نتائج البحث - "Samantha K. Hamrick"

1

Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for

المؤلفون: Dan, Ye, Wei, Zhou, Samantha K, Hamrick, David J, Tester, C S John, Kim, Hector, Barajas-Martinez, Dan, Hu, John R, Giudicessi, Charles, Antzelevitch, Michael J, Ackerman

المصدر: Circulation. Genomic and precision medicine. 15(5)

مصطلحات موضوعية: Male, Shal Potassium Channels, Gain of Function Mutation, Ventricular Fibrillation, Humans, Flavones, Brugada Syndrome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2f5fadfc6283d9541c9ec09009a5958b
https://pubmed.ncbi.nlm.nih.gov/35861988

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2

Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential

المؤلفون: Marissa J. Stutzman, C.S. John Kim, David J. Tester, Samantha K. Hamrick, Steven M. Dotzler, John R. Giudicessi, Marco C. Miotto, Jeevan B. GC, Joachim Frank, Andrew R. Marks, Michael J. Ackerman

المصدر: Stem Cell Reports. 17:2023-2036

مصطلحات موضوعية: Induced Pluripotent Stem Cells, Isoproterenol, Arrhythmias, Cardiac, Ryanodine Receptor Calcium Release Channel, Cell Biology, NAD, Biochemistry, Mutation, Tachycardia, Ventricular, Genetics, Humans, Calcium, Myocytes, Cardiac, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb2793eea260a1df3d18391d32d49ff
https://doi.org/10.1016/j.stemcr.2022.07.002

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3

Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic

المؤلفون: Samantha K, Hamrick, C S, John Kim, David J, Tester, John R, Giudicessi, Michael J, Ackerman

المصدر: Heart Rhythm. 19:822-827

مصطلحات موضوعية: Male, Adolescent, Induced Pluripotent Stem Cells, Black People, COVID-19, Arrhythmias, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Death, Sudden, Cardiac, Physiology (medical), Humans, Myocytes, Cardiac, Cardiology and Cardiovascular Medicine, Pandemics, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58cbea41bf1d77617c890648b616c56
https://doi.org/10.1016/j.hrthm.2021.12.029

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4

SGK1 Inhibition Attenuates the Action Potential Duration in Re-Engineered Heart Cell Models of Drug-Induced QT Prolongation

المؤلفون: Maengjo Kim, Philip T. Sager, David J. Tester, Sabindra Pradhananga, Samantha K. Hamrick, Dinesh Srinivasan, Saumya Das, Michael J. Ackerman

المصدر: Heart rhythm.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd81c8c3ce1f45f4ef57d3ff2163e98
https://pubmed.ncbi.nlm.nih.gov/36610526

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5

Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes

المؤلفون: Dan Ye, Wei Zhou, Samantha K. Hamrick, David J. Tester, C.S. John Kim, Hector Barajas-Martinez, Dan Hu, John R. Giudicessi, Charles Antzelevitch, Michael J. Ackerman

المصدر: Circulation: Genomic and Precision Medicine. 15

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::10e2526342e0fe36e1dc7e0cce1d2768
https://doi.org/10.1161/circgen.120.003238

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6

BS-452757-2 A SINGLE SUPPRESSION AND REPLACEMENT GENE THERAPY FOR ALL THREE CARDIAC CALMODULINOPATHIES

المؤلفون: Samantha K. Hamrick, Changsung J. Kim, David Tester, Kathryn E. Tobert, Martina Gluscevic, Michael J. Ackerman

المصدر: Heart Rhythm. 20:S53

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1db80c89453b8671103dddc2209aa5c8
https://doi.org/10.1016/j.hrthm.2023.03.311

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7

PO-615-05 ACACETIN, A POTENT TRANSIENT OUTWARD CURRENT BLOCKER, MAY BE A NOVEL THERAPEUTIC FOR KCND3-ENCODED KV4.3 GAIN-OF-FUNCTION-ASSOCIATED J-WAVE SYNDROMES

المؤلفون: Dan Ye, Wei Zhou, Samantha K. Hamrick, David Tester, Changsung John Kim, Hector M. Barajas-Martinez, Dan Hu, John R. Giudicessi, Charles Antzelevitch, Michael John Ackerman

المصدر: Heart Rhythm. 19:S108-S109

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::136b0fff89806d127ba61617f6b291a3
https://doi.org/10.1016/j.hrthm.2022.03.793

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8

Promise and Potential Peril With Lumacaftor for the Trafficking Defective Type 2 Long-QT Syndrome-Causative Variants, p.G604S, p.N633S, and p.R685P, Using Patient-Specific Re-Engineered Cardiomyocytes

المؤلفون: CS John Kim, Dan Ye, Samantha K. Hamrick, Michael J. Ackerman, Bailey J. O’Hare, David J. Tester

المصدر: Circulation. Genomic and precision medicine. 13(5)

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, ERG1 Potassium Channel, Long QT syndrome, hERG, Induced Pluripotent Stem Cells, Regulator, Mutation, Missense, Action Potentials, Aminopyridines, 030204 cardiovascular system & hematology, Pharmacology, medicine.disease_cause, Polymorphism, Single Nucleotide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Myocytes, Cardiac, Benzodioxoles, Ion channel, Mutation, biology, business.industry, Lumacaftor, General Medicine, Patient specific, medicine.disease, Potassium channel, Long QT Syndrome, Protein Subunits, 030104 developmental biology, Phenotype, chemistry, biology.protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407739a87a30448e5a132cebadd75178
https://pubmed.ncbi.nlm.nih.gov/32940533

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9

Molecular characterization of the calcium release channel deficiency syndrome

المؤلفون: Michael J. Ackerman, Joel Temple, Hannah M. Bombei, Luis A. Ochoa Nunez, Ian H. Law, CS John Kim, Bailey J. O’Hare, Dan Ye, Carla M Haglund-Turnquist, David J. Tester, Dianne L. Atkins, Samantha K. Hamrick, Kristi K Fitzgerald

المصدر: JCI Insight

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Induced Pluripotent Stem Cells, Cardiology, chemistry.chemical_element, Calcium, Catecholaminergic polymorphic ventricular tachycardia, Ryanodine receptor 2, Afterdepolarization, 03 medical and health sciences, 0302 clinical medicine, Nadolol, Gene Duplication, Internal medicine, Gene duplication, Genetics, medicine, Humans, Myocytes, Cardiac, Genetic variation, Child, Flecainide, Chemistry, Ryanodine receptor, Homozygote, Cell Differentiation, Ryanodine Receptor Calcium Release Channel, General Medicine, Cardiovascular disease, musculoskeletal system, medicine.disease, Pedigree, Phenotype, 030104 developmental biology, Endocrinology, Case-Control Studies, Child, Preschool, Ion channels, 030220 oncology & carcinogenesis, Tachycardia, Ventricular, cardiovascular system, Female, tissues, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5191ec41470713d80b2838ccecfd64
https://doi.org/10.1172/jci.insight.135952

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10

B-PO01-007 THE EFFICACY OF MEXILETINE TREATMENT IN PATIENT-SPECIFIC RE-ENGINEERED CARDIOMYOCYTE MODELS OF LONG QT SYNDROME TYPE 1, 2, AND 3

المؤلفون: Michael J. Ackerman, Wei Zhou, David J. Tester, Maengjo Kim, Samantha K. Hamrick, Xiaozhi Gao, Changsung John Kim

المصدر: Heart Rhythm. 18:S53

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Physiology (medical), Long QT syndrome, Internal medicine, Mexiletine, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, medicine.disease, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f930aaef6cba6e237426f312173b1da6
https://doi.org/10.1016/j.hrthm.2021.06.153

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11

B-PO04-001 CHARACTERIZATION OF EXTREME N-TERMINAL RYR2 VARIANTS FOUND OUTSIDE CPVT1 VARIANT CLUSTER REGIONS SHOW CA2+ HANDLING ABNORMALITIES CONSISTENT WITH CLASSICAL CPVT

المؤلفون: Dan Ye, Marissa J Stutzman, Michael J. Ackerman, Samantha K. Hamrick, Steven M. Dotzler, Daniel J. Clemens, Changsung John Kim, David J. Tester

المصدر: Heart Rhythm. 18:S280

مصطلحات موضوعية: Terminal (electronics), business.industry, Calcium handling, Physiology (medical), Cluster (physics), Medicine, Computational biology, Characterization (mathematics), Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b5c7d63510d435900fe770e5f57c8cbf
https://doi.org/10.1016/j.hrthm.2021.06.698

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12

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 Among Children With Exertion-Related Unexplained Sudden Deaths in the Amish Community

المؤلفون: Barbara G. Russell, Carla M Haglund-Turnquist, Dianne L. Atkins, Michael J. Ackerman, Samantha K. Hamrick, Kristi K Fitzgerald, Christopher L. Johnsrude, Beth A. Pitel, Ian H. Law, Luis A. Ochoa Nunez, Joel Temple, Hannah M. Bombei, Erik C. Thorland, CS John Kim, David J. Tester, John R. Giudicessi

المصدر: JAMA Cardiol

مصطلحات موضوعية: Male, Pediatrics, medicine.medical_specialty, DNA Copy Number Variations, Physical Exertion, Autopsy, Consanguinity, 030204 cardiovascular system & hematology, Catecholaminergic polymorphic ventricular tachycardia, Sudden death, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Gene Duplication, medicine, Humans, Genetic Testing, 030212 general & internal medicine, Copy-number variation, Child, Promoter Regions, Genetic, Exome, Genetic testing, medicine.diagnostic_test, business.industry, Siblings, Brief Report, Homozygote, Ryanodine Receptor Calcium Release Channel, Sudden cardiac arrest, Exons, medicine.disease, Pedigree, Death, Sudden, Cardiac, Child, Preschool, Tachycardia, Ventricular, Female, medicine.symptom, Amish, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b495e507ae68a0a3691e7ac4686cb
https://doi.org/10.1001/jamacardio.2019.5400

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