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1Academic Journal
المؤلفون: Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea
المصدر: PLoS ONE, Vol 16, Iss 11 (2021)
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
3Academic Journal
المؤلفون: Jonathan Phillips, Deepak Subedi, Steff C Lewis, Catriona Keerie, Owen Cronin, Mary Porteous, David Moore, Roseanne Cetnarskyj, Lakshminarayan Ranganath, Peter L Selby, Tolga Turgut, Geeta Hampson, Rama Chandra, Shu Ho, Jon Tobias, Steven Young-Min, Malachi J McKenna, Rachel K Crowley, William D Fraser, Jonathan CY Tang, Luigi Gennari, Rannuccio Nuti, Maria Luisa Brandi, Javier Del Pino-Montes, Jean-Pierre Devogelaer, Anne Durnez, Giovanni Carlo Isaia, Marco Di Stefano, Nuria Guanabens, Josep Blanch Rubio, Markus J Seibel, John P Walsh, Sarah L Rea, Mark Kotowicz, Geoffrey C Nicholson, Emma L Duncan, Gabor Major, Anne Horne, Nigel Gilchrist, Stuart H Ralston
مصطلحات موضوعية: Biomedical and clinical sciences, Clinical sciences, Immunology, Health sciences, Patient Reported Outcome Measures, Pharmacogenetics, Therapeutics, Clinical Research, Clinical Trials and Supportive Activities, Prevention, Rare Diseases, 6.1 Pharmaceuticals, 6 Evaluation of treatments and therapeutic interventions, Musculoskeletal
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4
المؤلفون: Nicole Polain, Wai Sin Kwong, Thomas Ratajczak, Sarah L. Rea, John P. Walsh, Carmel Cluning, Melanie A. Sultana, Jiake Xu, Nathan J. Pavlos
المصدر: PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259556 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)مصطلحات موضوعية: Scaffold protein, Gene Expression, Osteoclasts, Biochemistry, Cell Signaling, Animal Cells, Sequestosome-1 Protein, Medicine and Health Sciences, Musculoskeletal System, Connective Tissue Cells, Multidisciplinary, Cell Death, Chemistry, NF-kappa B, Cell biology, medicine.anatomical_structure, Oncology, Cell Processes, Connective Tissue, Medicine, Anatomy, Cellular Types, Cellular Structures and Organelles, Research Article, Signal Transduction, Protein Binding, Signal Inhibition, Science, Autophagic Cell Death, Blotting, Western, Signaling Complexes, DNA construction, Transfection, Research and Analysis Methods, Osteoclast, DNA-binding proteins, medicine, Genetics, Humans, Immunoprecipitation, Gene Regulation, Molecular Biology Techniques, Bone, Transcription factor, Molecular Biology, Skeleton, Autophagy, HEK 293 cells, Wild type, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Cell Biology, Regulatory Proteins, Biological Tissue, HEK293 Cells, Cell Signaling Structures, Cancer cell, Plasmid Construction, Protein Ajuba, Transcription Factors
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5
المؤلفون: A.D. Foster, Robert Layfield, Sarah L. Rea, Daniel Scott
المصدر: Molecular and Cellular Neuroscience. 98:32-45
مصطلحات موضوعية: 0301 basic medicine, NF-E2-Related Factor 2, Mutant, Mutation, Missense, Biology, medicine.disease_cause, Cell Line, Serine, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Sequestosome-1 Protein, medicine, Animals, Phosphorylation, Molecular Biology, Transcription factor, Neurons, Binding Sites, Kelch-Like ECH-Associated Protein 1, NF-kappa B, Wild type, Signal transducing adaptor protein, Cell Biology, KEAP1, Cell biology, Oxidative Stress, 030104 developmental biology, Frontotemporal Lobar Degeneration, 030217 neurology & neurosurgery, Oxidative stress, Protein Binding, Signal Transduction
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6
المؤلفون: Andrew J. Lee, Justin J. Yerbury, C. Cluning, Sarah L. Rea, P.A. Akkari, Jennilee M. Davidson, R. Mejzini, A. D. Foster, Flora Cheng, N. Polain, Loren L. Flynn, Natalie E. Farrawell, Robert Layfield
المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)مصطلحات موضوعية: Cell biology, Proteasome Inhibition, Molecular biology, Science, Cleavage (embryo), Article, Cell Line, Mice, Protein Aggregates, Sequestosome-1 Protein, mental disorders, Genetics, medicine, Animals, Amyotrophic lateral sclerosis, Mice, Knockout, Neurons, Multidisciplinary, Cell Death, Chemistry, Amyotrophic Lateral Sclerosis, nutritional and metabolic diseases, Frontotemporal lobar degeneration, medicine.disease, nervous system diseases, DNA-Binding Proteins, medicine.anatomical_structure, Gene Expression Regulation, Cytoplasm, Proteolysis, Medicine, Frontotemporal Lobar Degeneration, Neuron death, Nucleus, Neuroscience
وصف الملف:
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7
المؤلفون: Prashant Bharadwaj, Ralph N. Martins, Dona P.W. Jayatunga, Yasaswi Shrestha, Sarah L. Rea, Sharmeelavathi Krishnan
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6739, p 6739 (2020)مصطلحات موضوعية: Aging, autophagy, beta amyloid, Cell, Disease, Review, clearance, Protein aggregation, Catalysis, Inorganic Chemistry, lcsh:Chemistry, Alzheimer Disease, Stress, Physiological, Lysosome, medicine, Animals, Humans, Senile plaques, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Mechanism (biology), business.industry, Organic Chemistry, Autophagy, Keywords: beta amyloid, apoptosis, toxicity, General Medicine, stress response, Computer Science Applications, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Ageing, ageing, lysosome, business, Lysosomes, Neuroscience, Alzheimer’s disease
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8
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
9Image
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
10Image
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
11Image
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
12Image
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
13Image
المؤلفون: Melanie A. Sultana (11648379), Carmel Cluning (11648382), Wai-Sin Kwong (11648385), Nicole Polain (11648388), Nathan J. Pavlos (8628186), Thomas Ratajczak (11648391), John P. Walsh (280331), Jiake Xu (172032), Sarah L. Rea (11648394)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, transcription factor involved, paget &# 8217, nf -&# 954, p62 regulates proteins, p62 regulate signalling, scaffold protein sqstm1, b signalling leading, unstressed cells co, cells undergoing autophagy, protects ajuba levels, hek293 cells, altered levels, p62 reduces, p62 observed, p62 inhibits,
%22">xlink ">, wild type, various cancers, thereby impact, proteasome system, proteasomal stress, prolonged ajuba -
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المؤلفون: Nathan J. Pavlos, John P. Walsh, Melanie Sultana, Sarah L. Rea, L.C. Ward
المصدر: Bone Reports, Vol 10, Iss, Pp-(2019)
Bone Reportsمصطلحات موضوعية: 0301 basic medicine, Proband, lcsh:Diseases of the musculoskeletal system, Endocrinology, Diabetes and Metabolism, Protein Data Bank (RCSB PDB), 030209 endocrinology & metabolism, Genome-wide association study, Signalling, Biology, Osteoclast fusion, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Genetic predisposition, Orthopedics and Sports Medicine, DC-STAMP, Exome sequencing, Genetics, medicine.disease, Penetrance, Paget's disease of bone, Osteoclast, 030101 anatomy & morphology, lcsh:RC925-935
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المؤلفون: Wesley Lamont, Alistair Wood, Sarah L. Rea, Nicole Polain, Yuval Gurfinkel
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 4705, p 4705 (2021)
International Journal of Molecular Sciencesمصطلحات موضوعية: 0301 basic medicine, amyotrophic lateral sclerosis, Pathology, Review, 0302 clinical medicine, Ubiquitin, proteinopathy, TARDBP/TDP-43, Biology (General), Amyotrophic lateral sclerosis, Spectroscopy, Neurons, biology, General Medicine, Frontotemporal lobar degeneration, Computer Science Applications, DNA-Binding Proteins, Chemistry, frontotemporal lobar degeneration, medicine.medical_specialty, QH301-705.5, Models, Neurological, Protein Aggregation, Pathological, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Stress granule, mitochondrial dysfunction, mental disorders, Autophagy, medicine, Animals, Humans, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, RNA metabolism, proteostasis, Endoplasmic reticulum, Organic Chemistry, nutritional and metabolic diseases, medicine.disease, nervous system diseases, Disease Models, Animal, 030104 developmental biology, Proteostasis, Gene Expression Regulation, TDP-43 Proteinopathies, Mutation, Unfolded protein response, biology.protein, Protein Processing, Post-Translational, 030217 neurology & neurosurgery
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المؤلفون: Barry Shaw, Sarah L. Rea, Robert Layfield, Mark S. Searle, Alice Goode, Melanie Sultana
المصدر: Molecular and Cellular Neurosciences
مصطلحات موضوعية: 0301 basic medicine, SQSTM1/p62, LIR, LC3-interacting region, ARE, Antioxidant response element, mTORC1, ALS, Amyotrophic lateral sclerosis, PDB, Paget's disease of bone, SALS, Sporadic ALS, Sequestosome-1 Protein, Genetics, Kelch-Like ECH-Associated Protein 1, Nrf2, Nuclear erythroid 2-related factor 2, FTLD, Frontotemporal lobar degeneration, IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta, 3. Good health, Keap1, Kelch-like ECH-associated protein 1, Signal transduction, Protein Binding, Signal Transduction, ALS-FTLD, RBM45, RNA binding motif protein 45, NF-E2-Related Factor 2, NQO1, NAD(P)H dehydrogenase, Quinone 1, Mutation, Missense, Repressor, NFE2L2, Nuclear factor erythroid 2-like 2, UBA, Ubiquitin-associated (domain), Biology, Response Elements, Article, SOD1, Superoxide dismutase 1, 03 medical and health sciences, Cellular and Molecular Neuroscience, Humans, KIR, Keap1-interacting region, Gene, Transcription factor, Molecular Biology, Binding Sites, Amyotrophic Lateral Sclerosis, HEK 293 cells, Cell Biology, mTORC1, Mammalian target of rapamycin complex 1, KEAP1, HEK293 Cells, 030104 developmental biology, Oxidative stress, SQSTM1/p62, Sequestosome 1/p62 protein, Keap1-Nrf2, TDP-43, TAR DNA-binding protein 43, Frontotemporal Lobar Degeneration
وصف الملف: application/pdf; PDF
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المؤلفون: A. Stott, A.D. Foster, R. Layfield, Nicole Polain, P. Downing, E. Figredo, Sarah L. Rea
المصدر: Molecular and Cellular Neuroscience. 108:103539
مصطلحات موضوعية: 0301 basic medicine, Cell signaling, NF-E2-Related Factor 2, Protein Serine-Threonine Kinases, Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, TANK-binding kinase 1, Sequestosome-1 Protein, Mitophagy, Autophagy, Humans, Phosphorylation, Molecular Biology, Kinase, Amyotrophic Lateral Sclerosis, NF-kappa B, Wild type, Cell Biology, Cell biology, DNA-Binding Proteins, HEK293 Cells, 030104 developmental biology, Protein kinase domain, Mutation, Proteolysis, 030217 neurology & neurosurgery, HeLa Cells, Signal Transduction
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18
المؤلفون: Jennifer Tickner, Haotian Feng, Taksum Cheng, Thomas Ratajczak, Nathan J. Pavlos, Huazi Xu, Sipin Zhu, John P. Walsh, Jiake Xu, Sarah L. Rea
المصدر: Journal of Cellular Biochemistry. 117:1464-1470
مصطلحات موضوعية: musculoskeletal diseases, 0301 basic medicine, Osteoclasts, Biochemistry, Negative regulator, Mice, 03 medical and health sciences, chemistry.chemical_compound, Osteoclast, Sequestosome-1 Protein, medicine, Animals, Humans, Amines, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, Cell fusion, Bafilomycin, Protein level, Cell Differentiation, Cell Biology, Cell biology, RAW 264.7 Cells, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, chemistry, Calcium, Macrolides, Intracellular
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19
المؤلفون: Thomas Ratajczak, Suzanne J. Brown, Cameron Britton, Sarah L. Rea, L.C. Ward, John P. Walsh
المصدر: Calcified tissue international. 101(6)
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Sequestosome 1, Internal medicine, Sequestosome-1 Protein, Prevalence, Medicine, Humans, Orthopedics and Sports Medicine, Family history, education, Aged, Aged, 80 and over, education.field_of_study, Extensive Disease, business.industry, Incidence (epidemiology), Australia, Middle Aged, medicine.disease, Alkaline Phosphatase, Osteitis Deformans, Surgery, 030104 developmental biology, Paget's disease of bone, Mutation, Female, Presentation (obstetrics), business
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20
المؤلفون: Sarah L. Rea, Adriana Delice Foster
المصدر: Neural Regeneration Research, Vol 15, Iss 12, Pp 2186-2194 (2020)
Neural Regeneration Researchمصطلحات موضوعية: 0301 basic medicine, autophagy, p62/SQSTM1, Review, Protein degradation, lcsh:RC346-429, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Sequestosome 1, Developmental Neuroscience, Mitophagy, medicine, cell signaling, Amyotrophic lateral sclerosis, education, lcsh:Neurology. Diseases of the nervous system, amyotrophic lateral sclerosis-frontotemporal lobar degeneration, education.field_of_study, aggregate/inclusion body formation, mitophagy, p62/sqstm1, protein degradation, business.industry, Frontotemporal lobar degeneration, medicine.disease, 030104 developmental biology, Cancer research, Signal transduction, business, 030217 neurology & neurosurgery, Frontotemporal dementia
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