المؤلفون: Eteläinen, Tony S., Silva, M.Catarina, Uhari-Väänänen, Johanna K., De Lorenzo, Francesca, Jäntti, Maria H., Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R., Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H., Huttunen, Henri J., Haggarty, Stephen J., Myöhänen, Timo

المساهمون: Divisions of Faculty of Pharmacy, PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Drug Research Program, Research Services, Faculty of Pharmacy, Neuroscience Center, Henri Juhani Huttunen / Principal Investigator

مصطلحات موضوعية: Pharmacy

وصف الملف: application/pdf

Relation: Eteläinen , T S , Silva , M C , Uhari-Väänänen , J K , De Lorenzo , F , Jäntti , M H , Cui , H , Chavero-Pieres , M , Kilpeläinen , T , Mechtler , C , Svarcbahs , R , Seppälä , E , Savinainen , J R , Puris , E , Fricker , G , Gynther , M , Julku , U H , Huttunen , H J , Haggarty , S J & Myöhänen , T 2023 , ' A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy ' , Science translational medicine , vol. 15 , no. 691 , eabq2915 . https://doi.org/10.1126/scitranslmed.abq2915; ORCID: /0000-0002-1312-9837/work/151788180; ORCID: /0000-0002-9277-6687/work/151789140; ORCID: /0000-0002-9867-4438/work/151793867; http://hdl.handle.net/10138/570895; c256524d-bcd6-47a4-9836-a241d90d1d3c

الاتاحة: http://hdl.handle.net/10138/570895

المؤلفون: Mardon, Karine, Patel, Jayendra, Savinainen, Juha R., Stimson, Damion H. R., Oyagawa, Caitlin, Grimsey, Natasha, Migotto, Mary-anne, Njiru, Grace F. M., Hamilton, Brett R, Cowin, Gary, Yli-Kauhaluoma, Jari, Vanduffel, Wim, Blakey, Idriss, Bhalla, Rajiv, Cawthorne, Christopher, Celen, Sofie, Bormans, Guy, Thurecht, Kristofer J., Ahamed, Muneer

المساهمون: Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, Divisions of Faculty of Pharmacy, Medicinal Chemistry research group

مصطلحات موضوعية: Preclinical evaluation, Cannabinoid receptor, Cb1, Inhibitors, Ureas, Optimization, Radiotracer, Mechanism, System, Potent, Pharmacy

وصف الملف: application/pdf

Relation: Mardon , K , Patel , J , Savinainen , J R , Stimson , D H R , Oyagawa , C , Grimsey , N , Migotto , M , Njiru , G F M , Hamilton , B R , Cowin , G , Yli-Kauhaluoma , J , Vanduffel , W , Blakey , I , Bhalla , R , Cawthorne , C , Celen , S , Bormans , G , Thurecht , K J & Ahamed , M 2023 , ' Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6) ' , Journal of Medicinal Chemistry , vol. 66 , no. 1 , pp. 538-552 . https://doi.org/10.1021/acs.jmedchem.2c01485; ORCID: /0000-0003-0370-7653/work/128026786; ORCID: /0000-0002-2562-1888/work/128032240; http://hdl.handle.net/10138/568419; f67dba84-8a47-4352-b167-3b59647ee41a; 000899515300001

الاتاحة: http://hdl.handle.net/10138/568419

المؤلفون: Eteläinen, Tony S., Silva, M. Catarina, Uhari-Väänänen, Johanna K., De Lorenzo, Francesca, Jäntti, Maria H., Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R., Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H., Huttunen, Henri J., Haggarty, Stephen J., Myöhänen, Timo T.

المصدر: Science Translational Medicine ; volume 15, issue 691 ; ISSN 1946-6234 1946-6242

الاتاحة: https://doi.org/10.1126/scitranslmed.abq2915
https://www.science.org/doi/pdf/10.1126/scitranslmed.abq2915

المؤلفون: Eteläinen, Tony S., Silva, M.Catarina, Uhari-Väänänen, Johanna K., De Lorenzo, Francesca, Jäntti, Maria H., Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R., Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H., Huttunen, Henri J., Haggarty, Stephen J., Myöhänen, Timo

المساهمون: Farmasian tiedekunnan osastot, PREP in neurodegenerative disorders, Farmakologian ja lääkehoidon osasto, Drug Research Program, Tutkimuspalvelut, Farmasian tiedekunta, Neurotieteen tutkimuskeskus, Henri Juhani Huttunen / Vastuullinen tutkija

مصطلحات موضوعية: Farmasia

وصف الملف: application/pdf

Relation: Eteläinen , T S , Silva , M C , Uhari-Väänänen , J K , De Lorenzo , F , Jäntti , M H , Cui , H , Chavero-Pieres , M , Kilpeläinen , T , Mechtler , C , Svarcbahs , R , Seppälä , E , Savinainen , J R , Puris , E , Fricker , G , Gynther , M , Julku , U H , Huttunen , H J , Haggarty , S J & Myöhänen , T 2023 , ' Prolyylioligopeptidaasin estäjistä apua muistisairauksien pysäyttämiseen? ' , Duodecim , Vuosikerta. 139 , Nro 11 , Sivut 941 . < https://www.duodecimlehti.fi/lehti/2023/11/duo17679?keyword=in%20press >; ORCID: /0000-0002-1312-9837/work/151788181; ORCID: /0000-0002-9277-6687/work/151789141; ORCID: /0000-0002-9867-4438/work/151793868; http://hdl.handle.net/10138/577381; 92139ca6-7f67-4962-b5e1-8ab054345b5f

الاتاحة: http://hdl.handle.net/10138/577381

المؤلفون: Aaltonen, Niina, Singha, Prosanta K., Jakupovic, Hermina, Wirth, Thomas, Samaranayake, Haritha, Pasonen-Seppanen, Sanna, Rilla, Kirsi, Varjosalo, Markku, Edgington-Mitchell, Laura E., Kasperkiewicz, Paulina, Drag, Marcin, Kälvälä, Sara, Moisio, Eemeli, Savinainen, Juha R., Laitinen, Jarmo T.

المساهمون: University Management, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Joint Activities, Molecular Systems Biology

مصطلحات موضوعية: Activity-based protein profiling (ABPP), Brain cryosection, Glioblastoma multiforme (GBM), Immunohistochemistry, Serine hydrolase activity, Neutrophil serine protease (NSP), TAMRA-FP probe, Tumor-associated neutrophils, INHIBITORS, DISCOVERY, PROTEASES, AUTORADIOGRAPHY, METABOLISM, PROTEOMICS, LANDSCAPE, PROBES, CELLS, ABHD6, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: J.T.L. was supported by the Finnish Academy (grant no. 278212). L.E.M. was supported by a Grimwade Fellowship from the Russell and Mab Grimwade Miegunyah Fund at The University of Melbourne and a DECRA Fellowship from the Australian Research Council (ARC, DE180100418). Drag laboratory is supported by Foundation for Polish Science and National Science Centre in Poland. PK. is the beneficiary of a L'Oreal Poland and the Polish' Ministry of Science and Higher Education scholarships.; Aaltonen , N , Singha , P K , Jakupovic , H , Wirth , T , Samaranayake , H , Pasonen-Seppanen , S , Rilla , K , Varjosalo , M , Edgington-Mitchell , L E , Kasperkiewicz , P , Drag , M , Kälvälä , S , Moisio , E , Savinainen , J R & Laitinen , J T 2020 , ' High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils ' , Biological Procedures Online , vol. 22 , no. 1 , 6 . https://doi.org/10.1186/s12575-020-00118-4; ORCID: /0000-0002-1340-9732/work/77087683; http://hdl.handle.net/10138/317397; c0c698a8-9bf4-44a0-bc12-2ed174a583e2; 000520970600001

الاتاحة: http://hdl.handle.net/10138/317397

المؤلفون: Ahonen, Tiina J, Savinainen, Juha R, Yli-Kauhaluoma, Jari: Kalso, Eija, Laitinen, Jarmo T, Moreira, Vânia M

المساهمون: School of Medicine / Biomedicine

مصطلحات موضوعية: dehydroabietic acid, hABHD16A inhibitor, lysophosphatidylserine, metabolic serine hydrolase

وصف الملف: 1269–1273

Relation: ACS Medicinal Chemistry Letters; http://dx.doi.org/10.1021/acsmedchemlett.8b00442; 12; https://erepo.uef.fi/handle/123456789/7210

الاتاحة: https://erepo.uef.fi/handle/123456789/7210

المؤلفون: MANERA, CLEMENTINA, Malfitano, Anna Maria, Parkkari, Teija, Lucchesi, Valentina, CARPI, SARA, FOGLI, STEFANO, BERTINI, SIMONE, Laezza, Chiara, Ligresti, Alessia, SACCOMANNI, GIUSEPPE, Savinainen, Juha R, Ciaglia, Elena, Pisanti, Simona, Gazzerro, Patrizia, Di Marzo, Vincenzo, NIERI, PAOLA, MACCHIA, MARCO, Bifulco, Maurizio

المساهمون: Manera, Clementina, Malfitano, Anna Maria, Parkkari, Teija, Lucchesi, Valentina, Carpi, Sara, Fogli, Stefano, Bertini, Simone, Laezza, Chiara, Ligresti, Alessia, Saccomanni, Giuseppe, Savinainen, Juha R, Ciaglia, Elena, Pisanti, Simona, Gazzerro, Patrizia, Di Marzo, Vincenzo, Nieri, Paola, Macchia, Marco, Bifulco, Maurizio

مصطلحات موضوعية: 1,8-Naphthyridine-3-carboxamide, Anticancer activity, Cannabinoid CB2 receptor, Immunomodulation, Multiple sclerosi, Quinoline-3-carboxamide

Relation: info:eu-repo/semantics/altIdentifier/pmid/25935384; info:eu-repo/semantics/altIdentifier/wos/WOS:000356734600002; volume:97; firstpage:10; lastpage:18; numberofpages:9; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11568/750832; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84929190245; https://www.sciencedirect.com/science/article/pii/S0223523415002937

الاتاحة: http://hdl.handle.net/11568/750832
https://doi.org/10.1016/j.ejmech.2015.04.034
https://www.sciencedirect.com/science/article/pii/S0223523415002937

المؤلفون: Ahamed, Muneer, Atilli, Bala, van Veghel, Daisy, Ooms, Maarten, Berben, Philippe, Celen, Sofie, Koole, Michel, Declerq, Lieven, Savinainen, Juha R, Laitinen, Jarmo T, Verbruggen, Alfons, Bormans, Guy

المصدر: European Journal of Medicinal Chemistry, 136, 104-113, (2017-04-25)

مصطلحات موضوعية: MAGL, [11C]MA-PB-1, MJN110, biodistribution, PET imaging

Relation: https://zenodo.org/communities/inmind; https://zenodo.org/communities/eu; https://doi.org/10.1016/j.ejmech.2017.04.066; oai:zenodo.org:571108

الاتاحة: https://doi.org/10.1016/j.ejmech.2017.04.066

المؤلفون: Ahamed Muneer, Attili Bala, van Veghel Daisy, Ooms Maarten, Berben Philippe, Celen Sofie, Koole Michel, Declercq Lieven, Savinainen Juha R, Laitinen Jarmo T, Verbruggen Alfons, Bormans Guy

المساهمون: School of Medicine / Biomedicine

مصطلحات موضوعية: MAGL, [11C]MA-PB-1, MJN110, Biodistribution, PET imaging

وصف الملف: 104-113

Relation: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://dx.doi.org/10.1016/j.ejmech.2017.04.066; info:eu-repo/grantAgreement/EC/FP7/278850/EU/Imaging of Neuroinflammation in Neurodegenerative Diseases/INMIND; 136; https://erepo.uef.fi/handle/123456789/4289

الاتاحة: https://erepo.uef.fi/handle/123456789/4289

المؤلفون: Mardon, Karine, Patel, Jayendra Z., Savinainen, Juha R., Stimson, Damion H. R., Oyagawa, Caitlin R. M., Grimsey, Natasha L., Migotto, Mary-anne, Njiru, Grace F. M., Hamilton, Brett R., Cowin, Gary, Yli-Kauhaluoma, Jari, Vanduffel, Wim, Blakey, Idriss, Bhalla, Rajiv, Cawthorne, Christopher, Celen, Sofie, Bormans, Guy, Thurecht, Kristofer J, Ahamed, Muneer

المساهمون: National Health and Medical Research Council, Australian Research Council, Fonds Wetenschappelijk Onderzoek, Suomen Akatemia, University of Queensland

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 1, page 538-552 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c01485
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01485

المؤلفون: Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R., Laitinen, Jarmo T.

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Drug Discovery, Medicinal Chemistry research group

مصطلحات موضوعية: Pharmacy

وصف الملف: application/pdf

Relation: Parkkari , T , Haavikko , R , Laitinen , T , Navia-Paldanius , D , Rytilahti , R , Vaara , M , Lehtonen , M , Alakurtti , S , Yli-Kauhaluoma , J , Nevalainen , T , Savinainen , J R & Laitinen , J T 2014 , ' Discovery of Triterpenoids as Reversible Inhibitors of α/β hydrolase Domain Containing 12 (ABHD12) ' , PLoS One , vol. 9 , no. 5 , e98286 . https://doi.org/10.1371/journal.pone.0098286; ORCID: /0000-0003-0370-7653/work/28760615; ORCID: /0000-0002-2445-503X/work/29653849; http://hdl.handle.net/10138/160695; beb5cf37-5104-4fb8-8072-ff738aa184f1; 84902336189; 000338101500044

الاتاحة: http://hdl.handle.net/10138/160695

المؤلفون: Navia-Paldanius, Dina, Aaltonen, Niina, Lehtonen, Marko, Savinainen, Juha R, Taschler, Ulrike, Radner, Franz P.W., Zimmermann, Robert, Laitinen, Jarmo T

مصطلحات موضوعية: Monoacylglycerol lipase-knockout, [35S]GTPγS autoradiography, Desensitization, 2-arachidonoylglycerol, Endocannabinoid, Cannabinoid CB1 receptor

وصف الملف: 180-188

Relation: European Journal of Pharmaceutical Sciences; http://dx.doi.org/10.1016/j.ejps.2015.06.005; 77; Navia-Paldanius, Dina, Aaltonen, Niina, Lehtonen, Marko, Savinainen, Juha R., Taschler, Ulrike, Radner, Franz P.W., Zimmermann, Robert, Laitinen, Jarmo T. 2015. ncreased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase. European Journal of Pharmaceutical Sciences Vol.: 77. Elsevier BV. Doi:10.1016/j.ejps.2015.06.005. Issn: 0928-0987.; https://erepo.uef.fi/handle/123456789/98

الاتاحة: https://doi.org/10.1016/j.ejps.2015.06.005
https://erepo.uef.fi/handle/123456789/98

المؤلفون: Aaltonen, Niina, Kedzierska, Ewa, Orzelska-Górka, Jolanta, Lehtonen, Marko, Navia-Paldanius, Dina, Jakupovic, Hermina, Savinainen, Juha R., Nevalainen, Tapio, Laitinen, Jarmo T., Parkkari, Teija, Gynther, Mikko

المصدر: Aaltonen , N , Kedzierska , E , Orzelska-Górka , J , Lehtonen , M , Navia-Paldanius , D , Jakupovic , H , Savinainen , J R , Nevalainen , T , Laitinen , J T , Parkkari , T & Gynther , M 2016 , ' In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048) ' , Journal of Pharmacology and Experimental Therapeutics , vol. 359 , no. 1 , pp. 62-72 . https://doi.org/10.1124/jpet.116.233114

الاتاحة: https://researchprofiles.ku.dk/da/publications/in-vivo-characterization-of-the-ultrapotent-monoacylglycerol-lipase-inhibitor-4bisbenzod13dioxol5ylmethylpiperidin1yl1h124triazol1ylmethanone-jjkk048(ea94a35e-bc47-4b57-bca2-4234381e7807).html
https://doi.org/10.1124/jpet.116.233114
http://www.scopus.com/inward/record.url?scp=84989871077&partnerID=8YFLogxK

المؤلفون: Parkkari, Teija, Koskinen, Ari M.P., Myllymäki, Mikko, Savinainen, Juha R., Saario, Susanna M., Castillo-Melendez, Joel A., Laitinen, Jarmo T., Nevalainen, Tapio, Järvinen, Tomi

المساهمون: Department of Chemistry, Aalto-yliopisto, Aalto University

مصطلحات موضوعية: 2 AG, cannabinoidi, CB1 reseptor, enzymatic stability, stereoselective synthesis

وصف الملف: 2437-2440; application/pdf

Relation: Bioorganic & Medicinal chemistry letters; issue 16; PURE FILEURL: https://research.aalto.fi/files/7159710/ms126.pdf; https://aaltodoc.aalto.fi/handle/123456789/22329

الاتاحة: https://aaltodoc.aalto.fi/handle/123456789/22329
https://doi.org/10.1016/j.bmcl.2006.01.101

المؤلفون: Savinainen, Juha R., Patel, Jayendra Z., Parkkari, Teija, Navia-Paldanius, Dina, Marjamaa, Joona J. T., Laitinen, Tuomo, Nevalainen, Tapio, Laitinen, Jarmo T.

المساهمون: Bogyo, Matthew

المصدر: PLoS ONE ; volume 9, issue 10, page e109869 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0109869
http://dx.plos.org/10.1371/journal.pone.0109869

المؤلفون: Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R., Laitinen, Jarmo T.

المساهمون: Bogyo, Matthew

المصدر: PLoS ONE ; volume 9, issue 5, page e98286 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0098286
http://dx.plos.org/10.1371/journal.pone.0098286

المؤلفون: Aaltonen, Niina, Savinainen, Juha R., Ribas, Casandra Riera, Rönkkö, Jani, Kuusisto, Anne, Korhonen, Jani, Navia-Paldanius, Dina, Häyrinen, Jukka, Takabe, Piia, Käsnänen, Heikki, Pantsar, Tatu, Laitinen, Tuomo, Lehtonen, Marko, Pasonen-Seppänen, Sanna, Poso, Antti, Nevalainen, Tapio, Laitinen, Jarmo T.

المصدر: Chemistry & Biology ; volume 20, issue 3, page 379-390 ; ISSN 1074-5521

الاتاحة: http://dx.doi.org/10.1016/j.chembiol.2013.01.012
https://api.elsevier.com/content/article/PII:S1074552113000380?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1074552113000380?httpAccept=text/plain

المؤلفون: Navia-Paldanius, Dina, Savinainen, Juha R., Laitinen, Jarmo T.

المصدر: Journal of Lipid Research ; volume 53, issue 11, page 2413-2424 ; ISSN 0022-2275

الاتاحة: http://dx.doi.org/10.1194/jlr.m030411
https://api.elsevier.com/content/article/PII:S002222752041257X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S002222752041257X?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1194/jlr.M030411

المؤلفون: Singha, Prosanta K., Mäklin, Kiira, Vihavainen, Taina, Laitinen, Tuomo, Nevalainen, Tapio J., Patil, Mahadeo R., Tonduru, Arun K., Poso, Antti, Laitinen, Jarmo T., Savinainen, Juha R.

المساهمون: Academy of Finland, Institute of Biomedicine, Biocenter Finland/DDCB, CSC - IT Center for Science Ltd. Finland

المصدر: European Journal of Pharmaceutical Sciences ; volume 149, page 105321 ; ISSN 0928-0987

الاتاحة: http://dx.doi.org/10.1016/j.ejps.2020.105321
https://api.elsevier.com/content/article/PII:S092809872030110X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S092809872030110X?httpAccept=text/plain

المؤلفون: Grimsey, Natasha L., Savinainen, Juha R., Attili, Bala, Ahamed, Muneer

المساهمون: Australian Research Council Training Centre

المصدر: Drug Discovery Today ; volume 25, issue 2, page 330-343 ; ISSN 1359-6446

الاتاحة: http://dx.doi.org/10.1016/j.drudis.2019.10.004
https://api.elsevier.com/content/article/PII:S1359644619303873?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1359644619303873?httpAccept=text/plain