المؤلفون: David A. Candito (2169703), Yingchun Ye (2032282), Ryan V. Quiroz (10359236), Michael H. Reutershan (2470597), David Witter (10359239), Surendra B. Gadamsetty (10359242), Hongming Li (296020), Josep Saurí (1523239), Sebastian E. Schneider (2198083), Yu-hong Lam (1319184), Rachel L. Palte (8299626)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, heteroaryl group, PRMT 5 inhibitor program, late-stage glycosylation, 15 nM, PRMT 5-MEP, nucleoside analogues, Z 138 cell proliferation EC 50, 0.8 nM, Mitsunobu conditions, drug discovery programs, PRMT 5, Compound 1.1- C, PRMT 5 inhibitor, MCF -7 target engagement EC 50, work sets, Robust Synthesis, Wolfe type carboetherification, 3 nM, pyrrolopyrimidine base, furan Nucleoside Analogues, novel nucleoside chemical matter, IC 50, 1.3-

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Flexible_and_Robust_Synthesis_of_Tetrahydrofuro_3_4_i_b_i_furan_Nucleoside_Analogues/14272796

الاتاحة: https://doi.org/10.1021/acs.joc.0c02969.s001

المؤلفون: Ryan V. Quiroz (10359236), Michael H. Reutershan (2470597), Sebastian E. Schneider (2198083), David Sloman (10359430), Brian M. Lacey (2135143), Brooke M. Swalm (10359433), Charles S. Yeung (2302963), Craig Gibeau (1586212), Daniel S. Spellman (2649097), Danica A. Rankic (1858132), Dapeng Chen (528941), David Witter (10359239), Doug Linn (10359436), Erik Munsell (10359439), Guo Feng (413683), Haiyan Xu (148626), Jonathan M. E. Hughes (6912470), Jongwon Lim (163671), Josep Saurí (1523239), Kristin Geddes (10359442), Murray Wan (10359445), My Sam Mansueto (3384113), Nicole E. Follmer (10359448), Patrick S. Fier (1333728), Phieng Siliphaivanh (1822588), Pierre Daublain (1625986), Rachel L. Palte (8299626), Robert P. Hayes (9220508), Sandra Lee (273007), Shuhei Kawamura (1407448), Steven Silverman (10359451), Sulagna Sanyal (2918147), Timothy J. Henderson (2397364), Yingchun Ye (2032282), Yuanwei Gao (3951080), Benjamin Nicholson (2035678), Michelle R. Machacek (2639716)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel designs, Novel Classes, balancing bioavailability, structure-based drug designs, DNA repair, type II arginine methyltransferase, Additional efforts, optimization strategies, bicyclic nucleoside-derived classes, protein substrates, identification, dose projections, PRMT 5 activity, Cancer Protein arginine methyltrans., RNA, CYP 3A inhibition, strain energy calculations, compound docking, vivo activity, PRMT 5, PRMT 5 inhibitors

Relation: https://figshare.com/articles/journal_contribution/The_Discovery_of_Two_Novel_Classes_of_5_5-Bicyclic_Nucleoside-Derived_PRMT5_Inhibitors_for_the_Treatment_of_Cancer/14272906

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02083.s001

المؤلفون: David A Candito, David J. Witter, Josep Saurí, Yu-hong Lam, Surendra B Gadamsetty, Michael H. Reutershan, Yingchun Ye, Ryan V Quiroz, Sebastian Schneider, Rachel L. Palte, Hongming Li

المصدر: The Journal of Organic Chemistry. 86:5142-5151

مصطلحات موضوعية: Glycosylation, 010405 organic chemistry, Chemistry, Drug discovery, Organic Chemistry, Target engagement, Context (language use), Single step, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Furan, Yield (chemistry), Nucleoside

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2be696853f7f2484c20fd532369afef9
https://doi.org/10.1021/acs.joc.0c02969

المؤلفون: My Sam Mansueto, Brooke M Swalm, Patrick S. Fier, Rachel L. Palte, Sandra Lee, Kristin Geddes, Josep Saurí, Michael H. Reutershan, Charles S. Yeung, Benjamin Nicholson, David J. Witter, Murray Wan, Robert P Hayes, Haiyan Xu, David L. Sloman, Nicole Follmer, Daniel S. Spellman, Danica A. Rankic, Pierre Daublain, Timothy J. Henderson, Jongwon Lim, Dapeng Chen, Erik Munsell, Guo Feng, Steven M. Silverman, Ryan V Quiroz, Doug Linn, Sulagna Sanyal, Michelle R. Machacek, Craig R. Gibeau, Shuhei Kawamura, Yuanwei Gao, Jonathan M E Hughes, Sebastian Schneider, Phieng Siliphaivanh, Yingchun Ye, Brian M. Lacey

المصدر: Journal of medicinal chemistry. 64(7)

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, DNA repair, Antineoplastic Agents, Plasma protein binding, Computational biology, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Transcription (biology), Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Bicyclic molecule, Molecular Structure, Chemistry, Protein arginine methyltransferase 5, Nucleosides, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Docking (molecular), Drug Design, RNA splicing, Aminoquinolines, Molecular Medicine, Female, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9cca5e958fa221091b3803ef442cf
https://pubmed.ncbi.nlm.nih.gov/33755451

المؤلفون: Matthew C. Stevens, Ryan V. Quiroz, Paul A. Wender

المصدر: Accounts of Chemical Research

مصطلحات موضوعية: Biological Products, Chemical research, Extramural, Computer science, Management science, Organic chemicals, Nanotechnology, General Medicine, General Chemistry, Bryostatins, Ligands, Article, Drug Delivery Systems, Dna cleavage, Molecular function, Drug Design, Animals, Humans, DNA Cleavage, Organic Chemicals, Protein Kinase Inhibitors, Protein Kinase C

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67af73050a40969dd6beb1dcec4b41c1
https://doi.org/10.1021/acs.accounts.5b00004

المؤلفون: Steven M. Ryckbosch, Matthew S. Jeffreys, Paul A. Wender, Jack L. Sloane, Akira J. Shimizu, Matthew C. Stevens, Clayton Hardman, Jana K. Maclaren, Stephen Ho, Ryan V. Quiroz

المصدر: Science (New York, N.Y.). 358(6360)

مصطلحات موضوعية: Bryostatin 1, Longest linear sequence, Anti-HIV Agents, medicine.medical_treatment, Human immunodeficiency virus (HIV), HIV Infections, Computational biology, Biology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, Cancer immunotherapy, Adjuvants, Immunologic, medicine, Humans, Bryostatin, Disease Eradication, Multidisciplinary, 010405 organic chemistry, Extramural, Bryostatins, 0104 chemical sciences, Virus Latency, chemistry, Immunology, HIV-1, Adjuvant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3549dd319a2e3d199e88847e9f6f47
https://pubmed.ncbi.nlm.nih.gov/29026028

المؤلفون: Matthew S. Jeffreys, Dennis N. Fournogerakis, Ryan V. Quiroz, Magnus Pfaffenbach, Paul A. Wender, Fuyuhiko Inagaki

المصدر: Nature chemistry

مصطلحات موضوعية: chemistry.chemical_classification, Dual purpose, Molecular Structure, Diene, Stereochemistry, General Chemical Engineering, Alkyne, General Chemistry, Combinatorial chemistry, Article, Cycloaddition, Structural complexity, chemistry.chemical_compound, chemistry, Cyclization, Alkynes, Reagent, Molecule, Reactivity (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea27713eca4618a6d43bc3197ef4e2f
https://doi.org/10.1038/nchem.1917

المؤلفون: Alison D. Axtman, Jennifer E. Golden, Matthew C. Stevens, Lauren E. Sirois, Jung-Min Kee, Ryan V. Quiroz, Paul A. Wender

المصدر: Org. Chem. Front.. 1:1166-1171

مصطلحات موضوعية: Natural product, Chemistry, Kinase, Organic Chemistry, Cellular functions, Cycloaddition, chemistry.chemical_compound, Biochemistry, medicine, Staurosporine, Kinome, Protein kinase A, Function (biology), medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f50bd869f717ecfd549e7b602b8a88ce
https://doi.org/10.1039/c4qo00228h

المؤلفون: Ryan V. Quiroz, Fuyuhiko Inagaki, Magnus Pfaffenbach, Matthew S. Jeffreys, Dennis N. Fournogerakis, Paul A. Wender

المصدر: ChemInform. 45

مصطلحات موضوعية: chemistry.chemical_classification, Reaction conditions, chemistry.chemical_compound, Dual purpose, chemistry, Diene, Reagent, Alkyne, Reactivity (chemistry), General Medicine, Combinatorial chemistry, Cycloaddition, Structural complexity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::158a5689f8498050120cda62d8661991
https://doi.org/10.1002/chin.201441032