المؤلفون: Velasco, Inmaculada, Daza‐Dueñas, Silvia, Torres, Encarnación, Ruiz‐Pino, Francisco, Vázquez, María J., Tena‐Sempere, Manuel

المساهمون: HORIZON EUROPE Framework Programme, Instituto de Salud Carlos III, Agencia Estatal de Investigación, Junta de Andalucía, Universidad de Córdoba

المصدر: Journal of Neuroendocrinology ; volume 36, issue 10 ; ISSN 0953-8194 1365-2826

الاتاحة: http://dx.doi.org/10.1111/jne.13433
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jne.13433

المؤلفون: Amin, Hawraz Ibrahim M., Ruiz-Pino, Francisco, Collado, Juan A., Appendino, Giovanni, Tena-Sempere, Manuel, Munoz, Eduardo, Caprioglio, Diego

المساهمون: Amin, Hawraz Ibrahim M., Ruiz-Pino, Francisco, Collado, Juan A., Appendino, Giovanni, Tena-Sempere, Manuel, Munoz, Eduardo, Caprioglio, Diego

مصطلحات موضوعية: Despite their early discovery, the bioactivity of acidic cannabinoids was long overlooked. Issues of stability and a pharmacological focus on Δ9-THC and its biological profile combined to relegate the non-narcotic native form of phytocannabinoids to a sort of investigational limbo. Recent studies have disclosed an attractive bioactivity profile for specific acidic phytocannabinoids but concerns about their limited stability have remained substantially unaddressed. To solve this issue, we have developed the hydroxamate derivatives of Δ8-tetrahydrocannabinolic acid-A (Δ8-THCA-AH, 6) and cannabidiolic acid (CBDAH, 5) as novel acidic cannabinoid bioisosteres, and we report here their synthesis and bioactivity profile against specific cannabinoid targets, as well as promising in vivo activity in a murine model of polycystic ovary syndrome (PCOS) associated with obesity

Relation: volume:2; journal:FRONTIERS IN NATURAL PRODUCTS; https://hdl.handle.net/11579/177925; https://www.frontiersin.org/articles/10.3389/fntpr.2023.1190053/full

الاتاحة: https://hdl.handle.net/11579/177925
https://doi.org/10.3389/fntpr.2023.1190053
https://www.frontiersin.org/articles/10.3389/fntpr.2023.1190053/full

المؤلفون: Velasco, Inmaculada, Franssen, Delphine, Daza-Dueñas, Silvia, Skrapits, Katalin, Takács, Szabolcs, Torres, Encarnación, Rodríguez-Vazquez, Elvira, Ruiz-Cruz, Miguel, León, Silvia, Kukoricza, Krisztina, Zhang, Fu-Ping, Ruohonen, Suvi, Luque-Cordoba, Diego, Priego-Capote, Feliciano, Gaytan, Francisco, Ruiz-Pino, Francisco, Hrabovszky, Erik, Poutanen, Matti, Vázquez, María J, Tena-Sempere, Manuel

المساهمون: Göteborgs universitet, Sahlgrenska akademin, Centre for Bone and Arthritis Research, Gothenburg University, Sahlgrenska Academy, Centre for Bone and Arthritis Research, Göteborgs universitet, Sahlgrenska akademin, Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition, Gothenburg University, Sahlgrenska Academy, Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

المصدر: Metabolism: clinical and experimental. 144

مصطلحات موضوعية: Endokrinologi och diabetes, Endocrinology and Diabetes, Male, Female, Mice, Humans, Animals, Kisspeptins, genetics, Gonadotropins, Neurons, metabolism, Puberty, Gonadotropin-Releasing Hormone, Arcuate Nucleus of Hypothalamus, Fertility

URL الوصول: https://gup.ub.gu.se/publication/330388

المؤلفون: Romero-Picó, Amparo, Novelle, Marta G, Al-Massadi, Omar, Beiroa, Daniel, Tojo, Marta, Heras, Violeta, Ruiz-Pino, Francisco, Senra, Ana, López, Miguel, Blouet, Clemence, Tena-Sempere, Manuel, Nogueiras, Rubén, Diéguez, Carlos

المصدر: nlmid: 101092791 ; essn: 1422-0067

مصطلحات موضوعية: Estrogens, Obesity, Energy Expenditure, P70s6k, Kappa-opioid, Animals, Humans, Mice, Body Weight, Weight Gain, Receptors, Opioid, kappa, Ovariectomy, Energy Metabolism, Eating, Female, Adipose Tissue, Brown, TOR Serine-Threonine Kinases

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/336411

الاتاحة: https://doi.org/10.17863/CAM.83828
https://www.repository.cam.ac.uk/handle/1810/336411

المؤلفون: Romero Picó, Amparo, Garrido Novelle, Marta, Al-Massadi, Omar, Beiroa, Daniel, Tojo, Marta, Heras, Violeta, Ruíz Pino, Francisco, Senra, Ana, López, Miguel, Blouet, Clemence, Tena Sempere, Manuel, Nogueiras, Rubén, Diéguez, Carlos

مصطلحات موضوعية: 577.115, 612.39, Energy expenditure, Estrogens, Kappa-opioid, Obesity, p70S6K, Bioquímica (Biología), 2411.04 Fisiología Endocrina, 3206.10 Enfermedades de la Nutrición

وصف الملف: application/pdf

Relation: https://hdl.handle.net/20.500.14352/94507; https://www.mdpi.com/1422-0067/23/6/3118

الاتاحة: https://hdl.handle.net/20.500.14352/94507
https://doi.org/10.3390/ijms23063118
https://www.mdpi.com/1422-0067/23/6/3118

المؤلفون: Roa, Juan, Ruiz-Cruz, Miguel, Ruiz-Pino, Francisco, Onieva, Rocio, Vazquez, Maria J, Sanchez-Tapia, Maria J, Ruiz-Rodriguez, Jose M, Sobrino, Veronica, Barroso, Alexia, Heras, Violeta, Velasco, Inmaculada, Perdices-Lopez, Cecilia, Ohlsson, Claes, Avendaño, Maria Soledad, Prevot, Vincent, Poutanen, Matti, Pinilla, Leonor, Gaytan, Francisco, Tena-Sempere, Manuel

مصطلحات موضوعية: Animals, DEAD-box RNA Helicases, Female, Fertility, Kisspeptins, Male, Mice, MicroRNAs, Neurons, Ribonuclease III, Sexual Maturation

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10668/19541; PMC9363423; https://www.nature.com/articles/s41467-022-32347-4.pdf; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363423/pdf

الاتاحة: http://hdl.handle.net/10668/19541
https://doi.org/10.1038/s41467-022-32347-4
https://www.nature.com/articles/s41467-022-32347-4.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363423/pdf

المؤلفون: Del Río, Carmen, Ruiz-Pino, Francisco, Prados, María E, Fiebich, Bernd L, Tena-Sempere, Manuel, Muñoz, Eduardo

مصطلحات موضوعية: COL1A2, cannabidiol, fibrosis, non-alcoholic fatty liver disease, systemic sclerosis

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10668/20712; PMC9627610; https://www.frontiersin.org/articles/10.3389/fphar.2022.981817/pdf; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627610/pdf

الاتاحة: http://hdl.handle.net/10668/20712
https://doi.org/10.3389/fphar.2022.981817
https://www.frontiersin.org/articles/10.3389/fphar.2022.981817/pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627610/pdf

المؤلفون: Sanchez-Garrido, Miguel A., Serrano-Lopez, Victor, Ruiz-Pino, Francisco, Vazquez, Maria Jesus, Rodriguez-Martin, Andrea, Torres, Encarnacion, Velasco, Inmaculada, Rodriguez, Ana Belen, Chicano-Galvez, Eduardo, Mora-Ortiz, Marina, Ohlsson, Claes, 1965, Poutanen, Matti, Pinilla, Leonor, Gaytan, Francisco, Douros, Jonathan D., Yang, Bin, Mueller, Timo D., Dimarchi, Richard D., Tschoep, Matthias H., Finan, Brian, Tena-Sempere, Manuel

المصدر: Nature Communications. 15(1)

مصطلحات موضوعية: Endocrinology and Diabetes, Endokrinologi och diabetes

URL الوصول: https://gup.ub.gu.se/publication/342301

المؤلفون: Amin, Hawraz Ibrahim M., Ruiz-Pino, Francisco, Collado, Juan A., Appendino, Giovanni, Tena-Sempere, Manuel, Munoz, Eduardo, Caprioglio, Diego

المصدر: Frontiers in Natural Products; 2024, p1-8, 8p

مصطلحات موضوعية: CANNABINOID receptors, POLYCYSTIC ovary syndrome, BIOISOSTERES, OBESITY, PHARMACOLOGY

المؤلفون: Roa, Juan, Barroso, Alexia, Ruiz-Pino, Francisco, Vázquez, Maria Jesus, Seoane-Collazo, Patricia, Martínez-Sanchez, Noelia, García-Galiano, David, Ilhan, Tuncay, Pineda, Rafael, León, Silvia, Manfredi-Lozano, Maria, Heras, Violeta, Poutanen, Matti, Castellano, Juan M., Gaytan, Francisco, Diéguez, Carlos, Pinilla, Leonor, López, Miguel, Tena-Sempere, Manuel

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2018 Nov 01. 115(45), E10758-E10767.

URL الوصول: https://www.jstor.org/stable/26563225

المؤلفون: Vazquez, María J, Daza-Dueñas, Silvia, Velasco, Inmaculada, Ruiz-Pino, Francisco, Sanchez-Tapia, María J, Manfredi-Lozano, María, Torres-Granados, Carmen, Barroso, Alexia, Roa, Juan, Sánchez-Garrido, Miguel A, Dieguez, Carlos, Lomniczi, Alejandro, Nogueiras, Rubén, Tena-Sempere, Manuel

المصدر: Metabolism ; ISSN:1532-8600

مصطلحات موضوعية: Female reproduction, GnRH, Kiss1, Kisspeptins, Ovulation, SIRT1

Relation: https://doi.org/10.1016/j.metabol.2024.156125; https://pubmed.ncbi.nlm.nih.gov/39740742

الاتاحة: https://doi.org/10.1016/j.metabol.2024.156125
https://pubmed.ncbi.nlm.nih.gov/39740742

المؤلفون: Burgaz, Sonia, García, Concepción, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Ruiz-Pino, Francisco, Unciti, Juan Diego, Gómez-Cañas, María, Alcalde, Juan, Morales,Paula, Jagerovic, Nadine, Rodríguez-Cueto, Carmen, Lago, Eva de, Muñoz, Eduardo, Fernández-Ruiz, Javier

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid

مصطلحات موضوعية: Cannabinoids, GPR55 receptors, VCE-006.1, Chromenopyrazole, Parkinson’s disease, 6-hydroxydopamine, Lipopolysaccharide, Amyotrophic lateral sclerosis, mSOD1 mice, TDP-43 transgenic mice

Relation: Publisher's version; https://doi.org/10.3390/molecules2624764; Sí; Molecules 26(24) : 76432021 (2021); http://hdl.handle.net/10261/259274; http://dx.doi.org/10.13039/100012818

الاتاحة: http://hdl.handle.net/10261/259274
https://doi.org/10.3390/molecules26247643
https://doi.org/10.13039/100012818

المؤلفون: Ruiz-Pino, Francisco, Miceli, Desiree, Franssen, Delphine, Vazquez, Maria Jesus, Farinetti, Alice, Castellano, Juan Manuel, Panzica, GianCarlo, Tena-Sempere, Manuel

المساهمون: Ruiz-Pino, Francisco, Miceli, Desiree, Franssen, Delphine, Vazquez, Maria Jesu, Farinetti, Alice, Castellano, Juan Manuel, Panzica, GianCarlo, Tena-Sempere, Manuel

مصطلحات موضوعية: kisspeptin, development, bisphemol A, BPA, female, mouse, puberty onset, endocrine disruptors

Relation: info:eu-repo/semantics/altIdentifier/pmid/31652106; info:eu-repo/semantics/altIdentifier/wos/WOS:000492748900013; volume:127; issue:10 - 107011; firstpage:1; lastpage:14; numberofpages:14; journal:ENVIRONMENTAL HEALTH PERSPECTIVES; http://hdl.handle.net/2318/1714930; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074147263

الاتاحة: http://hdl.handle.net/2318/1714930
https://doi.org/10.1289/EHP5570
https://ehp.niehs.nih.gov/doi/full/10.1289/EHP5570

المؤلفون: Heras, Violeta, Castellano, Juan Manuel, Fernandois, Daniela, Velasco, Inmaculada, Rodríguez Vázquez, Elvira, Roa, Juan, Vázquez, María Jesús, Ruiz Pino, Francisco, Rubio, Matías, Pineda, Rafael, Torres, Encarnación, Avendaño, María Soledad, Paredes Vargas, Alfonso, Pinilla, Leonor, Belsham, Denise, Dieguez, Carlos, Gaytan, Francisco, Casals, Nuria, López, Miguel, Tena Sempere, Manuel

المصدر: Cell Metabolism

مصطلحات موضوعية: High-fat diet, Hypothalamic paraventricular nucleus, Polycystic-ovary-syndrome, Nerve growth-factor, Metabolic-control, Childhood obesity, Estrous-cycle, Hormone secretion, Reproductive axis

وصف الملف: application/pdf

Relation: Cell Metabolism Volumen: 32 Número: 6 Dec 2020; https://repositorio.uchile.cl/handle/2250/180372

الاتاحة: https://doi.org/10.1016/j.cmet.2020.10.001
https://repositorio.uchile.cl/handle/2250/180372

المؤلفون: Heras, Violeta, Sangiao-Alvarellos, Susana, Manfredi-Lozano, Maria, Sanchez-Tapia, María, J, Ruiz-Pino, Francisco, Roa, Juan, Lara-Chica, Maribel, Morrugares-Carmona, Rosario, Jouy, Nathalie, Abreu, Ana, P, Prevot, Vincent, Belsham, Denise, Vazquez, Maria, J, Calzado, Marco, A, Pinilla, Leonor, Gaytan, Francisco, Latronico, Ana, C, Kaiser, Ursula, B, Castellano, Juan, M, Tena-Sempere, Manuel

المساهمون: Department of Cell Biology, Physiology and Immunology Cordoue, Espagne, Universidad de Córdoba = University of Córdoba Córdoba -Instituto Maimonides de Investigación Biomédica de Córdoba Cordoue, Espagne (IMIBIC)-Hospital Universitario Reina Sofia Cordoue, Espagne, Department of Medicine La Corogne, Espagne, Faculty of Health Sciences La Corogne, Espagne, University of A Coruña (UDC)-University of A Coruña (UDC), Instituto de Investigación Biomédica de A Coruña La Corogne, Espagne (INIBIC), A Coruña University Hospital La Corogne, Espagne, Laboratory of Development and Plasticity of the Neuroendocrine Brain Lille, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Division of Endocrinology, Diabetes and Hypertension Boston, États-Unis, Harvard Medical School Boston (HMS)-Brigham and Women's Hospital Boston, Department of Physiology Toronto, ON, Canada, Medical Sciences Building Toronto, ON, Canada, University of Toronto-University of Toronto, CIBER Fisiopatología de la Obesidad y Nutrición Cordoue, Espagne (CIBEROBN), Instituto de Salud Carlos III Madrid (ISC), Unidade de Endocrinologia do Desenvolvimento São Paulo, Brésil, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), FiDiPro Program Turku, Finlande, Institute of Biomedicine Turku, Finlande, University of Turku-University of Turku, This work was supported by grants BFU2014-57581-P and BFU2017-83934-P (Ministerio de Economıa y Competitividad, Spain, co-funded with EU funds from FEDER Program), project PIE-00005 (Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain), Project P12-FQM-01943 (Junta de Andalucıa, Spain), and Project REP-655232 (ReprObesity, European Union). CIBER Fisiopatologıa de la Obesidad y Nutricion is an initiative of Instituto de Salud Carlos III., European Project: 655232,H2020,H2020-MSCA-IF-2014,ReprObesity(2016)

المصدر: ISSN: 1544-9173.

مصطلحات موضوعية: [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism

Relation: info:eu-repo/semantics/altIdentifier/pmid/31697675; info:eu-repo/grantAgreement//655232/EU/Overweight-induced Hypogonadism as major factor for the generation and/or perpetuation of Metabolic Co-morbidities of Obesity: Contribution of Epigenetic Regulatory Mechanisms/ReprObesity; PUBMED: 31697675; PUBMEDCENTRAL: PMC6863565

الاتاحة: https://inserm.hal.science/inserm-02433705
https://inserm.hal.science/inserm-02433705v1/document
https://inserm.hal.science/inserm-02433705v1/file/journal.pbio.3000532.pdf
https://doi.org/10.1371/journal.pbio.3000532

المؤلفون: Palomares, Belén, Ruiz-Pino, Francisco, Garrido-Rodriguez, Martin, Eugenia Prados, M, Sánchez-Garrido, Miguel A, Velasco, Inmaculada, Vazquez, María J, Nadal, Xavier, Ferreiro-Vera, Carlos, Morrugares, Rosario, Appendino, Giovanni, Calzado, Marco A, Tena-Sempere, Manuel, Muñoz, Eduardo

مصطلحات موضوعية: Cannabis, Inflammation, Obesity, Pparγ, Δ9-THCA-A, 3T3-L1 Cells, Adipogenesis, Adiposity, Animals, Anti-Inflammatory Agents, Cells, Cultured, Diet, High-Fat, Dronabinol, Fatty Liver, HEK293 Cells, Humans, Male, Metabolic Diseases, Mice, Inbred C57BL, PPAR gamma, Rosiglitazone

Relation: http://hdl.handle.net/10668/14663; https://www.biorxiv.org/content/biorxiv/early/2019/04/29/622035.full.pdf

الاتاحة: http://hdl.handle.net/10668/14663
https://doi.org/10.1016/j.bcp.2019.113693
https://www.biorxiv.org/content/biorxiv/early/2019/04/29/622035.full.pdf

المؤلفون: Seoane-Collazo, Patricia, Roa, Juan, Rial-Pensado, Eva, Liñares-Pose, Laura, Beiroa, Daniel, Ruíz-Pino, Francisco, López-González, Tania, Morgan, Donald A, Pardavila, José Ángel, Sánchez-Tapia, María Jesús, Martínez-Sánchez, Noelia, Contreras, Cristina, Fidalgo, Miguel, Diéguez, Carlos, Coppari, Roberto, Rahmouni, Kamal, Nogueiras, Rubén, Tena-Sempere, Manuel, López, Miguel

مصطلحات موضوعية: AMP-Activated Protein Kinases, Adipose Tissue, Brown, Animals, Body Composition, Diet, High-Fat, Energy Metabolism, Male, Neurons, Obesity, Oxygen Consumption, RNA Splicing Factors, Rats, Sprague-Dawley, Ventromedial Hypothalamic Nucleus

Relation: http://hdl.handle.net/10668/12830; PMC6198345; https://europepmc.org/articles/pmc6198345?pdf=render; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198345/pdf

الاتاحة: http://hdl.handle.net/10668/12830
https://doi.org/10.2337/db17-1538
https://europepmc.org/articles/pmc6198345?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198345/pdf

المؤلفون: Palomares, Belen, Ruiz-Pino, Francisco, Navarrete, Carmen, Velasco, Inmaculada, Sánchez-Garrido, Miguel A, Jimenez-Jimenez, Carla, Pavicic, Carolina, Vazquez, Maria J, Appendino, Giovanni, Bellido, M Luz, Calzado, Marco A, Tena-Sempere, Manuel, Muñoz, Eduardo

مصطلحات موضوعية: Adipogenesis, Adiposity, Animals, Biomarkers, Body Composition, Cannabidiol, Cell Differentiation, Diet, High-Fat, Feeding Behavior, Fibroblast Growth Factors, HEK293 Cells, Hormones, Humans, Insulin Resistance, Male, Mice, Inbred C57BL, Obesity, Osteoblasts, PPAR gamma, Weight Gain

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10668/13145; PMC6208444; https://www.nature.com/articles/s41598-018-34259-0.pdf; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208444/pdf

الاتاحة: http://hdl.handle.net/10668/13145
https://doi.org/10.1038/s41598-018-34259-0
https://www.nature.com/articles/s41598-018-34259-0.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208444/pdf

المؤلفون: González-García, Ismael, Contreras, Cristina, Estévez-Salguero, Ánxela, Ruíz-Pino, Francisco, Colsh, Benoit, Pensado, Iván, Liñares-Pose, Laura, Rial-Pensado, Eva, Martínez de Morentin, Pablo B, Fernø, Johan, Diéguez, Carlos, Nogueiras, Rubén, Le Stunff, Hervé, Magnan, Christophe, Tena-Sempere, Manuel, López, Miguel

مصطلحات موضوعية: brown adipose tissue, ceramides, endoplasmic reticulum stress, estradiol, hypothalamus, thermogenesis, Adipose Tissue, Brown, Animals, Energy Metabolism, Estrogens, Female, Homeostasis, Rats

Relation: http://hdl.handle.net/10668/13056; PMC6198289; http://www.cell.com/article/S2211124718314839/pdf

الاتاحة: http://hdl.handle.net/10668/13056
https://doi.org/10.1016/j.celrep.2018.09.038
http://www.cell.com/article/S2211124718314839/pdf

المؤلفون: Sanchez-Garrido, Miguel Angel, Ruiz-Pino, Francisco, Velasco, Inmaculada, Barroso, Alexia, Fernandois, Daniela, Heras, Violeta, Manfredi-Lozano, Maria, Vazquez, Maria Jesus, Castellano, Juan Manuel, Roa, Juan, Pinilla, Leonor, Tena-Sempere, Manuel

مصطلحات موضوعية: Animals, Fathers, Female, Kisspeptins, Male, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Wistar, Reproduction, Reproductive Health, Sex Characteristics, Signal Transduction

Relation: http://hdl.handle.net/10668/11978; https://academic.oup.com/endo/article-pdf/159/2/1005/23630448/en.2017-00705.pdf

الاتاحة: http://hdl.handle.net/10668/11978
https://doi.org/10.1210/en.2017-00705
https://academic.oup.com/endo/article-pdf/159/2/1005/23630448/en.2017-00705.pdf