المؤلفون: Sampathkumar, Krishnan, Kerwin, Bruce A.

المصدر: Journal of Pharmaceutical Sciences ; volume 113, issue 2, page 314-331 ; ISSN 0022-3549

الاتاحة: http://dx.doi.org/10.1016/j.xphs.2023.11.004
https://api.elsevier.com/content/article/PII:S002235492300477X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S002235492300477X?httpAccept=text/plain

المؤلفون: Pavel V. Bondarenko, Sejal Gandhi, Sampathkumar Krishnan, Gang Xiao, Da Ren, Christopher James Sloey, Margaret Speed Ricci

المصدر: Pharmaceutical Research. 29:209-224

مصطلحات موضوعية: Glycosylation, medicine.drug_class, Chemistry, Pharmaceutical, Drug Storage, Glutamine, Ion chromatography, Size-exclusion chromatography, Pharmaceutical Science, CHO Cells, Receptors, Fc, Monoclonal antibody, Peptide Mapping, Mass Spectrometry, chemistry.chemical_compound, Drug Stability, Glycation, Cricetinae, medicine, Animals, Humans, Trypsin, Pharmacology (medical), Deamidation, Pharmacology, Aspartic Acid, Chromatography, Reverse-Phase, Chromatography, Isoelectric focusing, Chemistry, Histocompatibility Antigens Class I, Organic Chemistry, Temperature, Antibodies, Monoclonal, Biological activity, Chromatography, Ion Exchange, Complementarity Determining Regions, Biochemistry, Immunoglobulin G, Chromatography, Gel, Molecular Medicine, Asparagine, Isoelectric Focusing, Chromatography, Liquid, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1933348e8d6e247e71b308dc914b2792
https://doi.org/10.1007/s11095-011-0536-0

المؤلفون: Andrei A. Raibekas, Sampathkumar Krishnan

المصدر: Biophysical Journal. 96(1):199-208

مصطلحات موضوعية: Models, Molecular, Population, Biophysics, Infrared spectroscopy, Supramolecular Assemblies, Activation energy, Protein Structure, Secondary, Turn (biochemistry), Phase (matter), Spectroscopy, Fourier Transform Infrared, Humans, education, Fluorescent Dyes, education.field_of_study, Chemistry, Intermolecular force, Temperature, Recombinant Proteins, Crystallography, Interleukin 1 Receptor Antagonist Protein, Kinetics, Interleukin 1 receptor antagonist, Models, Chemical, Intramolecular force, Microscopy, Electron, Scanning, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f86eb2967ad43a38ef3d0b8a5c9d277

المؤلفون: Eva Kras, Andrew C. Nichols, William J. Callahan, Gary D. Pipes, Sungae Park, Linda Zhou, David N. Brems, Szilan Fodor, Richard L. Remmele, Sampathkumar Krishnan, Pavel V. Bondarenko, Gerd R. Kleemann

المصدر: Journal of Pharmaceutical Sciences. 95:126-145

مصطلحات موضوعية: Molecular mass, Stereochemistry, Dimer, Temperature, Antibodies, Monoclonal, Pharmaceutical Science, Antineoplastic Agents, Antibodies, Monoclonal, Humanized, Protein tertiary structure, Adduct, Papain, chemistry.chemical_compound, Monomer, Protein structure, chemistry, Covalent bond, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2d29ce611833e237330b6a5107ac02
https://doi.org/10.1002/jps.20515

المؤلفون: Eva Y. Chi, Brent S. Kendrick, Byeong S. Chang, John F. Carpenter, Theodore W. Randolph, Sampathkumar Krishnan

المصدر: Protein Science. 12:903-913

مصطلحات موضوعية: Protein Denaturation, Protein Conformation, Activation energy, Biochemistry, Article, law.invention, Protein–protein interaction, Colloid, Protein structure, Drug Stability, law, Granulocyte Colony-Stimulating Factor, Spectroscopy, Fourier Transform Infrared, Humans, Colloids, Solubility, Molecular Biology, Chemistry, Recombinant Proteins, Solutions, Crystallography, Virial coefficient, Recombinant DNA, Biophysics, Thermodynamics, Conformational stability, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f75ccd191bf743113f97c26fe8a17fd
https://doi.org/10.1110/ps.0235703

المؤلفون: John F. Carpenter, Eva Y. Chi, Sampathkumar Krishnan, Theodore W. Randolph

المصدر: Pharmaceutical Research. 20:1325-1336

مصطلحات موضوعية: Pharmacology, Aqueous solution, Chromatography, Chemistry, Organic Chemistry, Pharmaceutical Science, Therapeutic protein, Protein aggregation, Protein structure, Biophysics, Molecular Medicine, Water chemistry, Pharmacology (medical), Physical stability, Protein folding, Biotechnology, Biotechnology industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::22aabbf6d90ed509344a22325bcf10b9
https://doi.org/10.1023/a:1025771421906

المؤلفون: William Garzon-Rodriguez, Brent S. Kendrick, Anja Leona Biere, John F. Carpenter, Theodore W. Randolph, Linda O Narhi, Stephen J. Wood, Jette Wypych, Eva Y. Chi, Cynthia Li, Martin Citron, Sampathkumar Krishnan

المصدر: Biochemistry. 42:829-837

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Parkinson's disease, Light, animal diseases, Dimer, Synucleins, Nerve Tissue Proteins, Oxidative phosphorylation, medicine.disease_cause, Biochemistry, Pathogenesis, chemistry.chemical_compound, Osmotic Pressure, mental disorders, medicine, Humans, Protein Isoforms, Scattering, Radiation, Chromatography, High Pressure Liquid, Alpha-synuclein, Osmolar Concentration, Temperature, Parkinson Disease, Fibrillogenesis, Hydrogen-Ion Concentration, medicine.disease, nervous system diseases, Oxidative Stress, Cross-Linking Reagents, Amino Acid Substitution, nervous system, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, alpha-Synuclein, Synuclein, Biophysics, Tyrosine, Spectrophotometry, Ultraviolet, Dimerization, Oxidation-Reduction, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc12f32fb20b661193d5c0c6fc47885f
https://doi.org/10.1021/bi026528t

المؤلفون: Dingjiang Liu, Wenjin Cao, Sampathkumar Krishnan, Margaret Speed Ricci, Feroz Jameel, Jian Hua Gu, Liang-Yu Shih

المصدر: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85(2)

مصطلحات موضوعية: High concentration, Chromatography, Chemistry, Chemistry, Pharmaceutical, Rational design, Pharmaceutical Science, Proteins, General Medicine, Diluent, Chemical instability, Freeze Drying, Drug Stability, Wetting Agents, Concentration protein, Injection volume, High doses, Drug product, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4199dde22f241462bd5f8291e4250f31
https://pubmed.ncbi.nlm.nih.gov/23702275

المؤلفون: Margaret Speed Ricci, Yong Xie, Wenjin Cao, Hong Lin, Sampathkumar Krishnan

المصدر: Pharmaceutical research. 30(1)

مصطلحات موضوعية: Sucrose, Pharmacology toxicology, Raman imaging, Pharmaceutical Science, Spectrum Analysis, Raman, law.invention, X-Ray Diffraction, law, Metastability, medicine, Pharmacology (medical), Mannitol, Crystallization, Pharmacology, Chromatography, Chemistry, Organic Chemistry, Proteins, Process conditions, Freeze Drying, Chemical engineering, Molecular Medicine, Powder Diffraction, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df29a9449180fe8abf0e6f6d115ece33
https://pubmed.ncbi.nlm.nih.gov/22907420

المؤلفون: Jennifer S. Laurence, Ranjini Ramachander, Karthik Nagapudi, Camille Vergara, Jihea Park, Sampathkumar Krishnan

المصدر: Pharmaceutical research. 30(4)

مصطلحات موضوعية: Sucrose, medicine.drug_class, Drug Storage, Pharmacology toxicology, Solid-state, Pharmaceutical Science, Monoclonal antibody, Protein Structure, Secondary, Excipients, Freeze-drying, Protein structure, Spectroscopy, Fourier Transform Infrared, medicine, Pharmacology (medical), Mannitol, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, Chromatography, Chemistry, Protein Stability, Organic Chemistry, Dynamics (mechanics), Temperature, Antibodies, Monoclonal, Protein Structure, Tertiary, Freeze Drying, Chemical engineering, Immunoglobulin G, Molecular Medicine, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b98df03c9c7cf4ddc6d903e638a045
https://pubmed.ncbi.nlm.nih.gov/23184227

المؤلفون: Margaret Speed Ricci, Monica Pallitto, Sampathkumar Krishnan

المصدر: Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

مصطلحات موضوعية: Fc fusion, Biochemistry, Chemistry, medicine.drug_class, medicine, Pharmacology, Monoclonal antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f57bff269e317fece1e530313ed74c2c
https://doi.org/10.1002/9780470595886.ch16

المؤلفون: Theodore W. Randolph, Sampathkumar Krishnan, John F. Carpenter, Renuka Thirumangalathu, David N. Brems, Margaret Speed Ricci

مصطلحات موضوعية: inorganic chemicals, Sucrose, Protein Conformation, Pharmaceutical Science, Polysorbates, Protein aggregation, Sodium Chloride, complex mixtures, Article, chemistry.chemical_compound, Colloid, Silicone, Chemical Precipitation, Silicone Oils, Transition Temperature, Lubricant, Chromatography, Aqueous solution, Protein Stability, technology, industry, and agriculture, Antibodies, Monoclonal, Water, Hydrogen-Ion Concentration, equipment and supplies, Silicone oil, stomatognathic diseases, chemistry, Ionic strength, Immunoglobulin G, Polysorbate 20, Emulsions, Adsorption, Streptavidin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020e96c61d12b2360a865f5849572ff5
https://europepmc.org/articles/PMC2751612/

المؤلفون: Nina Cauchon, Sampathkumar Krishnan, Yong Xie, Wenjin Cao, Hong Lin

المصدر: Pharmaceutical research. 25(10)

مصطلحات موضوعية: Chemistry, Pharmaceutical, Pharmacology toxicology, Pharmaceutical Science, Crystallography, X-Ray, Spectrum Analysis, Raman, Excipients, symbols.namesake, Pharmaceutical technology, medicine, Technology, Pharmaceutical, Pharmacology (medical), Mannitol, Pharmacology, Multivariate curve resolution, Chromatography, Chemistry, Organic Chemistry, Proteins, Freeze Drying, symbols, Molecular Medicine, Raman spectroscopy, Powder Diffraction, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078ab2c09969e4f6de941d987192a75c
https://pubmed.ncbi.nlm.nih.gov/18523875

المؤلفون: Theodore W. Randolph, Pavel V. Bondarenko, David N. Brems, Sampathkumar Krishnan, John F. Carpenter, Margaret Speed-Ricci, Renuka Thirumangalathu

المصدر: Biochemistry. 46(21)

مصطلحات موضوعية: Protein Denaturation, Protein Folding, Protein Conformation, Kinetics, Peptide, Protein oxidation, Biochemistry, law.invention, chemistry.chemical_compound, Reaction rate constant, Methionine, law, Humans, Hydrogen peroxide, chemistry.chemical_classification, Temperature, Recombinant Proteins, Interleukin 1 Receptor Antagonist Protein, Interleukin 1 receptor antagonist, chemistry, Biophysics, Recombinant DNA, Thermodynamics, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d9f70a38521522f2623ff463d53268
https://pubmed.ncbi.nlm.nih.gov/17480058

المؤلفون: Hong Lin, Sampathkumar Krishnan, Chen Mao, Nina Cauchon, Wendy Chen, Wenjin Cao

المصدر: Journal of pharmaceutical sciences. 95(9)

مصطلحات موضوعية: Spectroscopy, Near-Infrared, Chemistry, Surface Properties, Near-infrared spectroscopy, Analytical chemistry, Pharmaceutical Science, Humidity, Reproducibility of Results, Water, medicine.disease, Pharmaceutical Solutions, Freeze Drying, Models, Chemical, X-Ray Diffraction, Data Interpretation, Statistical, Thermogravimetry, Curve fitting, medicine, Mannitol, Dehydration, Spectroscopy, Hydrate, Surface water, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f986d35298fb75486385abae712719
https://pubmed.ncbi.nlm.nih.gov/16850397

المؤلفون: Theodore W. Randolph, John F. Carpenter, Sampathkumar Krishnan, David N. Brems, Renuka Thirumangalathu

المصدر: Journal of pharmaceutical sciences. 95(7)

مصطلحات موضوعية: Circular dichroism, Protein Folding, Sucrose, Spectrophotometry, Infrared, Stereochemistry, Population, Pharmaceutical Science, Protein aggregation, Protein Structure, Secondary, chemistry.chemical_compound, Granulocyte Colony-Stimulating Factor, Humans, education, Protein secondary structure, education.field_of_study, Circular Dichroism, Temperature, Deuterium Exchange Measurement, Hydrogen-Ion Concentration, Protein tertiary structure, Recombinant Proteins, Protein Structure, Tertiary, chemistry, Benzyl alcohol, Chromatography, Gel, Protein folding, Benzyl Alcohol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1488ffbf2b28112dc3a2d8dd263b7614
https://pubmed.ncbi.nlm.nih.gov/16729274

المؤلفون: Sampathkumar, Krishnan

المصدر: BiCMOS Technology and Applications ; page 349-377 ; ISBN 9781461364139 9781461532187

الاتاحة: http://dx.doi.org/10.1007/978-1-4615-3218-7_9
http://link.springer.com/content/pdf/10.1007/978-1-4615-3218-7_9

المؤلفون: John F. Carpenter, Bruce A. Kerwin, Sampathkumar Krishnan, Shouvik Roy, Theodore W. Randolph, Ye Zhang, LaToya S. Jones, Byeong S. Chang, Mark C. Manning

المصدر: Journal of pharmaceutical sciences. 93(12)

مصطلحات موضوعية: education.field_of_study, Aqueous solution, Stereochemistry, Sialoglycoproteins, Population, Size-exclusion chromatography, Pharmaceutical Science, Receptors, Interleukin-1, Water, Isothermal titration calorimetry, Protein aggregation, Medicinal chemistry, Protein tertiary structure, Recombinant Proteins, Solutions, chemistry.chemical_compound, Interleukin 1 Receptor Antagonist Protein, chemistry, Benzyl alcohol, Native state, Humans, education, Benzyl Alcohol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f87ac96ba1a6602b440be22ef41704a
https://pubmed.ncbi.nlm.nih.gov/15514986

المؤلفون: John F. Carpenter, William Garzon-Rodriguez, Suchart Chongprasert, Sampathkumar Krishnan, Theodore W. Randolph, Rebecca L. Koval, Nicholas W. Warne

المصدر: Journal of pharmaceutical sciences. 93(3)

مصطلحات موضوعية: Sucrose, Chromatography, Drug Storage, Size-exclusion chromatography, Disaccharide, Pharmaceutical Science, Protein aggregation, Hydroxyethyl starch, Disaccharides, Interleukin-11, Trehalose, Recombinant Proteins, Hydroxyethyl Starch Derivatives, chemistry.chemical_compound, Protein structure, Freeze Drying, chemistry, Drug Stability, medicine, Humans, Sugar, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c12f6292fd70480b44fbcf08bd4153f
https://pubmed.ncbi.nlm.nih.gov/14762907

المؤلفون: Eva Y, Chi, Sampathkumar, Krishnan, Theodore W, Randolph, John F, Carpenter

المصدر: Pharmaceutical research. 20(9)

مصطلحات موضوعية: Pharmaceutical Solutions, Protein Folding, Surface-Active Agents, Drug Stability, Protein Conformation, Drug Storage, Solvents, Temperature, Proteins, Water, Hydrogen-Ion Concentration

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fb6b22d8378b85df87c6857dc6986a59
https://pubmed.ncbi.nlm.nih.gov/14567625