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1Academic Journal
المؤلفون: Berankova, Michaela, Holoubek, Jiri, Hönig, Vaclav, Matusova, Zuzana, Palus, Martin, Salat, Jiri, Krayem, Imtissal, Vojtiskova, Jarmila, Svoboda, Pavel, Pranclova, Veronika, Valihrach, Lukas, Demant, Peter, Lipoldova, Marie, Ruzek, Daniel
المساهمون: Grantová Agentura České Republiky, Akademie Věd České Republiky, Univerzita Karlova v Praze, Ministerstvo Školství, Mládeže a Tělovýchovy
المصدر: Journal of Neuroinflammation ; volume 22, issue 1 ; ISSN 1742-2094
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2Academic Journal
المؤلفون: Krishnamurthy, Hari Krishnan, Jayaraman, Vasanth, Krishna, Karthik, Wang, Tianhao, Bei, Kang, Changalath, Chithra, Matilda, Shiny, Rai, Alex J., Welc-Falęciak, Renata, Pawełczyk, Agnieszka, Blanton, Lucas S., Chrdle, Aleš, Fořtová, Andrea, Růžek, Daniel, Nasrallah, Gheyath K., Abu-Raddadi, Laith J., Al-Sadeq, Duaa W., Abdallah, Marah Abed Alhakim, Lilleri, Daniele, Fornara, Chiara, D’Angelo, Piera, Furione, Milena, Söderlund-Venermo, Maria, Hedman, Klaus, Chochlakis, Dimosthenis, Makridaki, Eirini, Ntoula, Artemis, Psaroulaki, Anna, Escárcega-Ávila, Angélica, Rajasekaran, John J.
المصدر: Scientific Reports ; volume 15, issue 1 ; ISSN 2045-2322
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3Academic Journal
المؤلفون: Gervais, Adrian, Marchal, Astrid, Fortova, Andrea, Berankova, Michaela, Krbkova, Lenka, Pychova, Martina, Salat, Jiri, Zhao, Shuxiang, Kerrouche, Nacim, Le Voyer, Tom, Stiasny, Karin, Raffl, Simon, Schieber Pachart, Anne, Fafi-Kremer, Samira, Gravier, Simon, Robbiani, Davide, F, Abel, Laurent, Macdonald, Margaret, R, Rice, Charles, M, Weissmann, Gaia, Kamal Eldin, Tarek, Robatscher, Eva, Erne, Elke Maria, Pagani, Elisabetta, Borghesi, Alessandro, Puel, Anne, Bastard, Paul, Velay, Aurélie, Martinot, Martin, Hansmann, Yves, Aberle, Judith, H, Ruzek, Daniel, Cobat, Aurélie, Zhang, Shen-Ying, Casanova, Jean-Laurent
المساهمون: Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Veterinary Research Institute Brno (VRI), Masaryk University Brno (MUNI), Institute of Parasitology České Budějovice (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences Prague (CAS)-Czech Academy of Sciences Prague (CAS), St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University New York, Hopital Saint-Louis AP-HP (AP-HP), Medizinische Universität Wien = Medical University of Vienna, Hôpitaux Civils de Colmar, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Immuno-Rhumatologie Moléculaire (IRM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università della Svizzera italiana = University of Italian Switzerland (USI), Franz Tappeiner Hospital, General Hospital of Bolzano, Health Robotics S.r.l., Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), IRCCS "San Matteo" Hospital Foundation Pavie, Italie, Università degli Studi di Pavia Italia = University of Pavia Italy = Université de Pavie Italie (UNIPV), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology Zürich (ETH Zürich), Howard Hughes Medical Institute (HHMI), ANR-22-CE15-0046,AI2D,Autoanticorps anti-interférons et maladies infectieuses associées(2022), ANR-22-CE92-0004,GENFLU,Rôle de la prédisposition génétique et les autoanticorps anti-IFN dans le développement des infections grippales sévères ?(2022), ANR-21-LIBA-0002,AAILC,Autoanticorps contre les interférons de type I chez les patients libanais hospitalisés pour COVID-19.(2021), ANR-11-LABX-0070,TRANSPLANTEX,Nouveaux loci d'histocompatibilité/biomarqueurs en transplantation humaine: de la découverte à l'app(2011), ANR-18-CE17-0028,HuMABK,Les anticorps monoclonaux humains : une Nouvelle approche thérapeutique contre l'infection par le virus BK et les maladies associées(2018), ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020)
المصدر: ISSN: 0022-1007.
مصطلحات موضوعية: [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/39316018; PUBMED: 39316018; PUBMEDCENTRAL: PMC11448868
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4Academic Journal
المؤلفون: Nagy Gergely Ármin, Tombácz Dóra, Prazsák István, Csabai Zsolt, Dörmő Ákos, Gulyás Gábor, Kemenesi Gábor, Tóth Gábor Endre, Holoubek Jiří, Růžek Daniel, Kakuk Balázs, Boldogkői Zsolt
مصطلحات موضوعية: 01.06. Biológiai tudományok
وصف الملف: text
Relation: http://publicatio.bibl.u-szeged.hu/35026/1/nagy-et-al-2024-exploring-the-transcriptomic-profile-of-human-monkeypox-virus-via-cage-and-native-rna-sequencing.pdf; Nagy Gergely Ármin; Tombácz Dóra; Prazsák István; Csabai Zsolt; Dörmő Ákos; Gulyás Gábor; Kemenesi Gábor; Tóth Gábor Endre; Holoubek Jiří; Růžek Daniel; Kakuk Balázs; Boldogkői Zsolt: Exploring the transcriptomic profile of human monkeypox virus via CAGE and native RNA sequencing approaches. mSPHERE, 9 (9). ISSN 2379-5042 (2024)
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5Academic Journal
المؤلفون: Bae, Jinseung, Bednar, Petr, Zhu, Rong, Bong, Cheolwoo, Bak, Moon Soo, Stainer, Sarah, Kim, Kyoungjun, Lee, Junghun, Yoon, Chulsoo, Lee, Yugyeong, Ojowa, Omobolaji Taye, Lehner, Maximilian, Hinterdorfer, Peter, Ruzek, Daniel, Park, Sungsu, Oh, Yoo Jin
المساهمون: Samsung, Korea Health Industry Development Institute, European Commission, National Research Council of Science and Technology, Austrian Science Fund
المصدر: ACS Applied Materials & Interfaces ; volume 16, issue 37, page 49176-49185 ; ISSN 1944-8244 1944-8252
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6Academic Journal
المؤلفون: Anastasina, Maria, Füzik, Tibor, Domanska, Aušra, Pulkkinen, Lauri Ilmari Aurelius, Šmerdová, Lenka, Formanová, Petra Pokorná, Straková, Petra, Nováček, Jiří, Růžek, Daniel, Plevka, Pavel, Butcher, Sarah Jane
المساهمون: Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, Macromolecular structure and function
مصطلحات موضوعية: 11832 Microbiology and virology, Biochemistry, cell and molecular biology
وصف الملف: application/pdf
Relation: We thank P. Laurinm\u00E4ki of the Instruct-E RIC Centre Finland and the Biocenter Finland National CryoEM Facility, the CryoEM Swedish National Facility funded by the Knut and Alice Wallenberg, Family Erling Persson and Kempe Foundations, SciLifeLab, Stockholm University and Umea University, and the CSC-IT Center for Science Ltd. for providing reagents, technical assistance, and facilities to carry out the work. We thank O. Vapalahti for the kind gift of the TBEV Kuutsalo-14 isolate and S. Haarma, S. Kuivanen, I. Suomalainen, and S. M\u00E4ki for excellent technical help. We thank F. X. Heinz for the kind gift of TBEV strain Neudoerfl. Funding: The research was funded by the Swedish Research Council, reference number 2018-05851 (to S.J.B.); the Academy of Finland, grant number 315950 (to S.J.B.); the Sigrid Juselius Foundation, grant number 95-7202- 38 (to S.J.B.); the Jane and Aatos Erkko Foundation (to S.J.B.); European Commission Horizon 2020 Research and Innovation Programme under the Marie Sk\u0142odowska-C urie grant agreements number 799929 (to M.A.); the University of Helsinki Research Foundation (to L.I.A.P.); the University of Helsinki Doctoral School in Integrative Life Science (to L.I.A.P.); the Helsinki Institute of Life Sciences (to S.J.B.); European Commission Programme EXCELES project LX22NPO5103 \"National Institute of Virology and Bacteriology\" (to P.P. and D.R.); and the Czech Science Foundation Grant GX 19-25982X (to P.P.). P.P.F., P.S., and D.R. were supported by EEA and Norway Grants Fund for Regional Cooperation (project number 2018-1- 0659) and the project 23-07160S from the Czech Science Foundation. We acknowledge the Cryo-electron microscopy and tomography core facility CEITEC MU of CIISB, Instruct-C Z Centre, supported by MEYS CR (LM2023042) and European Regional Development Fund-Project \"UP CIISB\" (no. CZ.02.1.01/0.0/0.0/18_046/0015 974). Author contributions: Conceptualization: M.A., S.J.B., P.P., D.R., T.F., and P.S. Investigation: M.A., T.F., L.I.A.P., P.P.F., P.S., D.R., J.N., and A.D. Formal analysis: T.F. and M.A. Validation: M.A., T.F., S.J.B., A.D., and D.R. Writing-original draft: M.A., T.F., P.P., and P.S. Writing-review and editing: S.J.B., P.P., D.R., M.A., P.S., L.I.A.P., and A.D. Visualization: M.A. and T.F. Methodology: J.N., S.J.B., A.D., P.P., D.R., T.F., M.A., P.P.F., L.S., and P.S. Resources: S.J.B., D.R., M.A., and P.P.F. Data curation: L.I.A.P., P.S., and M.A. Supervision: S.J.B., P.P., D.R., J.N., and T.F. Funding acquisition: S.J.B., P.P., D.R., M.A., and L.I.A.P. Project administration: S.J.B., P.P., D.R., T.F., and P.S. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Cryo-E M density maps have been deposited in the Electron Microscopy Data Bank under EMD accession codes EMD-17809 (Kuutsalo-14 whole particle), EMD-17808 (Kuutsalo-14 prM3E3 spike localized reconstruction), EMD-17946 (Neudoerfl whole particle), EMD-17947 (Neudoerfl prM3E3 spike localized reconstruction), and EMD-17945 (Hypr whole particle). Atomic coordinates of models have been deposited to the Protein Data Bank (PDB) under accession codes 8PPQ (Kuutsalo-14 prM3E3) and 8PUV (Neudoerfl prM3E3). the Knut and Alice Wallenberg, Family erling Persson and Kempe Foundations, Scilifelab, Stockholm University and Ume\u00E5 University, and the cSc-it center for Science ltd. for providing reagents, technical assistance, and facilities to carry out the work. We thank O. vapalahti for the kind gift of the tBev Kuutsalo-14 isolate and S. haarma, S. Kuivanen, i. Suomalainen, and S. M\u00E4ki for excellent technical help. We thank F. X. heinz for the kind gift of tBev strain neudoerfl. Funding: the research was funded by the Swedish Research council, reference number 2018-05851 (to S.J.B.); the Academy of Finland, grant number 315950 (to S.J.B.); the Sigrid Juselius Foundation, grant number 95-7202-38 (to S.J.B.); the Jane and Aatos erkko Foundation (to S.J.B.); european commission horizon 2020 Research and innovation Programme under the Marie Sk\u0142odowska-curie grant agreements number 799929 (to M.A.); the University of helsinki Research Foundation (to l.i.A.P.); the University of helsinki doctoral School in integrative life Science (to l.i.A.P.); the helsinki institute of life Sciences (to S.J.B.); european commission Programme eXceleS project lX22nPO5103 \u201Cnational institute of virology and Bacteriology\u201D(to P.P. and d.R.); and the czech Science Foundation Grant GX 19-25982X (to P.P.). P.P.F., P.S., and d.R. were supported by eeA and norway Grants Fund for Regional cooperation (project number 2018-1-0659) and the project 23-07160S from the czech Science Foundation. We acknowledge the cryo-electron microscopy and tomography core facility ceitec MU of ciiSB, instruct-cZ centre, supported by MeYS cR (lM2023042) and european Regional development Fund-Project \u201CUP ciiSB\u201D(no. cZ.02.1.01/0.0/0.0/18_046/0015 974). Author contributions: conceptualization: M.A., S.J.B., P.P., d.R., t.F., and P.S. investigation: M.A., t.F., l.i.A.P., P.P.F., P.S., d.R., J.n., and A.d. Formal analysis: t.F. and M.A. validation: M.A., t.F., S.J.B., A.d., and d.R. Writing\u2014original draft: M.A., t.F., P.P., and P.S. Writing\u2014review and editing: S.J.B., P.P., d.R., M.A., P.S., l.i.A.P., and A.d. visualization: M.A. and t.F. Methodology: J.n., S.J.B., A.d., P.P., d.R., t.F., M.A., P.P.F., l.S., and P.S. Resources: S.J.B., d.R., M.A., and P.P.F. data curation: l.i.A.P., P.S., and M.A. Supervision: S.J.B., P.P., d.R., J.n., and t.F. Funding acquisition: S.J.B., P.P., d.R., M.A., and l.i.A.P. Project administration: S.J.B., P.P., d.R., t.F., and P.S. Competing interests: the authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. cryo-eM density maps have been deposited in the electron Microscopy data Bank under eMd accession codes eMd-17809 (Kuutsalo-14 whole particle), eMd-17808 (Kuutsalo-14 prM3e3 spike localized reconstruction), eMd-17946 (neudoerfl whole particle), eMd-17947 (neudoerfl prM3e3 spike localized reconstruction), and eMd-17945 (hypr whole particle). Atomic coordinates of models have been deposited to the Protein data Bank (PdB) under accession codes 8PPQ (Kuutsalo-14 prM3e3) and 8PUv (neudoerfl prM3e3). Acknowledgments: We thank P. laurinm\u00E4ki of the instruct-eRic centre Finland and the Biocenter Finland national cryoeM Facility, the cryoeM Swedish national Facility funded by; Anastasina , M , Füzik , T , Domanska , A , Pulkkinen , L I A , Šmerdová , L , Formanová , P P , Straková , P , Nováček , J , Růžek , D , Plevka , P & Butcher , S J 2024 , ' The structure of immature tick-borne encephalitis virus supports the collapse model of flavivirus maturation ' , Science Advances , vol. 10 , no. 27 , adl1888 . https://doi.org/10.1126/sciadv.adl1888; ORCID: /0000-0002-3772-6003/work/166162647; ORCID: /0000-0001-7060-5871/work/166163394; http://hdl.handle.net/10138/584741; 36ec83cc-c669-45cd-b735-51d4f6dada14; 85197686140; 001262993200012
الاتاحة: http://hdl.handle.net/10138/584741
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7Academic Journal
المؤلفون: Fořtová Andrea, Straková Petra, Haviernik Jan, Svoboda Pavel, Bartonička Tomáš, Kvičerová Jana, Růžek Daniel, Salát Jiří
المصدر: Infection, Genetics and Evolution
مصطلحات موضوعية: Brno loanvirus, Bats, Hantavirus, Nyctalus noctula
Relation: https://is.muni.cz/publication/2416482
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8Academic Journal
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9Academic Journal
المؤلفون: Cervantes Rincón, Tomás, Kapoor, Tania, Keeffe, Jennifer R., Simonelli, Luca, Hoffmann, Hans-Heinrich, Agudelo, Marianna, Jurado, Andrea, Peace, Avery, Lee, Yu E., Gazumyan, Anna, Guidetti, Francesca, Cantergiani, Jasmine, Cena, Benedetta, Bianchini, Filippo, Tamagnini, Elia, Moro, Simone G., Svoboda, Pavel, Costa, Federico, Reis, Mitermayer G., Ko, Albert I., Fallon, Brian A., Avila-Rios, Santiago, Reyes-Téran, Gustavo, Rice, Charles M., Nussenzweig, Michel C., Bjorkman, Pamela J., Ruzek, Daniel, Varani, Luca, MacDonald, Margaret R., Robbiani, Davide F.
المصدر: Cell Reports, 43(6), 114298, (2024-06-25)
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10Academic Journal
المؤلفون: Fajfr, Miroslav, Pajer, Petr, Ruzek, Daniel, Sleha, Radek, Janovska, Sylva, Bohonek, Milos, Kabickova, Hana, Kubicková, Pavla, Stefanik, Michal, Strakova, Petra, Bostik, Pavel
المساهمون: Ministerstvo Zdravotnictví Ceské Republiky, Ministerstvo Zemědělství, Ministerstvo Obrany České Republiky
المصدر: Scientific Reports ; volume 14, issue 1 ; ISSN 2045-2322
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11Academic Journal
المؤلفون: Vojnikova, Michaela, Sukupova, Martina, Stefanik, Michal, Strakova, Petra, Haviernik, Jan, Kapolkova, Katerina, Gruberova, Eliska, Raskova, Klara, Michalkova, Hana, Svec, Pavel, Kudlickova, Marie, Huvarova, Ivana, Ruzek, Daniel, Salat, Jiri, Pekarik, Vladimir, Eyer, Ludek, Heger, Zbynek
المصدر: International Journal of Nanomedicine ; volume Volume 19, page 3907-3917 ; ISSN 1178-2013
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12Academic Journal
المؤلفون: Ruzek, Daniel, Kaucka, Kristyna
المصدر: Ticks and Tick-borne Diseases ; volume 15, issue 3, page 102314 ; ISSN 1877-959X
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13Academic Journal
المؤلفون: Šimečková, Pavlína, Slavík, Josef, Fořtová, Andrea, Huvarová, Ivana, Králiková, Lucie, Stefanik, Michal, Svoboda, Pavel, Ruzek, Daniel, Machala, Miroslav
المساهمون: Czech Science Foundation, Ministry of Agriculture of the Czech Republic, Ministry of Education Youth and Sports of the Czech Republic, EEA Grants/Norway Grants
المصدر: Microbes and Infection ; page 105303 ; ISSN 1286-4579
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14Academic Journal
المؤلفون: Maryewski, Xenia A., Krasilnikov, Maxim S., Straková, Petra, Holoubek, Jiří, Frčková, Tereza, Panina, Irina S., Krylov, Nikolay A., Gvozdev, Daniil A., Denisov, Vladislav S., Semenov, Alexey N., Lotosh, Natalia Y., Selishcheva, Alla A., Chistov, Alexey A., Gulyak, Evgeny L., Kozhemyakin, Grigory L., Korshun, Vladimir A., Efremov, Roman G., Ustinov, Alexey V., Růžek, Daniel, Eyer, Luděk, Alferova, Vera A.
المساهمون: Russian Science Foundation, NextGenerationEU
المصدر: ACS Applied Materials & Interfaces ; volume 17, issue 3, page 4502-4528 ; ISSN 1944-8244 1944-8252
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15Academic Journal
المؤلفون: Lesiczka, Paulina Maria, Hrazdilová, Kristýna, Majerová, Karolina, Fonville, Manoj, Sprong, Hein, Hönig, Václav, Hofmannová, Lada, Papežík, Petr, Růžek, Daniel, Zurek, Ludek, Votýpka, Jan, Modrý, David
المصدر: Microbial Ecology, 2021 Oct 01. 82(3), 602-612.
URL الوصول: https://www.jstor.org/stable/27291234
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16Conference
المؤلفون: Füzik Tibor, Šmerdová Lenka, Nepovímová Lucie, Formanová Petra, Straková Petra, Růžek Daniel, Plevka Pavel
المصدر: NIVB meeting 2023
مصطلحات موضوعية: virus, flavivirus, tick, structure, nezralý, tick-borne encephalitis virus, flavirus, klíště, struktura, nezralost, virus klíšťové encefalitidy
Relation: https://is.muni.cz/publication/2347060
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17Academic Journal
المؤلفون: Saegerman, Claude, Humblet, Marie-France, Leandri, Marc, Gonzalez, Gaëlle, Heyman, Paul, Sprong, Hein, L'Hostis, Monique, Moutailler, Sara, Bonnet, Sarah I, Haddad, Nadia, Boulanger, Nathalie, Leib, Stephen L, Hoch, Thierry, Thiry, Etienne, Bournez, Laure, Kerlik, Jana, Velay, Aurélie, Jore, Solveig, Jourdain, Elsa, Gilot-Fromont, Emmanuelle, Brugger, Katharina, Geller, Julia, Studahl, Marie, Knap, Nataša, Avšič-Županc, Tatjana, Růžek, Daniel, Zomer, Tizza P, Bødker, René, Berger, Thomas F H, Martin-Latil, Sandra, De Regge, Nick, Raffetin, Alice, Lacour, Sandrine A, Klein, Matthias, Lernout, Tinne, Quillery, Elsa, Hubálek, Zdeněk, Ruiz-Fons, Francisco, Estrada-Peña, Agustín, Fravalo, Philippe, Kooh, Pauline, Etore, Florence, Gossner, Céline M, Purse, Bethan
المصدر: Viruses, 15 (3), 791 (2023-03-20)
مصطلحات موضوعية: Dermacentor reticulatus, TBEV, clustering analysis, drivers, expert elicitation, flavivirus, genus Ixodes, multi-criteria decision analysis (MCDA), sensitivity analysis, tick-borne encephalitis (TBE), ticks, uncertainty, Animals, Humans, Europe/epidemiology, Animals, Wild, Mammals, Encephalitis, Tick-Borne, Ixodes, Dermacentor, Europe, Infectious Diseases, Virology, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale
Relation: https://www.mdpi.com/1999-4915/15/3/791/pdf; urn:issn:1999-4915
URL الوصول: https://orbi.uliege.be/handle/2268/304424
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18Academic Journal
المؤلفون: Fořtová Andrea, Barkhash Andrey, Pýchová Martina, Krbková Lenka, Palus Martin, Salát Jiří, Růžek Daniel
المصدر: JOURNAL OF NEUROVIROLOGY
مصطلحات موضوعية: Tick-borne encephalitis, Genetics, Immunity genes, Single-nucleotide polymorphism, Predisposition
Relation: https://is.muni.cz/publication/2335308
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19Academic Journal
المؤلفون: Svoboda, Pavel, Haviernik, Jan, Bednar, Petr, Matkovic, Milos, Cervantes Rincón, Tomás, Keeffe, Jennifer, Palus, Martin, Salat, Jiri, Agudelo, Marianna, Nussenzweig, Michel C., Cavalli, Andrea, Robbiani, Davide F., Ruzek, Daniel
المصدر: Cell Reports, 42(9), 113149, (2023-09-26)
مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology
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20Academic Journal
المؤلفون: Kakuk, Balázs, Dörmő, Ákos, Csabai, Zsolt, Kemenesi, Gábor, Holoubek, Jiří, Růžek, Daniel, Prazsák, István, Dani, Virág Éva, Dénes, Béla, Torma, Gábor, Jakab, Ferenc, Tóth, Gábor E., Földes, Fanni V., Zana, Brigitta, Lanszki, Zsófia, Harangozó, Ákos, Fülöp, Ádám, Gulyás, Gábor, Mizik, Máté, Kiss, András Attila, Tombácz, Dóra, Boldogkői, Zsolt
المصدر: Scientific Data ; volume 10, issue 1 ; ISSN 2052-4463