المؤلفون: DAVID N. WHITTERN, JAMES B. MCALPINE, JILL E. HOCHLOWSKI, MICHAEL H. SCHERR, PRESTON HILL, RONALD R. RASMUSSEN, SARAH A. DORWIN

المصدر: The Journal of Antibiotics. 1994, 47(5):528

المؤلفون: Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik

المصدر: Chemical Biology & Drug Design. 69:395-404

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Molecular Sequence Data, Plasma protein binding, Bacterial genome size, medicine.disease_cause, Biochemistry, Mass Spectrometry, Microbiology, Haemophilus influenzae, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Animals, Amino Acid Sequence, Adenosine Triphosphatases, Pharmacology, B-Lymphocytes, biology, Drug discovery, Organic Chemistry, Genomics, biology.organism_classification, Anti-Bacterial Agents, Mechanism of action, Essential gene, Drug Design, Molecular Medicine, medicine.symptom, Antibacterial activity, Genome, Bacterial, Bacteria, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x

المؤلفون: James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch

المصدر: Journal of Medicinal Chemistry. 49:3563-3580

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Aminopyridines, Biological Availability, Crystallography, X-Ray, MAP2K7, Rats, Sprague-Dawley, Mitogen-Activated Protein Kinase 10, Cell Line, Tumor, Drug Discovery, Animals, Humans, Mitogen-Activated Protein Kinase 9, Mitogen-Activated Protein Kinase 8, ASK1, Phosphorylation, Kinase activity, Protein kinase A, MAPK14, biology, Kinase, Chemistry, c-jun, Rats, Biochemistry, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5bb3bc96de29a87b4ec28bbfc5f96f
https://doi.org/10.1021/jm060199b

المؤلفون: Richard S. Smith, Xumiao Zhao, Aparna V. Sarthy, Vicki L. Nienaber, Kent D. Stewart, Moshe Weitzberg, K. I. Hulkower, Christopher C Butler, Vered Klinghofer, Vincent L. Giranda, Todd W. Rockway, Paul G. Richardson, Sarah A. Dorwin, Michael D. Wendt, Tom Mcgonigal

المصدر: Biochemistry. 40:9125-9131

مصطلحات موضوعية: Serine Proteinase Inhibitors, Molecular Sequence Data, Amidines, Antineoplastic Agents, Thiophenes, Naphthalenes, Crystallography, X-Ray, Biochemistry, Amiloride, Carcinoma, Lewis Lung, Mice, Species Specificity, Tumor Cells, Cultured, medicine, Animals, Humans, Potency, Amino Acid Sequence, Binding site, chemistry.chemical_classification, Serine protease, Urokinase, Binding Sites, Sequence Homology, Amino Acid, biology, Blood Proteins, Urokinase-Type Plasminogen Activator, Blood proteins, Amino acid, Enzyme, chemistry, biology.protein, Sequence Alignment, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb2d632f905cfcfefc8eca0912cc0c5
https://doi.org/10.1021/bi010186u

المؤلفون: Robert C. Goldman, Seth W. Snyder, Tom Mcgonigal, Karl A. Walter, Uri S. Ladror, John O. Capobianco, Sarah A. Dorwin, Rohinton Edalji, David A. Egan, Thomas F. Holzman, Robert W. Johnson, Aparna V. Sarthy

المصدر: Protein Science. 7:2595-2601

مصطلحات موضوعية: Saccharomyces cerevisiae Proteins, Proteolysis, Molecular Sequence Data, Saccharomyces cerevisiae, Biology, Biochemistry, Fungal Proteins, Differential scanning calorimetry, medicine, Trypsin, Amino Acid Sequence, Molecular Biology, Peptide sequence, Chromatography, High Pressure Liquid, Fungal protein, Calorimetry, Differential Scanning, medicine.diagnostic_test, Peptide Elongation Factors, biology.organism_classification, Peptide Fragments, Elongation factor, Electrophoresis, Polyacrylamide Gel, Ultracentrifuge, Ultracentrifugation, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7c059e34682363bfa73fa29b741180
https://doi.org/10.1002/pro.5560071213

المؤلفون: Kimberly A. Klute, Rosalind Helfrich, Robert L. Simmer, Teresa McNally, Donald N. Halbert, Marlon D. Cowart, Elizabeth A. Kowaluk, Kenneth B. Idler, Joseph L. Meuth, Sarah A. Dorwin

المصدر: Biochemical and Biophysical Research Communications. 231:645-650

مصطلحات موضوعية: DNA, Complementary, Molecular Sequence Data, Biophysics, Adenosine kinase, Mitogen-activated protein kinase kinase, Biochemistry, Structure-Activity Relationship, medicine, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Adenosine Kinase, Molecular Biology, Base Sequence, biology, Brain, Cell Biology, Purinergic signalling, Adenosine A3 receptor, Adenosine, Recombinant Proteins, Rats, ADK, biology.protein, Cyclin-dependent kinase 9, Adenosine A2B receptor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6166e541765ecabd3c99b6c26c9685
https://doi.org/10.1006/bbrc.1997.6157

المؤلفون: Renaldo Mendoza, Andrew M. Petros, Jeffrey R. Huth, Chaohong Sun, Stephen W. Fesik, Saul H. Rosenberg, Karl A. Walter, Philip J. Hajduk, Sarah A. Dorwin, Cheol-Min Park, Wang Xilu, Thorsten Oost, Paul Nimmer, Emily Gramling, Haichao Zhang, Hong Ding, Uri S. Ladror, Steven W. Elmore, Jamey Mack

المصدر: Bioorganicmedicinal chemistry letters. 20(22)

مصطلحات موضوعية: Drug, Models, Molecular, Programmed cell death, Magnetic Resonance Spectroscopy, Chemistry, media_common.quotation_subject, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Highly selective, Biochemistry, Bcl-2 Inhibitor, Structure-Activity Relationship, Proto-Oncogene Proteins c-bcl-2, Apoptosis, Drug Discovery, Cancer cell, Cancer research, Molecular Medicine, Structure based, Molecular Biology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266548bc1402d6d8168c82edd71ea263
https://pubmed.ncbi.nlm.nih.gov/20870405

المؤلفون: Karl A. Walter, Jeffrey R. Huth, Renaldo Mendoza, Sarah A. Dorwin, Jamey Mack, Uri S. Ladror, Danying Song, Philip J. Hajduk, Jean M. Severin, Diane Bartley, Candice L. Black-Schaefer

المصدر: Chemical research in toxicology. 20(12)

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Drug-Related Side Effects and Adverse Reactions, Aldehyde dehydrogenase, Toxicology, Autoantigens, Superoxide dismutase, Nuclear magnetic resonance, Cytochrome P-450 Enzyme Inhibitors, Humans, Sulfhydryl Compounds, chemistry.chemical_classification, Reactive oxygen species, biology, Molecular Structure, Superoxide Dismutase, Cytochrome P450, General Medicine, Nuclear magnetic resonance spectroscopy, Aldehyde Dehydrogenase, Enzyme, chemistry, Biochemistry, Pharmaceutical Preparations, Ribonucleoproteins, Drug Design, biology.protein, Thiol, Microsomes, Liver, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c804192eb2e26635dbfaea8625341861
https://pubmed.ncbi.nlm.nih.gov/18001056

المؤلفون: Stephen W. Fesik, Sarah A. Dorwin, Diane Bartley, Karl A. Walter, Steven W. Elmore, Uri S. Ladror, Jun Chen, Jamey Mack, Sha Jin, Kunzer Aaron R, Russell A. Judge, Paul L. Richardson, Christopher L. Lynch, Philip J. Hajduk, Jean M. Severin, Chang Park, Stephen K. Tahir, Michael D. Wendt, Edward D. Matayoshi, Andrew M. Petros, Jeffrey R. Huth, Wang Xilu, Kerry M. Swift

المصدر: Chemical biologydrug design. 70(1)

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Molecular Sequence Data, Aminopyridines, Crystallography, X-Ray, Ligands, Biochemistry, Protein structure, Heat shock protein, Drug Discovery, Humans, HSP90 Heat-Shock Proteins, Enzyme Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Malignant phenotype, Pharmacology, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Active site, Hsp90, Peptide Fragments, Enzyme, chemistry, Chaperone (protein), Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f54c493dcea0e8a529f6519529554b
https://pubmed.ncbi.nlm.nih.gov/17630989

المؤلفون: Tanveer F. Ahmed, Karl A. Walter, T. F. Holzman, Laura J. Miesbauer, Robert W. Johnson, John E. Harlan, Rohinton Edalji, Sarah A. Dorwin, Richard S. Smith

المصدر: Analytical biochemistry. 341(1)

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Chromatography, Chemistry, Electrospray ionization, Biophysics, Analytical chemistry, Proteolytic enzymes, Cell Biology, Top-down proteomics, Mass spectrometry, Biochemistry, Fourier transform ion cyclotron resonance, Peptide Fragments, Recombinant Proteins, Matrix-assisted laser desorption/ionization, Fragmentation (mass spectrometry), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein purification, Animals, Cattle, Amino Acid Sequence, Rabbits, Molecular Biology, Chickens, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa6c57090500d59566ffc3d0c9ae346
https://pubmed.ncbi.nlm.nih.gov/15866524

المؤلفون: Preston Hill, Jill E. Hochlowski, Michael H. Scherr, James B. McAlpine, David N. Whittern, Ronald R. Rasmussen, Sarah A. Dorwin

المصدر: The Journal of antibiotics. 47(5)

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Endothelin Receptor Antagonists, Indoles, Magnetic Resonance Spectroscopy, Molecular Structure, Chemistry, Stereochemistry, Molecular Sequence Data, Nuclear magnetic resonance spectroscopy, Peptides, Cyclic, Amino acid, NMR spectra database, Chiral column chromatography, Acremonium, Hydrolysis, Heteronuclear molecule, Drug Discovery, Amino Acid Sequence, Long chain fatty acid, Amino Acids, Peptide sequence, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c88bc74acc76f6aaa89d423d58bce87
https://pubmed.ncbi.nlm.nih.gov/8040049

المؤلفون: Jeffrey R. Huth, Danying Song, Renaldo R. Mendoza, Candice L. Black-Schaefer, Jamey C. Mack, Sarah A. Dorwin, Uri S. Ladror, Jean M. Severin, Karl A. Walter, Diane M. Bartley, Philip J. Hajduk

المصدر: Chemical Research in Toxicology; Oct2007, Vol. 20 Issue 12, p1752-1759, 8p