-
1Academic Journal
المؤلفون: Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter
المصدر: eLife, Vol 9 (2020)
مصطلحات موضوعية: unfolded protein response, ER stress, apoptosis, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
2Academic Journal
المؤلفون: Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi
المصدر: eLife, Vol 8 (2019)
مصطلحات موضوعية: apoptosis, BAX, XBP1, cancer, hematopoietic, myeloma, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
3
المؤلفون: Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
-
4
المؤلفون: Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
-
5
المؤلفون: Paul J. Wolters, Elsa-Noah N’Diaye, Hsiao-Yen Ma, Bushra Husain, Thirumalai R. Ramalingam, Ryan P. Kelly, Alexander Arlantico, Katrina B. Morshead, Si Hyun Kim, Scot A. Marsters, Guiquan Jia, Charles Yu, Claire Emson, Merone Roose-Girma, Daryle Depianto, Ariel E. Feldstein, Lucinda Tam, Ryan LaCanna, Meredith Sagolla, Surinder Jeet, Zhiyu Huang, Hans Brightbill, Jason A. Vander Heiden, Aaron K. Wong, Nadia Martinez Martin, Ying Xi, Patrick Caplazi, Shuang Wu, Laura Lucio, Avi Ashkenazi, Ning Ding, Sarah Gierke
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: Cirrhosis, WNT1-inducible-signaling pathway protein 1, Fibrosis, business.industry, Myocardin, Cancer research, medicine, Steatohepatitis, Chronic liver disease, medicine.disease, business, Myofibroblast, Transcription factor
-
6
المؤلفون: Thomas D. Wu, Margaret Solon, Zora Modrusan, Monika Dohse, David A. Lawrence, Jonathan M. Harnoss, Peter Walter, David Kan, Ofer Guttman, Mike Reichelt, Ehud Segal, Adrien Le Thomas, Anna Shemorry, Avi Ashkenazi, Joachim Rudolph, Mark Merchant, Lisa Crocker, Hartmut Koeppen, Scot A. Marsters, Kathryn Mesh, Klara Totpal
المصدر: Cancer Res
Cancer research, vol 80, iss 11مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, X-Box Binding Protein 1, Cancer Research, Messenger, Angiogenesis Inhibitors, Triple Negative Breast Neoplasms, Mice, SCID, Gene Knockout Techniques, Mice, 0302 clinical medicine, Antineoplastic Agents, Immunological, Tumor Microenvironment, Triple-negative breast cancer, Tumor, Neovascularization, Pathologic, Protein-Serine-Threonine Kinases, Endoplasmic Reticulum Stress, medicine.anatomical_structure, Immunological, Oncology, 030220 oncology & carcinogenesis, Female, Pericyte, Oncology and Carcinogenesis, Antineoplastic Agents, Protein Serine-Threonine Kinases, SCID, Article, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Endoribonucleases, medicine, Animals, Humans, Oncology & Carcinogenesis, RNA, Messenger, Transcription factor, Neovascularization, Pathologic, Tumor microenvironment, business.industry, Endoplasmic reticulum, Gene signature, Xenograft Model Antitumor Assays, 030104 developmental biology, Cancer cell, Unfolded protein response, Cancer research, RNA, business
-
7
المؤلفون: Scot A. Marsters, Peter Walter, Avi Ashkenazi, Mable Lam
المصدر: eLife, Vol 9 (2020)
eLifeمصطلحات موضوعية: 0301 basic medicine, Protein Folding, TNF-Related Apoptosis-Inducing Ligand, 0302 clinical medicine, Receptors, cell biology, 2.1 Biological and endogenous factors, Aetiology, Biology (General), Caspase, biology, Chemistry, General Neuroscience, apoptosis, Hep G2 Cells, unfolded protein response, General Medicine, Endoplasmic Reticulum Stress, Cytoprotection, Cell biology, Ectodomain, 030220 oncology & carcinogenesis, Medicine, ER stress, Intracellular, Research Article, Human, QH301-705.5, 1.1 Normal biological development and functioning, Science, chemical biology, Cell fate determination, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Underpinning research, Biochemistry and Chemical Biology, biochemistry, Humans, human, General Immunology and Microbiology, Endoplasmic reticulum, Cell Biology, HCT116 Cells, Receptors, TNF-Related Apoptosis-Inducing Ligand, 030104 developmental biology, Apoptosis, biology.protein, Unfolded protein response, Generic health relevance, Biochemistry and Cell Biology
وصف الملف: application/pdf
-
8
المؤلفون: Peter Walter, Mable Lam, Scot A. Marsters, Avi Ashkenazi
مصطلحات موضوعية: Apoptosis, Chemistry, Endoplasmic reticulum, TNFRSF10B, Protein folding, Cell biology
-
9
المؤلفون: Avi Ashkenazi, Anna Shemorry, László G. Kőműves, David A. Lawrence, Jonathan M. Harnoss, Ofer Guttman, Scot A. Marsters
المصدر: eLife, Vol 8 (2019)
eLifeمصطلحات موضوعية: 0301 basic medicine, XBP1, Mouse, QH301-705.5, Science, Cell, Protein Serine-Threonine Kinases, Mitochondrion, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Endoribonucleases, medicine, Animals, Humans, cancer, Biology (General), hematopoietic, Caspase, Cancer Biology, General Immunology and Microbiology, biology, Chemistry, General Neuroscience, Endoplasmic reticulum, apoptosis, Cell Biology, General Medicine, Endoplasmic Reticulum Stress, Cell biology, 030104 developmental biology, medicine.anatomical_structure, myeloma, Cytoplasm, Apoptosis, BAX, Caspases, 030220 oncology & carcinogenesis, Proteolysis, Unfolded protein response, biology.protein, Medicine, Research Article, Human
-
10
المؤلفون: Heidi J.A. Wallweber, Diego Acosta-Alvear, Yung-Chia Ariel Chen, Maria N. Lorenzo, Jiansheng Wu, Mark Merchant, Anna Shemorry, Michael J VanWyngarden, Klara Totpal, Jonathan M. Harnoss, Alvin Gogineni, Adrien Le Thomas, Daniel W. Sherbenou, Susan Kaufman, Robby M. Weimer, Marie-Gabrielle Braun, David A. Lawrence, Weiru Wang, Kevin R Clark, Mike Reichelt, Tom De Bruyn, Steven T Laing, Min Lu, Avi Ashkenazi, David Kan, Benjamin Haley, Jing Qing, Maureen Beresini, Justin Ly, Amy Heidersbach, Ehud Segal, Wendy Sandoval, Martine Amiot, Peter Walter, Scot A. Marsters, Patricia Gomez-Bougie, Dong Lee, Joachim Rudolph
المساهمون: Department of Cancer Immunology, Genentech, Inc. [San Francisco], Translational Oncology [South San Francisco, CA, USA], Pathology [South San Francisco, CA, USA], Structural Biology [South San Francisco, CA, USA], Biochemical and Cellular Pharmacology [South San Francisco, CA, USA], Microchemistry, Proteomics and Lipidomics [South San Francisco, CA, USA], Protein Chemistry [South San Francisco, CA, USA], Drug Metabolism and Pharmacokinetics [South San Francisco, CA, USA], Molecular Biology [South San Francisco, CA, USA], Biomolecular Imaging [South San Francisco, CA, USA], Safety Assessment [South San Francisco, CA, USA], Department of Discovery Chemistry, Division of Hematology [Aurora, CO, USA] (Department of Medicine), University of Colorado Cancer Center [Aurora, CO, USA], Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Service d'Hématologie Clinique [CHU Nantes] (Unité d'Investigation Clinique), Centre hospitalier universitaire de Nantes (CHU Nantes), Department of Biochemistry and Biophysics [San Francisco], University of California, Howard Hughes Medical Institute [San Francisco, CA, USA], University of California [San Francisco] (UCSF), University of California-University of California, Bernardo, Elizabeth, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), University of California (UC), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC)
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 33
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201906999. ⟨10.1073/pnas.1906999116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, pp.201906999. ⟨10.1073/pnas.1906999116⟩مصطلحات موضوعية: Male, X-Box Binding Protein 1, Chemokine, Bortezomib, Mice, 0302 clinical medicine, kinase inhibitors, Lenalidomide, Multiple myeloma, media_common, 0303 health sciences, Multidisciplinary, biology, unfolded protein response, Biological Sciences, Middle Aged, Protein-Serine-Threonine Kinases, Endoplasmic Reticulum Stress, 3. Good health, Gene Expression Regulation, Neoplastic, multiple myeloma, PNAS Plus, 030220 oncology & carcinogenesis, Female, Antibody, medicine.drug, Signal Transduction, inositol-requiring enzyme 1, [SDV.CAN]Life Sciences [q-bio]/Cancer, Protein Serine-Threonine Kinases, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Endoribonucleases, medicine, media_common.cataloged_instance, Animals, Humans, Secretion, European union, Protein Kinase Inhibitors, 030304 developmental biology, Aged, Neoplastic, business.industry, Endoplasmic reticulum, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Gene Expression Regulation, Cancer research, biology.protein, business, Homeostasis
وصف الملف: application/pdf
-
11
المؤلفون: Scot A. Marsters, László G. Kőműves, Anna Shemorry, Jonathan M. Harnoss, Ofer Guttman, Avi Ashkenazi, David A. Lawrence
مصطلحات موضوعية: medicine.anatomical_structure, biology, Apoptosis, Chemistry, Endoplasmic reticulum, Cell, medicine, biology.protein, Cleavage (embryo), Caspase, Cell biology
-
12
المؤلفون: David A. Lawrence, Kevin R Clark, Tom De Bruyn, Justin Ly, Dong Lee, Yung-Chia Ariel Chen, Amy Heidersbachh, Joachim Rudolph, Wendy Sandoval, Alvin Gogineni, Klara Totpal, Michael J VanWyngarden, Martine Amiot, David Kan, Benjamin Haley, Peter Walter, Adrien Le Thomas, Robby M. Weimer, Scot A. Marsters, Patricia Gomez-Bougie, Weiru Wang, Diego Acosta-Alvear, Jiansheng Wu, Maria N. Lorenzo, Min Lu, Heidi J.A. Wallweber, Avi Ashkenazi, Ehud Segal, Jing Qing, Daniel W. Sherbenou, Marie-Gabrielle Braun, Susan Kaufman, Jonathan M. Harnoss, Maureen Beresini
مصطلحات موضوعية: Chemokine, biology, business.industry, Kinase, Bortezomib, medicine.disease, medicine.anatomical_structure, Protein kinase domain, medicine, biology.protein, Cancer research, Bone marrow, business, Transcription factor, Multiple myeloma, Lenalidomide, medicine.drug
-
13
المؤلفون: Jarrod Tremayne, Jing Peng, Yan Wu, Mark Merchant, Scot A. Marsters, Stevan Djakovic, Paul Carter, Avi Ashkenazi, Yiyuan Yin, Genee Lee, Richard M. Neve, Janet Tien
المصدر: Molecular Cancer Therapeutics. 14:2270-2278
مصطلحات موضوعية: musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, Phage display, Antineoplastic Agents, Mice, SCID, Plasma protein binding, Crystallography, X-Ray, Monospecific antibody, Epitope, Antibody Specificity, Cell Line, Tumor, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 2, Receptor, Tissue homeostasis, Mice, Inbred BALB C, integumentary system, biology, Antibodies, Monoclonal, Xenograft Model Antitumor Assays, Molecular biology, Cell biology, Molecular Docking Simulation, stomatognathic diseases, Oncology, Cell culture, Drug Design, biology.protein, Female, Antibody, Protein Binding
-
14
المؤلفون: Tom T. Chen, Scot A. Marsters, Ellen Filvaroff, Avi Ashkenazi, Adrian M. Jubb, Mark Merchant, Hartmut Koeppen, Jing Peng
المصدر: EBioMedicine, Vol 2, Iss 5, Pp 406-420 (2015)
EBioMedicineمصطلحات موضوعية: Vascular Endothelial Growth Factor A, X-Box Binding Protein 1, Intracrine, Intracellular Space, lcsh:Medicine, Receptor tyrosine kinase, Mice, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Neoplasms, PI3 kinase, HGF, Phosphorylation, lcsh:R5-920, Endoplasmic Reticulum-Associated Degradation, General Medicine, Proto-Oncogene Proteins c-met, respiratory system, VEGF, MEK, Up-Regulation, Cell biology, XBP1, DNA-Binding Proteins, Vascular endothelial growth factor, Vascular endothelial growth factor A, cardiovascular system, Original Article, Hepatocyte growth factor, Signal transduction, lcsh:Medicine (General), Protein Binding, Signal Transduction, medicine.drug, circulatory and respiratory physiology, Regulatory Factor X Transcription Factors, IRE1, Protein Serine-Threonine Kinases, Biology, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Cell Line, Tumor, Endoribonucleases, medicine, Animals, Humans, Cell Proliferation, Lysine, AKT, lcsh:R, Ubiquitination, Epithelial Cells, Kinase insert domain receptor, ERAD, Vascular Endothelial Growth Factor Receptor-2, chemistry, Proteolysis, Cancer research, biology.protein, Protein Processing, Post-Translational, Transcription Factors
-
15
المؤلفون: Alvin Gogineni, David A. Lawrence, Hai Ngu, Jeffrey Settleman, Avi Ashkenazi, Heather A. Flores, Pradeep M. Nair, Robert F. Kelley, Scot A. Marsters, László G. Kömüves, Meredith Sagolla, Richard Bourgon
المصدر: Proceedings of the National Academy of Sciences. 112:5679-5684
مصطلحات موضوعية: Programmed cell death, Fas Ligand Protein, Mice, Nude, Antineoplastic Agents, Apoptosis, Biology, Ligands, TNF-Related Apoptosis-Inducing Ligand, Cell membrane, Epitopes, Inhibitory Concentration 50, Mice, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Biotinylation, Cytotoxicity, Receptor, Caspase 8, Multidisciplinary, Ligand, Cell Membrane, Biological Sciences, Recombinant Proteins, Cell biology, medicine.anatomical_structure, Microscopy, Fluorescence, Ectodomain, Caspases, Immune System, Liposomes, Cancer cell, Immunotherapy, Neoplasm Transplantation, CD27 Ligand
-
16
المؤلفون: Peter Liu, David A. Lawrence, Tsun-Kai Chang, Jenille Tan, Avi Ashkenazi, Jonathan M. Harnoss, Min Lu, Wendy Sandoval, Scot A. Marsters, Scott E. Martin
المصدر: Molecular cell. 71(4)
مصطلحات موضوعية: 0301 basic medicine, X-Box Binding Protein 1, endocrine system, Programmed cell death, Endoribonuclease, Apoptosis, Biology, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, 03 medical and health sciences, eIF-2 Kinase, Cell Line, Tumor, Endoribonucleases, Humans, Molecular Biology, Transcription factor, Kinase, Endoplasmic reticulum, Cell Biology, Endoplasmic Reticulum Stress, Cell biology, Receptors, TNF-Related Apoptosis-Inducing Ligand, 030104 developmental biology, Proteostasis, HEK293 Cells, Gene Expression Regulation, Caspases, Proteolysis, Unfolded protein response, Unfolded Protein Response, Phosphorylation, Carrier Proteins, Signal Transduction
-
17
المؤلفون: Jean-Philippe Stephan, Avi Ashkenazi, Francois Gonzalvez, Becky Yang, Sharon Yee, Scot A. Marsters, Robert M. Pitti, Jennie R. Lill, David A. Lawrence, Victoria Pham
المصدر: Molecular Cell. 48(6):888-899
مصطلحات موضوعية: Cell signaling, TRAF2, Death Domain Receptor Signaling Adaptor Proteins, Proteasome Endopeptidase Complex, Cell Survival, Leupeptins, Molecular Sequence Data, Apoptosis, Caspase 8, Peptide Mapping, Enzyme activator, Mice, Ubiquitin, Catalytic Domain, Animals, Humans, Amino Acid Sequence, Molecular Biology, Caspase, Mice, Knockout, biology, Ubiquitination, Cell Biology, Cullin Proteins, HCT116 Cells, TNF Receptor-Associated Factor 2, Cell biology, Enzyme Activation, Mice, Inbred C57BL, Proteolysis, biology.protein, Tumor necrosis factor alpha, Proteasome Inhibitors, Protein Processing, Post-Translational
-
18
المؤلفون: Alvin Gogineni, Annie Yang, Suzana S. Couto, Scot A. Marsters, Howard M. Stern, Nicholas S. Wilson, Mallika Singh, Avi Ashkenazi, Becky Yang, Robby M. Weimer, Robert M. Pitti
المصدر: Cancer Cell. 22(1):80-90
مصطلحات موضوعية: Tumor microenvironment, Cancer Research, Cell division, Endothelium, Apoptosis, Cell Biology, Biology, Vascular endothelial growth inhibitor, Ligand (biochemistry), Cell biology, Mice, Receptors, TNF-Related Apoptosis-Inducing Ligand, medicine.anatomical_structure, Oncology, Neoplasms, Cancer cell, medicine, Animals, Humans, Endothelium, Vascular, Receptor, Cell Division
-
19
المؤلفون: Scot A. Marsters, Annie Yang, Stefanie Loeser, Gloria Meng, Avi Ashkenazi, Becky Yang, Robert M. Pitti, Cam Adams, Sarah G. Hymowitz, Dylan Daniel, Jean-Michel Vernes, David A. Lawrence, Bob Kelley, Yun Li, Sarajane Ross, Sharon Yee, Rienk Offringa, Klara Totpal, Nicholas S. Wilson, Yanmei Lu
المصدر: Cancer Cell. 19:101-113
مصطلحات موضوعية: Cancer Research, Apoptosis, Context (language use), Biology, Antibodies, Monoclonal, Humanized, Polymorphism, Single Nucleotide, Mice, Antigen, Cell Line, Tumor, Neoplasms, Leukocytes, medicine, Animals, Humans, Myeloid Cells, CD40 Antigens, Receptor, Mice, Knockout, B-Lymphocytes, Mice, Inbred BALB C, Receptor Aggregation, Receptors, IgG, NF-kappa B, Antibodies, Monoclonal, Cell Biology, HCT116 Cells, Xenograft Model Antitumor Assays, Immunoglobulin Fc Fragments, Cell biology, Killer Cells, Natural, Mice, Inbred C57BL, Receptors, TNF-Related Apoptosis-Inducing Ligand, Oncology, Mechanism of action, Immunoglobulin G, Mutation, Cancer cell, biology.protein, Female, medicine.symptom, Antibody, Function (biology), Protein Binding, Signal Transduction
-
20
المؤلفون: Stephen J. Russell, Avi Ashkenazi, Andrea G. Cochran, Klara Totpal, Scot A. Marsters, Sachdev S. Sidhu, Sarah G. Hymowitz, Bing Li, Deanne M. Compaan
المصدر: Journal of Molecular Biology. 361:522-536
مصطلحات موضوعية: Models, Molecular, Programmed cell death, Phage display, Protein Conformation, medicine.drug_class, Molecular Sequence Data, Apoptosis, Peptide, Complementarity determining region, Crystallography, X-Ray, Monoclonal antibody, Antibodies, Receptors, Tumor Necrosis Factor, Immunoglobulin Fab Fragments, Peptide Library, Structural Biology, Cell Line, Tumor, medicine, Humans, Amino Acid Sequence, Receptor, Peptide library, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Molecular biology, Cell biology, Receptors, TNF-Related Apoptosis-Inducing Ligand, chemistry, biology.protein, Antibody, Oligopeptides
Full Text Finder