نتائج البحث - "Sabate, Raimon"

1

Academic Journal

Piano-stool metal complexes as inhibitors of amyloid-β aggregation in vitro and in vivo

المؤلفون: Vigueras, Gloria, Sabate, Raimon, Barrios, Leoní A., Caballero, Ana B., Hernández-García, Samanta, Bayón, Pau, Gandía-Herrero, Fernando, Ruiz, José, Gamez, Patrick

المساهمون: European Commission, Institució Catalana de Recerca i Estudis Avançats

المصدر: Inorganic Chemistry Frontiers ; ISSN 2052-1553

الاتاحة: http://dx.doi.org/10.1039/d4qi01460j
http://pubs.rsc.org/en/content/articlepdf/2024/QI/D4QI01460J

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2

Academic Journal

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease

المؤلفون: Tonelli, Michele, Catto, Marco, Sabaté, Raimon, Francesconi, Valeria, Laurini, Erik, Pricl, Sabrina, Pisani, Leonardo, Miniero, Daniela Valeria, Liuzzi, Grazia Maria, Gatta, Elena, Relini, Annalisa, Gavín, Rosalina, Del Rio, Jose Antonio, Sparatore, Fabio, Carotti, Angelo

المساهمون: Tonelli, Michele, Catto, Marco, Sabaté, Raimon, Francesconi, Valeria, Laurini, Erik, Pricl, Sabrina, Pisani, Leonardo, Miniero, Daniela Valeria, Liuzzi, Grazia Maria, Gatta, Elena, Relini, Annalisa, Gavín, Rosalina, Del Rio, Jose Antonio, Sparatore, Fabio, Carotti, Angelo

مصطلحات موضوعية: AChE and BChE inhibition, Alzheimer's disease, Aβ and tau aggregation inhibition, Multitarget-directed ligands (MTDLs), Thioxanthene-9-one and xanthen-9-one derivatives

Relation: info:eu-repo/semantics/altIdentifier/pmid/36753881; info:eu-repo/semantics/altIdentifier/wos/WOS:000935691800001; volume:250; firstpage:115169; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11586/419456

الاتاحة: https://hdl.handle.net/11586/419456
https://doi.org/10.1016/j.ejmech.2023.115169

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3

Academic Journal

Coumarin derivatives against amyloid-beta 40 – 42 peptide and tau protein

المؤلفون: Kowalczyk Joanna, Skalicka-Wozniak Krystyna, Budzynska Barbara, Sayed Nesrine El, Espargaró Alba, Sabate Raimon

المصدر: Current Issues in Pharmacy and Medical Sciences, Vol 35, Iss 2, Pp 67-74 (2022)

مصطلحات موضوعية: neurodegeneration, tau, aβ40/42, in vitro, in cellulo, coumarins, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2300-6676

URL الوصول: https://doaj.org/article/9985ca9f89424c899e0afe2be237a08f

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4

Academic Journal

Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease

المؤلفون: Zaręba, Paula, Łątka, Kamil, Mazur, Gabriela, Gryzło, Beata, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Skrzypczak-Wiercioch, Anna, Hofner, Georg C., Latacz, Gniewomir, Maj, Maciej, Espargaró, Alba, Sabate, Raimon, Jóźwiak, Krzysztof, Wanner, Klaus T., Sałat, Kinga, Malawska, Barbara, Kulig, Katarzyna, Bajda, Marek

مصطلحات موضوعية: Alzheimer's disease, multifunctional ligands, BuChE inhibitors, BACE1 inhibitors, GAT inhibitors, calcium channel blockade, Aβ aggregation, molecular modeling, passive avoidance task, novel object recognition task

Relation: European Journal of Medicinal Chemistry, T. 261; https://ruj.uj.edu.pl/xmlui/handle/item/323468; https://www.sciencedirect.com/science/article/pii/S0223523423007997?via%3Dihub

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/323468
https://doi.org/10.1016/j.ejmech.2023.115832
https://www.sciencedirect.com/science/article/pii/S0223523423007997?via%3Dihub

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5

Academic Journal

Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and $\beta$-amyloid inhibitors for the treatment of Alzheimer’s disease

المؤلفون: Pasieka, Anna, Panek, Dawid, Zaręba, Paula, Sługocka, Emilia, Gucwa, Natalia, Espargaró, Alba, Latacz, Gniewomir, Khan, Nadia, Bucki, Adam, Sabaté, Raimon, Więckowska, Anna, Malawska, Barbara

مصطلحات موضوعية: Alzheimer’s disease, Butyrylcholinesterase inhibitors, β-amyloid, aggregation, drug-likeness, Fluorene scaffold

Relation: https://ruj.uj.edu.pl/xmlui/handle/item/312330; https://www.sciencedirect.com/science/article/pii/S0968089623001815?via%3Dihub

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/312330
https://doi.org/10.1016/j.bmc.2023.117333
https://www.sciencedirect.com/science/article/pii/S0968089623001815?via%3Dihub

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6

Academic Journal

New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer's disease

المؤلفون: Czarnecka, Kamila, Girek, Małgorzata, Kręcisz, Paweł, Skibiński, Robert, Łątka, Kamil, Jończyk, Jakub, Bajda, Marek, Szymczyk, Piotr, Galita, Grzegorz, Kabziński, Jacek, Majsterek, Ireneusz, Espargaro, Alba, Sabate, Raimon, Szymański, Paweł

مصطلحات موضوعية: acetylcholinesterase inhibitors, Alzheimer’s disease, molecular modelling, Ellman’s method, MTDL

Relation: Journal of Enzyme Inhibition and Medicinal Chemistry, T. 38, nr 1; https://ruj.uj.edu.pl/xmlui/handle/item/305938

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/305938
https://doi.org/10.1080/14756366.2022.2158822
https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2158822

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7

Academic Journal

Phosphorylation-driven aggregative proteins in neurodegenerative diseases: implications and therapeutics

المؤلفون: Espargaró, Alba, Sabate, Raimon

المصدر: Neural Regeneration Research ; volume 19, issue 5, page 966-968 ; ISSN 1673-5374 1876-7958

الاتاحة: https://doi.org/10.4103/1673-5374.382250
https://journals.lww.com/10.4103/1673-5374.382250

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8

Academic Journal

Design, synthesis, and in vitro, in silico and in cellulo evaluation of new Pyrimidine and Pyridine amide and Carbamate derivatives as multi-functional Cholinesterase Inhibitors

المؤلفون: Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi

المساهمون: Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi

مصطلحات موضوعية: acetylcholinesterase inhibitor, butyrylcholinesterase inhibitor, multifunctional compound, amyloid aggregation, tau aggregation, metal chelation

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/35745594; info:eu-repo/semantics/altIdentifier/wos/WOS:000818156100001; volume:15; issue:6; firstpage:1; lastpage:31; numberofpages:31; journal:PHARMACEUTICALS; https://hdl.handle.net/11365/1279838; https://pmc.ncbi.nlm.nih.gov/articles/PMC9227096/

الاتاحة: https://hdl.handle.net/11365/1279838
https://doi.org/10.3390/ph15060673
https://www.mdpi.com/1424-8247/15/6/673
https://pmc.ncbi.nlm.nih.gov/articles/PMC9227096/

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9

Academic Journal

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease

المؤلفون: Gandini, Annachiara, Gonçalves, Ana Elisa, Strocchi, Silvia, Albertini, Claudia, Janočková, Jana, Tramarin, Anna, Grifoni, Daniela, Poeta, Eleonora, Soukup, Ondrej, Muñoz-Torrero, Diego, Monti, Barbara, Sabaté, Raimon, Bartolini, Manuela, Legname, Giuseppe, Bolognesi, Maria Laura

المساهمون: Gandini, Annachiara, Gonçalves, Ana Elisa, Strocchi, Silvia, Albertini, Claudia, Janočková, Jana, Tramarin, Anna, Grifoni, Daniela, Poeta, Eleonora, Soukup, Ondrej, Muñoz-Torrero, Diego, Monti, Barbara, Sabaté, Raimon, Bartolini, Manuela, Legname, Giuseppe, Bolognesi, Maria Laura

مصطلحات موضوعية: aggregation inhibitor, bivalent ligand, multitarget-directed ligand, protein aggregate, tau protein, β-amyloid

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/36445009; info:eu-repo/semantics/altIdentifier/wos/WOS:000894025200001; volume:13; issue:23; firstpage:3314; lastpage:3329; numberofpages:16; journal:ACS CHEMICAL NEUROSCIENCE; https://hdl.handle.net/11585/917259; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143440253

الاتاحة: https://hdl.handle.net/11585/917259
https://doi.org/10.1021/acschemneuro.2c00357

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10

Academic Journal

Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

المؤلفون: Pont, Caterina, Sampietro, Anna, Pérez-Areales, F. Javier, Cristiano, Nunzia, Albalat, Agustí, Pérez, Belén, Bartolini, Manuela, De Simone, Angela, Andrisano, Vincenza, Barenys, Marta, Teixidó, Elisabet, Sabaté, Raimon, Loza, M. Isabel, Brea, José, Muñoz-Torrero, Diego

المساهمون: Pont, Caterina, Sampietro, Anna, Pérez-Areales, F. Javier, Cristiano, Nunzia, Albalat, Agustí, Pérez, Belén, Bartolini, Manuela, De Simone, Angela, Andrisano, Vincenza, Barenys, Marta, Teixidó, Elisabet, Sabaté, Raimon, Loza, M. Isabel, Brea, José, Muñoz-Torrero, Diego

مصطلحات موضوعية: Alzheimer’s disease, BACE-1 inhibitor, DMPK propertie, acetylcholinesterase inhibitor, butyrylcholinesterase inhibitor, multitarget drug, tau anti-aggregating agent, zebrafish embryo, β-amyloid anti-aggregating agents

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/39204327; info:eu-repo/semantics/altIdentifier/wos/WOS:001307249800001; volume:16; issue:8; firstpage:1; lastpage:20; numberofpages:20; journal:PHARMACEUTICS; https://hdl.handle.net/11585/981616

الاتاحة: https://hdl.handle.net/11585/981616
https://doi.org/10.3390/pharmaceutics16080982
https://www.mdpi.com/1999-4923/16/8/982

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11

Academic Journal

New pyrimidine and pyridine derivatives as multitarget cholinesterase inhibitors. Design, synthesis, and in vitro and in cellulo evaluation

المؤلفون: Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi

المساهمون: Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi

مصطلحات موضوعية: acetylcholinesterase inhibitor, amyloid aggregation, antioxidant, butyrylcholinesterase inhibitor, metal chelation, multifunctional compound, tau aggregation

Relation: info:eu-repo/semantics/altIdentifier/pmid/34652128; info:eu-repo/semantics/altIdentifier/wos/WOS:000715842900011; volume:12; issue:21; firstpage:4090; lastpage:4112; numberofpages:23; journal:ACS CHEMICAL NEUROSCIENCE; http://hdl.handle.net/11573/1584588; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118138783

الاتاحة: http://hdl.handle.net/11573/1584588
https://doi.org/10.1021/acschemneuro.1c00485

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12

Academic Journal

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease

المؤلفون: Purgatorio, Rosa, Gambacorta, Nicola, Catto, Marco, de Candia, Modesto, Pisani, Leonardo, Espargaró, Alba, Sabaté, Raimon, Cellamare, Saverio, Nicolotti, Orazio, Altomare, Cosimo D

المساهمون: Purgatorio, Rosa, Gambacorta, Nicola, Catto, Marco, de Candia, Modesto, Pisani, Leonardo, Espargaró, Alba, Sabaté, Raimon, Cellamare, Saverio, Nicolotti, Orazio, Altomare, Cosimo D

مصطلحات موضوعية: 3D-QSAR, antiamyloid agent, indole derivative, isatin hydrazone, multitarget-directed ligands

Relation: info:eu-repo/semantics/altIdentifier/pmid/33297547; info:eu-repo/semantics/altIdentifier/wos/WOS:000597592300001; volume:25; issue:23; firstpage:5773; journal:MOLECULES; https://hdl.handle.net/11586/346708

الاتاحة: https://hdl.handle.net/11586/346708
https://doi.org/10.3390/molecules25235773

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13

Academic Journal

Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation

المؤلفون: Hofmann, Julian, Ginex, Tiziana, Espargaró, Alba, Scheiner, Matthias, Gunesch, Sandra, Aragó, Marc, Stigloher, Christian, Sabaté, Raimon, Luque, F. Javier, Decker, Michael

مصطلحات موضوعية: ddc:540

وصف الملف: application/pdf

Relation: https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23898; urn:nbn:de:bvb:20-opus-238988; https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-238988; https://doi.org/10.1002/chem.202005263; https://opus.bibliothek.uni-wuerzburg.de/files/23898/CHEM_CHEM202005263.pdf

الاتاحة: https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23898
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-238988
https://doi.org/10.1002/chem.202005263
https://opus.bibliothek.uni-wuerzburg.de/files/23898/CHEM_CHEM202005263.pdf

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14

Academic Journal

Air Curtains Equipped With Hydroalcoholic Aerosol Sprayers for Massive COVID-19 Disinfection

المؤلفون: Raventós, Judit, Sabate, Raimon

المساهمون: Ministerio de Economía y Competitividad

المصدر: Frontiers in Public Health ; volume 8 ; ISSN 2296-2565

الاتاحة: http://dx.doi.org/10.3389/fpubh.2020.582782
https://www.frontiersin.org/articles/10.3389/fpubh.2020.582782/full

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15

Academic Journal

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects

المساهمون: Ministerio de Ciencia, Innovación y Universidades, Generalitat de Catalunya, Generalitat de Catalunya Agencia de Gestio d'Ajuts Universitaris i de Recerca, Ministerio de Educación, Cultura y Deporte, European Regional Development Fund, Agencia Estatal de Investigación

المصدر: European Journal of Medicinal Chemistry ; volume 225, page 113779 ; ISSN 0223-5234

الاتاحة: http://dx.doi.org/10.1016/j.ejmech.2021.113779
https://api.elsevier.com/content/article/PII:S0223523421006280?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0223523421006280?httpAccept=text/plain

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16

Academic Journal

Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau

المؤلفون: Wichur, Tomasz, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Góral, Izabella, Latacz, Gniewomir, Honkisz-Orzechowska, Ewelina, Bucki, Adam, Siwek, Agata, Głuch-Lutwin, Monika, Knez, Damijan, Brazzolotto, Xavier, Gobec, Stanislav, Kołaczkowski, Marcin, Sabate, Raimon, Malawska, Barbara, Więckowska, Anna

المصدر: European Journal of Medicinal Chemistry ; volume 225, page 113783 ; ISSN 0223-5234

الاتاحة: http://dx.doi.org/10.1016/j.ejmech.2021.113783
https://api.elsevier.com/content/article/PII:S0223523421006322?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0223523421006322?httpAccept=text/plain

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17

Academic Journal

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

المؤلفون: Pasieka, Anna, Panek, Dawid, Szałaj, Natalia, Espargaró, Alba, Więckowska, Anna, Malawska, Barbara, Sabaté, Raimon, Bajda, Marek

المساهمون: Narodowe Centrum Nauki, European Cooperation in Science and Technology, Ministerio de Ciencia, Innovaci?n y Universidades of Spain

المصدر: ACS Chemical Neuroscience ; volume 12, issue 11, page 2057-2068 ; ISSN 1948-7193 1948-7193

الاتاحة: http://dx.doi.org/10.1021/acschemneuro.1c00235
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00235

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18

Academic Journal

Proximity-Induced Pharmacology for Amyloid-Related Diseases.

المؤلفون: Bertran-Mostazo, Andrea, Putriūtė, Gabrielė, Álvarez-Berbel, Irene, Busquets, Maria Antònia, Galdeano, Carles, Espargaró, Alba, Sabate, Raimon

المصدر: Cells (2073-4409); Mar2024, Vol. 13 Issue 5, p449, 16p

مصطلحات موضوعية: DRUG discovery, ALZHEIMER'S disease, SMALL molecules, PHARMACOLOGY, AMYLOID beta-protein

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19

Academic Journal

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

المؤلفون: Pérez-Areales, F Javier, Turcu, Andreea L, Barniol-Xicota, Marta, Pont, Caterina, Pivetta, Deborah, Espargaró, Alba, Bartolini, Manuela, De Simone, Angela, Andrisano, Vincenza, Pérez, Belén, Sabate, Raimon, Sureda, Francesc X, Vázquez, Santiago, Muñoz-Torrero, Diego

المساهمون: Pérez-Areales, F Javier, Turcu, Andreea L, Barniol-Xicota, Marta, Pont, Caterina, Pivetta, Deborah, Espargaró, Alba, Bartolini, Manuela, De Simone, Angela, Andrisano, Vincenza, Pérez, Belén, Sabate, Raimon, Sureda, Francesc X, Vázquez, Santiago, Muñoz-Torrero, Diego

مصطلحات موضوعية: Acetylcholinesterase inhibitor, Brain permeability, Butyrylcholinesterase inhibitor, Multi-target-directed ligand, Multitarget compound, NMDA antagonists

Relation: info:eu-repo/semantics/altIdentifier/pmid/31351393; info:eu-repo/semantics/altIdentifier/wos/WOS:000488307100043; volume:180; firstpage:613; lastpage:626; numberofpages:14; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/2318/1719448; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85069721616

الاتاحة: http://hdl.handle.net/2318/1719448
https://doi.org/10.1016/j.ejmech.2019.07.051

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20

Academic Journal

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

المؤلفون: Szałaj, Natalia, Godyń, Justyna, Jończyk, Jakub, Pasieka, Anna, Panek, Dawid, Wichur, Tomasz, Więckowski, Krzysztof, Zaręba, Paula, Bajda, Marek, Pislar, Anja, Malawska, Barbara, Sabate, Raimon, Więckowska, Anna

Relation: https://ruj.uj.edu.pl/xmlui/handle/item/264508

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/264508
https://doi.org/10.1080/14756366.2020.1835882

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