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المؤلفون: Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)مصطلحات موضوعية: MCOLN1, mucolipin 1, Review, OPTN, optineurin, UPR, unfolded protein response, LIMP1, lysosomal integral membrane protein-1, General Pharmacology, Toxicology and Pharmaceutics, BNIP3L, BCL2 interacting protein 3 like, STBD1, starch-binding domain-containing protein 1, PLIN3, perilipin 3, LIR, LC3 interacting region, PPARα, peroxisomal proliferator-activated receptor-alpha, mTORC1, mammalian target of rapamycin complex 1, Translation (biology), WIPI1, WD repeat domain phosphoinositide-interacting protein 1, TBK1, serine/threonine-protein kinase, Cell biology, GIM, GABARAP-interacting motif, CREB, cAMP response element binding protein, PP2A, protein phosphatase 2a, Liver metabolism, CLN3, lysosomal/endosomal transmembrane protein, LALP70, lysosomal apyrase-like protein of 70 kDa, LD, lipid droplet, RETREG1, reticulophagy regulator 1, PINK1, phosphatase and tensin homolog (PTEN)-induced kinase 1, RM1-950, ATL3, Atlastin GTPase 3, RTNL3, a long isoform of RTN3, LAMP2, lysosomal-associated membrane protein-2, FXR, farnesoid X receptor, Farnesoid X receptor, Cryptochrome 1, FFA, free fatty acid, TFEB/TFE3, transcription factor EB, ULK1, Unc-51 like autophagy activating kinase 1, TRAC-1, thyroid-hormone-and retinoic acid-receptor associated co-repressor 1, RTN3, reticulon 3, S6K, P70-S6 kinase, SEC62, SEC62 homolog, preprotein translocation factor, GABARAPL1, GABA type A receptor associated protein like 1, TEX264, testis expressed 264, ER-phagy receptor, DFCP1, double FYVE-containing protein 1, LXRa, liver X receptor a, SLC36A1, solute carrier family 36 member 1, V-ATPase, vacuolar-ATPase, Regeneration (biology), Quality control, AIM, Atf8 interacting motif, VLDL, very-low-density lipoprotein, CYP7A1, cholesterol 7α-hydroxylase, NBR1, BRCA1 gene 1 protein, BCL2L13, BCL2 like 13, TGR5, takeda G protein receptor 5, NCoR1, nuclear receptor co-repressor 1, PKA, protein kinase A, Function (biology), CRY1, cryptochrome 1, LAMP1, lysosomal-associated membrane protein-1, Anabolism, S6RP, S6 ribosomal protein, LIMP3, lysosomal integral membrane protein-3, FAM134B, family with sequence similarity 134, member B, Nutrient regeneration, SPIN, spindling, FOXO1, Forkhead box O1, SCARB2, scavenger receptor class B member 2, PQLC2, PQ-loop protein, SQSTM1, sequestosome 1, CMA, chaperonin mediated autophagy, PLIN2, perilipin 2, PXR, pregnane X receptor, NPC-1, Niemann-Pick disease, type C1, SLC38A9, sodium-coupled neutral amino acid transporter 9, Lysosome, TRPML1, transient receptor potential mucolipin 1, BNIP3, BCL2 interacting protein 3, BA, bile acid, ATM, ATM serine/threonine kinase, CAR, constitutive androstane receptor, MFSD1, major facilitator superfamily domain containing 1, NAFLD, non-alcoholic fatty liver disease, PKB, protein kinase B, VDR, vitamin D3 receptor, SIRT1, sirtuin 1, LYAAT-1, lysosomal amino acid transporter 1, SNAT7, sodium-coupled neutral amino acid transporter 7, Biology, S1PR2, sphingosine-1-phosphate receptor 2, ROS, reactive oxygen species, CYP27A1, sterol 27-hydroxylase, Autophagy, NDP52, calcium-binding and coiled-coil domain-containing protein 2, ATGL, adipose triglyceride lipase, Signaling proteins, Catabolism, FUNDC1, FUN14 domain containing 1, CCPG1, cell cycle progression 1, LAAT-1, lysosomal amino acid transporter 1 homologue, PEX5, peroxisomal biogenesis factor 5, PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase, SLC38A7, solute carrier family 38 member 7, Therapeutics. Pharmacology, Homeostasis, Drug metabolism
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المؤلفون: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)مصطلحات موضوعية: LOX1, lectin-like oxidized LDL receptor 1, BUN, blood urea nitrogen, TGBM, thickness of glomerular basement membrane, NQO1, NAD(P)H:quinone oxidoreductase 1, STAT, signal transducers and activators of transcription, N/O, not observed, p62, sequestosome 1 protein, p-IRS1, phospho-IRS1, Review, NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4, OCP, oxidative carbonyl protein, Traditional Chinese medicine, AGEs, advanced glycation end-products, N/A, not applicable, TRAF5, tumor-necrosis factor receptor-associated factor 5, Health problems, 0302 clinical medicine, ESRD, end-stage renal disease, LDL, low-density lipoprotein, BMP-7, bone morphogenetic protein-7, TGFβR-I/II, TGF-β receptor I/II, Medicine, P70S6K, 70-kDa ribosomal protein S6 kinase, General Pharmacology, Toxicology and Pharmaceutics, SOCS, suppressor of cytokine signaling proteins, HO-1, heme oxygenase-1, 0303 health sciences, TG, triglyceride, BW, body weight, HDL-C, high density lipoprotein-cholesterol, RASI, renin-angiotensin system inhibitor, ATK, protein kinase B, TBARS, thiobarbituric acid-reactive substance, BCL-XL, B-cell lymphoma-extra large, Gαq, Gq protein alpha subunit, GCK, glucokinase, PI3K, phosphatidylinositol 3 kinases, Systematic review, TLR-2/4, toll-like receptor 2/4, IR, insulin receptor, PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase, 030220 oncology & carcinogenesis, CRP, C-reactive protein, IRS, insulin receptor substrate, AM, mesangial area, JAK, Janus kinase, FBG, fasting blood glucose, ETAR, endothelium A receptor, LDL-C, low density lipoprotein-cholesterol, CD2AP, CD2-associated protein, eIF2α, eukaryotic initiation factor 2α, RM1-950, mTOR, mammalian target of rapamycin, CHOP, C/EBP homologous protein, STZ, streptozotocin, 03 medical and health sciences, ADE, adverse event, PKC, protein kinase C, LC3, microtubule-associated protein light chain 3, ORP150, 150-kDa oxygen-regulated protein, PGE2, prostaglandin E2, IL-1β/6, interleukin 1β/6, Diabetic kidney disease, IGF-1, insulin-like growth factor 1, EP, E-prostanoid receptor, FN, fibronectin, eGFR, estimated GFR, MDA, malondialdehyde, Chinese medicine, MMP-2, matrix metallopeptidase 2, XBP-1, spliced X box-binding protein 1, TGF-β, tumor growth factor β, GRB 10, growth factor receptor-bound protein 10, medicine.disease, Clinical trial, GRP78, glucose-regulated protein 78, UP, urinary protein, IGF-1R, insulin-like growth factor 1 receptor, ACEI, angiotensin-converting enzyme inhibitor, BCL-2, B-cell lymphoma 2, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase, MYD88, myeloid differentiation primary response 88, PBG, postprandial blood glucose, RCT, randomized clinical trial, N/R, not reported, COL-I/IV, collagen I/IV, PINK1, PTEN-induced putative kinase 1, UACR, urinary albumin to creatinine ratio, C, control group, Diabetic nephropathy, GPX, glutathione peroxidase, ICAM-1, intercellular adhesion molecule-1, Bioinformatics, VCAM-1, vascular cell adhesion molecule-1, AMPKα, adenosine monophosphate-activated protein kinase α, DM, diabetes mellitus, TFEB, transcription factor EB, TNF-α, tumor necrosis factor α, Molecular target, IKK-β, IκB kinase β, Signaling pathway, GLUT4, glucose transporter type 4, BAX, BCL-2-associated X protein, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, PARP, poly(ADP-Ribose) polymerase, SMURF-2, SMAD ubiquitination regulatory factor 2, AREs, antioxidant response elements, MD, mean difference, SMAD, small mothers against decapentaplegic, MCP-1, monocyte chemotactic protein-1, VEGF, vascular endothelial growth factor, cAMP, cyclic adenosine monophosphate, ARB, angiotensin receptor blocker, PAI-1, plasminogen activator inhibitor-1, SMD, standard mean difference, JNK, c-Jun N-terminal kinase, NRF2, nuclear factor erythroid 2-related factor 2, IκB-α, inhibitory protein α, Herbal medicine, TCM, traditional Chinese medicine, DG, glomerular diameter, GSK-3, glycogen synthase kinase 3, SIRT1, sirtuin 1, D, duration, HbA1c, glycosylated hemoglobin, WMD, weight mean difference, CTGF, connective tissue growth factor, ER, endoplasmic reticulum, DN, diabetic nephropathy, ROS, reactive oxygen species, CCR, creatinine clearance rate, SOD, superoxide dismutase, Diabetes mellitus, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α, ET-1, endothelin-1, UMA, urinary microalbumin, SCr, serum creatinine, IRE-1α, inositol-requiring enzyme-1α, 030304 developmental biology, TII, tubulointerstitial injury index, RAGE, receptors of AGE, business.industry, GFR, glomerular filtration rate, PTEN, phosphatase and tensin homolog, CI, confidence interval, TC, total cholesterol, SD-rat, Sprague–Dawley rat, UAER, urinary albumin excretion rate, DKD, diabetic kidney disease, T, treatment group, Molecular targets, Therapeutics. Pharmacology, α-SMA, α smooth muscle actin, SD, standard deviation, business, DAG, diacylglycerol, GCLC, glutamate-cysteine ligase catalytic subunit, Kidney disease
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المؤلفون: Hui-Fang Chiu, Chin-Kun Wang, Kamesh Venkatakrishnan
المصدر: Journal of Traditional and Complementary Medicine, Vol 10, Iss 5, Pp 434-439 (2020)
Journal of Traditional and Complementary Medicineمصطلحات موضوعية: MAPK, Mitogen-activated protein kinase, 0211 other engineering and technologies, lcsh:Medicine, Complementary therapy, Review Article, 02 engineering and technology, Disease, Resveratrol, AD, Alzheimer’s disease, Bioinformatics, 01 natural sciences, Neuroprotection, Neuroprotective agents, SIRT1, Sirtuin 1, chemistry.chemical_compound, Nutraceutical, 021105 building & construction, Medicine, Adverse effect, PD, Parkinson’s disease, NF-κB, Nuclear factor Kappa B, Coenzyme Q10, NDDs, neurodegenerative diseases, business.industry, Neurodegenerative diseases, lcsh:R, Nrf2, Nuclear factor-E2-related factor, PI3K, Phosphatidylinositol-3-kinase, BBB, Blood-brain barrier, HO-1, Heme Oxygenase-1, HD, Huntington’s disease, 0104 chemical sciences, Clinical trial, JNK, c-Jun N-terminal Kinase, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, ATP, Adenosine triphosphate, business
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المؤلفون: Wen Li, Hiroshi Kurihara, Chang Yan, Zhuo Luo, Rong-Rong He, Yi-Fang Li, Robert Dallmann, Xue Li
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)مصطلحات موضوعية: TRKA, tropomyosin receptor kinase A, CTCF, CCCTC-binding factor, GREs, GR response elements, viruses, Cell, GRs, glucocorticoid receptors, SGKs, serum and glucocorticoid-regulated protein kinases, Stimulation, Review, PTMs, post-translational modifications, Herpes simplex virus type 1, medicine.disease_cause, 0302 clinical medicine, NK cells, natural killer cells, REST, RE1-silencing transcription factor, H3K9, histone H3 on lysines 9, sncRNAs, small non-coding RNAs, HSV-1, herpes simplex virus type 1, General Pharmacology, Toxicology and Pharmaceutics, ICP, infected cell polypeptide, MOI, multiplicity of infection, 0303 health sciences, PDK1, pyruvate dehydrogenase lipoamide kinase isozyme 1, TRIM14, tripartite motif-containing 14, PRRs, pattern-recognition receptors, OCT-1, octamer binding protein 1, Reactivation, HSV-1, RANKL, receptor activator of NF-κB ligands, T3, thyroid hormone, humanities, medicine.anatomical_structure, 4E-BP, eIF4E-binding protein, CPE, cytopathic effect, 030220 oncology & carcinogenesis, Latency, HPK, herpetic simplex keratitis, AD, Alzheimer's disease, DCs, dendritic cells, TCM, traditional Chinese medicine, TRM, tissue resident memory T cells, Recurrent infections, HPT axis, hypothalamic–pituitary–thyroid axis, LAT, latency-associated transcripts, SIRT1, sirtuin 1, AMPK, AMP-dependent kinase, NGF, nerve growth factor, TK, thymidine kinase, DEX, dexamethasone, HPA axis, hypothalamo–pituitary–adrenal axis, mTOR, mammalian target of rapamycin, MAVS, mitochondrial antiviral-signaling protein, ORFs, open reading frames, Biology, Stress, CNS, central nervous system, Inhibitory postsynaptic potential, AKT, protein kinase B, HCF-1, host cell factor 1, Virus, 03 medical and health sciences, ROS, reactive oxygen species, CORT, corticosterone, PRC1, protein regulator of cytokinesis 1, PAMPs, pathogen-associated molecular patterns, medicine, Latency (engineering), 030304 developmental biology, Balance (ability), PML, promyelocytic leukemia protein, IRF3, interferon regulatory factor 3, lcsh:RM1-950, ND10, nuclear domains 10, LSD1, lysine-specific demethylase 1, CTL, cytotoxic T lymphocyte, HDACs, histone deacetylases, LRF, Luman/CREB3 recruitment factor, CoREST, REST corepressor 1, lcsh:Therapeutics. Pharmacology, cGAS, cyclic GMP-AMP synthase, Herpes simplex virus, TG, trigeminal ganglia, Susceptibility, PI3K, phosphoinositide 3-kinases, DAMPs, damage-associated molecular patterns, Immunology, PNS, peripheral nervous system, BCL-2, B-cell lymphoma 2, KLF15, Krüppel-like transcription factor 15
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المؤلفون: Maria Camilla Bergonzi, Anna Rita Bilia
المصدر: Journal of Ginseng Research, Vol 44, Iss 2, Pp 179-193 (2020)
Journal of Ginseng Researchمصطلحات موضوعية: 0301 basic medicine, FEF50, forced expiratory flow50, Energy and physical performance, SB, single-blind, Immune and cognitive functions, RVIP, rapid visual information processing, FER, forced expiratory ratio, HDL-c, high-density lipoprotein, MVV, maximum ventilation volume, Review, CDR, cognitive drug research, PGC-1α, proliferator-activated receptor gamma coactivator-1α, LA, lipoic acid, FEF75, forced expiratory flow75, Ginseng, 0302 clinical medicine, lcsh:Botany, PEFR, peak expiration flow rate, Medicine, media_common, CDRI, cognitive drug research index, Traditional medicine, TG, triglyceride, Chronic obstructive pulmonary disease, CO, crossover, AMPK, 5′ AMP-activated protein kinase, 3′,5′-AMP, adenosine 3′5′ monophosphate, lcsh:QK1-989, Safety profile, R, randomized, 030220 oncology & carcinogenesis, GACPs, good agricultural and collection practices, DB, double-blind, LDLc, low-density lipoprotein, Biotechnology, Drug, SIgA, secretory immunoglobulin A, ATP, adenosine triphosphate, SIRT1, sirtuin 1, FBG, fasting blood glucose, media_common.quotation_subject, Context (language use), HbAlc, glycated hemoglobin, PFTs, pulmonary function tests, Biochemistry, Genetics and Molecular Biology (miscellaneous), PEF, peak expiration flow, WHO, World Health Organization, GMPs, good manufacturing practices, S-SIgA, SIgA secretion rate, 03 medical and health sciences, FEV1, forced expiration volume in one second, GINSENG EXTRACT, pO2, partial oxygen pressure, G115, standardized root extract of P. ginseng Meyer, PC, placebo-controlled, Blood glucose and lipid regulation, Quality (business), G115 standardized ginseng extract, DER, drug extract ratio, SFR, saliva flow rate, business.industry, VLDL, very-low-density lipoprotein, PS, pilot study, VO2 max, maximal oxygen consumption, Clinical trial, TC, total cholesterol, 030104 developmental biology, Clinical research, Complementary and alternative medicine, COPD, chronic obstructive pulmonary disease, FVC, forced vital capacity, PG, parallel group, PaO2, blood oxygen pressure, business, FEV1/FVC, ratio of FEV1/FVC, HMPs, herbal medicinal products
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المؤلفون: Murat Oz, Nadine Kabbani, Dietrich E. Lorke
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: 0301 basic medicine, MAP, mitogen-activated protein, Angiotensin-Converting Enzyme Inhibitors, Disease, medicine.disease_cause, Bioinformatics, Renin-Angiotensin System, ACE, Angiotensin I converting enzyme, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, S protein, spike protein, Pharmacology (medical), ACE-Inh., Angiotensin I converting enzyme inhibitor, NOS, nitric oxide synthase, T2DM, Type 2 diabetes mellitus, Coronavirus, Ang-II, Angiotensin II, IBD, inflammatory bowel disease, DABK, [des-Arg9]-bradykinin, ADAM17, A Disintegrin And Metalloprotease 17, COPD, chronic obstructive lung disease, 030220 oncology & carcinogenesis, Angiotensin-converting enzyme 2, AT1-R, Angiotensin II type 1-receptor, Steroids, Angiotensin-Converting Enzyme 2, BK, bradykinin, TCM, Traditional Chinese medicine, MRB, Mineralocorticoid receptor blocker, HS, heparan sulfate, 25HC, 25-hydroxycholesterol, COVID-19, Coronavirus disease-2019, Article, SARS-CoV, Severe acute respiratory syndrome coronavirus, CH25H, cholesterol-25-hydroxylase, NSAID, Non-steroid anti-inflammatory drug, ARB, Angiotensin II type 1-receptor blocker, SIRT1, Sirtuin 1, 03 medical and health sciences, Downregulation and upregulation, Viral entry, Diabetes mellitus, ARDS, Acute respiratory distress syndrome, Renin–angiotensin system, medicine, Animals, Humans, HSPG, heparan sulfate proteoglycan, UFH, unfractionated heparin, TMPRSS2, Transmembrane protease, serine 2, CCB, Calcium channel blockers, Pharmacology, SARS-CoV-2, βARB, β-adrenergic receptor blockers, business.industry, MERS, Middle East respiratory syndrome, TNF, Tumor necrosis factor, COVID-19, medicine.disease, SH, spontaneously hypertensive, COVID-19 Drug Treatment, COX, cyclooxygenase, AMPK, AMP-activated protein kinase, 030104 developmental biology, Heart failure, RAS, Renin-angiotensin system, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business
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المؤلفون: Vera Maria Morsch, Karine Paula Reichert, Milagros Fanny Vera Castro, Naiara Stefanello, Vanessa Valéria Miron, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger, Charles Elias Assmann, Nathieli B. Bottari
المصدر: Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111273-(2021)
Biomedicine & Pharmacotherapyمصطلحات موضوعية: BP, blood pressure, HIF-1α, hypoxia-inducible factor-1α, Adenosine, Up4A, uridine adenosine tetraphosphate, Cell Communication, Review, APCs, antigen presenting cells, BFR, blood flow restriction, 0302 clinical medicine, PNP, purine nucleoside phosphorylase, Diabetic cardiomyopathy, Purinergic P2 Receptor Antagonists, HIAE, high intensity aerobic, Medicine, NOS, nitric oxide synthase, 5'-Nucleotidase, 5′-NT, CD73, ecto-5′-nucleotidase, Ectonucleotidases, GLP-1, glucagon-like peptide-1, General Medicine, PAP, prostatic acid phosphatase, GLUT, glucose transporter, NTPDase1/CD39, E-NTPDase family, 030220 oncology & carcinogenesis, TReg, regulatory T cells, ATP, adenosine 5′-triphosphate, P1, purinergic receptors family 1, DBP, diastolic blood pressure, RM1-950, ADP, adenosine 5′-diphosphate, STZ, streptozotocin, LIAE, low intensity aerobic exercise, HIIT, high-intensity intermittent training, 03 medical and health sciences, Antigens, CD, Diabetes Mellitus, Humans, Exercise, Ado, Adenosine, PBMCs, peripheral blood mononuclear cells, Pharmacology, NO, nitric oxide, Receptors, Purinergic P2, UTP, uridine-5′-triphosphate, Receptors, Purinergic P1, T2DM, type 2 diabetes mellitus, medicine.disease, IL, interleukin, CGA, chlorogenic acid, 030104 developmental biology, Glucose, ER, endoplasmatic reticulum, GABA, gamma-aminobutyric acid, Ino, inosine, PKA, protein kinase A, SHR, spontaneously hypertensive rat, 0301 basic medicine, Adenosine Deaminase, STAT3, signal transducer and activator of transcription 3, SIT, sprint interval training, UDP, uridine diphosphate, Bioinformatics, Adenosine deaminase, VO2máx, maximal oxygen uptake, DM, diabetes mellitus, E-NPP, ecto-nucleotide pyrophosphatase/phosphodiesterase, Receptor, ADA, adenosine deaminase, NOD-mice, Non-obese diabetic mice, NF-κB, nuclear factor kappa B, TNF-α, tumor necrosis factor α, biology, AMP, adenosine 5′-monophosphate, Apyrase, T1DM, type 1 diabetes mellitus, Purinergic receptor, E-NTPDase, ecto-nucleoside triphosphate diphosphohydrolase, eNOS, endothelial nitric oxide synthase, MICT, moderate intensity continuous training, Purinergic signalling, IRS-1, insulin receptor substrate 1, VEGF, vascular endothelial growth factor, mRNA, messenger RNA, MSNA, muscle sympathetic nerve activity, Hypertension, Ap3A, diadenosine triphosphate, Blood pressure, Diet, Healthy, DCs, dendritic cells, Purinergic receptors, Signal Transduction, medicine.drug, P2Y, purinergic metabotropic receptor family 2, TNAP, tissue-nonspecific alkaline phosphatase, HbA1c, glycosylated hemoglobin, P2 receptor, CNS, central nervous system, APs, alkaline phosphatases, SIRT1, Sirtuin 1, GPCRs, G-protein-coupled receptors, L-NAME, L-NG-nitroarginine methyl ester, P2X, purinergic ionotropic receptor family 2, Diabetes mellitus, Animals, TXA2, thromboxane A2, ComputingMethodologies_COMPUTERGRAPHICS, NLRP3, NLR family pyrin domain containing 3, cAMP, cyclic adenosine 5′-monophosphate, business.industry, SBP, systolic blood pressure, AngII, angiotensin-II, ATP, AMPK, AMP-activated protein kinase, NFAT, nuclear factor of activated T-cells, Purinergic P1 Receptor Antagonists, DAMP, molecular pattern associated with damage, Purines, TGF-β1, transforming growth factor-beta 1, biology.protein, Therapeutics. Pharmacology, business, DAG, diacylglycerol
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المؤلفون: Manuela Viola, Davide Vigetti, Paola Moretto, Evgenia Karousou, Alberto Passi, Ilaria Caon, Arianna Parnigoni
المصدر: Matrix Biology Plus
Matrix Biology Plus, Vol 11, Iss, Pp 100060-(2021)مصطلحات موضوعية: Gene isoform, HAS2-AS1, Histology, HA, hyaluronan, PTM, post-translational modification, SIRT1, sirtuin 1, QH301-705.5, 4-MUG, 4-methylumbelliferyl glucuronide, Biophysics, HAS2–AS1, hyaluronan synthase 2 natural antisense 1, EMT, epithelial to mesenchymal transition, miRNA, micro-RNA, UDP-GlcNAc, UDP-N-acetylglucosamine, Biology, 4-MU, 4-methylubelliferone, Hyaluronan Synthase 2, Biochemistry, Article, Extracellular matrix, lncRNA, long non-coding RNA, Downregulation and upregulation, GAG, glycosaminoglycans, HIFs, hypoxia-inducible factors, Gene expression, Genetics, SMCs, smooth muscle cells, Biology (General), UDP-GlcUA, UDP-glucuronic acid, HAS2, hyaluronan synthase 2, Molecular Biology, HAS1, Glycosaminoglycans, Cancer, Regulation of gene expression, Atherosclerosis, Epigenetics, HAS2, Proteoglycans, TNF-α, tumour necrosis factor alpha, PG, proteoglycan, Cell Biology, Cell biology, ECM, extracellular matrix, Cancer cell, NF-κB, nuclear factor κ–light-chain enhancer of activated B cell, ceRNA, competitive endogenous RNA, RBP, RNA-binding protein
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المؤلفون: Bhushan Thakur, Kazuho Ishine, Noriaki Shimizu, Mirit I. Aladjem, Ryonosuke Taniguchi, Koichi Utani
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, gene amplification, RIGS, repeat-induced gene silencing, FISH, fluorescence in situ hybridization, extrachromosomal element, HDAC, histone deacetylase, BFB, breakage-fusion-bridge, Biology, Biochemistry, Genomic Instability, sirtuin1, 03 medical and health sciences, Gene Knockout Techniques, SIRT1, Sirtuin 1, Sirtuin 1, DM, double minute, Extrachromosomal DNA, Cell Line, Tumor, Gene duplication, Gene expression, Gene silencing, Humans, Gene Silencing, Scaffold/matrix attachment region, Molecular Biology, Gene, protein expression, MAR, matrix attachment region, Reporter gene, 030102 biochemistry & molecular biology, HSR, homogeneously staining region, DSB, double strand breakage, Cell Biology, Amplicon, repeat-induced gene silencing, Cell biology, 030104 developmental biology, histone deacetylase, gene expression, d2EGFP, destabilized enhanced GFP, biological phenomena, cell phenomena, and immunity, DIG, digoxigenin, hormones, hormone substitutes, and hormone antagonists, Research Article
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المؤلفون: David G. Le Couteur, Sun Woo Sophie Kang, Glen P Lockwood, Nicholas J. Hunt, Victoria C. Cogger
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019)مصطلحات موضوعية: Systemic disease, LSEC, liver sinusoidal endothelial cell, Review Article, IL-8, interleukin 8, Biochemistry, miR, microRNA, AMPK, 5′ adenosine monophosphate-activated protein kinase, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, FOXO, forkhead box O, Structural Biology, Hepatocyte, αSMA, alpha smooth muscle actin, 0303 health sciences, VEGF, vascular endothelial growth factor, Phenotype, HSC, hepatic stellate cell, 3. Good health, Computer Science Applications, Cell biology, IL-6, interleukin 6, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine.symptom, KC, Küpffer cell, Biotechnology, Senescence, NAFLD, non-alcoholic fatty liver disease, PDGF, platelet derived growth factor, SIRT1, sirtuin 1, CR, caloric restriction, lcsh:Biotechnology, Biophysics, TNFα, tumor necrosis factor alpha, Inflammation, mTOR, mammalian target of rapamycin, Nutrient sensing, Biology, Endothelial, 03 medical and health sciences, ROS, reactive oxygen species, Genetic, lcsh:TP248.13-248.65, Nutrient sensing pathways, Genetics, medicine, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-α, 030304 developmental biology, NO, nitric oxide, Epigenome, medicine.disease, IGF-1, insulin like growth factor 1, Mitochondrial dysfunction, Function (biology)
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المؤلفون: Jun Liu, Huiping Chen, Xiaorong Ma, Miao Xu, Yan Xiao, Tianxiang Ouyang, Tao Liu, Yingying Huang
المصدر: Redox Biology, Vol 20, Iss, Pp 195-203 (2019)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Mitochondrial ROS, 3-TYP, 3-(1H-1,2,3-triazol-4-yl)pyridine, Light, Clinical Biochemistry, Apoptosis, Biochemistry, 5-ALA, 5-aminolevulinic acid, chemistry.chemical_compound, 0302 clinical medicine, SRT1720, Sirtuin 1, NAD, nicotinamide adenine dinucleotide, Sirtuin 3, skin and connective tissue diseases, lcsh:QH301-705.5, lcsh:R5-920, Photosensitizing Agents, Chemistry, Superoxide, mROS, mitochondrial reactive oxygen species, IP, immunoprecipitation, PDT, photodynamic therapy, 5-aminolevulinic acid, Keloid, lcsh:Medicine (General), Signal Transduction, Research Paper, Programmed cell death, SIRT3, SIRT1, sirtuin 1, SOD2, SOD2, superoxide dismutase 2, mitochondrial, 03 medical and health sciences, ROS, reactive oxygen species, SIRT1, FBS, fetal bovine serum, Autophagy, Humans, SQSTM1/p62, sequestosome 1, SIRT3, sirtuin 3, Superoxide Dismutase, Organic Chemistry, Fibroblasts, Levulinic Acids, Oxidative Stress, 030104 developmental biology, Photochemotherapy, lcsh:Biology (General), Cancer research, Reactive Oxygen Species, 030217 neurology & neurosurgery, 3-MA, 3-methyladenine
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المؤلفون: Yangyang Hu, Ting Yuan, Huan Chen, Ting Yang, Jing Wang, Hong Yu, Qing Yuan, Danli Fu, Xiang Xie, Wenfeng Xu
المصدر: Redox Biology
Redox Biology, Vol 20, Iss, Pp 247-260 (2019)مصطلحات موضوعية: Intracellular Space, Review Article, ACC, acetyl-CoA carboxylase, AGEs, advanced glycation end-products, TNF-α, tumor necrosis factor-α, Biochemistry, VCAM-1, vascular cell adhesion molecule 1, Diabetes mellitus, 0302 clinical medicine, SR, scavenger receptor, GSH, glutathione, IKK, IkB kinase, iNOS, inducible NOS, IL-6, interleukin-6, T2DM, Type 2 diabetes mellitus, lcsh:QH301-705.5, PARP, poly ADP-ribose polymerase, ApoE, apolipoprotein E, chemistry.chemical_classification, TMAO, trimethylamine N-oxide, GLP-1, glucagon-like peptide-1, Cell biology, nNOS, neuronal NOS, CRP, C-reactive protein, lcsh:Medicine (General), GAPDH, glyceraldehydes-3-phosphate dehydrogenase, Gut microbiota, CVD, cardiovascular disease, Diabetes Complications, HIF-α, hypoxia inducible factor α, 03 medical and health sciences, PKC, protein kinase C, AR, aldose reductase, Humans, miRNAs, microRNAs, Protein kinase A, ERK1/2, extracellular regulating kinase 1/2, SREBP-1c, sterol regulatory-element-binding protein-1c, IκB, inhibitor of κB, SUMOylation, small ubiquitin-related modifier conjugation, Adiponectin, AKR, aldo-keto reductase, medicine.disease, 030104 developmental biology, chemistry, Hyperglycemia, MMPs, matrix metalloproteinases, MAPK, mitogen-activated protein kinase, 030217 neurology & neurosurgery, MIP-1, macrophage inflammatory protein-1, Glycation End Products, Advanced, 0301 basic medicine, C/EBPα, CCAAT/enhancer binding protein α, CAD, coronary artery disease, Clinical Biochemistry, ICAM-1, intercellular adhesion molecule-1, medicine.disease_cause, TLR4, toll-like receptor 4, H2S, hydrogen sulphide, ox-LDL, oxidized-low density lipoprotein, Polyol pathway, Nrf2, nuclear factor erythoid 2-related factor 2, Glycation, AdipoR, adiponectin receptor, Protein Kinase C, p90RSK, p90 ribosomal S6 kinase, lcsh:R5-920, eNOS, endothelial nitric oxide synthase, MicroRNA, MCP-1, monocyte chemotactic protein-1, PGC-1α, PPARγ coactivator 1 α, KLF, Kruppel-like factors, Mitochondria, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, medicine.symptom, VSMCs, vascular smooth muscle cells, Signal Transduction, SIRT1, sirtuin 1, HDL, high-density lipoprotein cholesterol, Grxs, glutaredoxins, NF-κB, nuclear factor-κB, Drp-1, dynamic-related protein 1, Inflammation, FOXO1, forkhead box O1, RAGE, receptor for AGEs, ER, endoplasmic reticulum, ROS, reactive oxygen species, Insulin resistance, miR-128-1, miRNA-128-1, medicine, Animals, UPS, ubiquitin-proteasome system, PPAR, peroxisome proliferator activated receptor, Reactive oxygen species, Organic Chemistry, Atherosclerosis, Gastrointestinal Microbiome, MicroRNAs, Oxidative Stress, AMPK, AMP-activated protein kinase, lcsh:Biology (General), Insulin Resistance, DAG, diacylglycerol, NLRP3, NOD-like receptor family, pyrin domain-containing 3, Oxidative stress
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المؤلفون: Xiaochuan Li, Chao Yang, Yuan Fang, Guochao Liao, Bin Yu, Qingchun Mu, Zhiqiang Yu
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 621-631 (2021)
Acta Pharmaceutica Sinica Bمصطلحات موضوعية: CD11b, integrin alpha M, Cancer therapy, TCP, tranylcypromine, HDAC, histone deacetylase, MMA, methylmalonic acid, chemistry.chemical_compound, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myeloid leukemia, iPS, induced pluripotent stem, CCC, cut countercurrent chromatography, ΔΨm, mitochondrial transmembrane potential, Histone demethylase, Natural products, Tm, melting temperature, 0303 health sciences, CD86, cluster of differentiation 86, Drug discovery, H3K4, histone H3 lysine 4, HRP, horseradish peroxidase, α-MG, α-mangostin, FAD, flavin adenine dinucleotide, mRNA, messenger RNA, LSD1, lysine-specific histone demethylase 1A, 030220 oncology & carcinogenesis, Identification (biology), CoREST, RE1-silencing transcription factor co-repressor, Histone Demethylases, CD14, cluster of differentiation 14, EMT, epithelial-mesenchymal transition, MHC, myosin heavy chain, animal structures, SIRT1, sirtuin 1, THF, tetrahydrofolate, SPR, surface plasmon resonance, Computational biology, Biology, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, Natural (archaeology), Epigenetic regulation, 03 medical and health sciences, Lead (geology), Epigenetics, COVID-19, coronavirus disease, PDX, patient-derived xenograft, 030304 developmental biology, EVOO, extra virgin olive oil, NTRK2, neurotrophic receptor tyrosine kinase 2, Natural product, LSD1 inhibitors, lcsh:RM1-950, H3K9, histone H3 lysine 9, MAO-A, monoamine oxidase A, Kt, competitive inhibition constant, SOX2, sex determining region Y-box 2, Chemical space, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, chemistry, SARs, structure‒activity relationship studies, siRNA, small interfering RNA, EdU, 5-ethynyl-20-deoxyuridine, GGA, geranylgeranoic acid
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المؤلفون: Yu-Jui Yvonne Wan, Mohamed R. Ali, Prasant Kuma Jena, Ying Hu, Lili Sheng, Hui Xin Liu
المصدر: JHEP reports : innovation in hepatology, vol 2, iss 2
JHEP Reports, Vol 2, Iss 2, Pp-(2020)
JHEP Reportsمصطلحات موضوعية: FGF21, Steatosis, insulin tolerance test, ALT, ITT, HDAC, histone deacetylase, PFUs, Pharmacology, PPREs, sirtuin 1, 0302 clinical medicine, obeticholic acid, HDAC, Aetiology, PHHs, Western diet, RARβ, retinoic acid receptor β, 0303 health sciences, Liver Disease, Gastroenterology, 3. Good health, FXR, 030220 oncology & carcinogenesis, alcoholic steatosis, CD, control diet, PPREs, peroxisome proliferative-response elements, non-alcoholic steatohepatitis, PHHs, primary human hepatocytes, RT-PCR, 03 medical and health sciences, peroxisome proliferative-response elements, FXR, farnesoid X receptor, SIRT1, OCA, NPCs, non-parenchymal cells, ALP, alkaline phosphatase, RT-PCR, reverse transcription PCR, medicine.disease, 3' untranslated region, PFUs, plaque-forming units, primary human hepatocytes, chemistry, histone deacetylase, Metabolic syndrome, Digestive Diseases, GLP-1, farnesoid X receptor, retinoic acid receptor β, FGF21, fibroblast growth factor 21, chemistry.chemical_compound, non-parenchymal cells, reverse transcription PCR, 2.1 Biological and endogenous factors, Immunology and Allergy, WD, Western diet, Diabetes, Fatty liver, lipopolysaccharide, Obeticholic acid, NPCs, CD, OCA, obeticholic acid, PGC1α, PPAR-activated receptor-γ coactivator-1α, plaque-forming units, LPS, lipopolysaccharide, alkaline phosphatase, Research Article, Biotechnology, LPS, SIRT1, sirtuin 1, glucagon-like peptide, alanine aminotransferase, Chronic Liver Disease and Cirrhosis, fibroblast growth factor 21, PPAR-activated receptor-γ coactivator-1α, metabolic syndrome, Insulin resistance, WD, ALT, alanine aminotransferase, PGC1α, GLP-1, glucagon-like peptide, Internal Medicine, medicine, insulin sensitivity, lcsh:RC799-869, Metabolic and endocrine, ITT, insulin tolerance test, Nutrition, 030304 developmental biology, RARβ, Hepatology, 3'-UTR, 3' untranslated region, AMPK, control diet, ALP, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, 3'-UTR
وصف الملف: application/pdf
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المؤلفون: Yulija Manusha, Yurii H. Burmak, Yeugen Petrov, Yurii M. Kazakov, Igor Kaidashev, Nataliya I Chekalina, Zinaida Borisova
المصدر: Indian Heart Journal, Vol 70, Iss 5, Pp 593-597 (2018)
Indian Heart Journalمصطلحات موضوعية: 0301 basic medicine, Male, ASVD, atherosclerosis, NF-kB, nuclear factor of transcription kappa B, BMI, body mass index, CAD, coronary artery disease, Coronary Artery Disease, 030204 cardiovascular system & hematology, Systemic inflammation, IKKα, IkB-kinase α, HF, heart failure, Antioxidants, Coronary artery disease, chemistry.chemical_compound, 0302 clinical medicine, ET, vascular endothelium, LVEF, left ventricular ejection fraction, LOX, lipoxygenase, Aspirin, NF-kappa B, IL-10, interleukin-10, Middle Aged, Nuclear factor of transcription kappa B, Echocardiography, Doppler, CVD, cardiovascular diseases, Akt, protein kinase B α, Cytokines, Tumor necrosis factor alpha, Quercetin, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.drug, CSI, chronic systemic inflammation, Signal Transduction, medicine.medical_specialty, IL-1β, interleukin-1β, SIRT1, sirtuin 1, RD1-811, SCORE, Systematic COronary Risk Evaluation, W, Watt standard unit of power measurement, Echo, Doppler echocardiography, TNFα, tumor necrosis factor, Real-Time Polymerase Chain Reaction, Peripheral blood mononuclear cell, 03 medical and health sciences, Internal medicine, medicine, Real-time PCR, real-time polymerase chain reaction, Humans, Diseases of the circulatory (Cardiovascular) system, Gene, AMPK, protein kinase activated by adenosine monophosphate, MAP3K, protein kinase activated by mitogen 3, Aged, CK, cytokines, business.industry, medicine.disease, TRAF6, TNF-α-associated factor 6, Chronic systemic inflammation, COX, cyclooxygenase, AP-1, activating protein 1, 030104 developmental biology, Endocrinology, chemistry, Gene Expression Regulation, Heart failure, FC II, functional class, RC666-701, IkBα, inhibitor of kappa B α, Exercise Test, RNA, Surgery, Clinical and Preventive Cardiology, business
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المؤلفون: Hong-Min Ni, Wen-Xing Ding, Xiaojuan Chao
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 885-886 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: HFD, high-fat diet, S100A11, S100 calcium binding protein A11, Datasets as Topic, CIDEC, cell death-inducing DFFA-like effector c, Mice, RFP, red fluorescent protein, HFHC, high-fat and high-cholesterol diet, Non-alcoholic Fatty Liver Disease, LDL-c, low-density lipoprotein c, HDAC6, histone deacetylase 6, TBA, tubastatin A, Medicine, co-IP, co-immunoprecipitation, Original Research, TG, triglyceride, Forkhead Box Protein O1, Liver Diseases, FOXO1, S100 Proteins, Fatty liver, Gastroenterology, ATG7, autophagy related 7, mRNA, messenger RNA, Up-Regulation, Gene Expression Regulation, Neoplastic, HFLC, high-fat low-cholesterol, Editorial, Liver, LD, lipid droplets, CON, control, Ac-FOXO1, acetylated forkhead box O1, LC3-II, LC3-phosphatidylethanolamine conjugate, qPCR, quantitative polymerase chain reaction, SILAC, stable isotope labeling technology of amino acids in cell culture, Signal Transduction, SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, Mice, Transgenic, Diet, High-Fat, FOXO1, forkhead box O1, CE, cholesterol ester, SIRT1, Sirtuin 1, Text mining, Cell Line, Tumor, NAFLD, Autophagy, Animals, Humans, lcsh:RC799-869, DGAT2, diacylglycerol O-acyltransferase 2, GRB2, growth factor receptor-bound protein 2, Hepatology, business.industry, Lipogenesis, Tupaiidae, OA, oleic acid, Lipid Metabolism, medicine.disease, WT, wild-type, Disease Models, Animal, MS, mass spectrometry, S100A11, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats/cas9, Hepatocytes, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, business
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المؤلفون: Ching Hsia Hung, Yung Hsin Cheng, Huei Chen Lin, Jhih Yuan Shih, Shih Hung Chan, Kun Ling Tsai, Pei-Ling Hsieh, Pei Ming Chu
المصدر: Redox Biology
Redox Biology, Vol 14, Iss, Pp 116-125 (2018)مصطلحات موضوعية: 0301 basic medicine, and AMPK, AMP-activated protein kinase, Male, rac1 GTP-Binding Protein, CAD, coronary artery disease, Clinical Biochemistry, 030204 cardiovascular system & hematology, medicine.disease_cause, Biochemistry, Coronary artery disease, Mice, 0302 clinical medicine, Methionine, Sirtuin 1, Malondialdehyde, lcsh:QH301-705.5, LOX-1, lectin-like oxidized low density lipoprotein receptor-1, lcsh:R5-920, NADPH oxidase, biology, GPx, glutathione peroxidase, NF-kappa B, Scavenger Receptors, Class E, Up-Regulation, medicine.anatomical_structure, NADPH Oxidase 1, medicine.symptom, lcsh:Medicine (General), Research Paper, Signal Transduction, Hyperhomocysteinemia, medicine.medical_specialty, Endothelium, SIRT1, sirtuin 1, Carbazoles, Inflammation, 03 medical and health sciences, Internal medicine, Physical Conditioning, Animal, PKC, protein kinase C, medicine, Animals, Protein kinase B, business.industry, Superoxide Dismutase, Organic Chemistry, Neuropeptides, AMPK, Hcy, homocysteine, medicine.disease, HHcy, hyperhomocysteinemia, Atherosclerosis, SOD, superoxidase dismutase, Mice, Inbred C57BL, Oxidative Stress, 030104 developmental biology, Endocrinology, lcsh:Biology (General), biology.protein, Endothelium, Vascular, business, Oxidative stress
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المؤلفون: Rita Valenzuela, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Begoña Villar-Cheda, Maria A. Costa-Besada
المصدر: Progress in Neurobiology
مصطلحات موضوعية: 0301 basic medicine, Intracrine, NO, mitochondrial nitric oxide, Intracellular Space, Review Article, Cell biology/structural biology, PGC-1α, peroxisome proliferator-activated receptor γ co-activator 1 α, Renin-Angiotensin System, Angiotensin, 0302 clinical medicine, ACE, angiotensin converting enzyme, AT1, ang II type 1 receptor, NOS, nitric oxide synthase, Nox, NADPH-oxidase complex, SHRs, spontaneously hypertensive rats, General Neuroscience, Dopaminergic, AREs, antioxidant response elements, Mitochondria, CNS, Central Nervous System, OS, oxidative stress, AT2, ang II type 2 receptor, mitoKATP, mitochondrial ATP-sensitive potassium channels, Intracellular, medicine.drug, GCPR, G-protein coupled receptor, SIRT1, sirtuin 1, Biology, Nucleus, ER, endoplasmic reticulum, 03 medical and health sciences, Paracrine signalling, Cell signaling/signal transduction, ROS, reactive oxygen species, Dopamine, Renin–angiotensin system, PRR, prorenin receptors, medicine, Extracellular, Animals, Humans, ACE/angiotensin receptors/renin angiotensin system, IGF-1, insulin-like growth factor 1, Ang II, angiotensin II, SARS-CoV-2, Dopaminergic Neurons, COVID-19, RAS, renin-angiotensin system, Oxidative Stress, 030104 developmental biology, NAC, N-acetyl cysteine, NFE2, L2, nuclear factor- erythroid 2 related factor 2, Oxidant stress, Neuroscience, 030217 neurology & neurosurgery, Homeostasis
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المؤلفون: Ruijuan Guan, Defu Li, Jian Wang, Hongwei Yao, Ziying Li, Zhou Cai, Wenju Lu, Bingxian Deng, Jingyi Xu, Lan Wang, Wei Liu, Yuanyuan Li
المصدر: Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)مصطلحات موضوعية: 0301 basic medicine, Male, Clinical Biochemistry, CS, cigarette smoke, medicine.disease_cause, Biochemistry, Transactivation, Mice, 0302 clinical medicine, Sirtuin 1, Smoke, Hydrogen Sulfide, lcsh:QH301-705.5, lcsh:R5-920, biology, Chemistry, Airway remodeling, MMP, matrix metalloproteinase, TGF-β1, transforming growth factor-β1, Collagen, Signal transduction, lcsh:Medicine (General), EMT, epithelial-mesenchymal transition, Signal Transduction, Research Paper, Epithelial-Mesenchymal Transition, FSP-1, fibroblast specific protein-1, NAC, N-Acetyl-l-cysteine, Cell Line, α-SMA, α-smooth muscle actin, H2S, hydrogen sulfide, 03 medical and health sciences, SIRT1, Sirtuin 1, ROS, reactive oxygen species, Downregulation and upregulation, In vivo, Tobacco, medicine, Animals, Humans, COPD, Epithelial–mesenchymal transition, SOD2, superoxide dismutase 2, MDA, malondialdehyde, Organic Chemistry, In vitro, respiratory tract diseases, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), Gene Expression Regulation, COPD, chronic obstructive pulmonary disease, CK, Cytokeratin, biology.protein, Cancer research, TGFβR1, TGF-β1 receptor type Ⅰ, CAT, catalase, CSE, cigarette smoke extract, 030217 neurology & neurosurgery, Oxidative stress
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المؤلفون: Mercedes Lopez-Santalla, Juan A. Bueren, Marina I. Garin
المصدر: EBioMedicine, Vol 69, Iss, Pp 103427-(2021)
EBioMedicineمصطلحات موضوعية: Oncology, ID, intradermal, RANTES, regulated upon activation normal T cells expressed and presumably secreted, AS, arthritis score, RA, rheumatoid arthritis, PPAR, peroxisome proliferator-activated receptor, Etanercept, TNF-α, tumour necrosis factor α, Bzb, bortezomib, iLNs, inguinal lymph nodes, CXCR3, chemokine receptor 3-alternative, BMZ, betamethasone, Medicine, CIA, collagen-induced arthritis, PP, peyer's patch, GIP, gastric inhibitory polypeptide, D, days, EVs, extracellular vesicles, Mtx, methotrexate, mAIA, antigen-induced arthritis in mouse, MTC, Masson´s trichrome, 030220 oncology & carcinogenesis, Rheumatoid arthritis, CTLA4, cytotoxic T lymphocyte antigen, iNOS, inducible nitric oxide synthase, KC, keratinocyte chemo-attractant, OCPs, osteoclast precursors, MCP-1, monocyte chemotactic protein 1, PTPN22, protein tyrosine-phosphatase 22, medicine.medical_specialty, rAIA, adjuvant-induced arthritis in rats, MensMSCs, MSCs from menstrual fluid, BM-MSCs, MSCs from bone marrow, MIP-2, macrophage inflammatory protein 2, 03 medical and health sciences, R5-920, IP10, IFN-γ-induced protein 10, IM, intramuscular, NRP-1, neuropilin-1, S, syngeneic, ESR, erythrocyte sedimentation rate, MPs, microparticles, PBMCs, peripheral blood mononuclear cells, AD, adipose tissue, MVs, microvesicles, P, placenta, sCIA, collagen-induced arthritis in sheep, Bregs, regulatory B cells, X, xenogeneic, Improvements in MSC-based therapy, AD-MSCs, MSCs from adipose tissue, 030104 developmental biology, TF, tissue factor, Protocols, Gilz, glucocorticoid-induced leucine zipper, DM, dexamethasone, STAT3, signal transducer and activator of transcription 3, ANA, Anti-nuclear antibodies, SAA, serum amyloid-A, ERDF, European Regional Development Fund, µCT, micro computed tomography imaging, Arthritis, Rheumatoid, T-AOC, total antioxidant capacity, rCIA, collagen-induced arthritis in rats, ISCT, international society for cellular therapy, NF-κB, nuclear factor-kappa B, RORγT, retinoic acid-related orphan receptor, TCR, T cell receptor, OVAIA, ovalbumin-induced arthritis, UC, umbilical cord, CAIA, collagen-antibody induced arthritis, Flk, tyrosine kinase receptor for vascular endothelial growth factor, IDO, indoleamine 2,3-dioxygenase, MMP, matrix metalloproteinase, Tr1, IL-10-expressing T cells, SM, synovial membrane, medicine.anatomical_structure, IAA, indoleacetic acid, MPCs, mesenchymal precursor cells, SNP, sodium nitroprusside, medicine.drug, NA, not available, IL-1RA, IL-1 receptor antagonist, CD, cluster of differentiation, DMARDs, antirheumatic drugs, TBO, toluidine blue O, =, similar to or equal, SM-MSCs, MSCs from synovial membrane, Mesenchymal Stem Cell Transplantation, PB, peripheral blood, G, gingiva tissue, IFA, incomplete Freund´s adjuvant, OVA, ovalbumin, MSCs, mesenchymal stem/ stromal cells, SO, safranin, TRAF, tumour necrosis factor receptor-associated factor, Animals, SP, spleen, ILA, indole-3-lactic acid, mBSA, methylated bovine serum albumin, business.industry, F, female, SF, synovial fluid, Th, T helper cells, TLR, toll-like receptors, BM, bone marrow, Bone marrow, Synovial membrane, MRI, magnetic resonance imaging, WT, wild type, Medicine (General), IHC, immunohistochemical analysis, Review, miR, microRNA, TRACP, tartrate-resistant acid phosphatase, AAV, adeno-associated virus, 0302 clinical medicine, GSH, glutathione, SVF, stromal vascular fraction, H/E, haematoxylin/eosin staining, GITR, glucocorticoid-induced tumour necrosis factor receptor, pLNs, popliteal lymph nodes, FOXP3, General Medicine, IFI, indirect immunofluorescence, Tregs, regulatory T cells, M, male, RF, rheumatoid factor, RNA, ribonucleic acid, TNFR, tumour necrosis factor receptor, <, worse than, IP, intraperitoneal, NuMa, nuclear mitotic apparatus, COMP, cartilage oligomeric matrix protein, GSH-Px, glutathione peroxidase, >, better than, LP, lamina propria, LPS, lipopolysaccharide, IN, intranodal, AT, antithrombin, General Biochemistry, Genetics and Molecular Biology, CM, conditioned medium, Consec., consecutive, RAGE, receptor for advanced glycation products, ETN, etanercept, Humans, dLNs, draining lymph nodes, MDA, malondialdehyde, IFN-γ, interferon gamma, ALP, alkaline phosphatase, HSCs, hematopoietic stem cells, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, EMA, European medicine agency, IL, interleukin, CFA, Freund's complete adjuvant, DAB, 3,3´-diaminobenzidine, OPG, osteoprotegerin, HMGB-1, high-mobility group box-1, CRP, C reactive protein, Tol-DCs, tolerogenic dendritic cells, 0301 basic medicine, CII, collagen II, SF-MSCs, MSCs from synovial fluid, MPO, myeloperoxidease, A, allogeneic, LDL, low density lipoprotein, APCP, α, β methylene selective A2A adenosine receptor competitive antagonist (CD73 inhibitor), Translational Research, Biomedical, SSEA, severe spontaneous erosive arthritis, mLNs, mesenteric lymph nodes, PGIA, proteoglycan-induced arthritis, Exos, small vesicles/Exosomes, FOXP3, forkhead box P3, RANKL, receptor activator of nuclear factor κB ligand, TGF-β, transforming growth factor β, Stromal vascular fraction, NSAIDs, non-steroidal anti-inflammatory drugs, VEGF, vascular endothelial growth factor, Animal models, AhR, aryl hydrocarbon receptor, DCs, dendritic cells, IV, intravenous, Stromal cell, IA, intra-articular, SIRT1, sirtuin 1, O-MSCs, MSCs from nasal tissue, PA, peri-articular, Tfh, follicular T helper cells, AxLNs, axillar lymph nodes, NK, natural killer cells, T-MSCs, MSCs from tonsil tissue, SOD, superoxide dismutase, Internal medicine, MHC, major histocompatibility complex, GLP-1, glucagon-like peptide 1, G-MSCs, MSCs from gingiva tissue, Mesenchymal stem/stromal cells, PG, proteoglycan, HLA-II, human leukocyte antigen-II, PLGA, poly-lactic-co-glycolic acid, HDL, high density lipoprotein, Ig, immunoglobulin, SC, subcutaneous, P-MSCs, MSCs from placenta tissue, POM-1, sodium polyoxotungstate (CD39 inhibitor), UC-MSCs, MSCs from umbilical cord, business, sIL6R, soluble IL-6 receptor