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    المساهمون: The present study was conducted as part of the implementation of the topic of the State task “Development of a new device for supplying nitric oxide synthesized from atmospheric air to artificial and auxiliary blood circulation devices”, No. 123021000129-1., Настоящее исследование проведено в рамках выполнения темы Государственного задания «Разработка нового устройства для подачи оксида азота, синтезированного из атмосферного воздуха, в аппараты искусственного и вспомогательного кровообращения», № 123021000129-1.

    المصدر: Translational Medicine; Том 11, № 2 (2024); 181-190 ; Трансляционная медицина; Том 11, № 2 (2024); 181-190 ; 2410-5155 ; 2311-4495

    وصف الملف: application/pdf

    Relation: https://transmed.almazovcentre.ru/jour/article/view/915/566; Phillips J, Henderson AC. Hemolytic Anemia: Evaluation and Differential Diagnosis. Am Fam Physician. 2018 Sep 15; 98(6):354–361. PMID: 30215915.; Cook LS. The Many Faces of Hemolysis. J Infus Nurs. 2023 Jan-Feb 01; 46(1):14–27. DOI:10.1097/NAN.0000000000000491. PMID: 36571824.; Spina S, Lei C, Pinciroli R, Berra L. Hemolysis and Kidney Injury in Cardiac Surgery: The Protective Role of Nitric Oxide Therapy. Semin Nephrol. 2019 Sep; 39(5):484–495. DOI:10.1016/j.semnephrol.2019.06.008. PMID: 31514912.; Kristiansen M, Graversen JH, Jacobsen C, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001 Jan 11; 409(6817):198–201. DOI:10.1038/35051594. PMID: 11196644.; Morris CR, Kato GJ, Poljakovic M, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA. 2005 Jul 6;294(1):81–90. DOI:10.1001/jama.294.1.81.; Boucher JL, Moali C, Tenu JP. Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol Life Sci. 1999 Jul;55(8-9):1015–28. DOI:10.1007/s000180050352. PMID: 10484661.; Landburg PP, Teerlink T, Biemond BJ, et al. CURAMAstudy group. Plasma asymmetricdimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype. Blood Cells Mol Dis. 2010 Apr 15; 44(4):229–32. DOI:10.1016/j.bcmd.2010.02.005.; Roumenina LT, Rayes J, Lacroix-Desmazes S, Dimitrov JD. Heme: Modulator of Plasma Systems in Hemolytic Diseases. Trends Mol Med. 2016 Mar; 22(3):200– 213. DOI:10.1016/j.molmed.2016.01.004.; Belcher JD, Chen C, Nguyen J, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014 Jan 16; 123(3):377–90. DOI:10.1182/blood-2013-04-495887.; Chen G, Zhang D, Fuchs TA, et al. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood. 2014 Jun 12;123(24):3818–27. DOI:10.1182/blood-2013-10-529982.; Schaer DJ, Buehler PW, Alayash AI, et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013;121(8):1276–1284. DOI:10.1182/blood-2012-11-451229.; Reiter CD, Wang X, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat. Med. 2002; 8, 1383–1389. DOI:10.1038/nm1202-799.; Мальцева И.В. Характеристика резистентности эритроцитов у кардиохирургических больных с различной степенью гемолиза. Бюллетень сибирской медицины. 2013; 12(1):69–74. https://doi.org/10.20538/1682-0363-2013-1-69-74; Козловский В.И., Акулёнок А.В. Низкоинтенсивный внутрисосудистый гемолиз при атеросклерозе и артериальной гипертензии // Монография – Витебск: ВГМУ, 2016. С. 281.; Дементьева И.И., Морозов Ю.А., Чарная М.А. Интраоперационное повышение концентрации свободного гемоглобина в плазме крови (гемолиз) в кардиохирургии. Кардиология и сердечно-сосудистая хирургия. 2008; 6:60–63.; Чумакова С.П., Шипулин В.М., Уразова О.И. и др. Влияние механической резистентности эритроцитов на выраженность гемолиза после операции с искусственным кровообращением. Патология кровообращения и кардиохирургия. 2012; 1:65–69.; Баутин А.Е., Маричев А.О., Карпова Л.И. и др. Факторы, определяющие динамику содержания свободного гемоглобина в плазме крови при выполнении кардиохирургических вмешательств в условиях искусственного кровообращения: проспективное наблюдательное исследование. Вестник интенсивной терапии им. А. И. Салтанова. 2024;1:69–81.; Huen SC, Parikh CR. Predicting acute kidney injury after cardiac surgery: a systematic review. Ann Thorac Surg. 2012 Jan; 93(1):337–47. DOI:10.1016/j.athoracsur.2011.09.010.; Vermeulen Windsant IC, Snoeijs MG, Hanssen SJ, et al. Hemolysis is associated with acute kidney injury during major aortic surgery. Kidney Int. 2010 May; 77(10):913–20. DOI:10.1038/ki.2010.24.; Minneci PC, Deans KJ, Zhi H, et al. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005;115(12):3409–3417. DOI:10.1172/JCI25040.; Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide. 2009 Mar;20(2):88–94. DOI:10.1016/j.niox.2008.10.005.; Meegan JE, Bastarache JA, Ware LB. Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L429–L439. DOI:10.1152/ajplung.00018.2021.; Wang D, Piknova B, Solomon SB, et al. In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion. 2013 Dec;53(12):3149–63. DOI:10.1111/trf.12162.; Мухамадияров Р.А., Кривая Е.В., Круч М.А., Плотников М.Б. Оценка препаратами на модели осмотического гемолиза // Современные проблемы науки и образования. 2012. № 4. URL: https://science-education.ru/ru/article/view?id=6862; Баутин А.Е., Селемир В.Д., Шафикова А.И. и др. Оценка клинической эффективности и безопасности терапии оксидом азота, синтезированным из атмосферного воздуха, в послеоперационном периоде кардиохирургических вмешательств. Трансляционная медицина. 2021;8(1):38–50. DOI:10.18705/2311-4495-2021-8-1-38-50. https://doi.org/10.18705/2311-4495-2021-8-1-38-50; Буранов С.Н., Карелин В.И., Селемир В.Д. и др. Аппарат для ингаляционной NO-терапии. Приборы и техника эксперимента. 2019;5:158–159. DOI:10.1134/s0032816219040037.; Niebler RA, Chiang-Ching H, Daley K, et al. Nitric oxide added to the sweep gas of the oxygenator during cardiopulmonary bypass in infants: A pilot randomized controlled trial. Artif Organs. 2021 Jan;45(1):22–28. DOI:10.1111/aor.13788.; Figueiredo LF, Mathru M, Jones JR, et al. Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results. Crit Care. 1997;1(3):111–116. DOI:10.1186/cc114.; https://transmed.almazovcentre.ru/jour/article/view/915

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    المصدر: Pedagogy, Psychology, Society; ; Педагогика, психология, общество: от теории к практике

    وصف الملف: text/html

    Relation: https://phsreda.com/e-articles/10516/Action10516-107445.pdf; Brodeur A., Gray D. A literature review of the Economics of COVID-19. june 2020. – 63 p. [Electronic resource]. – Access mode: https://docs.iza.org/dp13411.pdf; Donelly R., Patrinos H. A review of learning loss during COVID-19, 2021 [Electronic resource]. – Access mode: https://library.iated.org/view/ PATRINOS2021ARE; Garbe A., Ogurlu U., Logan N., & Cook P. (2020). COVID-19 and Remote Learning: Experiences of Parents with Children during the Pandemic. American Journal of Qualitative Research, 4 (3), 45–65 [Electronic resource]. – Access mode: https://doi.org/10.29333/ajqr/8471; Melissa Diliberti. Prepared for a Pandemic? How Schools' Preparedness Related to Their Remote Instruction During COVID-19. – 2020; Schools and society during the COVID-19 pandemic. – Springer; 1st ed. 2022. – 481р.; Reimers F. and Marmolejo F. (Eds.) University and School Collaborations during a Pandemic Sustaining Educational Opportunity and Reinventing Education. Cham, Switzerland: Springer, 2021.; Sandeep Kumar Mathivanan. Adoption of E-Learning during Lockdown in India // International Journal of System Assurance Engineering and Management, 24 February 2021.; https://phsreda.com/files/Books/10516/Cover-10516.jpg?req=107445; https://phsreda.com/article/107445/discussion_platform

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    المساهمون: This work was supported by the Russian Foundation for Basic Research and Government of Novosibirsk region of the Russian Federation, grant 18-415-540012, Исследование выполнено при финансовой поддержке РФФИ и Правительства Новосибирской области в рамках научного проекта № 18-415-540012р_а

    المصدر: Siberian journal of oncology; Том 19, № 2 (2020); 49-61 ; Сибирский онкологический журнал; Том 19, № 2 (2020); 49-61 ; 2312-3168 ; 1814-4861 ; 10.21294/1814-4861-2020-19-2

    وصف الملف: application/pdf

    Relation: https://www.siboncoj.ru/jour/article/view/1398/728; WittenM., Parker C.C. Screening mammography: recommendations and controversies. Surg Clin North Am. 2018 Aug; 98(4): 667-75. doi:10.1016/j.suc.2018.03.003.; Tamkovich S.N., Tutanov O.S., LaktionovP.P. Exosomes: generation, structure, transport, biological activity, and diagnostic application. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 2016 Oct; 10(3): 163-73. doi:10.1134/S1990747816020112.; Yanez-MoM., Siljander P.R., Andreu Z., Zavec A.B., BorraF.E., Bu-zasE.I., BuzasK., CasalE., CappelloF., Carvalh o J., ColaE., SilvaA.C. Fais S., Falcon-Perez J.M., Ghobrial IM., Giebel B., Gimona M., Gra-ner M., Gursel I., Gursel M., Heegaard N.H.H., Hendrix A., Kierulf P., KokubunK., KosanovicM., Kralj-Iglic V, Kramer-AlbersE.-M, Laitinen S., Lasser S., Lener T., Ligeti E., Line A., Lipps G., Llorente A., Lotvall J., Mancek-Keber M., Marcilla A., Mittelbrunn M., Nazarenko I., Hoen E.N.M., Nyman T.A., O’Driscoll L., Olivan M., Oliveira C., Pall-inger E., del Portillo HA., Reventos J., Rigau M., Rohde E., Sammar M., Sanchez-Madrid F., Santarem N., Schallmoser K., Ostenfeld M.S., Stoorvo-gel W., StukeljR., Van der Grein S.G., VasconcelosM.H., WaubenM.H.M., De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015 May; 4: 27066. doi:10.3402/jev.v4.27066.; Aghebati-Maleki A., Nami S., Baghbanzadeh A., Karzar B.H., Noorolyai S., FotouhiA., Aghebati-MalekiL. Implications of exosomes as diagnostic and therapeutic strategies in cancer. J Cell Physiol. 2019 Jun. doi:10.1002/jcp.28875.; Clark D.J., Fondrie W.E., Liao Z., Hanson P.I., Fulton A., Mao L., YangA.J. Redefining the breast cancer exosome proteome by tandem mass tag quantitative proteomics and multivariate cluster analysis. Anal Chem. 2015 Oct; 87(20): 10462-9. doi:10.1021/acs.analchem.5b02586.; Pant S., Hilton H., Burczynski M.E. The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol. 2012 Jun; 83(11): 1484-94. doi:10.1016/j.bcp.2011.12.037.; Koumangoye R.B., SakweA.M., Goodwin J.S., Patel T., Ochieng J. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One. 2011 Sep; 6(9): e24234. doi:10.1371/journal.pone.0024234.; Tamkovich S.N., Bakakina Y.S., Tutanov O.S., Somov A.K., Ki-rushina N.A., Dubovskaya L.V., Volotovski I.D., Laktionov P.P. Proteome analysis of circulating exosomes in health and breast cancer. Russian Journal of Bioorganic Chemistry 2017 Jul; 43(2): 126-34. doi:10.1134/S1068162017020157.; ЛактионовП.П., Скворцова Т.Э., МорозкинЕ.С., Бондарь АА., МилейкоВ.А., Власов В.В.; ООО «ЦСБГеномика». Способ получения суммарной фракции внеклеточных нуклеиновых кислот из крови. Патент № 2554746 РФ, МПК G01N 33/48. № 2014120562/15; Заявл. 21.05.14; Опубл. 01.06.15.; GorgA., Weiss W. Horizontal SDS-PAGE for IPG-Dalt. Meth Mol Biol. 1999; 112: 235-44.; Blum H., Beier H., Gross H.J. Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis. 1987 Feb; 8(2): 93-9. doi:10.1002/elps.1150080203.; Tamkovich S.N., Serdukov D.S., Tutanov O.S., Duzhak T. G., Laktionov P.P. Identification of proteins in blood nucleoprotein complexes. 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Biochemistry (Moscow) Supplement Series. B. Biomedical. Chemistry. 2018 Oct; 12(2): 151-5. doi:10.1134/S1990750818020130.; Tamkovich S., Grigor’eva A., Eremina A., Tupikin A., Kabilov M., Chernykh V, Vlassov V, Ryabchikova E. What information can be obtained from the tears of a patient with primary open angle glaucoma? Clin Chem Acta 2019 Aug; 495: 529-37. doi:10.1016/j.cca.2019.05.028.; Wu A.Y., Ueda K., Lai C.P. Proteomic analysis of extracellular vesicles for cancer diagnostics. Proteomics. 2019 Jan; 19(1-2): e1800162. doi:10.1002/pmic.201800162.; Cufaro M.C., Pieragostino D., Lanuti P., Rossi C., Cicalini I., Federici L., De Laurenzi V., Del Boccio P. Extracellular vesicles and their potential use in monitoring cancer progression and therapy: the contribution of proteomics. J Oncol. 2019 Jun; 2019: 1639854. doi:10.1155/2019/1639854.; Boukouris S., Mathivanan S. Exosomes in bodily fluids are a highly stable resource of disease biomarkers. Proteomics Clin Appl. 2015 Apr; 9(3-4): 358-67. doi:10.1002/prca.201400114.; Nazarenko I., Rana S., Baumann A., McAlear J., Hellwig A., TrendelenburgM., Lochnit G., PreissnerK.T., ZollerM. Cell surface tet-raspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 2010 Feb; 70(4): 1668-78. doi:10.1158/0008-5472.CAN-09-2470.; Mathivanan S., Ji H., Simpson R.J. Exosomes: extracellular organelles important in intercellular communication. J Proteomics 2010 Sep; 73(10): 1907-20. doi:10.1016/j.jprot.2010.06.006.; Calzolari A., Raggi C., Deaglio S., Sposi N.M., Stafsnes M., Fecchi K., Parolini I., Malavasi F, Peschle C., Sargiacomo M., Testa U. TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway. J Cell Sci. 2006 Nov; 119: 4486-98.; Clayton A., Turkes A., Dewitt S., Steadman R., Mason M.D., Hal-lett M.B. Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 2004 Jun; 18(9): 977-9.; Danesh A., Inglis H.C., Jackman R.P., Wu S., Deng X., Muench M.O., Heitman J.W., Norris PJ. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood 2014 Jan; 123(5): 687-96. doi:10.1182/blood-2013-10-530469.; Minciacchi VR., FreemanM.R., Di VizioD. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large on-cosomes. Semin Cell Dev Biol. 2015 Apr; 40: 41-51. doi:10.1016/j.semcdb.2015.02.010.; Tamkovich S., Tutanov O., Efimenko A., Grigor’eva A., Ryabchikova E., Kirushina N., Vlassov V, Tkachuk V, Laktionov P. Blood circulating exosomes contain distinguishable fractions of free and cell-surface-associated vesicles. Curr Mol Med. 2019 Mar; 19(4): 273-85. doi:10.2174/1566524019666190314120532.; https://www.siboncoj.ru/jour/article/view/1398

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    المصدر: Scientific Reports
    Scientific reports, vol 11, iss 1
    Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

    وصف الملف: application/pdf

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