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1
المؤلفون: Jessica Mancuso, Angela C. Doran, Li Di, Bo Feng, Larry M. Tremaine, Jennifer L. Liras, Sarah M. Osgood, Christopher L. Shaffer, Mark A. West
المصدر: Journal of Pharmaceutical Sciences. 107:2225-2235
مصطلحات موضوعية: Male, 0301 basic medicine, Abcg2, Pharmaceutical Science, Blood–brain barrier, Models, Biological, 030226 pharmacology & pharmacy, Madin Darby Canine Kidney Cells, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, 0302 clinical medicine, Cerebrospinal fluid, Drug Discovery, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Pharmacokinetics, ATP Binding Cassette Transporter, Subfamily B, Member 1, Protein Kinase Inhibitors, P-glycoprotein, biology, Chemistry, Imidazoles, Brain, Biological Transport, Transporter, Human brain, Penetration (firestop), Molecular biology, In vitro, Neoplasm Proteins, 030104 developmental biology, medicine.anatomical_structure, Blood-Brain Barrier, Models, Animal, Imatinib Mesylate, biology.protein, Azabicyclo Compounds
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2
المؤلفون: Stephanie Fraser, Sarah M. Osgood
المصدر: Bioanalysis. 9:1827-1837
مصطلحات موضوعية: 0301 basic medicine, Process (engineering), Computer science, Clinical Biochemistry, Guidelines as Topic, Nanotechnology, Analytical Chemistry, 03 medical and health sciences, Animal model, Glucosides, Drug Discovery, Animals, Humans, Benzhydryl Compounds, General Pharmacology, Toxicology and Pharmaceutics, Biomarker discovery, Scope (project management), Retinoic Acid Receptor alpha, Disease progression, Target engagement, General Medicine, Medical Laboratory Technology, 030104 developmental biology, Diabetes Mellitus, Type 2, Drug development, Risk analysis (engineering), Leukemia, Myeloid, Biomarker (medicine), Biomarkers
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3
المؤلفون: Sven Akkerman, Christopher L. Shaffer, Sarah M. Osgood, Arjan Blokland, P. Cremers, Jos Prickaerts, N.P. van Goethem, Harry W.M. Steinbusch
المساهمون: RS: FPN NPPP II, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, Neuropsychology & Psychopharmacology
المصدر: Neuropharmacology, 97, 233-239. Elsevier Science
مصطلحات موضوعية: Male, Time Factors, Sildenafil, Scopolamine, Central effects, Administration, Oral, Pharmacology, TYPE-5 INHIBITORS, PULMONARY-HYPERTENSION, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Pharmacokinetics, Vardenafil Dihydrochloride, Memory, PHOSPHODIESTERASE INHIBITORS, SYNAPTIC PLASTICITY, medicine, Memory impairment, Animals, Learning, Phosphodiesterase, Rats, Wistar, DEPENDENT PROTEIN-KINASE, CONSOLIDATION, Cyclic Nucleotide Phosphodiesterases, Type 5, Memory Disorders, CGMP, Mechanism (biology), Pde5 inhibition, Brain, Recognition, Psychology, Phosphodiesterase 5 Inhibitors, Phosphodiesterase Type 5 Inhibitors, SILDENAFIL, Disease Models, Animal, Infusions, Intraventricular, Acquisition, chemistry, OBJECT RECOGNITION MEMORY, Vardenafil, Synaptic plasticity, CEREBRAL-BLOOD-FLOW, Psychology, medicine.drug
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4
المصدر: Neuropharmacology. 86:174-180
مصطلحات موضوعية: Male, Normalization (statistics), Pharmacology, Tritium, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Species Specificity, Memory, medicine, Animals, Ketamine, Receptor, IC50, Active metabolite, Depression, Chemistry, Rats, Macaca fascicularis, Pharmacodynamics, NMDA receptor, Antidepressant, Dizocilpine Maleate, Excitatory Amino Acid Antagonists, medicine.drug
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5
المصدر: Journal of Pharmaceutical Sciences. 103:1557-1562
مصطلحات موضوعية: Male, Microdialysis, Pharmaceutical Science, Pharmacology, Blood–brain barrier, Rats, Sprague-Dawley, Dogs, Interstitial fluid, Preclinical pharmacokinetics, medicine, Animals, Drug transport, Drug disposition, Chemistry, Diphenhydramine, Brain, Biological Transport, Extracellular Fluid, Nonhuman primate, Rats, Macaca fascicularis, medicine.anatomical_structure, Blood-Brain Barrier, Female, Oxycodone, medicine.drug, Large animal
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6
المؤلفون: Gary Seitis, Chang-Ning Liu, Betty Pettersen, Sarah M. Osgood, Chris J. Somps
المصدر: Cutaneous and Ocular Toxicology. 33:206-211
مصطلحات موضوعية: Male, medicine.medical_specialty, genetic structures, Glycine Plasma Membrane Transport Proteins, Toxicology, Retina, Rats, Sprague-Dawley, Glycine transporter, Internal medicine, Electroretinography, medicine, Animals, Scotopic vision, medicine.diagnostic_test, Chemistry, Imidazoles, General Medicine, eye diseases, Vitreous Body, Endocrinology, medicine.anatomical_structure, Glycine, sense organs, Azabicyclo Compounds, Erg, Photic Stimulation, Photopic vision
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7
المؤلفون: James Offord, Susan M. Lotarski, Charles Taylor, Sarah M. Osgood, Sean D. Donevan, Julie Poe, Ayman El-Kattan
المصدر: Journal of Pharmacology and Experimental Therapeutics. 338:615-621
مصطلحات موضوعية: Male, Mice, 129 Strain, Gabapentin, medicine.drug_class, Protein subunit, Mutant, Pregabalin, Anxiety, Pharmacology, Arginine, Anxiolytic, Conflict, Psychological, Mice, Mice, Congenic, medicine, Animals, Point Mutation, gamma-Aminobutyric Acid, chemistry.chemical_classification, Alanine, Voltage-dependent calcium channel, Chemistry, Mice, Mutant Strains, Amino acid, Mice, Inbred C57BL, Anti-Anxiety Agents, Molecular Medicine, Phenobarbital, Calcium Channels, medicine.drug
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8
المؤلفون: Laura McDowell, Sarah M. Osgood, Shari L. DeNinno, Hans Rollema, Chris L. Shaffer, Robert J. Mather, Brenda R. Ellerbrock, Jotham Wadsworth Coe, Theresa Tritto, Rouba Kozak, Jen Sadlier, Raymond S. Hurst, Weldon Horner, Roxanne R Gorczyca, Mary C. MacDougall, F. David Tingley, Mark J. Majchrzak, Lei Zhang, Alka Shrikhande, John A. Lowe, Scot Richard Mente, Karen M. Ward, David E. Johnson
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4749-4752
مصطلحات موضوعية: Agonist, Bicyclic molecule, Chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, In vitro, Nicotinic agonist, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, Molecular Biology, Acetylcholine receptor
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9
المؤلفون: Eric Feyfant, Natasha M. Kablaoui, Heather McInnes, Sarah M. Osgood, Michelle Vanase-Frawley, Ramin Darvari, Angela C. Doran, Kari R. Fonseca, Derek L. Buhl, Mark J. Majchrzak, Meera E. Modi
المصدر: The Journal of Pharmacology and Experimental Therapeutics
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.medical_specialty, medicine.drug_class, Endogeny, CHO Cells, Stimulus (physiology), Pharmacology, Oxytocin, Peptides, Cyclic, Polyethylene Glycols, 03 medical and health sciences, Mice, 0302 clinical medicine, Cricetulus, Pharmacokinetics, Internal medicine, Cricetinae, Conditioning, Psychological, Drug Discovery, medicine, Animals, Receptor, Drug Administration Routes, Immobility Response, Tonic, Fear, Oxytocin receptor, Peripheral, Rats, 030104 developmental biology, Endocrinology, Receptors, Oxytocin, Behavioral Pharmacology, Molecular Medicine, Psychology, 030217 neurology & neurosurgery, medicine.drug
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10
المؤلفون: Raymond S. Hurst, Nandini Chaturbhai Patel, Dina McGinnis, Xinjun J. Hou, Mihály Hajós, Dianne K. Bryce, Cheng Chang, Christopher J. O’Donnell, JianHua Liu, William E. Hoffmann, Patricia A. Seymour, Laigao Chen, Renato J. Scialis, Yunjing Wei, Karki Kapil Kumar, R. Scott Obach, Longfei Xie, Jacob Bradley Schwarz, John T. Lazzaro, Kenneth R. Zasadny, Sarah M. Osgood, Christopher J. Schmidt, Christopher L. Shaffer, Jayvardhan Pandit, Susan M. Lotarski, Mark L. Weber
المصدر: Journal of medicinal chemistry. 58(10)
مصطلحات موضوعية: Adult, Male, Adolescent, Stereochemistry, Protein Conformation, Drug Evaluation, Preclinical, Administration, Oral, Ether, AMPA receptor, Thiophenes, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Young Adult, Therapeutic index, Dogs, Drug Stability, Drug Discovery, Animals, Humans, Receptors, AMPA, Receptor, Tetrahydrofuran, Aged, Sulfonamides, Binding Sites, Dose-Response Relationship, Drug, Chemistry, Potentiator, Middle Aged, Mice, Inbred C57BL, Disease Models, Animal, Memory, Short-Term, Schizophrenia, Molecular Medicine, Female, Selectivity, Lead compound
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11
المؤلفون: Sarah M. Osgood, Jos. J. Schall
المصدر: Parasitology. 128:23-29
مصطلحات موضوعية: Male, Plasmodium, Biology, Parasitemia, Statistics, Nonparametric, Apicomplexa, Random Allocation, medicine, Gametocyte, Animals, Parasite hosting, Sex Ratio, Phenotypic plasticity, Genetic Variation, Lizards, biology.organism_classification, medicine.disease, Infectious Diseases, Immunology, Female, Animal Science and Zoology, Parasitology, Plasmodium mexicanum, Inbreeding, Sex ratio, Malaria
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12
المؤلفون: Sarah M. Osgood, Jos. J. Schall, Susan L. Perkins
المصدر: Molecular Ecology. 7:1587-1590
مصطلحات موضوعية: biology, Lizard, Prevalence, Anatomy, biology.organism_classification, medicine.disease, Epizootiology, Virology, Plasmodium, law.invention, Blood smear, law, biology.animal, Genetics, medicine, Plasmodium mexicanum, Ecology, Evolution, Behavior and Systematics, Polymerase chain reaction, Malaria
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13
المؤلفون: Sarah M. Osgood, Christopher L. Shaffer, JianHua Liu
المصدر: Bioanalysis. 5(21)
مصطلحات موضوعية: Male, Bioanalysis, Clinical Biochemistry, Plasma protein binding, Pharmacology, Analytical Chemistry, Tandem Mass Spectrometry, medicine, Animals, Ketamine, General Pharmacology, Toxicology and Pharmaceutics, health care economics and organizations, Analgesics, Plasma samples, Chemistry, General Medicine, Plasma, Blood Proteins, Small molecule, humanities, Nonhuman primate, Medical Laboratory Technology, Macaca fascicularis, Anesthetic, medicine.drug, Chromatography, Liquid, Protein Binding
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14
المؤلفون: Christopher J. Schmidt, Frank S. Menniti, Christopher L. Shaffer, Ashley N. Hanks, John T. Lazzaro, JianHua Liu, Renato J. Scialis, Dianne K. Bryce, Susan M. Lotarski, Sarah M. Osgood, Raymond S. Hurst, Mark L. Weber, Mihály Hajós, William E. Hoffmann
المصدر: The Journal of pharmacology and experimental therapeutics. 347(1)
مصطلحات موضوعية: Male, Allosteric regulation, Stimulation, AMPA receptor, Thiophenes, Pharmacology, Rats, Sprague-Dawley, Mice, Random Allocation, Dogs, Allosteric Regulation, Seizures, Convulsion, medicine, Excitatory Amino Acid Agonists, Animals, Humans, Receptors, AMPA, Receptor, Cells, Cultured, Chemistry, HEK 293 cells, Long-term potentiation, Potentiator, Rats, Mice, Inbred C57BL, Macaca fascicularis, HEK293 Cells, Treatment Outcome, Molecular Medicine, Female, medicine.symptom, Psychomotor Performance
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15
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 40(11)
مصطلحات موضوعية: Male, Primates, Brain chemistry, Stereochemistry, Pharmaceutical Science, Thiophenes, Toxicology, Rats, Sprague-Dawley, Dogs, Paliperidone Palmitate, Animals, Acute dose, ATP Binding Cassette Transporter, Subfamily B, Member 1, Pharmacology, Brain Chemistry, Chemistry, Brain, Biological Transport, Isoxazoles, Risperidone, Nonhuman primate, Rats, Sprague dawley, Pyrimidines, Blood-Brain Barrier, Large animal
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16
المؤلفون: Stefanus J. Steyn, Doug Johnson, Patrick Robert Verhoest, Sarah M. Osgood, Kelly R. Bales, Yasong Lu, Kathleen M. Wood, Jennifer L. Liras, Karin Wallace, Emily Miller, Stacey L. Becker, Emily Sylvain, Martin Pettersson, Michael Marconi
المصدر: Alzheimer's & Dementia. 8
مصطلحات موضوعية: Guinea pig, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, Exposure response, Gamma secretase
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17
المؤلفون: Louis Leung, Michael Aaron Brodney, Stacey L. Becker, Douglas S. Johnson, Charles E. Nolan, Emily H. Miller, Ashley Robshaw, Eva Hajos-Korcsok, Kathleen M. Wood, Jason Barricklow, Sarah M. Osgood, Yasong Lu, Brian T. O’Neill, Liming Zhang, Elaine E. Tseng, Martin Pettersson, Kelly R. Bales, David Riddell
المصدر: The Journal of pharmacology and experimental therapeutics. 342(2)
مصطلحات موضوعية: Male, Mice, 129 Strain, Amyloid β, Guinea Pigs, Pharmacology, Rats, Sprague-Dawley, Mice, Cerebrospinal fluid, Pharmacokinetics, Alzheimer Disease, Animals, Protease Inhibitors, Cerebrospinal Fluid, Amyloid beta-Peptides, Chemistry, Drug discovery, Brain, Multiple species, Preclinical data, Rats, Pharmacodynamics, Molecular Medicine, Biomarker (medicine), Amyloid Precursor Protein Secretases, Biomarkers
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18
المؤلفون: Leslie R. Pustilnik, David Riddell, Andrew J. Hallgren, Chakrapani Subramanyam, Ashley Robshaw, Kevin Atchison, Sarah M. Osgood, Ivan Viktorovich Efremov, Antonia F. Stepan, Liming Zhang, Yasong Lu, Emily H. Miller, Stacey L. Becker, Charles E. Nolan
المصدر: The Journal of pharmacology and experimental therapeutics. 339(3)
مصطلحات موضوعية: Mice, 129 Strain, Transgene, Drug Evaluation, Preclinical, Mice, Transgenic, Pharmacology, Biology, Small Molecule Libraries, Amyloid beta-Protein Precursor, Mice, Cerebrospinal fluid, Pharmacokinetics, Drug Discovery, Animals, Humans, γ secretase, Enzyme Inhibitors, Oxadiazoles, Sulfonamides, Alanine, Amyloid beta-Peptides, Drug discovery, Preclinical pharmacology, Brain, Azepines, Small molecule, Pharmacodynamics, Models, Animal, Molecular Medicine, Amyloid Precursor Protein Secretases
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19
المؤلفون: John A, Lowe, Shari L, DeNinno, Jotham W, Coe, Lei, Zhang, Scot, Mente, Raymond S, Hurst, Robert J, Mather, Karen M, Ward, Alka, Shrikhande, Hans, Rollema, David E, Johnson, Weldon, Horner, Roxanne, Gorczyca, F David, Tingley, Rouba, Kozak, Mark J, Majchrzak, Theresa, Tritto, Jen, Sadlier, Chris L, Shaffer, Brenda, Ellerbrock, Sarah M, Osgood, Mary C, MacDougall, Laura L, McDowell
المصدر: Bioorganicmedicinal chemistry letters. 20(16)
مصطلحات موضوعية: Structure-Activity Relationship, Sulfonamides, Nicotinic Agonists, Receptors, Nicotinic, Azabicyclo Compounds
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20
المؤلفون: Mohammed Shahid, Brian Henry, Sarah Grimwood, Susan Buist, Christopher J. Bowman, Betsy Galvan, Lisa Buchholz, Sarah M. Osgood, Christopher S. Knauer, Jeffrey E. Campbell, Erik H. F. Wong
المصدر: European journal of pharmacology. 591(1-3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Ketanserin, Pharmacology, Rats, Sprague-Dawley, Piperidines, In vivo, Internal medicine, medicine, Asenapine, Animals, Humans, Receptor, Serotonin, 5-HT2A, Tissue Distribution, Psychopharmacologic agent, Receptor, Clozapine, 5-HT receptor, Dose-Response Relationship, Drug, Chemistry, Ligand binding assay, Brain, Rats, Fluorobenzenes, Endocrinology, Positron-Emission Tomography, Serotonin Antagonists, medicine.drug, Antipsychotic Agents, Protein Binding