نتائج البحث - "Ruprecht Zierz"

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Academic Journal

IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

المؤلفون: Dennis Kirchhoff, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Antje Margret Wengner, Oliver von Ahsen, Pascale Buchmann, Stephan Märsch, Christoph Mahlert, Simone Greven, Lisa Dietz, Michael Erkelenz, Ruprecht Zierz, Sandra Johanssen, Dominik Mumberg, Anette Sommer

المصدر: Cancers; Volume 12; Issue 11; Pages: 3464

مصطلحات موضوعية: acute myeloid leukemia, antibody-drug conjugate, CD123, IL3RA, kinesin spindle protein inhibitor

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers12113464

الاتاحة: https://doi.org/10.3390/cancers12113464

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2

Supplementary Materials and Methods and Supplementary Figure Legends from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c478be8710ef66729548c4c9955f34ef
https://doi.org/10.1158/0008-5472.22413215

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3

Data from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44ebc0b49659b36c8a0e1db50afdb784
https://doi.org/10.1158/0008-5472.c.6508652.v1

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4

Supplementary Figure S2 from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a269fcddc4ad2bbabdf8b05b57ef15
https://doi.org/10.1158/0008-5472.22413218

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Supplementary Table S1 from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f3b511ae57fea3e60618670122dbb8
https://doi.org/10.1158/0008-5472.22413212.v1

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6

Antibody-drug Conjugates with Novel Kinesin Spindle Protein Inhibitor Payloads and a Tailor-made Linker Chemistry

المؤلفون: Dennis Kirchhoff, Sandra Johanssen, Pascale Lejeune, Hannah JÖRIßEN, Stephan Märsch, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Leo Marx, Anette Sommer, Lisa Dietz, Ruprecht Zierz, Anne-Sophie Rebstock, Sven Wittrock, Simone Greven

المصدر: ADC Review / Journal of Antibody-drug Conjugates.

مصطلحات موضوعية: Drug, biology, Chemistry, Proteinase inhibitor, Mechanical Engineering, media_common.quotation_subject, Energy Engineering and Power Technology, Management Science and Operations Research, body regions, Biochemistry, Hardware_INTEGRATEDCIRCUITS, biology.protein, Kinesin, Hardware_ARITHMETICANDLOGICSTRUCTURES, Antibody, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION, Linker, media_common, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e82f03c28658701b2284dce2d292d811
https://doi.org/10.14229/jadc.2019.11.12.002

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7

Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

المصدر: Cancer Research. 76:6331-6339

مصطلحات موضوعية: musculoskeletal diseases, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, Antibody-drug conjugate, Immunoconjugates, medicine.drug_class, Pharmacology, Biology, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Cytotoxic T cell, Potency, Aminobenzoates, Receptor, Fibroblast Growth Factor, Type 2, Mice, Inbred BALB C, integumentary system, Antibodies, Monoclonal, Cancer, medicine.disease, Xenograft Model Antitumor Assays, stomatognathic diseases, 030104 developmental biology, Oncology, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, embryonic structures, Monoclonal, Female, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f282dd79ad32afbccf3ff32c85dd67f
https://doi.org/10.1158/0008-5472.can-16-0180

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Abstract 1771: BAY 1834942 is an immunotherapeutic antibody blocking the novel immune checkpoint regulator CEACAM6 (CD66c)

المصدر: Cancer Research. 78:1771-1771

مصطلحات موضوعية: Cancer Research, Tumor-infiltrating lymphocytes, T cell, ZAP70, Cancer, Biology, medicine.disease, Immune checkpoint, medicine.anatomical_structure, Oncology, Pancreatic cancer, medicine, Cancer research, Adenocarcinoma, Tumor necrosis factor alpha

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34ee3a37f29cde47828164a13773f746
https://doi.org/10.1158/1538-7445.am2018-1771

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Abstract 2089: Therapeutic index prediction of the agonistic aglycosylated TWEAK receptor binding antibody BAY-356

المؤلفون: Lisa Dietz, Ruprecht Zierz, Anders Viberg, Sandra Berndt, Sabine Wittemer-Rump, Eva L. Hanze

المصدر: Cancer Research. 76:2089-2089

مصطلحات موضوعية: Cancer Research, Bladder cancer, business.industry, Cancer, Pharmacology, medicine.disease, NONMEM, Therapeutic index, Oncology, Pharmacokinetics, Tolerability, Toxicity, medicine, Dosing, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5fdd71ed734b5e65a611293618be0c53
https://doi.org/10.1158/1538-7445.am2016-2089

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Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356

المؤلفون: Bertolt Kreft, Berndt Sandra, Anna-Lena Frisk, Stefanie Hammer, Jakob Walter, Heiner Apeler, Ruprecht Zierz, Christian Votsmeier

المصدر: Cancer Research. 76:1210-1210

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0fdae28590dd9547a030278b557902a4
https://doi.org/10.1158/1538-7445.am2016-1210

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Abstract 1683: Pharmacokinetic/pharmacodynamic (PK/PD) and toxicokinetic/toxicodynamic (TK/TD) modeling of preclinical data of FGFR2-ADC (BAY 1187982) to guide dosing in phase 1

المؤلفون: Klaas Prins, Charlotte Christine Kopitz, Ruprecht Zierz, Jörg Lippert, Manuela Braun, D. Laurent, Kirstin Meyer, Anette Sommer, Christoph Schatz, Hung Huynh, Sabine Wittemer-Rump

المصدر: Cancer Research. 75:1683-1683

مصطلحات موضوعية: Cancer Research, Antibody-drug conjugate, business.industry, Pharmacology, Regimen, Therapeutic index, Oncology, Pharmacokinetics, Pharmacodynamics, Toxicity, Medicine, Dosing, business, PK/PD models

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ef3ab31b1a8889eae85bc936628eb9c
https://doi.org/10.1158/1538-7445.am2015-1683

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12

Abstract 1684: Preclinical anti-tumor efficacy of FGFR2-ADC BAY 1187982 in patient-derived gastric, breast and ovarian cancer models

المؤلفون: Joachim Schuhmacher, Frank Reetz, Manuela Braun, Klaas Prins, Bertolt Kreft, Anette Sommer, Charlotte Christine Kopitz, Ruprecht Zierz, Hung Huynh, Karl Ziegelbauer, Christoph Schatz, Sabine Wittemer-Rump

المصدر: Cancer Research. 75:1684-1684

مصطلحات موضوعية: musculoskeletal diseases, Oncology, Cancer Research, medicine.medical_specialty, Fibroblast growth factor receptor 2, Colorectal cancer, business.industry, Cancer, medicine.disease, body regions, Breast cancer, Tolerability, In vivo, Internal medicine, Cancer cell, medicine, Ovarian cancer, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6bd726b9f566435321dd04e1d8744459
https://doi.org/10.1158/1538-7445.am2015-1684

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13

Abstract DDT02-01: In vitro and in vivo characterization of a novel anti-fibroblast growth factor receptor (FGFR) 2 antibody (BAY 1179470) for the treatment of gastric cancer

المؤلفون: Beatrix Stelte-Ludwig, Bertolt Kreft, Hung Huynh, Frank Reetz, Ekkehard May, Karl Ziegelbauer, Ruprecht Zierz, Axel Harrenga, Anette Sommer, Sabine Wittemer-Rump, Christoph Schatz, Stefanie Hammer, Charlotte Kopitz, Frank Dittmer

المصدر: Cancer Research. 74:DDT02-01

مصطلحات موضوعية: Cancer Research, biology, business.industry, Fibroblast growth factor receptor 2, Cancer, medicine.disease, Receptor tyrosine kinase, Oncology, Growth factor receptor, Fibroblast growth factor receptor, In vivo, Immunology, medicine, biology.protein, Cancer research, Antibody, business, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc50ae2289890e1b94a40a835d41d7e
https://doi.org/10.1158/1538-7445.am2014-ddt02-01

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14

BAY 94–9027, a PEGylated Recombinant Human FVIII, Shows Less Immunogenicity Compared to Un-PEGylated Recombinant FVIII

المؤلفون: Thomas A McDonald, Inge A Ivens, Ruprecht Zierz, Jesper Haaning

المصدر: Blood. 116:2214-2214

مصطلحات موضوعية: biology, business.industry, Immunogenicity, Immunology, Cell Biology, Hematology, Pharmacology, Bethesda unit, Biochemistry, Epitope, law.invention, Titer, Antigen, law, PEG ratio, biology.protein, Recombinant DNA, Medicine, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::31dd6541ff1c01439cbf0e90ec6b7bb8
https://doi.org/10.1182/blood.v116.21.2214.2214

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