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المؤلفون: Nigel J. Pyne, Rothwelle J. Tate, Federico Torta, David R. Adams, Jeongah Oh, Susan Pyne, Ryan D. R. Brown, Margaret R. Cunningham, Ben E.P. Veerman
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, translocation, Chromosomal translocation, plasma membrane, Biochemistry, chemistry.chemical_compound, AUC, area under the curve, Mice, Sph, sphingosine, Sphingosine, R-loop, regulatory loop, structural biology, PA, phosphatidic acid, ERK, extracellular signal–regulated protein kinase, PLAs, proximity ligation assays, chemistry.chemical_classification, biology, Chemistry, PS, phosphatidylserine, CTD, C-terminal domain, Cell biology, Amino acid, Phosphotransferases (Alcohol Group Acceptor), Protein Transport, Sphingosine kinase 1, PLD2, phospholipase D2, PM, plasma membrane, MCF-7 Cells, Female, fluorescence, FIPI, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide hydrochloride, Research Article, PMA, phorbol 12-myristate 13-acetate, LBL-1, lipid-binding loop 1, hSK1, human SK1, Breast Neoplasms, SK1, sphingosine kinase 1, RS, RC0254, 03 medical and health sciences, Membrane Microdomains, Animals, Humans, enzyme mechanism, Sphingosine-1-phosphate, NTD, N-terminal domain, Sphingosine-1-phosphate (S1P), PLD, phospholipase D, Molecular Biology, S1P, sphingosine-1-phosphate, 030102 biochemistry & molecular biology, Phospholipase D, Cell Membrane, Cell Biology, Lipid signaling, QR, 030104 developmental biology, mSK1, mouse SK1, Phorbol, biology.protein, BuMe, butanol:methanol, mutagenesis in vitro, lipid signaling, FCS, fetal calf serum, Lysophospholipids, Protein Multimerization, DAPI, 4′,6-diamidino-2-phenylindole
وصف الملف: application/pdf
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المؤلفون: Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
المصدر: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)مصطلحات موضوعية: RPS6, ribosomal protein S6, S1PR1, sphingosine -1-phosphate receptor 1, MMP2, matrix metalloproteinase 2, Sphingolipid, MA3PK, mitogen activated protein kinase kinase kinase, chemistry.chemical_compound, S1P, sphingosine-1 Phosphate, Sph, sphingosine, TIMP1, tissue inhibitor of metalloproteinase 1, TGFβ, transforming growth factor β, Medicine, S1PR1, Cardiac fibroblasts, biology, Dihydrosphingosine, Cell biology, S1PRs, sphingosine 1 phosphate receptor 1-5, Collagen synthesis, Sphingosine kinase 1, Coll1a1, collagen 1a1, mTOR, mammalian target for rapamycin, d7dhSph, deuterated dihydrosphingosine, lipids (amino acids, peptides, and proteins), MAPK, mitogren activated protein kinase, Cardiology and Cardiovascular Medicine, Ceramide, Cer, ceramide, SK1, sphingosine kinase 1, TAK1, transforming growth factor β activating kinase 1, CTGF, connective tissue growth factor, TGFβ, TGF beta signaling pathway, Diseases of the circulatory (Cardiovascular) system, Cer1P, ceramide 1 phosphate, Sphingosine-1-phosphate, NCF, neonatal cardiac fibroblasts, ComputingMethodologies_COMPUTERGRAPHICS, Original Paper, dhCer, dihydroceramide, Sphingosine, business.industry, dhS1P, dihydrosphingosine 1 phosphate, Degs1, dihydroceramide desaturase 1 gene, chemistry, RC666-701, ECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα/β), Akt, protein kinase B, biology.protein, MI, myocardial infarct, business, Des-1, dihydroceramide desaturase 1 enzyme, Transforming growth factor
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المؤلفون: Ola D. A. Shammout, Zainab M. Al Shareef, Sarra B. Shakartalla, Sameh S. M. Soliman, Razan B. Alhumaidi, Naglaa S. Ashmawy
المصدر: Infection, Genetics and Evolution
مصطلحات موضوعية: 0301 basic medicine, lysoPC, Lyso-phosphatidylcholine, viruses, ERK, Extracellular signal-regulated kinases, Disease, Review, HETEs, Hydroxyeicosatetraenoic acids, Gastroenterology, Lipid-lowering agents, chemistry.chemical_compound, Breast cancer, Th, T helper cells, EETs, Epoxyeicosatrienoic acids, SR-BI, Scavenger receptor class B type I, LOX, Lipoxygenases, PE, Phosphatidylethanolamine, Respiratory system, Cause of death, Hypolipidemic Agents, lysoPE, Lyso-phosphatidylethanolamine, VLDL, Very-low-density lipoproteins, CT, CTP-choline cytidylyltransferase, Incidence (epidemiology), COVID-19, Corona virus disease-19, HDL, High- density lipoproteins, S1PR1, Sphingosine kinase 1 receptor 1, Infectious Diseases, mPGES-1, Microsomal prostaglandin E synthase-1, ChoK, Choline kinases, ATP, Adenosine triphosphate, Female, Microbiology (medical), medicine.medical_specialty, COX, Cyclooxygenases, PC, Phosphatidylcholine, 030106 microbiology, CHPT, CDP-choline diacylglycerol phosphocholinetransferase, PG, Prostaglandins, Breast Neoplasms, Biology, TX, Thromboxanes, Microbiology, HMGCR, Hydroxymethylglutaryl-coenzyme A reductase, LDL, Low-density lipoproteins, SARS-CoV, Severe acute respiratory syndrome coronavirus, 03 medical and health sciences, Internal medicine, Genetics, medicine, Humans, MAPK, Mitogen-activated protein kinases, PLA2G2D, Phospholipase A2 group IID, Molecular Biology, C1P, Ceramide-1-phophate, LT, Leukotrienes, Ecology, Evolution, Behavior and Systematics, Dyslipidemias, DMVs, Double membrane vesicles, cPLA2α, Cytosolic phospholipase A2α enzyme, S1P, Sphingosine-1-phophate, Cholesterol, SARS-CoV-2, PCho, Phosphocholine, TNF, Tumor necrosis factor, Cancer, COVID-19, IL-1β, Interleukin-1β, PI3K, Phosphatidylinositol-3-kinase, medicine.disease, SK1, Sphingosine kinase 1, 030104 developmental biology, chemistry, Dyslipidemia, ACE-2, Angiotensin converting enzyme-2, IDL, Intermediate-density lipoproteins, HPETEs, Hydroperoxyeicosatetraenoic acids
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المؤلفون: Anne Nègre-Salvayre, Robert Salvayre, Mélanie Pucelle, Caroline Camaré
المساهمون: Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Régulations cellulaires: lipidoses et atherosclerose, IFR 31 Louis Bugnard (IFR 31), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3)
المصدر: Redox Biology
Redox Biology, Elsevier, 2017, 12, pp.18-34. ⟨10.1016/j.redox.2017.01.007⟩
Redox Biology, Vol 12, Iss, Pp 18-34 (2017)مصطلحات موضوعية: Apolipoprotein E, SMC, smooth muscle cell, nNOS, neuronal nitric oxide synthase, RTKs, receptor tyrosine kinase, Review Article, Matrix metalloproteinase, Fibroblast growth factor, Biochemistry, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, RCT, reverse cholesterol transport, Medicine, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, ApoE, apolipoprotein E, ICAM-1, InterCellular Adhesion Molecule-1, Neovascularization, Pathologic, NADPH, H+, nicotinamide adenine dinucleotide phosphate, VCAM-1, Vascular Cell Adhesion Molecule-1, ABCG1, ATP-binding cassette sub-family G member 1, Plaque, Atherosclerotic, ECM, extracellular matrix, 3. Good health, S1PR, S1P receptors, FAK, focal adhesion kinase, S1P, sphingosine 1-phosphate, iNOS, inducible nitric oxide synthase, Disease Progression, lcsh:Medicine (General), ADMA, assymetric methylarginine, PI3K, phosphoinositide 3 kinase, Spns2, S1P carry spinster homolog 2, Hypercholesterolemia, PHD, prolyl hydroxylase, 03 medical and health sciences, TGF-β, transforming growth factor-β, PKC, protein kinase C, PUFA, polyunsaturated fatty acid, Humans, FGF, basic fibroblast growth factor, NRP-1, neuropilin-1, EGF, epidermal growth factor, NO, nitric oxide, SRC, Sarcoma tyrosine kinase, Cholesterol, TIMPs, Tissue Inhibitor of Metalloproteinases, Flt-1, fms-like tyrosine kinase-1, HDL, high density lipopoprotein, 030104 developmental biology, chemistry, NF-kB, nuclear factor kappaB, Immunology, FGFR, FGF receptor, Angiogenesis, PDGFR, PDGF receptor, 0301 basic medicine, [SDV]Life Sciences [q-bio], AC, adenylate cyclase, Clinical Biochemistry, Angiogenesis Inhibitors, 030204 cardiovascular system & hematology, PDGF, platelet-derived growth factor, LDLs, low density lipoproteins, TGFβR, TGF-β receptor, Neovascularization, chemistry.chemical_compound, HUVEC, human umbilical vein endothelial cell, ROCK, Rho associated protein kinase, LOX, lipoxygenase, nSMase2, neutral sphingomyelinase-2, APOE, human ApoE gene, Clinical Trials as Topic, lcsh:R5-920, SK1, sphingosine kinase −1, eNOS, endothelial nitric oxide synthase, VEGF, vascular endothelial growth factor, VEGF, MMP, matrix metalloproteinase, H2O2, hydrogen peroxide, Dll4, Delta-like-4, EGFR, EGF receptor, medicine.symptom, TLR, Toll-like receptor, Inflammation, HIF, Hypoxia inducible factor, ARNT, aryl hydrocarbon nuclear translocator, PLC, phospholipase C, ROS, reactive oxygen species, Animals, CPT1A, carnitine palmityl transferase, VCAM-1, PAI-1, plasminogen activator inhibitor 1, PPAR, peroxisome proliferator activated receptor, VEGFR, VEGF receptor, AIBP, ApoA-I binding protein, business.industry, TK, tyrosine kinase, Organic Chemistry, Apoe, animal ApoE gene, Atherosclerosis, ApoE−/− mice, homozygous ApoE-deficient mice, HSP, heparan sulfate proteoglycans, COX, cyclooxygenase, Oxidative Stress, lcsh:Biology (General), Cancer research, business, MAPK, mitogen activated protein kinase
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المؤلفون: Yoonjung Park, Xiuping Chen, Hanrui Zhang, Kevin C. Dellsperger, Cuihua Zhang, Jiyeon Yang, Sewon Lee, Junxi Wu
المصدر: Clinical Science (London, England : 1979)
مصطلحات موضوعية: Aging, medicine.medical_treatment, PGI2, prostacyclin, RA, rheumatoid arthritis, Review Article, ICAM-1, intercellular adhesion molecule-1, 030204 cardiovascular system & hematology, medicine.disease_cause, TNF, tumour necrosis factor, VCAM-1, vascular cell adhesion molecule-1, Pathogenesis, ZOF rat, Zucker Obese Fatty rat, DC, dendritic cell, 0302 clinical medicine, EPC, endothelial progenitor cell, EET, epoxyeicosatrienoic acid, macrovascular circulation, iNOS, inducible NOS, Endothelial dysfunction, IKK, IκB kinase, IκB, inhibitor of NF-κB, NOS, NO synthase, HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA, 0303 health sciences, Stem Cells, tumour necrosis factor-α (TNF-α), General Medicine, cNOS, constitutive NOS, 3. Good health, nNOS, neuronal NOS, medicine.anatomical_structure, Cytokine, CRP, C-reactive protein, Tumor necrosis factor alpha, NF-κB, nuclear factor κB, medicine.symptom, TNFR, TNF receptor, Blood vessel, Endothelium, HDL, high-density lipoprotein, Inflammation, SK1, sphingosine kinase 1, IHD, ischaemic heart disease, reactive oxygen species (ROS), RAGE, receptor for AGEs, 03 medical and health sciences, ROS, reactive oxygen species, nitric oxide, TA164, Dietary Carbohydrates, eNOS, endothelial NOS, medicine, Animals, Humans, Vascular Diseases, t-PA, tissue plasminogen activator, Exercise, HUVEC, human umbilical vein EC, 030304 developmental biology, XO, xanthine oxidase, microvascular circulation, Tumor Necrosis Factor-alpha, EC, endothelial cell, SCF, stem cell factor, business.industry, EDHF, endothelium-dependent hyperpolarizing factor, I/R, ischaemia/reperfusion, Lipid Metabolism, medicine.disease, Dietary Fats, ONOO−, peroxynitrite, Sph1P, sphingosine-1-phosphate, AMI, acute myocardial infarction, IL, interleukin, AGE, advanced glycation end-product, inflammation, Immunology, O2•−, superoxide radical, Endothelium, Vascular, Reactive Oxygen Species, ACEI, angiotensin-converting enzyme inhibitor, ASS, argininosuccinate synthase, business, Oxidative stress
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d598f52c7162d673fa00720379d51f81
https://strathprints.strath.ac.uk/77910/1 /Zhang_etal_CS_2009_Role_of_TNF_alpha_in_vascular.pdf