المؤلفون: MacKenzie, Tim MG, Abderemane-Ali, Fayal, Garrison, Catherine E, Minor, Daniel L, Bois, J Du

المصدر: Cell Chemical Biology. 29(4)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Batrachotoxins, Esters, Sodium, Voltage-Gated Sodium Channels, Na(V) fast inactivation, Na(V) slow inactivation, batrachotoxin, electrophysiology, voltage-gated sodium channels (Na(V))

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4g38v2nn
https://escholarship.org/content/qt4g38v2nn/qt4g38v2nn.pdf

المؤلفون: Ong, Seow, Tyagi, Anu, Chandy, K, Bhushan, Shashi

مصطلحات موضوعية: C-type inactivation, Kv1.3, Shaker-IR, cryo-EM, dalazatide, hydrogen bond network, slow inactivation, voltage-gated potassium (Kv) channels

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7pj6g6tt
https://escholarship.org/content/qt7pj6g6tt/qt7pj6g6tt.pdf

المؤلفون: George, Kiran, Lopez-Mateos, Diego, El-Aziz, Tarek Mohamed Abd, Xiao, Yucheng, Kline, Jake, Bao, Hong, Raza, Syed, Stockand, James D, Cummins, Theodore R, Fornelli, Luca, Rowe, Matthew P, Yarov-Yarovoy, Vladimir, Rowe, Ashlee H

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Chronic Pain, Pain Research, 1.1 Normal biological development and functioning, Underpinning research, Nav1, 8, voltage-gated sodium channel, AZ bark scorpion, grasshopper mice, NaTx36, slow inactivation, venom, neurotoxin, Nav1.8, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5hc4788g
https://escholarship.org/content/qt5hc4788g/qt5hc4788g.pdf

المؤلفون: Chih-Yu Ting, Chia-Lung Shih, Meng-Cheng Yu, Chao-Liang Wu, Sheng-Nan Wu

المصدر: Biomedicines; Volume 11; Issue 5; Pages: 1351

مصطلحات موضوعية: myosin activator, omecamtiv mecarbil, voltage-gated Na + current, transient Na + current, late Na + current, window Na + current, cumulative inactivation, slow inactivation

وصف الملف: application/pdf

Relation: Cell Biology and Pathology; https://dx.doi.org/10.3390/biomedicines11051351

الاتاحة: https://doi.org/10.3390/biomedicines11051351

المؤلفون: Osteen, Jeremiah D, Sampson, Kevin, Iyer, Vivek, Julius, David, Bosmans, Frank

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(26)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Neurodegenerative, Brain Disorders, 1.1 Normal biological development and functioning, Neurological, Acetamides, Animals, Humans, Ion Channel Gating, Mutation, NAV1.1 Voltage-Gated Sodium Channel, Protein Domains, Spider Venoms, Spiders, Thiazoles, Xenopus laevis, Na(v)1.1, fast inactivation, slow inactivation, Hm1a spider toxin, ICA-121431, Nav1.1

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/36f012n1
https://escholarship.org/content/qt36f012n1/qt36f012n1.pdf

المؤلفون: Kubota, Tomoya, Durek, Thomas, Dang, Bobo, Finol-Urdaneta, Rocio K, Craik, David J, Kent, Stephen BH, French, Robert J, Bezanilla, Francisco, Correa, Ana M

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(10)

مصطلحات موضوعية: Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Animals, Binding Sites, Boron Compounds, Energy Transfer, Kinetics, Lanthanoid Series Elements, Membrane Potentials, Muscle Proteins, Muscle, Skeletal, Oocytes, Patch-Clamp Techniques, Rats, Scorpion Venoms, Sodium Channels, Voltage-Gated Sodium Channels, Xenopus, mu-conotoxin, voltage gating, relaxed state, slow inactivation, beta-scorpion toxin, β-scorpion toxin, μ-conotoxin

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9179n4hb

المؤلفون: Seow Theng Ong, Anu Tyagi, K. George Chandy, Shashi Bhushan

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: voltage-gated potassium (Kv) channels, C-type inactivation, slow inactivation, Kv1.3, hydrogen bond network, cryo-EM, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.924289/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/827421028ee94b0188d27e06ffec8e9d

المؤلفون: Kiran George, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Ashlee H. Rowe

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: Nav1.8, voltage-gated sodium channel, AZ bark scorpion, grasshopper mice, NaTx36, slow inactivation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.846992/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/0dc9b79a83a742afa9602e8aab884a62

المؤلفون: Anastasia K. Zaytseva, Aleksandr S. Boitsov, Anna A. Kostareva, Boris S. Zhorov

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: sodium channelopathies, Brugada syndrome, cardiac arrhythmias, fast inactivation, slow inactivation, channel gating, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.742508/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/a35295a238c34c0d8e9cdadc249a5083

المؤلفون: Carlos AZ Bassetto, João Luis Carvalho-de-Souza, Francisco Bezanilla

المصدر: eLife, Vol 10 (2021)

مصطلحات موضوعية: v-sensing, pore domain coupling, S4-S5 segments, W434F, slow inactivation, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/63077; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/4a8f26c6723e401f90ae49dd4e0d2b44

المؤلفون: Labau, J.I.R., Alsaloum, M., Estacion, M., Tanaka, B., Dib-Hajj, F.B., Lauria, G., Smeets, H.J.M., Faber, C.G., Dib-Hajj, S., Waxman, S.G.

المصدر: Labau , J I R , Alsaloum , M , Estacion , M , Tanaka , B , Dib-Hajj , F B , Lauria , G , Smeets , H J M , Faber , C G , Dib-Hajj , S & Waxman , S G 2021 , ' Lacosamide Inhibition of Na(V)1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore ' , Frontiers in Pharmacology , vol. 12 , 791740 . https://doi.org/10.3389/fphar.2021.791740

مصطلحات موضوعية: voltage-gated sodium channels, local anesthetics, manual and automated electrophysiolgy, voltage-sensing domain, molecular docking, GATED SODIUM-CHANNELS, QUALITY-OF-LIFE, CHRONIC PAIN, NEUROPATHIC PAIN, DRUG-BINDING, SLOW INACTIVATION, LOCAL-ANESTHETICS, PREVALENCE, LIDOCAINE, MECHANISM

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/dff29302-6019-42eb-a17f-2f11e49e27ee
https://doi.org/10.3389/fphar.2021.791740

المؤلفون: Chiung-Wei Huang, Pi-Chen Lin, Jian-Lin Chen, Ming-Jen Lee

المصدر: Biomedicines; Volume 9; Issue 9; Pages: 1141

مصطلحات موضوعية: cannabidiol, Na v 1.4 channel, myotonia, fast inactivation, slow-inactivation

وصف الملف: application/pdf

Relation: Neurobiology and Neurologic Disease; https://dx.doi.org/10.3390/biomedicines9091141

الاتاحة: https://doi.org/10.3390/biomedicines9091141

المؤلفون: Glynis B. Mattheisen, Timur Tsintsadze, Stephen M. Smith

المصدر: Cell Reports, Vol 23, Iss 9, Pp 2770-2781 (2018)

مصطلحات موضوعية: G-protein, G-protein-coupled receptor, GPCR, voltage-gated sodium channel, VGSC, calcium-sensing receptor, CaSR, excitability, synaptic transmission neuron, slow inactivation, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718307095; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/cbcf3479476c44709d4a75dfe9f6cde5

المؤلفون: Osteen, Jeremiah D., Sampson, Kevin, Iyer, Vivek, Julius, David, Bosmans, Frank

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun . 114(26), 6836-6841.

URL الوصول: https://www.jstor.org/stable/26484995

المؤلفون: Labau, Julie I. R., Estacion, Mark, Tanaka, Brian S., de Greef, Bianca T. A., Hoeijmakers, Janneke G. J., Geerts, Margot, Gerrits, Monique M., Smeets, Hubert J. M., Faber, Catharina G., Merkies, Ingemar S. J., Lauria, Giuseppe, Dib-Hajj, Sulayman D., Waxman, Stephen G.

المصدر: Labau , J I R , Estacion , M , Tanaka , B S , de Greef , B T A , Hoeijmakers , J G J , Geerts , M , Gerrits , M M , Smeets , H J M , Faber , C G , Merkies , I S J , Lauria , G , Dib-Hajj , S D & Waxman , S G 2020 , ' Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy ' , Brain , vol. 143 , pp. 771-782 . https://doi.org/10.1093/brain/awaa016

مصطلحات موضوعية: small fibre neuropathy, lacosamide, Na(v)1.7 mutations, neuropathic pain, electrophysiology, VOLTAGE-GATED SODIUM, MOLECULAR DETERMINANTS, SLOW-INACTIVATION, NA+ CHANNELS, PAIN, MUTATION, BINDING, INHIBITION, EFFICACY, NEURONS

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/a9f1eeb3-e7c8-4d71-baf8-2841e9dc7828
https://doi.org/10.1093/brain/awaa016

المؤلفون: Toffano, Alberto A., Chiarot, Giacomo, Zamuner, Stefano, Marchi, Margherita, Salvi, Erika, Waxman, Stephen G., Faber, Catharina G., Lauria, Giuseppe, Giacometti, Achille, Simeoni, Marta

المصدر: Toffano , A A , Chiarot , G , Zamuner , S , Marchi , M , Salvi , E , Waxman , S G , Faber , C G , Lauria , G , Giacometti , A & Simeoni , M 2020 , ' Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes ' , Scientific Reports , vol. 10 , no. 1 , 17930 . https://doi.org/10.1038/s41598-020-74591-y

مصطلحات موضوعية: GATED SODIUM-CHANNELS, NA(V)1.7 MUTATION, DISORDER MUTATIONS, SLOW-INACTIVATION, SCN9A MUTATIONS, ALPHA-SUBUNIT, ERYTHROMELALGIA, ERYTHERMALGIA, CARBAMAZEPINE, PREDICTION

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/47026939-13b0-4059-9de2-639453c8c3b8
https://doi.org/10.1038/s41598-020-74591-y

المؤلفون: Coonen, Laura, Mayeur, Evy, De Neuter, Nicolas, Snyders, Dirk J., Cuello, Luis G., Labro, Alain J

المصدر: BIOPHYSICAL JOURNAL ; ISSN: 0006-3495 ; ISSN: 1542-0086

مصطلحات موضوعية: Medicine and Health Sciences, Biophysics, C-TYPE INACTIVATION, POTASSIUM-CHANNEL, K+ CHANNEL, MOLECULAR DETERMINANTS, SLOW INACTIVATION, CRYSTAL-STRUCTURE, ION CONDUCTION, PORE, ACTIVATION, GATES

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/8704916; http://hdl.handle.net/1854/LU-8704916; http://dx.doi.org/10.1016/j.bpj.2020.03.032; https://biblio.ugent.be/publication/8704916/file/8710056

الاتاحة: https://biblio.ugent.be/publication/8704916
http://hdl.handle.net/1854/LU-8704916
https://doi.org/10.1016/j.bpj.2020.03.032
https://biblio.ugent.be/publication/8704916/file/8710056

المؤلفون: Olcese, Riccardo, Sigg, Daniel, Latorre, Ramon, Bezanilla, Francisco, Stefani, Enrico

المصدر: The Journal of General Physiology. 117(2)

مصطلحات موضوعية: Brain Disorders, Animals, Artifacts, Electric Conductivity, Ion Channel Gating, Kinetics, Membrane Potentials, Mutagenesis, Oocytes, Patch-Clamp Techniques, Potassium Channels, Probability, Shaker Superfamily of Potassium Channels, Xenopus laevis, gating current, slow inactivation, C/P-type inactivation, nonstationary noise analysis, Physiology, Medical Physiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/98p904h9

المؤلفون: Kontis, Kris J, Goldin, Alan L

المصدر: The Journal of General Physiology. 110(4)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Neurosciences, Amino Acid Sequence, Animals, Brain Chemistry, Electrophysiology, Ion Channel Gating, Kinetics, Membrane Potentials, Molecular Sequence Data, Mutation, Oocytes, Patch-Clamp Techniques, Rats, Sodium Channel Blockers, Sodium Channels, Xenopus laevis, voltage sensor, slow inactivation, expression, mutagenesis, Physiology, Biochemistry and cell biology, Zoology, Medical physiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/75w500n0

المؤلفون: de Greef, Bianca T. A., Hoeijmakers, Janneke G. J., Geerts, Margot, Oakes, Mike, Church, Tim J. E., Waxman, Stephen G., Dib-Hajj, Sulayman D., Faber, Catharina G., Merkies, Ingemar S. J.

المصدر: de Greef , B T A , Hoeijmakers , J G J , Geerts , M , Oakes , M , Church , T J E , Waxman , S G , Dib-Hajj , S D , Faber , C G & Merkies , I S J 2019 , ' Lacosamide in patients with Na(v)1.7 mutations-related small fibre neuropathy : a randomized controlled trial ' , Brain , vol. 142 , pp. 263-275 . https://doi.org/10.1093/brain/awy329

مصطلحات موضوعية: small fibre neuropathy, lacosamide, Na(v)1, 7 mutations, neuropathic pain, RCT, SODIUM-CHANNELS, SLOW-INACTIVATION, DOUBLE-BLIND, PAIN, EFFICACY, SAFETY, PATHOPHYSIOLOGY, CRMP2

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/3633f07c-77c4-4156-982c-986c085d8a7f
https://doi.org/10.1093/brain/awy329