المؤلفون: Samantha B Nicholls, Sarah L DeVos, Caitlin Commins, Chloe Nobuhara, Rachel E Bennett, Diana L Corjuc, Eduardo Maury, Bahareh Eftekharzadeh, Ololade Akingbade, Zhanyun Fan, Allyson D Roe, Shuko Takeda, Susanne Wegmann, Bradley T Hyman

المصدر: PLoS ONE, Vol 12, Iss 5, p e0177914 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5439699?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/6b7577e645ef4883bb7ef913fa08713d

المؤلفون: Alain Beck, Christine Nowak, Deborah Meshulam, Kristina Reynolds, David Chen, Dennis B. Pacardo, Samantha B. Nicholls, Gregory J. Carven, Zhenyu Gu, Jing Fang, Dongdong Wang, Amit Katiyar, Tao Xiang, Hongcheng Liu

المصدر: Antibodies; Volume 11; Issue 4; Pages: 73

مصطلحات موضوعية: charge variants, comparability, critical quality attributes, monoclonal antibodies, specification

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/antib11040073

الاتاحة: https://doi.org/10.3390/antib11040073

المؤلفون: Samantha B. Nicholls, Ryan Faucette, David Chen, Sanela Bilic, Constance Martin, Ashish Kalra, Brian T. Welsh, Thomas Schurpf, Janice A. Lansita

المصدر: International Journal of Toxicology

مصطلحات موضوعية: medicine.drug_class, medicine.medical_treatment, Cmax, Antineoplastic Agents, Pharmacology, Antibodies, Monoclonal, Humanized, Toxicology, Monoclonal antibody, Transforming Growth Factor beta1, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cancer immunotherapy, Animals, Humans, TGFβ inhibitors, Medicine, SRK-181, Neoplasm Metastasis, Cells, Cultured, 030304 developmental biology, 0303 health sciences, cancer immunotherapy, biology, latent TGFβ1, business.industry, Original Articles, Immunotherapy, Rats, Disease Models, Animal, Macaca fascicularis, Cytokine, 030220 oncology & carcinogenesis, biology.protein, Antibody, business, Transforming growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fc4be78ca0e0c6fa9df455a1a7bd00
https://doi.org/10.1177/1091581821998945

المؤلفون: Noura B. El Khoury, Maud Gratuze, Franck Petry, Marie-Amélie Papon, Carl Julien, François Marcouiller, Françoise Morin, Samantha B. Nicholls, Frédéric Calon, Sébastien S. Hébert, André Marette, Emmanuel Planel

المصدر: Neurobiology of Disease, Vol 88, Iss , Pp 55-65 (2016)

مصطلحات موضوعية: Alzheimer's disease, Diabetes mellitus, db/db mice, Tau hyperphosphorylation, Hippocampus, Kinase, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116300055; https://doaj.org/toc/1095-953X; https://doaj.org/article/5a746145e58844518d7dad8e612afb3f

الاتاحة: https://doi.org/10.1016/j.nbd.2016.01.005
https://doaj.org/article/5a746145e58844518d7dad8e612afb3f

المؤلفون: Frederick C. Streich, Susan C Lin, Samantha B. Nicholls, Ryan Faucette, Justin W. Jackson, Chris J Boston, Capili Allan, Anastasia Nikiforov, Kevin B. Dagbay, Erin Treece, Gregory J. Carven

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, muscle atrophy, Cell signaling, proteolysis, growth differentiation factor 8 (GDF8), medicine.drug_class, Myostatin, Monoclonal antibody, Cleavage (embryo), Biochemistry, Epitope, 03 medical and health sciences, Extracellular, medicine, cell signaling, Humans, skeletal muscle, Molecular Biology, X-ray crystallography, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, Protein Stability, Antibodies, Monoclonal, Cell Biology, musculoskeletal system, Antibodies, Neutralizing, Cell biology, Molecular Docking Simulation, 030104 developmental biology, monoclonal antibody, Protein Structure and Folding, hydrogen exchange mass spectrometry, biology.protein, inhibition mechanism, transforming growth factor β (TGF-β), Transforming growth factor, Conformational epitope, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6815c125823f4c0659cd139d3e3e71
http://europepmc.org/articles/PMC7170532

المؤلفون: Ana C. Amaral, Bradley T. Hyman, Samantha B. Nicholls, Julia Schiantarelli, Zhanyun Fan, Molly J. Kirk, Ashley B. Robbins, Louis Delorme, Danny McKenzie, Nahel Tunio, Susanne Wegmann, Miwei Hu, Eloise Hudry, Rachel E. Bennett

المصدر: Science Advances
Science advances 5(6), eaaw6404 (2019). doi:10.1126/sciadv.aaw6404

مصطلحات موضوعية: Male, Transgene, Tau protein, Hippocampus, Diseases and Disorders, Mice, Transgenic, tau Proteins, Striatum, Biology, Cell Line, 03 medical and health sciences, Immunolabeling, Mice, 0302 clinical medicine, Alzheimer Disease, mental disorders, Animals, Humans, Mantle (mollusc), Research Articles, 030304 developmental biology, Neurons, 0303 health sciences, Multidisciplinary, HEK 293 cells, SciAdv r-articles, Brain, Entorhinal cortex, metabolism [tau Proteins], Mice, Inbred C57BL, Disease Models, Animal, HEK293 Cells, metabolism [Brain], metabolism [Neurons], biology.protein, Disease Progression, Female, ddc:500, Neuroscience, metabolism [Alzheimer Disease], 030217 neurology & neurosurgery, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb8596ab151a00a9cf08b827a83f41c
http://europepmc.org/articles/PMC6594764

المؤلفون: Jeanne A. Hardy, Peng Wu, Samantha B. Nicholls

المصدر: Biophysical Journal. 104:1605-1614

مصطلحات موضوعية: Models, Molecular, Proteases, medicine.medical_treatment, Proteolysis, Green Fluorescent Proteins, Biophysics, Protein Engineering, Protein Structure, Secondary, Green fluorescent protein, Recognition sequence, Human proteome project, medicine, Humans, Caspase, Enzyme Assays, Protease, biology, medicine.diagnostic_test, Protein engineering, Cell biology, Biochemistry, Caspases, Molecular Probes, biology.protein, Proteins and Nucleic Acids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5bdd346d5f6ed2e1a448b270ce934b
https://doi.org/10.1016/j.bpj.2013.01.058

المؤلفون: Jeanne A. Hardy, Samantha B. Nicholls

المصدر: Protein Science. 22:247-257

مصطلحات موضوعية: Proteases, medicine.diagnostic_test, biology, Chemistry, Proteolysis, fungi, Proteolytic enzymes, Biochemistry, Green fluorescent protein, Cell biology, Protein structure, Apoptosis, medicine, biology.protein, Protein folding, Molecular Biology, Caspase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::281d2bd89511fc390b9833e5bd67dae4
https://doi.org/10.1002/pro.2188

المؤلفون: Franck R, Petry, Samantha B, Nicholls, Sébastien S, Hébert, Emmanuel, Planel

المصدر: Methods in molecular biology (Clifton, N.J.). 1523

مصطلحات موضوعية: Mice, Knockout, Mice, Antibody Specificity, Blotting, Western, Animals, Antibodies, Monoclonal, Brain, Point Mutation, Immunoglobulin Light Chains, tau Proteins, Phosphorylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3e3f216f5791197af72bdd726f9a7157
https://pubmed.ncbi.nlm.nih.gov/27975255

المؤلفون: Sébastien S. Hébert, Franck R. Petry, Samantha B. Nicholls, Emmanuel Planel

المصدر: Methods in Molecular Biology ISBN: 9781493965960

مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, medicine.drug_class, Tau protein, Hyperphosphorylation, Monoclonal antibody, Primary and secondary antibodies, Molecular biology, Blot, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, mental disorders, Monoclonal, medicine, biology.protein, Far-western blotting, Antibody, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::18b717096d132aba452f7b57a0062e60
https://doi.org/10.1007/978-1-4939-6598-4_15

المؤلفون: Zhanyun Fan, Samantha B. Nicholls, Susanne Wegmann, Shuko Takeda, Bradley T. Hyman

المصدر: Journal of neurochemistry. 139(6)

مصطلحات موضوعية: 0301 basic medicine, media_common.quotation_subject, Tau protein, Mice, Transgenic, tau Proteins, Biochemistry, Article, law.invention, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mice, law, mental disorders, Animals, Humans, Internalization, Cells, Cultured, media_common, biology, Dose-Response Relationship, Drug, Chemistry, Neurofibrillary Tangles, Crystallography, 030104 developmental biology, HEK293 Cells, biology.protein, Recombinant DNA, Biophysics, Protein Multimerization, Intracellular, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa16f5674c1c299d44049ed147ccfdf
https://pubmed.ncbi.nlm.nih.gov/27731899

المؤلفون: Rose Pitstick, Sarah L. DeVos, Samantha B. Nicholls, Ana T. Trisini Lipsanopoulos, Shuko Takeda, Murray A. Raskind, Chloe K. Nobuhara, Caitlin Commins, Bradley T. Hyman, Alexis E. Sherman, Allyson D. Roe, George A. Carlson, Susanne Wegmann, Clemens R. Scherzer, Ge Li, Elaine R. Peskind, Matthew P. Frosch, Thomas J. Montine, Zhanyun Fan, Isabel Costantino

المصدر: Annals of neurology. 80(3)

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Male, Pathology, medicine.medical_specialty, Mice, Transgenic, tau Proteins, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Cerebrospinal fluid, Interstitial fluid, Alzheimer Disease, Extracellular, Medicine, Animals, Humans, Aged, business.industry, Neurodegeneration, food and beverages, Brain, Extracellular Fluid, Middle Aged, medicine.disease, In vitro, 030104 developmental biology, Neurology, Biomarker (medicine), Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Intracellular, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7f496eedf69eedf586df046d834fcb
https://pubmed.ncbi.nlm.nih.gov/27351289

المؤلفون: Christopher William, Sarah L. DeVos, Eduardo A Maury, Bradley T. Hyman, Lubna Saqran, Ozge Cagsal-Getkin, Zhanyun Fan, Rose Pitstick, Molly J. Kirk, Tara L. Spires-Jones, Amy M. Pooler, Allyson D. Roe, Samantha B. Nicholls, Susanne Wegmann, Shuko Takeda, George A. Carlson

المصدر: Spires-Jones, T, Wegmann, S K, Maury, E A, Kirk, M, Saqran, L, Roe, A D & DeVos, S 2015, ' Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity ', EMBO Journal, vol. 34, no. 24, pp. 3028-3041 . https://doi.org/10.15252/embj.201592748
The EMBO Journal

مصطلحات موضوعية: Genetically modified mouse, Tau protein, Mutation, Missense, tau Proteins, Endogeny, General Biochemistry, Genetics and Molecular Biology, Tangle, Mice, Alzheimer Disease, mental disorders, medicine, Animals, Entorhinal Cortex, News & Views, Molecular Biology, Cells, Cultured, Neurons, General Immunology and Microbiology, biology, General Neuroscience, Neurodegeneration, Neurotoxicity, Articles, Entorhinal cortex, medicine.disease, Virology, Cell biology, Mice, Inbred C57BL, biology.protein, Alzheimer's disease, Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9b0fa2f4ee9028fba7adac083773e1
https://europepmc.org/articles/PMC4687785/

المؤلفون: Eduardo A Maury, Samantha B. Nicholls, Rose Pitstick, Shuko Takeda, Lubna Saqran, Sarah L. DeVos, Christopher William, Bradley T. Hyman, George A. Carlson, Zhanyun Fan, Amy M. Pooler, Tara L. Spires-Jones, Molly J. Kirk, Susanne Wegmann, Allyson D. Roe

المصدر: Alzheimer's & Dementia. 11

مصطلحات موضوعية: Genetically modified mouse, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Toxicity, Endogeny, Neurology (clinical), Geriatrics and Gerontology, Biology, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b28828902d2d04127e8845e6591ff371
https://doi.org/10.1016/j.jalz.2015.07.159

المؤلفون: Chloe K. Nobuhara, Caitlin Commins, Samantha B. Nicholls, Allyson D. Roe, Sarah L. DeVos, Bradley T. Hyman, Shuko Takeda, Isabel Costantino, Daniel Irimia, George A. Carlson, Susanne Wegmann, Matthew P. Frosch, Daniel J. Müller, Rose Pitstick, Hansang Cho

المصدر: Nature communications. 6

مصطلحات موضوعية: Male, Cell Survival, General Physics and Astronomy, Endogeny, Mice, Transgenic, tau Proteins, Disease, Biology, General Biochemistry, Genetics and Molecular Biology, Interstitial fluid, Alzheimer Disease, mental disorders, medicine, Animals, Humans, Phosphorylation, Aged, Aged, 80 and over, Neurons, Multidisciplinary, Disease progression, HEK 293 cells, Brain, General Chemistry, Anatomy, Microfluidic Analytical Techniques, medicine.disease, 3. Good health, Cell biology, Mice, Inbred C57BL, HEK293 Cells, Biomarker (medicine), Female, Alzheimer's disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe7a224475ed7093fbe70b91805be2b
https://pubmed.ncbi.nlm.nih.gov/26526534

المؤلفون: Samantha B, Nicholls, Bradley T, Hyman

المصدر: Methods in enzymology. 544

مصطلحات موضوعية: Enzyme Activation, Caspases, Positron-Emission Tomography, Green Fluorescent Proteins, Fluorescence Resonance Energy Transfer, Animals, Humans, Apoptosis, Enzyme Assays, Fluorescent Dyes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d2128daed6c5e0c8d77191c1dffd1759
https://pubmed.ncbi.nlm.nih.gov/24974293

المؤلفون: Bradley T. Hyman, Samantha B. Nicholls

مصطلحات موضوعية: Programmed cell death, Proteases, biology, Biochemistry, Apoptosis, In vivo, biology.protein, Luciferase, Small molecule, Caspase, Green fluorescent protein, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d4cb3e16a22c6b981e86310ac7549997
https://doi.org/10.1016/b978-0-12-417158-9.00010-8

المؤلفون: Alix de Calignon, Manuela Polydoro, Kevin R Kay, Allyson D. Roe, Rose Pitstick, Marc Suárez-Calvet, Laura Sanchez, Bradley T. Hyman, George A. Carlson, Teresa Gomez-Isla, Tara L. Spires-Jones, Samantha B. Nicholls

المصدر: Polydoro, M, de Calignon, A, Suárez-Calvet, M, Sanchez, L, Kay, K R, Nicholls, S B, Roe, A D, Pitstick, R, Carlson, G A, Gómez-Isla, T, Spires-Jones, T L & Hyman, B T 2013, ' Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer's Disease ', Journal of Neuroscience, vol. 33, no. 33, pp. 13300-11 . https://doi.org/10.1523/JNEUROSCI.0881-13.2013
JOURNAL OF NEUROSCIENCE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Transgene, Blotting, Western, Tau protein, Mice, Transgenic, tau Proteins, Biology, Real-Time Polymerase Chain Reaction, Mice, chemistry.chemical_compound, Alzheimer Disease, Biological neural network, medicine, Animals, Entorhinal Cortex, Humans, Reverse Transcriptase Polymerase Chain Reaction, General Neuroscience, Dentate gyrus, Neurofibrillary Tangles, Articles, Entorhinal cortex, medicine.disease, Immunohistochemistry, Acetylcholinesterase, Phenotype, Disease Models, Animal, chemistry, Tissue Array Analysis, biology.protein, Alzheimer's disease, Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a16c14baf826dd807e7174b4ae101
https://www.pure.ed.ac.uk/ws/files/13530721/Reversal_of_Neurofibrillary_Tangles_and_Tau_Associated_Phenotype_in_the_rTgTauEC_Model_of_Early_Alzheimer_s_Disease.pdf

المؤلفون: Rose Pitstick, A Patrick McKinney, Laura Sanchez, Tara L. Spires-Jones, Volodymyr Dzhala, Kevin J. Staley, Samantha B. Nicholls, Bradley T. Hyman, George A. Carlson, Amy M. Pooler, Manuela Polydoro

المصدر: Acta neuropathologica. 127(2)

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Presynaptic Terminals, Hippocampus, Mice, Transgenic, Nerve Tissue Proteins, tau Proteins, Biology, Article, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Mice, Alzheimer Disease, Neuroplasticity, medicine, Animals, Entorhinal Cortex, Humans, Arc (protein), Neuronal Plasticity, Perforant Pathway, Neurodegeneration, medicine.disease, Entorhinal cortex, Electrophysiological Phenomena, Mice, Inbred C57BL, Cytoskeletal Proteins, Disease Models, Animal, Synaptic plasticity, Neurology (clinical), Alzheimer's disease, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f48ff71c2165e3fbed9d9e660d5f91
https://pubmed.ncbi.nlm.nih.gov/24271788

المؤلفون: Jeanne A. Hardy, Gustavo E. López, Inara Colón-Díaz, Anthony Cruz, Scott M. Auerbach, Samantha B. Nicholls, Sumana Ghosh, Usha Viswanathan

المصدر: The journal of physical chemistry. A. 116(4)

مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Proton, Peptide, Electronic structure, Affinities, Protein Structure, Secondary, chemistry.chemical_compound, Crystallography, Dipole, Protein structure, chemistry, Chemical physics, Imidazole, Quantum Theory, Density functional theory, Physical and Theoretical Chemistry, Protons, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2e7849a9789e5793fa75b8378684a0
https://pubmed.ncbi.nlm.nih.gov/22188565