يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Saville, Harry"', وقت الاستعلام: 0.43s تنقيح النتائج
  1. 1
    Academic Journal
    SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

    المؤلفون: Bland, Philip, Saville, Harry, Wai, Patty T., Curnow, Lucinda, Muirhead, Gareth, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie Beatrix, Hedayat, Somaieh, Barker, Holly E., Wright, James, Yu, Lu, Mavrommati, Ioanna, Read, Abigail, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen N., Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Pratt, Guy, Oldreive, Ceri, Stankovic, Tatjana, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah E., Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti S., Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Natrajan, Rachael

    المساهمون: Breast Cancer Now, RCUK | Medical Research Council, Cancer Research UK, Site de Recherche Integree sur le Cancer (SiRIC2) Institute Curie, Wellcome Trust

    المصدر: Nature Genetics ; volume 55, issue 8, page 1311-1323 ; ISSN 1061-4036 1546-1718

    الاتاحة: http://dx.doi.org/10.1038/s41588-023-01460-5
    https://www.nature.com/articles/s41588-023-01460-5.pdf
    https://www.nature.com/articles/s41588-023-01460-5

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  2. 2
    Academic Journal
    Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes

    المؤلفون: Saint-Dizier, François, Matthews, Thomas P., Gregson, Aaron M., Prevet, Hugues, McHardy, Tatiana, Colombano, Giampiero, Saville, Harry, Rowlands, Martin, Ewens, Caroline, McAndrew, P. Craig, Tomlin, Kathy, Guillotin, Delphine, Mak, Grace Wing-Yan, Drosopoulos, Konstantinos, Poursaitidis, Ioannis, Burke, Rosemary, van Montfort, Rob, Linardopoulos, Spiros, Collins, Ian

    المساهمون: Breast Cancer Now, Merck KGaA, Institute of Cancer Research, Cancer Research UK

    المصدر: Journal of Medicinal Chemistry ; volume 66, issue 4, page 2622-2645 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c01591
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01591

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  3. 3
    Academic Journal
    C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

    المؤلفون: Le Bihan, Yann-Vaï, Lanigan, Rachel M., Atrash, Butrus, McLaughlin, Mark G., Velupillai, Srikannathasan, Malcolm, Andrew G., England, Katherine S., Ruda, Gian Filippo, Mok, N. Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M., Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I., Fedorov, Oleg, Brennan, Paul, Burke, Rosemary, van Montfort, Rob L.M., Rossanese, Olivia W., Blagg, Julian, Bavetsias, Vassilios

    المصدر: Le Bihan , Y-V , Lanigan , R M , Atrash , B , McLaughlin , M G , Velupillai , S , Malcolm , A G , England , K S , Ruda , G F , Mok , N Y , Tumber , A , Tomlin , K , Saville , H , Shehu , E , McAndrew , C , Carmichael , L , Bennett , J M , Jeganathan , F , Eve , P , Donovan , A , Hayes , A , Wood , F , Raynaud , F I , Fedorov , ....

    وصف الملف: application/pdf

    الاتاحة: https://pure.qub.ac.uk/en/publications/983d3300-53f4-4aad-bd9c-aa7c8d566aa9
    https://doi.org/10.1016/j.ejmech.2019.05.041
    https://pureadmin.qub.ac.uk/ws/files/472502275/1_s2.0_S0223523419304519_main.pdf

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  4. 4
    Academic Journal
    Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

    المؤلفون: Colombano, Giampiero, Caldwell, John J., Matthews, Thomas P., Bhatia, Chitra, Joshi, Amar, McHardy, Tatiana, Mok, Ngai Yi, Newbatt, Yvette, Pickard, Lisa, Strover, Jade, Hedayat, Somaieh, Walton, Michael I., Myers, Stephanie M., Jones, Alan M., Saville, Harry, McAndrew, Craig, Burke, Rosemary, Eccles, Suzanne A., Davies, Faith E., Bayliss, Richard, Collins, Ian

    المساهمون: Cancer Research UK, Institute of Cancer Research, Royal Cancer Hospital, Janssen Biotech

    المصدر: Journal of Medicinal Chemistry ; volume 62, issue 5, page 2447-2465 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.8b01721
    http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01721
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01721

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  5. 5
    Academic Journal
    Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N 2 -(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N 8 -neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

    المؤلفون: Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

    المساهمون: Breakthrough Breast Cancer, Cancer Research UK, European Investment Fund

    المصدر: Journal of Medicinal Chemistry ; volume 61, issue 18, page 8226-8240 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.8b00690
    http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00690
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00690

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  6. 6
    Academic Journal
    Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

    المؤلفون: Innocenti, Paolo, Woodward, Hannah L., Solanki, Savade, Naud, Sébastien, Westwood, Isaac M., Cronin, Nora, Hayes, Angela, Roberts, Jennie, Henley, Alan T., Baker, Ross, Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Matijssen, Berry, Burke, Rosemary, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

    المساهمون: Breakthrough Breast Cancer, Cancer Research UK, National Health Service, Cancer Research Technology Pioneer Fund, Sixth Element Capital LLP

    المصدر: Journal of Medicinal Chemistry ; volume 59, issue 8, page 3671-3688 ; ISSN 0022-2623 1520-4804

    الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.5b01811
    https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01811

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  7. 7
    Periodical
    SF3B1hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

    المؤلفون: Bland, Philip, Saville, Harry, Wai, Patty T., Curnow, Lucinda, Muirhead, Gareth, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie Beatrix, Hedayat, Somaieh, Barker, Holly E., Wright, James, Yu, Lu, Mavrommati, Ioanna, Read, Abigail, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen N., Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Pratt, Guy, Oldreive, Ceri, Stankovic, Tatjana, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah E., Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti S., Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Natrajan, Rachael

    المصدر: Nature Genetics; 20230101, Issue: Preprints p1-13, 13p


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  8. 8
    Academic Journal
    The effects of adaptive working memory training and mindfulness meditation training on processing efficiency and worry in high worriers

    المؤلفون: Course-Choi, Jenna, Saville, Harry, Derakshan, Nazanin

    المصدر: Behaviour Research and Therapy ; volume 89, page 1-13 ; ISSN 0005-7967

    الاتاحة: http://dx.doi.org/10.1016/j.brat.2016.11.002
    https://api.elsevier.com/content/article/PII:S0005796716301899?httpAccept=text/plain
    https://api.elsevier.com/content/article/PII:S0005796716301899?httpAccept=text/xml

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  9. 9
    Academic Journal
    Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4‑d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2‑(2-Ethoxy-4-(4-methyl‑4H‑1,2...

    المؤلفون: Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O'Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M.

    المصدر: Journal of Medicinal Chemistry; 9/27/2018, Vol. 61 Issue 18, p8226-8240, 15p


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  10. 10
    Periodical
    Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

    المؤلفون: Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

    المصدر: Journal of Medicinal Chemistry; August 2018, Vol. 61 Issue: 18 p8226-8240, 15p


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