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1
المؤلفون: Roland Kousek, Dirk Kessler, Stephan Karl Zahn, Jens Bruchhaus, Darryl B. McConnell, Mark Pearson, Franziska Moser, Bernhard Wolkerstorfer, Dennis Breitsprecher, Maximilian Scharnweber, Teresa Puchner, Georg Dahmann, Philipp Baaske, Julian E. Fuchs, Sandra Döbel, Wolfgang Hela, Christiane Kofink, Klaus Rumpel, Leonhard Geist, Simon Wöhrle, Andreas Bergner, Moriz Mayer, Jark Böttcher, Patrick Werni, Markus Zeeb, Maike Dettling, Tuncay Ciftci
المصدر: Chemmedchem
مصطلحات موضوعية: Tumor suppressor gene, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Small Molecule Libraries, PROTAC, Structure-Activity Relationship, BCL9, Very Important Paper, Drug Discovery, Humans, fragment-based screening, Protein Interaction Maps, General Pharmacology, Toxicology and Pharmaceutics, Binding site, beta Catenin, Pharmacology, Binding Sites, 010405 organic chemistry, Chemistry, Communication, WaterLOGSY, Organic Chemistry, Wnt signaling pathway, TCF4, β-catenin, microscale thermophoresis, Small molecule, Communications, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Catenin, Armadillo repeats, Molecular Medicine
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2
المؤلفون: Zhulin Tan, Nitinchandra D. Patel, Harald Engelhardt, Mark Petronczki, Georg Egger, Elisabeth Grondal, Lyne Lamarre, Joyce C. Leung, Bernadette Sharps, Nizar Haddad, Anke Baum, Andreas Bergner, Andreas Schrenk, Renate Schnitzer, Eugene Chong, Tobias Wunberg, Moriz Mayer, Thomas Gerstberger, Dietrich Böse, Andreas Zoephel, Darryl B. McConnell, Christian Engelhardt, Monika Kriz, Nina C. Gonnella, Mariusz Krawiec, Heinz Stadtmüller, Peter Ettmayer, Jonathan T. Reeves, Julian E. Fuchs, Barbara Hopfgartner, Dirk Scharn, Andreas Grimm, Biljana Peric Simov, Flavio Solca, Gerd Bader, Sandra Döbel, Roland Kousek
المصدر: Journal of Medicinal Chemistry. 62:10272-10293
مصطلحات موضوعية: Lung Neoplasms, Protein Conformation, Entropy, Transgene, Antineoplastic Agents, Mice, Transgenic, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, T790M, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Epidermal growth factor receptor, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Mutation, biology, Chemistry, Xenograft Model Antitumor Assays, respiratory tract diseases, 0104 chemical sciences, ErbB Receptors, 010404 medicinal & biomolecular chemistry, Protein kinase domain, Cyclization, Cell culture, Hepatocytes, Cancer research, biology.protein, Molecular Medicine, Benzimidazoles, Female, Tyrosine kinase
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3
المؤلفون: Gerhard Fischer, Jark Böttcher, Dirk Kessler, Alexander Weiss-Puxbaum, Melanie Hinkel, Sandra Döbel, Barbara Müllauer, Darryl B. McConnell, Andreas Bergner
المصدر: Future medicinal chemistry. 12(21)
مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Gene isoform, GTPase, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, Neoplasms, Drug Discovery, medicine, Humans, HRAS, Enzyme Inhibitors, neoplasms, Gene, 030304 developmental biology, Pharmacology, 0303 health sciences, 010405 organic chemistry, Chemistry, Small molecule, digestive system diseases, 0104 chemical sciences, Isoenzymes, Cancer research, ras Proteins, Molecular Medicine, KRAS