المؤلفون: Rolf W. Hartmann, Enrico Perspicace, Sandrine Marchais-Oberwinkler

المصدر: Molecules, Vol 18, Iss 4, Pp 4487-4509 (2013)

مصطلحات موضوعية: thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines, quinazolinones, conformationally restricted analogues, enzyme inhibitors, 17b-hydroxysteroid dehydrogenase type 2, osteoporosis, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/18/4/4487; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/44a8faa8cf2a4f78bd3d77197f9fd589

المؤلفون: Emanuele M Gargano, Giuseppe Allegretta, Enrico Perspicace, Angelo Carotti, Chris Van Koppen, Martin Frotscher, Sandrine Marchais-Oberwinkler, Rolf W Hartmann

المصدر: PLoS ONE, Vol 10, Iss 7, p e0134754 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4521925?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/0bc4d2b54c854517a63ff00bf9fcb5c9

المؤلفون: Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher

المصدر: PLoS ONE, Vol 7, Iss 1, p e29252 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22242164/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/8b5b42ff1bff47bcaee02bfde7a2d7c2

المؤلفون: Emanuele M. Gargano (11724212), Abdelrahman Mohamed (8691030), Ahmed S. Abdelsamie (3352139), Giuseppe F. Mangiatordi (11724215), Hanna Drzewiecka (11724218), Paweł P. Jagodziński (11724221), Arcangela Mazzini (11724224), Chris J. van Koppen (11724227), Matthias W. Laschke (6855236), Orazio Nicolotti (168458), Angelo Carotti (168453), Sandrine Marchais-Oberwinkler (189194), Rolf W. Hartmann (124550), Martin Frotscher (189200)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, rationally designed library, potential treatment option, pharmacological profile renders, new therapeutic approaches, clinical challenge posed, biological screening led, 1 cell proliferation, 1 , vivo <, viable target, selective inhibitors, rational approach, proof existed, present need, nsclc ), hold promise, high selectivity, fighting nsclc

Relation: https://figshare.com/articles/journal_contribution/17_-Hydroxysteroid_Dehydrogenase_Type_1_Inhibition_A_Potential_Treatment_Option_for_Non-Small_Cell_Lung_Cancer/17040809

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00462.s001

المؤلفون: Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler

المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

المصدر: ACS medicinal chemistry letters
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

مصطلحات موضوعية: business.industry, Organic Chemistry, Treatment options, medicine.disease, Biochemistry, Docking, respiratory tract diseases, Drug Discovery, Cancer research, Medicine, Non small cell, Hydroxysteroid dehydrogenase, business, Lung cancer, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
https://hdl.handle.net/10033/623149

المؤلفون: Nicole Bertoletti, Aline Keils, Sandrine Marchais-Oberwinkler, Gerhard Klebe, Andreas Heine, Mohammed J. Badran

المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 189:135-144

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 17-Hydroxysteroid Dehydrogenases, Protein Conformation, Stereochemistry, Endocrinology, Diabetes and Metabolism, Dimer, Clinical Biochemistry, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Oxidoreductase, Enzyme Stability, Catalytic triad, Humans, Enzyme kinetics, Molecular Biology, chemistry.chemical_classification, biology, Substrate (chemistry), Active site, Cell Biology, Ligand (biochemistry), Amino acid, 030104 developmental biology, Amino Acid Substitution, chemistry, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, biology.protein, Molecular Medicine, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86adecf4ffb8f73d2261c051fb5d72b8
https://doi.org/10.1016/j.jsbmb.2019.02.009

المؤلفون: Lorenz Siebenbuerger, Sandrine Marchais-Oberwinkler, Michael D. Menger, Martin Frotscher, Ahmed S. Abdelsamie, Carsten Boerger, Rolf W. Hartmann, Victor Hernandez-Olmos, Claudia Scheuer, Chris J. van Koppen, Matthias W. Laschke

المصدر: Journal of Medicinal Chemistry. 61:10724-10738

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Pharmacology, 01 natural sciences, Targeted therapy, Estradiol Dehydrogenases, Mice, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Potency, Tissue Distribution, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, chemistry.chemical_classification, 010405 organic chemistry, Water, In vitro, 0104 chemical sciences, 030104 developmental biology, Enzyme, Solubility, S9 fraction, chemistry, Drug Design, Osteoporosis, Molecular Medicine, Female, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a7ff0cde1f64d87d00e9445907fc28
https://doi.org/10.1021/acs.jmedchem.8b01373

المؤلفون: Patricia Kruchten, Ruth Werth, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Erika Ziegler, Alexander Oster, Martin Frotscher, Rolf W. Hartmann

وصف الملف: application/pdf; image/vnd.djvu

Relation: CRCHIM_2009__12_10-11_1110_0; https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2009.05.005/; oai:centre-mersenne.org:CRCHIM_2009__12_10-11_1110_0; citation: Comptes Rendus. Chimie, 12, no. 10-11 (2009) p 1110-1116

الاتاحة: https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2009.05.005/

المؤلفون: Martin Frotscher, Ahmed S. Abdelsamie, Rolf W. Hartmann, Sebastian Müller, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Matthias W. Laschke, Lorenz Siebenbürger, Mohamed Salah, Ahmed Merabet, Claudia Scheuer, Oliver Zierau, Michael D. Menger, Günter Vollmer

المصدر: Journal of medicinal chemistry. 62(15)

مصطلحات موضوعية: medicine.drug_class, Osteoporosis, Estrogen receptor, Administration, Oral, Pharmacology, 01 natural sciences, Bone resorption, Estradiol Dehydrogenases, 03 medical and health sciences, Mice, Drug Delivery Systems, Drug Discovery, medicine, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Rats, Wistar, IC50, Testosterone, 030304 developmental biology, 0303 health sciences, Bone Density Conservation Agents, Chemistry, medicine.disease, In vitro, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Estrogen, Drug Design, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab02369095497d2b4ea68f6ffabf214
https://pubmed.ncbi.nlm.nih.gov/31343176

المؤلفون: Rolf W. Hartmann, Sebastian Müller, Ahmed S. Abdelsamie, Ahmed Merabet, Oliver Zierau, Sophie Pählig, Günter Vollmer, Sandrine Marchais-Oberwinkler, Chris J. van Koppen

المصدر: The Journal of steroid biochemistry and molecular biology. 192

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, 17-Hydroxysteroid Dehydrogenases, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Ovariectomy, Clinical Biochemistry, Osteoporosis, Estrone, Biochemistry, Bone and Bones, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, Internal medicine, medicine, Animals, Humans, Tissue Distribution, Enzyme Inhibitors, Rats, Wistar, Molecular Biology, Testosterone, business.industry, Uterus, Hormone replacement therapy (menopause), Cell Biology, Organ Size, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, Estrogen, 030220 oncology & carcinogenesis, Estradiol benzoate, Molecular Medicine, Female, business, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed4593cfc0c68897f5617fd778f1e46
https://pubmed.ncbi.nlm.nih.gov/31185280

المؤلفون: Pauline Banachowicz, Rolf W. Hartmann, Susanne Maria Weber, Christoph P. Sager, Matthias Negri, Gabriele Möller, Sandrine Marchais-Oberwinkler, Jerzy Adamski

المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 206:105790

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Mutagenesis (molecular biology technique), Dehydrogenase, Molecular Dynamics Simulation, Ligands, Topology, Biochemistry, Catalysis, Estradiol Dehydrogenases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Humans, Homology modeling, Amino Acids, Enzyme Inhibitors, Site-directed mutagenesis, Molecular Biology, chemistry.chemical_classification, Cell Biology, Ligand (biochemistry), Enzyme structure, Amino acid, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, Molecular Medicine, NAD+ kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd1b40b75a21e82ee7d608eec4ef80e
https://doi.org/10.1016/j.jsbmb.2020.105790

المؤلفون: Michael D. Menger, Martin Frotscher, Lorenz Siebenbürger, Matthias W. Laschke, Rolf W. Hartmann, Carsten Börger, Steven C. Herath, Mohamed Salah, Yannik Biskupek, Tim Pohlemann, Ahmed S. Abdelsamie, Claudia Scheuer, Sandrine Marchais-Oberwinkler, Chris J. van Koppen

المصدر: Journal of medicinal chemistry. 62(3)

مصطلحات موضوعية: medicine.medical_specialty, Intracrine, 17-Hydroxysteroid Dehydrogenases, medicine.medical_treatment, Bone healing, 01 natural sciences, Proof of Concept Study, Bone resorption, Targeted therapy, 03 medical and health sciences, Mice, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Testosterone, 030304 developmental biology, Fracture Healing, 0303 health sciences, Chemistry, Bone fracture, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Steroid hormone, Endocrinology, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936062b4a4834811593a989e57dd5b07
https://pubmed.ncbi.nlm.nih.gov/30645111

المؤلفون: Jerzy Adamski, Gerhard Klebe, Andreas Heine, Ahmed S. Abdelsamie, Florian Braun, Torsten Steinmetzer, Gabriele Möller, Nicole Bertoletti, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Mohamed Salah

المصدر: Journal of medicinal chemistry. 59(23)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 17-Hydroxysteroid Dehydrogenases, Stereochemistry, Crystallography, X-Ray, Cofactor, 03 medical and health sciences, Structure-Activity Relationship, Oxidoreductase, Drug Discovery, Structure–activity relationship, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Active site, Ligand (biochemistry), 030104 developmental biology, Enzyme, Drug Design, biology.protein, Molecular Medicine, NAD+ kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f9f8b680bc5b3af2db85c1e288b288
https://pubmed.ncbi.nlm.nih.gov/27933965

المؤلفون: Nicole Bertoletti, Jerzy Adamski, Andreas Heine, Sandrine Marchais-Oberwinkler, Florian Braun, Gabriele Möller, Gerhard Klebe, Mahalia Lepage

المصدر: J. Med. Chem. 59, 6961-6967 (2016)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 17-Hydroxysteroid Dehydrogenases, Stereochemistry, Pyridines, Estrone, Crystallography, X-Ray, Ligands, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Oxidoreductase, Drug Discovery, Structure–activity relationship, Humans, Binding site, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Ligand, 3. Good health, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine, Steroids, NAD+ kinase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7671aadf4d04baca7a9cb40de3e3ac7b
https://pubmed.ncbi.nlm.nih.gov/27362750

المؤلفون: Jerzy Adamski, Rolf W. Hartmann, Marie Wetzel, Sandrine Marchais-Oberwinkler, Enrico Perspicace, Alex Odermatt, Gabriele Möller, Arne Meyer, Matthias Negri, Kuiying Xu

المصدر: Journal of Medicinal Chemistry. 56:167-181

مصطلحات موضوعية: Models, Molecular, 17-Hydroxysteroid Dehydrogenases, Stereochemistry, Estrogen receptor, Thiophenes, Estradiol Dehydrogenases, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Cell Line, Tumor, Microsomes, Amide, Drug Discovery, Thiophene, Animals, Humans, Moiety, Phenyl group, Hydroxysteroid dehydrogenase, Enzyme Assays, Bone Density Conservation Agents, Cell-Free System, biology, Chemistry, Active site, Callithrix, Amides, Rats, HEK293 Cells, biology.protein, Osteoporosis, Molecular Medicine, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252c800317f091134200f3ee3d263019
https://doi.org/10.1021/jm3014053

المؤلفون: Martin Frotscher, Sandrine Marchais-Oberwinkler, Ágnes Berényi, George Falkay, Renáta Minorics, István Zupkó, Rolf W. Hartmann, Imre Ocsovszki

المساهمون: Department of Pharmacodynamics and Biopharmacy, University of Szeged , Szeged , Hungary.

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry. 28:695-703

مصطلحات موضوعية: 17-Hydroxysteroid Dehydrogenases, Population, Antineoplastic Agents, Biology, Pharmacology, HeLa, Structure-Activity Relationship, Drug Discovery, Tumor Cells, Cultured, Humans, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, education, Cell Proliferation, education.field_of_study, Dose-Response Relationship, Drug, Molecular Structure, General Medicine, Cell cycle, biology.organism_classification, In vitro, Apoptosis, Cell culture, Cancer cell, MCF-7 Cells, Drug Screening Assays, Antitumor, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e863bef463fb64f4dc9b49e5902e8652
https://doi.org/10.3109/14756366.2012.672414

المؤلفون: Martin Frotscher, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Almuth Einspanier, Claudia Henn

المصدر: Journal of Medicinal Chemistry. 55:3307-3318

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Placenta, Endometriosis, Estrogen receptor, Estrone, Dehydrogenase, Naphthols, Estradiol Dehydrogenases, Structure-Activity Relationship, chemistry.chemical_compound, Species Specificity, Pregnancy, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Estrogen Receptor beta, Humans, chemistry.chemical_classification, Sulfonamides, biology, Estrogen Receptor alpha, Callithrix, biology.organism_classification, Sulfonamide, chemistry, Estrogen, Molecular Medicine, Female, hormones, hormone substitutes, and hormone antagonists, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f05e4dcd44b653acb4a7c063d9be809
https://doi.org/10.1021/jm201735j

المؤلفون: Stefan Hinsberger, Rolf W. Hartmann, Emanuele M. Gargano, Marie Wetzel, Sandrine Marchais-Oberwinkler

المصدر: European Journal of Medicinal Chemistry. 47:1-17

مصطلحات موضوعية: Models, Molecular, Pharmacology, Bicyclic molecule, Stereochemistry, Drug discovery, Organic Chemistry, Molecular Conformation, Substrate (chemistry), Dehydrogenase, Estrone, General Medicine, Estradiol Dehydrogenases, Benzophenones, Inhibitory Concentration 50, chemistry.chemical_compound, Receptors, Estrogen, chemistry, Drug Discovery, Osteoporosis, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Selectivity, IC50, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d229ca07fca7e00a9c0489631e86e3
https://doi.org/10.1016/j.ejmech.2011.09.004

المؤلفون: Rolf W. Hartmann, Yaseen A. Al-Soud, Sandrine Marchais-Oberwinkler, Marie Wetzel, Kuiying Xu

المصدر: European Journal of Medicinal Chemistry. 46:5978-5990

مصطلحات موضوعية: Pharmacology, medicine.drug_class, Stereochemistry, Organic Chemistry, Estrogen Receptor alpha, Triazole, Estradiol Dehydrogenases, Estrogen receptor, Estrone, General Medicine, Triazoles, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Estrogen, Drug Discovery, medicine, Estrogen Receptor beta, Humans, Osteoporosis, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Estrogen receptor alpha, Estrogen receptor beta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28a14077adc22d24123c271e30d4915
https://doi.org/10.1016/j.ejmech.2011.10.010

المؤلفون: Sandrine Marchais-Oberwinkler, Gabriele Möller, Rolf W. Hartmann, Jerzy Adamski, Enrico Perspicace, Marie Wetzel

المصدر: Journal of Medicinal Chemistry. 54:7547-7557

مصطلحات موضوعية: medicine.medical_specialty, 17-Hydroxysteroid Dehydrogenases, medicine.drug_class, Placenta, Osteoporosis, Estrogen receptor, Dehydrogenase, Estrone, Naphthols, In Vitro Techniques, Binding, Competitive, Estradiol Dehydrogenases, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Phenols, Pregnancy, Cell Line, Tumor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Hydroxysteroid dehydrogenase, chemistry.chemical_classification, Callithrix, medicine.disease, Rats, Endocrinology, Enzyme, Receptors, Estrogen, chemistry, Estrogen, Microsomes, Liver, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7397cc1193066bc31fc8df8f602c748
https://doi.org/10.1021/jm2008453