يعرض 1 - 17 نتائج من 17 نتيجة بحث عن '"Schnell, Sathya M"', وقت الاستعلام: 0.54s تنقيح النتائج
  1. 1
    Academic Journal
    Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R

    المؤلفون: Ericson, Mark D, Haslach, Erica M, Schnell, Sathya M, Freeman, Katie T, Xiang, Zhimin M, Portillo, Frederico P, Speth, Robert, Litherland, Sally A, Haskell-Luevano, Carrie

    المصدر: HPD Articles

    مصطلحات موضوعية: Macrocyclic peptide, inverse agonism, mutant hMC4R, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences

    وصف الملف: application/pdf

    Relation: https://nsuworks.nova.edu/hpd_facarticles/50; https://nsuworks.nova.edu/context/hpd_facarticles/article/1049/viewcontent/Ericson2021_Discovery_of_Molecular.pdf

    الاتاحة: https://nsuworks.nova.edu/hpd_facarticles/50
    https://doi.org/10.1021/acschemneuro.0c00755
    https://nsuworks.nova.edu/context/hpd_facarticles/article/1049/viewcontent/Ericson2021_Discovery_of_Molecular.pdf

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  2. 2
    Academic Journal
    Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

    المؤلفون: Lensing, Cody J, Freeman, Katie T, Schnell, Sathya M, Speth, Robert Charles, Zarth, Adam T, Haskell-Luevano, Carrie

    المصدر: Faculty Articles

    مصطلحات موضوعية: Allosteric Regulation, Bioluminescence Resonance Energy Transfer Techniques, Cyclic AMP, Dimerization, Drug Design, HEK293 Cells, Humans, Ligands, Models, Molecular, Receptors, Melanocortin, Signal Transduction, beta-Arrestin 2, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences

    وصف الملف: application/pdf

    Relation: https://nsuworks.nova.edu/hpd_corx_facarticles/113; https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1149/viewcontent/nihms974300.pdf

    الاتاحة: https://nsuworks.nova.edu/hpd_corx_facarticles/113
    https://doi.org/10.1021/acs.jmedchem.8b00238
    https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1149/viewcontent/nihms974300.pdf

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  3. 3
    Academic Journal
    Discovery of Molecular Interactions of the Human Melanocortin‑4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G‑Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse...

    المؤلفون: Ericson, Mark D., Haslach, Erica M., Schnell, Sathya M., Freeman, Katie T., Xiang, Zhimin M., Portillo, Frederico P., Speth, Robert, Litherland, Sally A., Haskell-Luevano, Carrie

    المصدر: ACS Chemical Neuroscience; 2/3/2021, Vol. 12` Issue 3, p542-556, 15p


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  4. 4
    Academic Journal
    A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

    المؤلفون: Lensing, Cody J, Adank, Danielle N, Wilber, Stacey L, Freeman, Katie T, Schnell, Sathya M, Speth, Robert Charles, Zarth, Adam T, Haskell-Luevano, Carrie

    المصدر: Faculty Articles

    مصطلحات موضوعية: melanocortin homodimer, obesity, metabolic serum stability, melanotropin, MC3R-MC4R heterodimer, BRET, interleukin-6 (IL-6), magnetic resonance imagining (MRI), metabolic syndrome, Animals, Eating, Energy Metabolism, HEK293 Cells, Humans, Ligands, Mice, Oligopeptides, Receptors, Melanocortin, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences

    وصف الملف: application/pdf

    Relation: https://nsuworks.nova.edu/hpd_corx_facarticles/107; https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1155/viewcontent/nihms913862.pdf

    الاتاحة: https://nsuworks.nova.edu/hpd_corx_facarticles/107
    https://doi.org/10.1021/acschemneuro.6b00399
    https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1155/viewcontent/nihms913862.pdf

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  5. 5
    Academic Journal
    Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa

    المؤلفون: Doering, Skye R, Freeman, Katie T, Schnell, Sathya M, Haslach, Erica M, Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G, Giulianotti, Marc A, Pinilla, Clemencia, Appel, Jon R, Speth, Robert Charles, Houghten, Richard A, Haskell-Luevano, Carrie

    المصدر: Faculty Articles

    مصطلحات موضوعية: Amino Acid Sequence, Animals, Drug Discovery, Mice, Oligopeptides, Peptide Library, Receptor, Melanocortin, Type 3, Type 4, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences

    Relation: https://nsuworks.nova.edu/hpd_corx_facarticles/109; https://www.ncbi.nlm.nih.gov/pubmed/28453292

    الاتاحة: https://nsuworks.nova.edu/hpd_corx_facarticles/109
    https://www.ncbi.nlm.nih.gov/pubmed/28453292

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  6. 6
    Academic Journal
    Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2

    المؤلفون: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh, Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert Charles, Houghten, Richard A., Haskell-Luevano, Carrie

    المصدر: Mathematics Faculty Articles

    مصطلحات موضوعية: Chemistry, Mathematics, Medicinal-Pharmaceutical Chemistry, Physical Sciences and Mathematics

    Relation: https://nsuworks.nova.edu/math_facarticles/242

    الاتاحة: https://nsuworks.nova.edu/math_facarticles/242

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  7. 7
    Academic Journal
    1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization

    المؤلفون: Tala, Srinivasa R., Singh, Anamika, Lensing, Cody J., Schnell, Sathya M., Freeman, Katie T., Rocca, James R., Haskell-Luevano, Carrie

    المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases

    المصدر: ACS Chemical Neuroscience ; volume 9, issue 5, page 1001-1013 ; ISSN 1948-7193 1948-7193

    الاتاحة: http://dx.doi.org/10.1021/acschemneuro.7b00422
    https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.7b00422

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  8. 8
    Academic Journal
    Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa 1 -Arg-(pI)DPhe-Xaa 4 -NH 2

    المؤلفون: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert C., Houghten, Richard A., Haskell-Luevano, Carrie

    المساهمون: NIH Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Drug Abuse, Executive Office of the Governor Office of Tourism, Trade, and Economic Development, Georgetown-Howard Universities Center for Clinical and Translational Science

    المصدر: Journal of Medicinal Chemistry ; volume 60, issue 10, page 4342-4357 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.7b00301
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00301

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  9. 9
    Academic Journal
    A Macrocyclic Agouti-Related Protein/[Nle 4 ,DPhe 7 ]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

    المؤلفون: Ericson, Mark D., Freeman, Katie T., Schnell, Sathya M., Haskell-Luevano, Carrie

    المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases

    المصدر: Journal of Medicinal Chemistry ; volume 60, issue 2, page 805-813 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.6b01707
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01707

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  10. 10
    Academic Journal
    Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor

    المؤلفون: Ericson, Mark D., Freeman, Katie T., Schnell, Sathya M., Fleming, Katlyn A., Haskell-Luevano, Carrie

    المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases

    المصدر: Journal of Medicinal Chemistry ; volume 60, issue 19, page 8103-8114 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.7b00856
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00856

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  11. 11
    Academic Journal
    An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers

    المؤلفون: Lensing, Cody J, Freeman, Katie T, Schnell, Sathya M, Adank, Danielle N, Speth, Robert Charles, Haskell-Luevano, Carrie

    المصدر: Faculty Articles

    مصطلحات موضوعية: Melanotropin, peptide, GPCR dimers, homobivalent, homodimer, obesity, feeding, Animals, Binding, Competitive, Chemistry Techniques, Synthetic, Cyclic AMP, Drug Design, Drug Evaluation, Preclinical, Eating, Female, Humans, Infusions, Intraventricular, Ligands, Male, Mice, Inbred C57BL, Peptides, Protein Multimerization, Receptor, Melanocortin, Type 1

    وصف الملف: application/pdf

    Relation: https://nsuworks.nova.edu/hpd_corx_facarticles/102; https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1160/viewcontent/nihms913844.pdf

    الاتاحة: https://nsuworks.nova.edu/hpd_corx_facarticles/102
    https://doi.org/10.1021/acs.jmedchem.5b01894
    https://nsuworks.nova.edu/context/hpd_corx_facarticles/article/1160/viewcontent/nihms913844.pdf

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  12. 12
    Academic Journal
    A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

    المؤلفون: Ericson, Mark D., Schnell, Sathya M., Freeman, Katie T., Haskell-Luevano, Carrie

    المساهمون: NIH

    المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 25, issue 22, page 5306-5308 ; ISSN 0960-894X

    الاتاحة: http://dx.doi.org/10.1016/j.bmcl.2015.09.046
    https://api.elsevier.com/content/article/PII:S0960894X15300809?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0960894X15300809?httpAccept=text/plain

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  13. 13
    Academic Journal
    Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa¹-Arg-(pI)DPhe-Xaa4-NH2.

    المؤلفون: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert C., Houghten, Richard A., Haskell-Luevano, Carrie

    المصدر: Journal of Medicinal Chemistry; 5/25/2017, Vol. 60 Issue 10, p4342-4357, 16p


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  14. 14
    Periodical
    Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

    المؤلفون: Lensing, Cody J., Freeman, Katie T., Schnell, Sathya M., Speth, Robert C., Zarth, Adam T., Haskell-Luevano, Carrie

    المصدر: Journal of Medicinal Chemistry; January 2019, Vol. 62 Issue: 1 p144-158, 15p


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  15. 15
    Academic Journal
    A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.

    المؤلفون: Ericson, Mark D., Freeman, Katie T., Schnell, Sathya M., Haskell-Luevano, Carrie

    المصدر: Journal of Medicinal Chemistry; Jan2017, Vol. 60 Issue 2, p805-813, 9p


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  16. 16
    Academic Journal
    An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.

    المؤلفون: Lensing, Cody J., Freeman, Katie T., Schnell, Sathya M., Adank, Danielle N., Speth, Robert C., Haskell-Luevano, Carrie

    المصدر: Journal of Medicinal Chemistry; 4/14/2016, Vol. 59 Issue 7, p3112-3128, 17p


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  17. 17
    Academic Journal
    Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides.

    المؤلفون: Tala, Srinivasa R.1, Schnell, Sathya M.1, Haskell-Luevano, Carrie1 chaskell@umn.edu

    المصدر: Bioorganic & Medicinal Chemistry Letters. Dec2015, Vol. 25 Issue 24, p5708-5711. 4p.

    مصطلحات موضوعية: *MICROWAVE chemistry, *SOLID-phase synthesis, *SUBSTITUENTS (Chemistry), *LACTAMS, *CYCLIC peptides synthesis, *BIOCHEMISTRY


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