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1
المؤلفون: Simon Schenk, Matthew R. Bliss, Thomas D.Y. Chung, Janna Kiselar, Michael P Hedrick, Tomas Mustelin, Laurie A. Bankston, Fusayo Yamamoto, Vida Zhang, Jiwen Zou, Jinghua Yu, Yingge Liu, Stephanie M. Stanford, Andrey A. Bobkov, Robert Ardecky, Nunzio Bottini, Antonio Barquilla, Shilpi Khare, Gregory W. Cadwell, Alexander E. Aleshin, Anthony B. Pinkerton, Santhi Ganji, Robert C. Liddington
المصدر: Nature chemical biology, vol 13, iss 6
مصطلحات موضوعية: 0301 basic medicine, Drug Evaluation, Preclinical, Mice, Obese, Type 2 diabetes, Protein tyrosine phosphatase, Pharmacology, Obese, Mice, Models, Tyrosine, Enzyme Inhibitors, Mice, Knockout, biology, Molecular Structure, Chemistry, Diabetes, Preclinical, 3. Good health, Biochemistry, Phosphorylation, Type 2, Biochemistry & Molecular Biology, Knockout, Phosphatase, Models, Biological, Small Molecule Libraries, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Insulin resistance, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Molecular Biology, Metabolic and endocrine, Binding Sites, 030102 biochemistry & molecular biology, Prevention, Cell Biology, medicine.disease, Biological, Enzyme Activation, Molecular Weight, Insulin receptor, 030104 developmental biology, Diabetes Mellitus, Type 2, biology.protein, Drug Evaluation, Biochemistry and Cell Biology, Protein Tyrosine Phosphatases, Gene Deletion
وصف الملف: application/pdf
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2
المؤلفون: John C. Reed, Curt T. Hauser, Marcos González-López, Robert Ardecky, Kate Welsh, Nicholas D. P. Cosford, Hongbin Yuan, Darren Finlay, Trina R. Cooley, Kristiina Vuori, Ying Su, Mitchell Vamos, Santhi Ganji
المصدر: Molecular Cancer Therapeutics. 13:5-15
مصطلحات موضوعية: Cancer Research, Ubiquitin-Protein Ligases, Antineoplastic Agents, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Biology, Inhibitor of apoptosis, Article, Inhibitor of Apoptosis Proteins, Small Molecule Libraries, TNF-Related Apoptosis-Inducing Ligand, Cell Line, Tumor, Neoplasms, Baculoviral IAP Repeat-Containing 3 Protein, Humans, Molecular Targeted Therapy, Cytotoxicity, Inhibitor of apoptosis domain, Caspase 8, Cell biology, XIAP, Oncology, Drug Resistance, Neoplasm, Cancer cell, Tumor necrosis factor alpha, Signal Transduction
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المؤلفون: John C. Reed, Pooi San Lee, Kate Welsh, Kristiina Vuori, Darren Finlay, Nicholas D. P. Cosford, Palaniyandi Ravanan, Peter D. Mace, Marcos González-López, Robert Ardecky, Stefan J. Riedl, Santhi Ganji
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4253-4257
مصطلحات موضوعية: Cell Survival, Peptidomimetic, Clinical Biochemistry, Pharmaceutical Science, X-Linked Inhibitor of Apoptosis Protein, Plasma protein binding, Inhibitor of apoptosis, Biochemistry, Article, TNF-Related Apoptosis-Inducing Ligand, Structure-Activity Relationship, Biomimetic Materials, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Binding Sites, Chemistry, Organic Chemistry, Rational design, Ligand (biochemistry), Protein Structure, Tertiary, XIAP, Molecular Docking Simulation, Drug Resistance, Neoplasm, Apoptosis, Drug Design, Cancer research, Molecular Medicine, Oligopeptides, Protein Binding
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المؤلفون: José Luis Millán, Pooi San Lee, Colin Farquharson, Nicholas D. P. Cosford, Eduard Sergienko, Raveendra Panickar Dhanya, Layton H. Smith, Peter Teriete, Yalda Bravo, Tina Kiffer-Moreira, Russell Dahl, Santhi Ganji
مصطلحات موضوعية: Phosphoric monoester hydrolases, Clinical Biochemistry, Phosphatase, Pharmaceutical Science, Biochemistry, Article, Small Molecule Libraries, Mice, Structure-Activity Relationship, Drug Discovery, High-Throughput Screening Assays, Structure–activity relationship, Animals, Humans, Benzothiazoles, Enzyme Inhibitors, Molecular Biology, ADME, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Hydrogen-Ion Concentration, Small molecule, In vitro, Phosphoric Monoester Hydrolases, Drug Design, Benzamides, Hepatocytes, Molecular Medicine
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المؤلفون: Russell Dahl, Sonoko Narisawa, Shenghua Shi, Craig Rosenstein, Stefan Vasile, Ying Su, Jiwen Zou, Santhi Ganji, Ian Pass, Anton Cheltsov, Tina Kiffer-Moreira, José Luis Millán, Carlton Gasior, Anthony B. Pinkerton, Flávia Godoy Iano, Brock Brown, Justin Rascon, Jonathan D. Kaunitz, Eduard Sergienko, Marc Hoylaerts, Robert Ardecky, Michael P Hedrick, Thomas D.Y. Chung, Ekaterina V. Bobkova, Anita H. Forster
المصدر: Bioorganic & medicinal chemistry letters, vol 24, iss 3
مصطلحات موضوعية: High-throughput screening, 1.1 Normal biological development and functioning, Medicinal & Biomolecular Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Article, Inflammatory bowel disease, Intestinal alkaline phosphatase, Dephosphorylation, Mice, Medicinal and Biomolecular Chemistry, Underpinning research, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, 2.1 Biological and endogenous factors, Secretion, Enzyme Inhibitors, Aetiology, Molecular Biology, Sulfonamides, biology, Chemistry, Inhibitors, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, biology.organism_classification, Alkaline Phosphatase, Molecular biology, In vitro, Enzymes, body regions, Enzyme Activation, medicine.anatomical_structure, Molecular Medicine, Alkaline phosphatase, Acetanilides, Germ cell, Bacteria
وصف الملف: application/pdf
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6
المؤلفون: John C. Reed, Scott J. Snipas, Nicholas D. P. Cosford, Mitchell Vamos, Darren Finlay, Monica L. Gonzalez, Guy S. Salvesen, Kate Welsh, Pooi San Lee, Peter D. Mace, Kristiina Vuori, Santhi Ganji, Stefan J. Riedl, Robert Ardecky
مصطلحات موضوعية: Models, Molecular, Fluorescence Polarization, Inhibitor of apoptosis, Biochemistry, Article, Inhibitor of Apoptosis Proteins, medicine, Fibroblast, Melanoma, Caspase, biology, Cancer, General Medicine, medicine.disease, Caspase Inhibitors, XIAP, body regions, medicine.anatomical_structure, Cell culture, Apoptosis, Drug Design, Cancer cell, biology.protein, Cancer research, Molecular Medicine
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7Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
المؤلفون: John C. Reed, Kristiina Vuori, Stefan J. Riedl, Richard A. Houghten, Kate Welsh, Marcos González-López, Robert Ardecky, Darren Finlay, Shu-ichi Matsuzawa, Peter Teriete, Santhi Ganji, Nicholas D. P. Cosford, Clemencia Pinilla, Snezana Milutinovic
المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0161952 (2016)مصطلحات موضوعية: 0301 basic medicine, Physiology, Cytotoxicity, lcsh:Medicine, Apoptosis, Toxicology, Pathology and Laboratory Medicine, Biochemistry, Inhibitor of Apoptosis Proteins, 0302 clinical medicine, Immune Physiology, Medicine and Health Sciences, lcsh:Science, Caspase, Innate Immune System, Multidisciplinary, Cell Death, biology, Intracellular Signaling Peptides and Proteins, Chemical Synthesis, Recombinant Proteins, 3. Good health, XIAP, Chemistry, Optical Equipment, Cell Processes, 030220 oncology & carcinogenesis, Physical Sciences, Cytokines, Engineering and Technology, Tumor necrosis factor alpha, biological phenomena, cell phenomena, and immunity, Research Article, Protein Binding, Biosynthetic Techniques, Immunology, Equipment, Fluorescence Polarization, Research and Analysis Methods, Inhibitor of apoptosis, Phosphates, Mitochondrial Proteins, 03 medical and health sciences, Cell Line, Tumor, Protein Concentration Assays, Humans, Molecular Biology Techniques, Molecular Biology, Peptide Synthesis, Transcription factor, Molecular Biology Assays and Analysis Techniques, Tumor Necrosis Factor-alpha, lcsh:R, Molecular Mimicry, Chemical Compounds, Biology and Life Sciences, Proteins, Prisms, Cell Biology, Molecular Development, Molecular biology, 030104 developmental biology, Immune System, Cancer cell, Cancer research, biology.protein, lcsh:Q, Apoptosis Regulatory Proteins, Developmental Biology
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المؤلفون: Kristiina Vuori, Peter Teriete, John C. Reed, Nicholas D. P. Cosford, Kate Welsh, Marcos González-López, Stefan J. Riedl, Hongbin Yuan, Robert Ardecky, Peter D. Mace, Santhi Ganji, Ying Su, Darren Finlay
المصدر: Bioorganicmedicinal chemistry letters. 21(14)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Peptide, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Plasma protein binding, Biochemistry, Article, Mitochondrial Proteins, TNF-Related Apoptosis-Inducing Ligand, Protein structure, Biomimetic Materials, Cell Line, Tumor, Drug Discovery, Humans, Computer Simulation, Binding site, Molecular Biology, chemistry.chemical_classification, Binding Sites, Chemistry, Organic Chemistry, Rational design, Intracellular Signaling Peptides and Proteins, Ligand (biochemistry), In vitro, XIAP, Protein Structure, Tertiary, Drug Design, Molecular Medicine, Apoptosis Regulatory Proteins, Protein Binding