المؤلفون: Mohammed L. Abba, Vladimir Riabov, Daniel Nowak, Wolf-Karsten Hofmann, Tobias Boch

المصدر: Frontiers in Oncology, Vol 14 (2024)

مصطلحات موضوعية: myelodysplastic neoplasms, erythroferrone, iron overload, SF3B1 mutations, hepcidin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1404817/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/831c8603311d446a8091d0cdad71b2c6

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/journal_contribution/Summary_of_SF3B1_mutations_in_human_cancers_/16914036

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s012

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/journal_contribution/RNA-seq_samples_and_reads_in_this_study_/16914039

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s013

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/journal_contribution/Primers_used_in_this_study_/16914054

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s018

المؤلفون: Dogrusoz, Mehmet, Brouwer, Niels J., de Geus, Stefan J. R., Ly, Long, Böhringer, Stefan, van Duinen, Sjoerd G., Kroes, Wilma G. M., van der Velden, Pieter A., Haasnoot, Geert W., Marinkovic, Marina, Luyten, Gregorius P. M., Kivelä, Tero T., Jager, Martine J.

المساهمون: HUS Head and Neck Center, Silmäklinikka, University of Helsinki, Helsinki University Hospital Area

مصطلحات موضوعية: oncology, tumor, ocular, prognosis, genetics, CILIARY BODY, REPRODUCTIVE FACTORS, CHOROIDAL MELANOMA, SF3B1 MUTATIONS, SURVIVAL, DEATH, PREDICTORS, MONOSOMY-3, WOMEN, RISK, Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

Relation: Supported by grants from the Eye Cancer Foundation (New York, NY, USA), Stichting Blindenpenning (the Netherlands), Horizon 2020 grant no. 667787 UM CURE (European Commission), and the Sigrid Juselius Foundation (Finland). The authors alone are responsible for the content and writing of the paper.; Dogrusoz , M , Brouwer , N J , de Geus , S J R , Ly , L , Böhringer , S , van Duinen , S G , Kroes , W G M , van der Velden , P A , Haasnoot , G W , Marinkovic , M , Luyten , G P M , Kivelä , T T & Jager , M J 2020 , ' Prognostic Factors Five Years After Enucleation for Uveal Melanoma ' , Investigative Ophthalmology & Visual Science , vol. 61 , no. 3 , 31 . https://doi.org/10.1167/iovs.61.3.31; http://hdl.handle.net/10138/314718; 2e517220-a3b1-4991-9b7f-c832f0a90fbd; 000524168000031

الاتاحة: http://hdl.handle.net/10138/314718

المؤلفون: Sebastian Grosicki, Fritz Offner, Ira Gupta, Ann Janssens, Panagiotis Panagiotidis, Hartmut Döhner, Daniel Mertens, Alexandra Skorupa, Billy J. Jebaraj, Celine Pallaud, Eugen Tausch, Lars Bullinger, Jiri Mayer, Richard F. Schlenk, Deyan Y. Yosifov, Anna Dolnik, Astrid McKeown, Stephan Stilgenbauer, Peter Hillmen, Philipp Beck, K Govind Babu

المصدر: Haematologica
HAEMATOLOGICA

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Chronic lymphocytic leukemia, NOTCH1 MUTATIONS, Gene mutation, Ofatumumab, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, SF3B1 MUTATIONS, Internal medicine, Multicenter trial, Medicine and Health Sciences, medicine, Humans, TP53, Prospective Studies, Receptor, Notch1, CLINICAL IMPACT, Prospective cohort study, BIRC3, Univariate analysis, Science & Technology, Chlorambucil, business.industry, Editorials, Hematology, OPEN-LABEL, Phosphoproteins, Prognosis, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Fludarabine, RECURRENT MUTATIONS, chemistry, 030220 oncology & carcinogenesis, Mutation, SURVIVAL, RNA Splicing Factors, FLUDARABINE, business, Life Sciences & Biomedicine, CLL, 030215 immunology, medicine.drug

وصف الملف: application/pdf; Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dafcc78b6b6cdc7eabcd184a2827bed
https://doi.org/10.3324/haematol.2019.229161

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Construction_of_i_sf3b1-H698D_i_and_i_-H698R_i_mutant_strains_/16914000

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s001

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/The_i_sf3b1-698_i_mutants_are_defective_in_fecundity_and_lifespan_/16914003

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s002

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Total_numbers_of_DS_events_in_the_two_i_sf3b1-H698_i_mutants_/16914009

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s004

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Validation_of_AS_changes_in_the_two_sf3b1_mutant_strains_by_RT-PCR_/16914012

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s005

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Scatter_plots_of_significantly_changed_AS_events_from_genes_that_are_involved_in_neural_development_in_the_i_sf3b1-H698_i_mutants_/16914015

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s006

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Sashimi_plots_of_six_alternative_splicing_changed_genes_in_the_i_WT_i_and_i_sf3b1-H698_i_mutant_strains_/16914018

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s007

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Alternative_splicing_isoforms_of_the_i_Mef2_i_gene_in_i_Drosophila_i_/16914021

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s008

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Significantly_changed_USSs_in_the_sf3b1_mutants_/16914024

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s009

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/The_H662_residue_of_SF3B1_interacts_with_the_pre-mRNA_in_the_activated_spliceosomal_B_sup_act_sup_complex_/16914033

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s011

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/Identification_of_used_branch_sites_and_their_frequencies_in_the_i_WT_i_and_i_sf3b1-H698_i_mutant_strains_/16914027

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s010

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/dataset/Significantly_changed_gene_expression_in_the_i_sf3b1_i_mutants_/16914042

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s014

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/dataset/Significantly_changed_AS_events_in_the_i_sf3b1_i_mutants_/16914045

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s015

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/dataset/Significantly_changed_AS_events_in_the_muscle_and_neural-related_genes_in_the_i_sf3b1_i_mutants_/16914048

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.s016

المؤلفون: Bei Zhang (428038), Zhan Ding (3799741), Liang Li (46069), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Yong-Zhen Xu (6428087)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Developmental Biology, Biological Sciences not elsewhere classified, notable opposite charges, lariat sequencing reveals, intronic branch sites, including less egg, impaired immune response, hotspot mutation sites, div >< p, corresponding residue his698, immune response genes, decreased hatching rates, splicing changes caused, changed alternative splicing, >, partly rescues, sf3b1 mutations occur, related genes, decreased resistance, two mutations, vivo evidence, study provides, shorter lifespans, sf3b1 <

Relation: https://figshare.com/articles/figure/_i_sf3b1_i_mutant_strains_are_defective_in_reproduction_development_and_fungi-infection_resistance_/16914060

الاتاحة: https://doi.org/10.1371/journal.pgen.1009861.g002