methionine, small-molecule inhibitors, cancer cells, block proliferation, Previous attempts, xenograft tumors, iterative structure-guided design, enzyme methionine adenosyltransferase 2, methylthioadenosine phosphorylase, SAM levels, MAT 2A, Fragment screening, bioavailable MAT 2A inhibitors, AG -270, target MAT 2A, MAT 2A inhibitors, CDKN 2A, First-in-Class Oral MAT 2A Inhibitor, NCT, tissue culture

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_AG-270_a_First-in-Class_Oral_MAT2A_Inhibitor_for_the_Treatment_of_Tumors_with_Homozygous_i_MTAP_i_Deletion/14387567

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01895.s001

المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2082a01fe43de83bde9d3812f1570
https://doi.org/10.1158/1535-7163.c.6542857

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936

المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4ca858542c027e4592c9d144d2e2b
https://doi.org/10.1158/1535-7163.22520980.v1

المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0375725bf558a85632625bf90c45d1f
https://doi.org/10.1158/1535-7163.22520971

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939

المؤلفون: Janeta Popovici-Muller, Lenny Dang, Scott A. Biller, Nelamangala Nagaraja, Hua Yang, Shinsan M. Su, Yue Chen, Liping Yan, Hyeryun Kim, Lemieux Rene M, Luke Utley, Bin Fan

المصدر: Drug Metabolism and Disposition. 49:870-881

مصطلحات موضوعية: IDH1, CYP2B6, Metabolic Clearance Rate, Pyridines, Glycine, Pharmaceutical Science, Antineoplastic Agents, Drug Elimination Routes, Pharmacology, Glutarates, Mice, Dogs, Cytochrome P-450 Enzyme System, Pharmacokinetics, In vivo, Animals, Humans, Point Mutation, Drug Interactions, Dose-Response Relationship, Drug, CYP3A4, Chemistry, Myeloid leukemia, Haplorhini, Xenograft Model Antitumor Assays, Isocitrate Dehydrogenase, Rats, Leukemia, Myeloid, Acute, Isocitrate dehydrogenase, Ketoglutaric Acids, Drug metabolism, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f57647f928757a03f343f00f8fa0f98
https://doi.org/10.1124/dmd.120.000234

المؤلفون: Joshua Murtie, Anil K. Padyana, Lei Jin, Marc L. Hyer, Zhixiao Liu, Scott A. Biller, Jeremy Travins, Amelia Barnett, Katya Marjon, Brandon Nicolay, Wentao Wei, Raj Nagaraja, Cheng Fang, Yi Gao, Yabo Sun, Ye Zhixiong, Fan Jiang, Peter Kalev, Stefan Gross, Zenon D. Konteatis, Byron DeLaBarre, Zhihua Sui, Kevin Marks, Lenny Dang, Jie Yu, Everton Mandley, Yue Chen

المصدر: Journal of Medicinal Chemistry. 64:4430-4449

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Methionine, Allosteric regulation, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Enzyme, chemistry, CDKN2A, Methionine Adenosyltransferase, Drug Discovery, Cancer cell, Cancer research, Molecular Medicine, Structure–activity relationship, Binding site, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::97283e129d6853ac6b9ff735db2724ec
https://doi.org/10.1021/acs.jmedchem.0c01895

المؤلفون: Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: S-Adenosylmethionine, Drug Design, Neoplasms, Drug Discovery, Molecular Medicine, Brain, Humans, Methionine Adenosyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4665a566b3b92c2d5c0229953dea0
https://pubmed.ncbi.nlm.nih.gov/35293760

المؤلفون: Brandon Nicolay, Ingo K. Mellinghoff, Paolo Codega, Hua Yang, Zenon D. Konteatis, Janeta Popovici-Muller, Katharine E. Yen, Rohini Narayaraswamy, Raj Nagaraja, Zhihua Sui, Shinsan M. Su, Erin Artin, Kimberly Straley, Zhenwei Cai, Feng Wang, Shuilong Tong, Lei Jin, Yue Chen, Cui Dawei, Carl Campos, Zhiyong Luo, Cheng Fang, Xiaobing Lv, Lenny Dang, Ding Zhou, Anil K. Padyana, Huachun Tang, Scott A. Biller

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: chemistry.chemical_classification, IDH1, Organic Chemistry, Mutant, Dual inhibitor, 2-hydroxyglutarate, medicine.disease, Biochemistry, Featured Letter, Isocitrate dehydrogenase, vorasidenib, chemistry.chemical_compound, Enzyme, AG-881, chemistry, Glioma, Drug Discovery, medicine, Cancer research, Binding site, mutant IDH1/mIDH2, Penetrant (biochemical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b32007fc702636fdd2a4b9ade51afa
https://doi.org/10.1021/acsmedchemlett.9b00509

المؤلفون: Zenon, Konteatis, Jeremy, Travins, Stefan, Gross, Katya, Marjon, Amelia, Barnett, Everton, Mandley, Brandon, Nicolay, Raj, Nagaraja, Yue, Chen, Yabo, Sun, Zhixiao, Liu, Jie, Yu, Zhixiong, Ye, Fan, Jiang, Wentao, Wei, Cheng, Fang, Yi, Gao, Peter, Kalev, Marc L, Hyer, Byron, DeLaBarre, Lei, Jin, Anil K, Padyana, Lenny, Dang, Joshua, Murtie, Scott A, Biller, Zhihua, Sui, Kevin M, Marks

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: S-Adenosylmethionine, Structure-Activity Relationship, Binding Sites, Purine-Nucleoside Phosphorylase, Drug Design, Neoplasms, Homozygote, Humans, Methionine Adenosyltransferase, Enzyme Inhibitors, Molecular Dynamics Simulation, Crystallography, X-Ray

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6ec9204e0504cb32589dbe975f9a1cd3
https://pubmed.ncbi.nlm.nih.gov/33829783

المؤلفون: Scott A. Biller

المصدر: 2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviews

مصطلحات موضوعية: Drug, media_common.quotation_subject, Criminology, Psychology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0551817eb6fd6669698696200286851b
https://doi.org/10.29200/acsmedchemrev-v55.ch2

المؤلفون: K. Satish Reddy, Scott A. Biller, Kavitha Nellore, Siva Sanjeeva Rao, Anil K. Padyana, Georg Lenz, Thomas Antony, Charles Locuson, Jonathan Hurov, Mya Steadman, Tabea Erdmann, Mark Fletcher, Zi Peng Fan, Kevin Truskowski, Sreevalsam Gopinath, Alan Mann, Danielle Ulanet, Rohini Narayanaswamy, Sebastien Ronseaux, Gabrielle McDonald, Sung Choe, Zhihua Sui, John Coco, Lenny Dang, Kevin Marks, Victor Chubukov, Erin Artin, Sebastian Hayes, Josh Murtie, Lei Jin, Nelamangala Nagaraja, Hosahalli Subramanya, Sunil Kumar Panigrahi

المصدر: Molecular cancer therapeutics. 19(12)

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Cancer Research, Oxidoreductases Acting on CH-CH Group Donors, Cell Survival, Chemical biology, Dihydroorotate Dehydrogenase, Antineoplastic Agents, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Cell Line, Tumor, medicine, Extracellular, Humans, Enzyme Inhibitors, Neoplasm Staging, Genomics, medicine.disease, Uridine, Lymphoma, Metabolic pathway, 030104 developmental biology, Pyrimidines, Oncology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Cancer research, Dihydroorotate dehydrogenase, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4f845cc62e9703a40911be67f90bd8
https://pubmed.ncbi.nlm.nih.gov/33082276

المؤلفون: Lingling Huang, Kevin Marks, Shengfang Jin, Sung Choe, Scott A. Biller, Joshua Murtie, Gromoslaw A. Smolen, Janeta Popovici-Muller, Eric L. Allen, Rohini Narayanaswamy, Stefan Gross, Yingjia Zhang, Wei Liu, Thomas P. Roddy, Gabrielle McDonald, Nelamangala Nagaraja, Marion Dorsch, Anil K. Padyana, Christopher E. Mahoney, Taryn Sleger, Meina Liu, Yue Chen, Stuart Murray, Victor Chubukov, Sebastian Hayes, Giovanni Cianchetta, Ying Chen, Zi Peng Fan, David Pirman

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Squalene monooxygenase, Science, Cell, Chemical biology, General Physics and Astronomy, Antineoplastic Agents, 02 engineering and technology, Neuroendocrine tumors, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, lcsh:Science, Regulation of gene expression, Multidisciplinary, Cancer, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Cholesterol, Squalene Monooxygenase, Cell culture, Cancer cell, Cancer research, lcsh:Q, Drug Screening Assays, Antitumor, 0210 nano-technology, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9963f98863abf7bfee5a9413bdfc9
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

المؤلفون: Justin Taylor, Fabian Correa, Craig B. Thompson, Bo Wang, Gregory A. Petsko, Zenon D. Konteatis, Noushin Farnoud, Maria E. Arcila, Bin Wu, Ariën S. Rustenburg, Sung Choe, Mikhail Roshal, Naofumi Takemoto, Ross L. Levine, Vidushi Durani, Andrew M. Intlekofer, Steven K. Albanese, Hui Liu, Christopher Famulare, Eytan M. Stein, Scott A. Biller, Elli Papaemmanuil, Minal Patel, Justin R. Cross, Abbas Nazir, Martin S. Tallman, Alan H. Shih, John D. Chodera

المصدر: Nature

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Myeloid, Glutamine, Mutant, cancer metabolism, Aminopyridines, Drug resistance, medicine.disease_cause, Pathogenesis, Mice, AG-221, glioma, Enzyme Inhibitors, Mutation, Multidisciplinary, Clinical Trials, Phase I as Topic, Triazines, Chemistry, leukemia, Isocitrate Dehydrogenase, 3. Good health, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Disease Progression, enasidenib, IDH1, Female, IDH2, epigenetic, Allosteric Site, metabolite, Enasidenib, Article, Glutarates, AG-120, 03 medical and health sciences, Clinical Trials, Phase II as Topic, medicine, Animals, Humans, Isoleucine, Alleles, ivosidenib, medicine.disease, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, Mutant Proteins, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755791ce937d711d3a623bbe5c5e1c5
https://doi.org/10.1038/s41586-018-0251-7