المؤلفون: Stockwell, Simon R, Scott, Duncan E, Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy PC, Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R, Blundell, Tom L, Spring, David R, McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R, Hyvönen, Marko

مصطلحات موضوعية: Humans, Animals, Aurora Kinase A, Cell Cycle Proteins, Antimitotic Agents, Cell Line, Tumor, Microtubule-Associated Proteins, Mice, Nuclear Proteins, Protein Kinase Inhibitors, Xenograft Model Antitumor Assays, Antineoplastic Agents, Structure-Activity Relationship, Paclitaxel, Nude

وصف الملف: text/xml; application/zip; application/pdf

Relation: https://doi.org/10.2210/pdb8c1m; https://doi.org/10.2210/pdb8c1e; https://doi.org/10.2210/pdb8c15; https://doi.org/10.2210/pdb8c1i; https://doi.org/10.2210/pdb8c1f; https://doi.org/10.2210/pdb8c1h; https://doi.org/10.2210/pdb8c1d; https://doi.org/10.2210/pdb8c1k; https://doi.org/10.2210/pdb8c1g; https://doi.org/10.2210/pdb8c14; https://www.repository.cam.ac.uk/handle/1810/373674

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/373674

المؤلفون: Stockwell, Simon R., Scott, Duncan E., Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P. C., Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R., Blundell, Tom L., Spring, David R., McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R., Hyvönen, Marko

المساهمون: Wellcome Trust

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 17, page 15521-15536 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.4c01165
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01165

المؤلفون: Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

المساهمون: Alzheimer's Research UK

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 1, page 804-821 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c01693
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01693

المؤلفون: Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

المساهمون: Alzheimer's Research Trust

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 4, page 3359-3370 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.1c01819
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01819

المؤلفون: Stockwell, Simon R., Scott, Duncan E., Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P. C., Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R., Blundell, Tom L., Spring, David R., McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R., Hyvönen, Marko

المصدر: Journal of Medicinal Chemistry; September 2024, Vol. 67 Issue: 17 p15521-15536, 16p

المؤلفون: Huggins, David J., Baell, Jonathan, Brennan, Paul E., Burgin, Alex, Scott, Duncan E.

المصدر: Nature Reviews Drug Discovery ; ISSN 1474-1776 1474-1784

الاتاحة: https://doi.org/10.1038/d41573-024-00142-z
https://www.nature.com/articles/d41573-024-00142-z.pdf
https://www.nature.com/articles/d41573-024-00142-z

المؤلفون: Scott, Duncan E, Francis-Newton, Nicola J, Marsh, May E, Coyne, Anthony G, Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R, Sharpe, Timothy D, Haas, Kalina T, Barber, Lorraine, Valenzano, Chiara R, Srinivasan, Rajavel, Huggins, David J, Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L, Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R, Abell, Chris

مصطلحات موضوعية: BRCA2, DNA repair, RAD51, RAD51 inhibitor, cancer therapy, homologous recombination, protein-protein interaction inhibition, radiosensitizer, structure-guided drug discovery, BRCA2 Protein, Cell Death, Crystallography, X-Ray, DNA Damage, Humans, Models, Molecular, Molecular Conformation, Protein Binding, Rad51 Recombinase, Small Molecule Libraries, Tumor Cells, Cultured

وصف الملف: Print-Electronic; application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/317313

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/317313
https://doi.org/10.17863/CAM.64431

المؤلفون: Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris

المساهمون: Wellcome Trust, Astex Pharmaceuticals, Medical Research Council, European Synchrotron Radiation Facility

المصدر: Cell Chemical Biology ; volume 28, issue 6, page 835-847.e5 ; ISSN 2451-9456

الاتاحة: http://dx.doi.org/10.1016/j.chembiol.2021.02.006
https://api.elsevier.com/content/article/PII:S2451945621000581?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2451945621000581?httpAccept=text/plain

المؤلفون: Rooney, Timothy PC, Aldred, Gregory G, Boffey, Helen K, Willems, Henriëtte MG, Edwards, Simon, Chawner, Stephen J, Scott, Duncan E, Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P

مصطلحات موضوعية: Humans, Protein Isoforms, Signal Transduction, Neoplasms, Brain, Protein Kinase Inhibitors

وصف الملف: application/pdf; application/zip; text/xml

Relation: https://www.repository.cam.ac.uk/handle/1810/345339

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/345339
https://doi.org/10.17863/CAM.92762

المؤلفون: Boffey, Helen K, Rooney, Timothy PC, Willems, Henriette MG, Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E, Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P

مصطلحات موضوعية: Adenosine Triphosphate, Allosteric Regulation, Binding, Competitive, Crystallography, X-Ray, Humans, Models, Molecular, Molecular Docking Simulation, Phosphotransferases (Alcohol Group Acceptor), Protein Kinase Inhibitors, Quinazolines, Substrate Specificity, Thiophenes

وصف الملف: Print-Electronic; application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/334446

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/334446
https://doi.org/10.17863/CAM.81861

المؤلفون: Scott, Duncan E, Marsh, May, Blundell, Tom L, Abell, Chris, Hyvönen, Marko

مصطلحات موضوعية: RAD51, X-ray crystallography, alanine scanning, biophysics/ITC, peptides, protein-protein interaction, Amino Acid Motifs, Amino Acid Sequence, BRCA2 Protein, Conserved Sequence, Humans, Models, Molecular, Mutation, Protein Binding, Protein Structure, Secondary, Rad51 Recombinase, Structure-Activity Relationship

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/254565

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/254565

المؤلفون: Marsh, May E, Scott, Duncan E, Ehebauer, Matthias T, Abell, Chris, Blundell, Tom L, Hyvönen, Marko

مصطلحات موضوعية: ATPase, RAD51, RadA, homologous recombination, nucleotide‐binding site, specificity

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/254444

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/254444

المؤلفون: Scott, Duncan E., Marsh, May, Blundell, Tom L., Abell, Chris, Hyvönen, Marko

المساهمون: Wellcome Trust

المصدر: FEBS Letters ; volume 590, issue 8, page 1094-1102 ; ISSN 0014-5793 1873-3468

الاتاحة: http://dx.doi.org/10.1002/1873-3468.12139
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1873-3468.12139
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.12139

المؤلفون: Marsh, May E., Scott, Duncan E., Ehebauer, Matthias T., Abell, Chris, Blundell, Tom L., Hyvönen, Marko

المساهمون: Wellcome Trust

المصدر: FEBS Open Bio ; volume 6, issue 5, page 372-385 ; ISSN 2211-5463 2211-5463

الاتاحة: http://dx.doi.org/10.1002/2211-5463.12052
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F2211-5463.12052
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12052

المؤلفون: Moschetti, Tommaso, Sharpe, Timothy, Fischer, Gerhard, Marsh, May E., Ng, Hong Kin, Morgan, Matthew, Scott, Duncan E., Blundell, Tom L., R. Venkitaraman, Ashok, Skidmore, John, Abell, Chris, Hyvönen, Marko

المساهمون: Wellcome Trust Translational, Seeding Drug Discovery Initiative

المصدر: Journal of Molecular Biology ; volume 428, issue 23, page 4589-4607 ; ISSN 0022-2836

الاتاحة: http://dx.doi.org/10.1016/j.jmb.2016.10.009
https://api.elsevier.com/content/article/PII:S0022283616304247?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022283616304247?httpAccept=text/plain

المؤلفون: Scott, Duncan E, Coyne, Anthony G, Venkitaraman, Ashok, Blundell, Tom L, Abell, Chris, Hyvönen, Marko

مصطلحات موضوعية: BRCA2, RAD51, biophysics, homologous recombination, inhibitors, protein-protein interactions, Amino Acid Motifs, BRCA2 Protein, Binding Sites, Drug Design, Humans, Molecular Dynamics Simulation, Protein Binding, Protein Structure, Tertiary, Pyrococcus furiosus, Rad51 Recombinase, Small Molecule Libraries, Structure-Activity Relationship, Thermodynamics

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/246495

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/246495

المؤلفون: Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

المصدر: Journal of Medicinal Chemistry; 1/12/2023, Vol. 66 Issue 1, p804-821, 18p

المؤلفون: Scott, Duncan E., Ehebauer, Matthias T., Pukala, Tara, Marsh, May, Blundell, Tom L., Venkitaraman, Ashok R., Abell, Chris, Hyvönen, Marko

المصدر: ChemBioChem ; volume 14, issue 3, page 332-342 ; ISSN 1439-4227 1439-7633

الاتاحة: http://dx.doi.org/10.1002/cbic.201200521
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201200521
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201200521/fullpdf

المؤلفون: Scott, Duncan E, Rooney, Timothy PC, Bayle, Elliott D, Mirza, Tashfina, Willems, Henriette MG, Clarke, Jonathan H, Andrews, Stephen P, Skidmore, John

المساهمون: Scott, Duncan [0000-0003-1917-9576], Rooney, Timothy [0000-0001-6788-5526], Willems, Henriette [0000-0001-7196-5975], Clarke, Jonathan [0000-0002-4079-5333], Andrews, Stephen [0000-0001-6021-6899], Skidmore, John [0000-0001-9108-7858], Apollo - University of Cambridge Repository

مصطلحات موضوعية: PROTACs, androgen receptor, medicinal chemistry, drug discovery

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd43522c4e29901c0e9b0db677ca134

المؤلفون: Scott Duncan, E. J., Kournikakis, Bill, Ho, Jim, Hill, Ira

المصدر: Inhalation Toxicology ; volume 21, issue 2, page 141-152 ; ISSN 0895-8378 1091-7691

الاتاحة: http://dx.doi.org/10.1080/08958370802412629
http://www.tandfonline.com/doi/pdf/10.1080/08958370802412629