المؤلفون: Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: tissue pharmacokinetics, intratumoral, paclitaxel, pharmacokinetics, esophageal cancer, ABCB1, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.759146/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/2da8bb17075a4bb7a21f579be94bb87f

المؤلفون: Tessa A. M. Mulder, Ruben A. G. van Eerden, Mirjam de With, Laure Elens, Dennis A. Hesselink, Maja Matic, Sander Bins, Ron H. J. Mathijssen, Ron H. N. van Schaik

المصدر: Frontiers in Genetics, Vol 12 (2021)

مصطلحات موضوعية: cytochrome P450, CYP3A4, CYP3A4∗22, genotyping, genotype-guided dosing, rs35599367, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.711943/full; https://doaj.org/toc/1664-8021

URL الوصول: https://doaj.org/article/80b85a597c65408aa28ded486cfab7e7

المؤلفون: Ruben A. G. van Eerden, Esther Oomen-de Hoop, Aad Noordam, Ron H. J. Mathijssen, Stijn L. W. Koolen

المصدر: Pharmaceuticals, Vol 14, Iss 2, p 119 (2021)

مصطلحات موضوعية: small molecule kinase inhibitor, trough level, Cmin, therapeutic drug monitoring, implementation, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/2/119; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/9145dc98665a4501ad77c46a2e711500

المؤلفون: Florence Atrafi, Ruben A. G. van Eerden, Stijn L. W. Koolen, Peter de Bruijn, Cristianne J. F. Rijcken, Rob Hanssen, Ferry A. L. M. Eskens, Martijn P. Lolkema, Esther Oomen-de Hoop, Jeffrey Damman, Ron H. J. Mathijssen

المصدر: Cancers; Volume 13; Issue 15; Pages: 3741

مصطلحات موضوعية: nanoparticles, toxicity, docetaxel, pharmacokinetics, pharmacodynamics, chemotherapy, skin

وصف الملف: application/pdf

Relation: Cancer Therapy; https://dx.doi.org/10.3390/cancers13153741

الاتاحة: https://doi.org/10.3390/cancers13153741

المؤلفون: Ron H.J. Mathijssen, Ruben A G van Eerden, Femke M. de Man, Gerdien M van Doorn, Joris N. Veraart, Henk K van Halteren, Yorick Sandberg, Esther Oomen-de Hoop, Ron W. F. de Bruin, Stijn L.W. Koolen, Teun van Gelder, Adriaan Moelker, Martijn E.T. Dollé, Jan N. M. IJzermans, Joanne F. Olieman, Peter de Bruijn, Martijn P. Lolkema

المساهمون: Medical Oncology, Internal Medicine, Pharmacy, Radiology & Nuclear Medicine, Surgery

المصدر: Clinical Pharmacology and Therapeutics, 109(5), 1304-1313. Wiley-Blackwell

مصطلحات موضوعية: Diarrhea, Male, medicine.medical_specialty, Neutropenia, Normal diet, Irinotecan, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, SDG 3 - Good Health and Well-being, intra-tumoral, Internal medicine, medicine, Diet, Protein-Restricted, Humans, Pharmacology (medical), protein and calorie restriction, Aged, Caloric Restriction, Pharmacology, business.industry, Liver Neoplasms, Area under the curve, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Toxicity, Female, diet, business, pharmacokinetics, Febrile neutropenia, medicine.drug, Blood sampling

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfd65e1ae87a83ad993df24d8e22649
http://www.scopus.com/inward/record.url?scp=85097045452&partnerID=8YFLogxK

المؤلفون: Ron H.J. Mathijssen, Martijn P. Lolkema, Stijn L.W. Koolen, Ruben A G van Eerden, Cristianne J.F. Rijcken, Marte A.M. van Hylckama Vlieg, Alex Sparreboom, Ferry A.L.M. Eskens, Florence Atrafi, Esther Oomen-de Hoop, Rob Hanssen, Adriaan Moelker, Peter de Bruijn

المساهمون: Medical Oncology, Radiology & Nuclear Medicine

المصدر: Clinical Cancer Research, 26(14), 3537-3545. American Association for Cancer Research Inc.

مصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Neutropenia, Biopsy, Urology, 02 engineering and technology, Docetaxel, urologic and male genital diseases, Intratumoral chemotherapy, Metastatic lesion, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, SDG 3 - Good Health and Well-being, Neoplasms, medicine, Humans, In patient, Tissue Distribution, Infusions, Intravenous, neoplasms, Response Evaluation Criteria in Solid Tumors, Aged, Aged, 80 and over, Drug Carriers, Cross-Over Studies, Adult patients, business.industry, organic chemicals, Middle Aged, 021001 nanoscience & nanotechnology, Tumor tissue, Drug Liberation, Oncology, 030220 oncology & carcinogenesis, Nanoparticles, Female, Sampling time, 0210 nano-technology, business, therapeutics, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee1475ea1715c8d2117e42481df6b4
http://www.scopus.com/inward/record.url?scp=85087591926&partnerID=8YFLogxK

المؤلفون: Ruben A G van Eerden, Cristianne J.F. Rijcken, Ferry A.L.M. Eskens, Stijn L.W. Koolen, Martijn P. Lolkema, Peter de Bruijn, Florence Atrafi, Rob Hanssen, Ron H.J. Mathijssen, Jeffrey Damman, Esther Oomen-de Hoop

المساهمون: Medical Oncology, Pharmacy, Pathology

المصدر: Cancers, Vol 13, Iss 3741, p 3741 (2021)
Cancers, 13(15):3741. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, skin, medicine.medical_treatment, 02 engineering and technology, urologic and male genital diseases, chemotherapy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, SDG 3 - Good Health and Well-being, Internal medicine, pharmacodynamics, Medicine, docetaxel, Nuclear atypia, neoplasms, RC254-282, Chemotherapy, integumentary system, business.industry, organic chemicals, Communication, toxicity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 021001 nanoscience & nanotechnology, Skin toxicity, Oncology, Docetaxel, Apoptosis, 030220 oncology & carcinogenesis, Pharmacodynamics, Toxicity, nanoparticles, 0210 nano-technology, business, therapeutics, pharmacokinetics, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02af220cc2a5db71d2f54643cfa95b5
https://www.mdpi.com/2072-6694/13/15/3741

المؤلفون: Stijn L.W. Koolen, Ron H.J. Mathijssen, Ruben A G van Eerden

المساهمون: Medical Oncology, Pharmacy

المصدر: International Journal of Nanomedicine
International Journal of Nanomedicine, 15, 8151-8166. Dove Medical Press Ltd.

مصطلحات موضوعية: medicine.medical_specialty, Biophysics, Pharmaceutical Science, Bioengineering, Antineoplastic Agents, 02 engineering and technology, Review, 010402 general chemistry, 01 natural sciences, taxane, Biomaterials, drug delivery systems, SDG 3 - Good Health and Well-being, Neoplasms, Drug Discovery, medicine, Animals, Humans, cancer, Intensive care medicine, Adverse effect, Drug Carriers, Taxane, business.industry, nanoparticle, Organic Chemistry, Cancer, General Medicine, 021001 nanoscience & nanotechnology, medicine.disease, nanomedicine, 0104 chemical sciences, Review article, Nanostructures, Active compound, Drug delivery, Taxoids, 0210 nano-technology, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fb7c332664a48fb2be0919faf27831
https://pubmed.ncbi.nlm.nih.gov/33132699

المؤلفون: Alwin D. R. Huitema, Stefanie L. Groenland, Jos H. Beijnen, Niels de Vries, Bas Thijssen, Hilde Rosing, Ruben A G van Eerden, Stijn L.W. Koolen, Remy B. Verheijen, Ron H.J. Mathijssen, Neeltje Steeghs

المساهمون: Medical Oncology, Pharmacy

المصدر: Clinical Pharmacokinetics, 59(7), 941-948. Adis
Clinical Pharmacokinetics, 59(7), 941. Adis International Ltd

مصطلحات موضوعية: medicine.medical_specialty, Indazoles, medicine.drug_class, Urology, Cmax, 030226 pharmacology & pharmacy, Tyrosine-kinase inhibitor, Pazopanib, 03 medical and health sciences, Cmin, 0302 clinical medicine, Pharmacokinetics, SDG 3 - Good Health and Well-being, Interquartile range, medicine, Humans, Pharmacology (medical), Dosing, Prospective Studies, Carcinoma, Renal Cell, Pharmacology, Sulfonamides, business.industry, Kidney Neoplasms, Pyrimidines, Tolerability, 030220 oncology & carcinogenesis, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8523041abf904f0a19949668d37b9b9e
https://pure.eur.nl/en/publications/31c7fb36-4788-426f-8676-2c471695966c

المؤلفون: Tessa A. M. Mulder (11096109), Ruben A. G. van Eerden (11096112), Mirjam de With (11096115), Laure Elens (534159), Dennis A. Hesselink (9083915), Maja Matic (11096118), Sander Bins (6815102), Ron H. J. Mathijssen (8638971), Ron H. N. van Schaik (9366224)

مصطلحات موضوعية: Genetics, Genetic Engineering, Biomarkers, Developmental Genetics (incl. Sex Determination), Epigenetics (incl. Genome Methylation and Epigenomics), Gene Expression (incl. Microarray and other genome-wide approaches), Genome Structure and Regulation, Genomics, Genetically Modified Animals, Livestock Cloning, Gene and Molecular Therapy, cytochrome P450, CYP3A4, CYP3A4∗22, genotyping, genotype-guided dosing, rs35599367, pharmacogenetics, personalized medicine

Relation: https://figshare.com/articles/dataset/Table_3_CYP3A4_22_Genotyping_in_Clinical_Practice_Ready_for_Implementation_docx/14930946

الاتاحة: https://doi.org/10.3389/fgene.2021.711943.s003

المؤلفون: Tessa A. M. Mulder, Ruben A. G. van Eerden, Mirjam de With, Laure Elens, Dennis A. Hesselink, Maja Matic, Sander Bins, Ron H. J. Mathijssen, Ron H. N. van Schaik

مصطلحات موضوعية: Genetics, Genetic Engineering, Biomarkers, Developmental Genetics (incl. Sex Determination), Epigenetics (incl. Genome Methylation and Epigenomics), Gene Expression (incl. Microarray and other genome-wide approaches), Genome Structure and Regulation, Genomics, Genetically Modified Animals, Livestock Cloning, Gene and Molecular Therapy, cytochrome P450, CYP3A4, CYP3A4∗22, genotyping, genotype-guided dosing, rs35599367, pharmacogenetics, personalized medicine

Relation: https://figshare.com/articles/dataset/Table_2_CYP3A4_22_Genotyping_in_Clinical_Practice_Ready_for_Implementation_docx/14930943

الاتاحة: https://doi.org/10.3389/fgene.2021.711943.s002
https://figshare.com/articles/dataset/Table_2_CYP3A4_22_Genotyping_in_Clinical_Practice_Ready_for_Implementation_docx/14930943

المؤلفون: Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, tissue pharmacokinetics, intratumoral, paclitaxel, pharmacokinetics, esophageal cancer, ABCB1

Relation: https://figshare.com/articles/dataset/DataSheet1_Tissue_Type_Differences_in_ABCB1_Expression_and_Paclitaxel_Tissue_Pharmacokinetics_in_Patients_With_Esophageal_Cancer_DOCX/16987522

الاتاحة: https://doi.org/10.3389/fphar.2021.759146.s001
https://figshare.com/articles/dataset/DataSheet1_Tissue_Type_Differences_in_ABCB1_Expression_and_Paclitaxel_Tissue_Pharmacokinetics_in_Patients_With_Esophageal_Cancer_DOCX/16987522

المؤلفون: Remy B. Verheijen, Nielka P. van Erp, Stijn L.W. Koolen, Anna K.L. Reyners, Ruben A G van Eerden, Neeltje Steeghs, Ron H.J. Mathijssen, Ingrid M.E. Desar, Hans Gelderblom, Stefanie L. Groenland, Alwin D. R. Huitema, Dirk Jan A.R. Moes

المساهمون: Medical Oncology, Pharmacy, Targeted Gynaecologic Oncology (TARGON), Guided Treatment in Optimal Selected Cancer Patients (GUTS)

المصدر: Therapeutic Drug Monitoring, 41(5), 561-567. Lippincott Williams & Wilkins
Therapeutic Drug Monitoring, 41(5), 561-567. LIPPINCOTT WILLIAMS & WILKINS
Therapeutic Drug Monitoring, 41, 561-567
Therapeutic Drug Monitoring, 41(5), 561. Lippincott Williams and Wilkins
Therapeutic Drug Monitoring, 41, 5, pp. 561-567

مصطلحات موضوعية: PK, EXPOSURE-RESPONSE ANALYSIS, Administration, Oral, Medical Oncology, 030226 pharmacology & pharmacy, 0302 clinical medicine, RENAL-CELL CARCINOMA, Medicine, Drug Interactions, Pharmacology (medical), Prospective Studies, HUMAN PLASMA, Prospective cohort study, Non-U.S. Gov't, media_common, medicine.diagnostic_test, Research Support, Non-U.S. Gov't, personalized dosing, Treatment Outcome, PHASE-I, Tolerability, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Drug Monitoring, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Drug, medicine.medical_specialty, media_common.quotation_subject, oral anticancer drugs, Antineoplastic Agents, Research Support, IMATINIB, PAZOPANIB, TDM, 03 medical and health sciences, Cmin, Pharmacokinetics, individualized dosing, Journal Article, Humans, DOSE-ESCALATION, Dosing, TAMOXIFEN, Intensive care medicine, Pharmacology, business.industry, KINASE INHIBITORS, QUANTIFICATION, Therapeutic drug monitoring, Concomitant, business

وصف الملف: application/pdf; image/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcecc96f69f99850f826d4ac63c8ae88
https://hdl.handle.net/1887/122407

المؤلفون: Femke M. de Man, Ron H.J. Mathijssen, Joris N. Veraart, Ate van der Gaast, Leni van Doorn, Ruben A G van Eerden, Esther Oomen-de Hoop, Nadia van Doorn

المساهمون: Medical Oncology

المصدر: Cancers, Vol 11, Iss 6, p 826 (2019)
Cancers
Volume 11
Issue 6
Cancers, 11(6):826. Multidisciplinary Digital Publishing Institute (MDPI)

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Palliative care, medicine.medical_treatment, efficacy, Neutropenia, Gastroenterology, lcsh:RC254-282, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Interquartile range, Internal medicine, parasitic diseases, medicine, 030212 general & internal medicine, Progression-free survival, esophageal cancer, business.industry, palliative treatment, toxicity, Retrospective cohort study, Hematology, Esophageal cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Carboplatin, Radiation therapy, induction treatment, Regimen, Oncology, chemistry, Esophagectomy, 030220 oncology & carcinogenesis, business, Febrile neutropenia

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d2a327c1fb5d2ec464e94b7b69febd
https://www.mdpi.com/2072-6694/11/6/826

المؤلفون: Esther van Meerten, Ruben A G van Eerden, Alexander Constantinides, Alexandra R. M. Brandt-Kerkhof, Femke M. de Man, Geert Jan Creemers, Stijn L.W. Koolen, Checca Bakkers, Onno Kranenburg, Eva V. E. Madsen, Maarten J. Deenen, Nadine L. de Boer, Ignace H. J. T. de Hingh, Ron H.J. Mathijssen, Marjolein Diepeveen, Rachida Bouamar, Jacobus W. A. Burger, Cornelis Verhoef, Koen P. Rovers

المساهمون: Surgery, Medical Oncology, Pharmacy

المصدر: BMJ Open, 9(12), e034508. BMJ Publishing Group
BMJ Open, 9(12):e034508. BMJ Publishing Group
BMJ Open

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Organoplatinum Compounds, Bevacizumab, Colorectal cancer, Leucovorin, colorectal cancer, Irinotecan, intraperitoneal chemotherapy, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Protocol, Journal Article, medicine, Humans, Multicenter Studies as Topic, systemic chemotherapy, Infusions, Parenteral, 030212 general & internal medicine, Peritoneal Neoplasms, Medicine(all), Clinical Trials, Phase I as Topic, Performance status, business.industry, palliative treatment, General Medicine, medicine.disease, Oxaliplatin, dose-escalation study, peritoneal metastases, Research Design, Conventional PCI, Peritoneal Cancer Index, Hyperthermic intraperitoneal chemotherapy, Fluorouracil, Colorectal Neoplasms, business, 030217 neurology & neurosurgery, medicine.drug

وصف الملف: image/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0113b0c7b6e2a1610f78c97e45b8a8f9
https://doi.org/10.1136/bmjopen-2019-034508

المؤلفون: Ruben A G van Eerden, Alwin D. R. Huitema, Ron H.J. Mathijssen, Neeltje Steeghs, Remy B. Verheijen, Stefanie L. Groenland

المصدر: Journal of Clinical Oncology. 37:3119-3119

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Boosting (doping), business.industry, Soft tissue sarcoma, medicine.disease, Pazopanib, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Renal cell carcinoma, 030220 oncology & carcinogenesis, Internal medicine, Medicine, business, 030215 immunology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07564fe49ef9195ff8bbae9e74b5cdfd
https://doi.org/10.1200/jco.2019.37.15_suppl.3119

المؤلفون: Cristianne J.F. Rijcken, Esther Oomen-de Hoop, Rob Hanssen, Stijn L.W. Koolen, Ruben A G van Eerden, Ron H.J. Mathijssen, Ferry A.L.M. Eskens, Florence Atrafi, Marte A.M. van Hylckama Vlieg, Peter de Bruijn

المصدر: Journal of Clinical Oncology. 37:3096-3096

مصطلحات موضوعية: Drug, Cancer Research, Chemotherapy, business.industry, medicine.medical_treatment, media_common.quotation_subject, Nanoparticle, Drug levels, Oncology, Docetaxel, medicine, Cancer research, Nanomedicine, In patient, business, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d5ebecc431c6c0aa8fc3e818d2ca4504
https://doi.org/10.1200/jco.2019.37.15_suppl.3096