المؤلفون: Singh, Isha, Seth, Anubha, Billesbølle, Christian B, Braz, Joao, Rodriguiz, Ramona M, Roy, Kasturi, Bekele, Bethlehem, Craik, Veronica, Huang, Xi-Ping, Boytsov, Danila, Pogorelov, Vladimir M, Lak, Parnian, O'Donnell, Henry, Sandtner, Walter, Irwin, John J, Roth, Bryan L, Basbaum, Allan I, Wetsel, William C, Manglik, Aashish, Shoichet, Brian K, Rudnick, Gary

المصدر: Cell. 186(10)

مصطلحات موضوعية: Animals, Mice, Serotonin, Fluoxetine, Ibogaine, Molecular Conformation, Serotonin Plasma Membrane Transport Proteins, Small Molecule Libraries, Selective Serotonin Reuptake Inhibitors, depression, docking, functional selectivity, serotonin transporter, ultra-large libraries, Substance Misuse, Neurosciences, Drug Abuse (NIDA only), Biological Sciences, Medical and Health Sciences, Developmental Biology

URL الوصول: https://escholarship.org/uc/item/5cg0t59n

المؤلفون: Kwan, Alex C, Olson, David E, Preller, Katrin H, Roth, Bryan L

المصدر: Nature Neuroscience. 25(11)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Biological Psychology, Neurosciences, Psychology, Pharmacology and Pharmaceutical Sciences, Basic Behavioral and Social Science, Mental Health, Behavioral and Social Science, 1.1 Normal biological development and functioning, Neurological, Hallucinogens, Cognition, Serotonin Receptor Agonists, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2zk3113t
https://escholarship.org/content/qt2zk3113t/qt2zk3113t.pdf

المؤلفون: Kaplan, Anat Levit, Confair, Danielle N, Kim, Kuglae, Barros-Álvarez, Ximena, Rodriguiz, Ramona M, Yang, Ying, Kweon, Oh Sang, Che, Tao, McCorvy, John D, Kamber, David N, Phelan, James P, Martins, Luan Carvalho, Pogorelov, Vladimir M, DiBerto, Jeffrey F, Slocum, Samuel T, Huang, Xi-Ping, Kumar, Jain Manish, Robertson, Michael J, Panova, Ouliana, Seven, Alpay B, Wetsel, Autumn Q, Wetsel, William C, Irwin, John J, Skiniotis, Georgios, Shoichet, Brian K, Roth, Bryan L, Ellman, Jonathan A

المصدر: Nature. 610(7932)

مصطلحات موضوعية: Theory Of Computation, Information and Computing Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Women's Health, 1.1 Normal biological development and functioning, Animals, Mice, Antidepressive Agents, Cryoelectron Microscopy, Fluoxetine, Hallucinogens, Ligands, Pyrrolidines, Receptor, Serotonin, 5-HT2A, Small Molecule Libraries, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/87f9q9sd
https://escholarship.org/content/qt87f9q9sd/qt87f9q9sd.pdf

المؤلفون: Zhang, Shicheng, Chen, He, Zhang, Chengwei, Yang, Ying, Popov, Petr, Liu, Jing, Krumm, Brian E, Cao, Can, Kim, Kuglae, Xiong, Yan, Katritch, Vsevolod, Shoichet, Brian K, Jin, Jian, Fay, Jonathan F, Roth, Bryan L

المصدر: Nature Structural & Molecular Biology. 29(7)

مصطلحات موضوعية: 1.1 Normal biological development and functioning, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Humans, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Serotonin Receptor Agonists, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biophysics, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2zf12404

المؤلفون: Kaplan, Anat Levit, Strachan, Ryan T, Braz, Joao M, Craik, Veronica, Slocum, Samuel, Mangano, Thomas, Amabo, Vanessa, O’Donnell, Henry, Lak, Parnian, Basbaum, Allan I, Roth, Bryan L, Shoichet, Brian K

المصدر: Journal of Medicinal Chemistry. 65(5)

مصطلحات موضوعية: Chronic Pain, Pain Research, Substance Misuse, Drug Abuse (NIDA only), Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Humans, Ligands, Pain, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

URL الوصول: https://escholarship.org/uc/item/5mc8k3v1

المؤلفون: Alon, Assaf, Lyu, Jiankun, Braz, Joao M, Tummino, Tia A, Craik, Veronica, O’Meara, Matthew J, Webb, Chase M, Radchenko, Dmytro S, Moroz, Yurii S, Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L, Irwin, John J, Basbaum, Allan I, Shoichet, Brian K, Kruse, Andrew C

المصدر: Nature. 600(7890)

مصطلحات موضوعية: Theory Of Computation, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Information and Computing Sciences, Neurosciences, Neurodegenerative, Chronic Pain, Pain Research, Peripheral Neuropathy, 5.1 Pharmaceuticals, Animals, Ligands, Mice, Neuralgia, Receptors, sigma, Structure-Activity Relationship, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/9gp7838k

المؤلفون: Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W, Liu, Jing, Gumpper, Ryan H, Bender, Brian J, Slocum, Samuel T, Krumm, Brian E, Lansu, Katherine, McCorvy, John D, Kroeze, Wesley K, English, Justin G, DiBerto, Jeffrey F, Olsen, Reid HJ, Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y, Abraham, Soman N, Jin, Jian, Shoichet, Brian K, Fay, Jonathan F, Roth, Bryan L

المصدر: Nature. 600(7887)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Chronic Pain, Pain Research, 2.1 Biological and endogenous factors, Generic health relevance, Cryoelectron Microscopy, Drug Inverse Agonism, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Models, Molecular, Nerve Tissue Proteins, Pruritus, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/78f5d3k9

المؤلفون: Wang, Chunyu, Liu, Yongfeng, Lanier, Marion, Yeager, Adam, Singh, Isha, Gumpper, Ryan H., Krumm, Brian E., DeLeon, Chelsea, Zhang, Shicheng, Boehm, Marcus, Pittner, Richard, Baron, Alain, Dvorak, Lisa, Bacon, Corinne, Shoichet, Brian K., Martinborough, Esther, Fay, Jonathan F., Cao, Can, Roth, Bryan L.

المساهمون: University of North Carolina, Nvidia, NIH

المصدر: Cell Reports ; volume 43, issue 12, page 114942 ; ISSN 2211-1247

الاتاحة: https://doi.org/10.1016/j.celrep.2024.114942
https://api.elsevier.com/content/article/PII:S2211124724012932?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2211124724012932?httpAccept=text/plain

المؤلفون: Bedard, Madigan L., Huang, Xi-Ping, Murray, Jackson G., Nowlan, Alexandra C., Conley, Sara Y., Mott, Sarah E., Loyack, Samuel J., Cline, Calista A., Clodfelter, Caroline G., Dasgupta, Nabarun, Krumm, Brian, Roth, Bryan L., McElligott, Zoe A.

المصدر: Addiction Neuroscience, 11

مصطلحات موضوعية: politicians, decision, policy, considerations, health crisis, naloxone precipitated withdrawal, drug supply, naloxone efficacy, behavior, ongoing health crisis, withdrawal, public health officials, opioid antagonism, sensitivity, impact, combination, effect, drug, supply, fentanyl, agonists, public health considerations, rate, pharmacology, kappa, officials, potential mechanisms, xylazine, data, opioid receptors

Relation: https://cdr.lib.unc.edu/downloads/ww72br769?file=thumbnail; https://cdr.lib.unc.edu/downloads/ww72br769

الاتاحة: https://doi.org/10.17615/g2dk-3k56
https://cdr.lib.unc.edu/downloads/ww72br769?file=thumbnail
https://cdr.lib.unc.edu/downloads/ww72br769

المؤلفون: Kaplan, Anat Levit, Strachan, Ryan T, Braz, Joao M, Craik, Veronica, Slocum, Samuel, Mangano, Thomas, Amabo, Vanessa, O’Donnell, Henry, Lak, Parnian, Basbaum, Allan I, Roth, Bryan L, Shoichet, Brian

مصطلحات موضوعية: Theory Of Computation, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Information and Computing Sciences, Pharmacology and Pharmaceutical Sciences, Chronic Pain, Pain Research, Neurosciences, Mental Health

URL الوصول: https://escholarship.org/uc/item/96g45357

المؤلفون: Huang, Xi-Ping, Kenakin, Terrence P, Gu, Shuo, Shoichet, Brian K, Roth, Bryan L

المصدر: Biochemistry. 59(38)

مصطلحات موضوعية: Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Allosteric Regulation, Amino Acid Sequence, Calcium, HEK293 Cells, Histidine, Humans, Hydrogen-Ion Concentration, Magnesium, Metals, Heavy, Mutation, Protons, Receptors, G-Protein-Coupled, Medicinal and Biomolecular Chemistry, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9bg4r1x9

المؤلفون: Kim, Kuglae, Che, Tao, Panova, Ouliana, DiBerto, Jeffrey F, Lyu, Jiankun, Krumm, Brian E, Wacker, Daniel, Robertson, Michael J, Seven, Alpay B, Nichols, David E, Shoichet, Brian K, Skiniotis, Georgios, Roth, Bryan L

المصدر: Cell. 182(6)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Brain Disorders, Mental Health, Depression, Substance Misuse, Aetiology, 2.1 Biological and endogenous factors, Mental health, Animals, Cryoelectron Microscopy, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Expression, HEK293 Cells, Hallucinogens, Humans, Ligands, Lysergic Acid Diethylamide, Methiothepin, Models, Chemical, Mutation, Protein Conformation, alpha-Helical, Receptor, Serotonin, 5-HT2A, Recombinant Proteins, Serotonin, Spodoptera, GPCR, LSD, psychedelic, sertotonin receptor, signal transduction, structural biology, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0wc7m3gg

المؤلفون: Pottel, Joshua, Armstrong, Duncan, Zou, Ling, Fekete, Alexander, Huang, Xi-Ping, Torosyan, Hayarpi, Bednarczyk, Dallas, Whitebread, Steven, Bhhatarai, Barun, Liang, Guiqing, Jin, Hong, Ghaemi, S Nassir, Slocum, Samuel, Lukacs, Katalin V, Irwin, John J, Berg, Ellen L, Giacomini, Kathleen M, Roth, Bryan L, Shoichet, Brian K, Urban, Laszlo

المصدر: Science. 369(6502)

مصطلحات موضوعية: 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Drug Compounding, Drug Evaluation, Preclinical, Excipients, Humans, Molecular Targeted Therapy, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/27x6b8vj

المؤلفون: Stein, Reed M, Kang, Hye Jin, McCorvy, John D, Glatfelter, Grant C, Jones, Anthony J, Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S, Stauch, Benjamin, Johansson, Linda C, Cherezov, Vadim, Kenakin, Terry, Irwin, John J, Shoichet, Brian K, Roth, Bryan L, Dubocovich, Margarita L

المصدر: Nature. 579(7800)

مصطلحات موضوعية: Sleep Research, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Animals, Circadian Rhythm, Darkness, Drug Evaluation, Preclinical, Drug Inverse Agonism, Female, Humans, Ligands, Light, Male, Mice, Mice, Knockout, Molecular Docking Simulation, Receptor, Melatonin, MT1, Receptor, Melatonin, MT2, Receptors, Melatonin, Small Molecule Libraries, Substrate Specificity, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3sp0d3rw

المؤلفون: Lee, So Jeong, Pearson, Torben D., Dhaynaut, Maeva, MacDonagh, Alexander C., Wey, Hsiao-Ying, Wilks, Moses Q., Roth, Bryan L., Hooker, Jacob M., Normandin, Marc D.

المساهمون: National Institute of Mental Health, Department of Radiology, Massachusetts General Hospital

المصدر: Journal of Medicinal Chemistry ; ISSN 0022-2623 1520-4804

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c02287
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c02287

المؤلفون: Lyu, Jiankun, Wang, Sheng, Balius, Trent E, Singh, Isha, Levit, Anat, Moroz, Yurii S, O’Meara, Matthew J, Che, Tao, Algaa, Enkhjargal, Tolmachova, Kateryna, Tolmachev, Andrey A, Shoichet, Brian K, Roth, Bryan L, Irwin, John J

المصدر: Nature. 566(7743)

مصطلحات موضوعية: Theory Of Computation, Medicinal and Biomolecular Chemistry, Chemical Sciences, Built Environment and Design, Information and Computing Sciences, Design, Neurosciences, 5.1 Pharmaceuticals, Bacterial Proteins, Crystallography, X-Ray, Dopamine Agonists, Humans, Ligands, Machine Learning, Molecular Docking Simulation, Observation, Receptors, Dopamine D4, Small Molecule Libraries, beta-Lactamase Inhibitors, beta-Lactamases, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2k01p3zc
https://escholarship.org/content/qt2k01p3zc/qt2k01p3zc.pdf

المؤلفون: Oprea, Tudor I, Jan, Lily, Johnson, Gary L, Roth, Bryan L, Ma'ayan, Avi, Schürer, Stephan, Shoichet, Brian K, Sklar, Larry A, McManus, Michael T

المصدر: PLoS biology. 16(12)

مصطلحات موضوعية: Genome, Research, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/72c8g3s4

المؤلفون: Weiss, Dahlia R, Karpiak, Joel, Huang, Xi-Ping, Sassano, Maria F, Lyu, Jiankun, Roth, Bryan L, Shoichet, Brian K

المصدر: Journal of Medicinal Chemistry. 61(15)

مصطلحات موضوعية: Neurosciences, Drug Evaluation, Preclinical, Ligands, Molecular Docking Simulation, Protein Conformation, Receptor, Serotonin, 5-HT2A, Receptors, Dopamine D2, Substrate Specificity, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/96n832dt

المؤلفون: Wang, Sheng, Che, Tao, Levit, Anat, Shoichet, Brian K, Wacker, Daniel, Roth, Bryan L

المصدر: Nature. 555(7695)

مصطلحات موضوعية: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Mental Health, Schizophrenia, Neurosciences, Mental Illness, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Antipsychotic Agents, Binding Sites, Crystallography, X-Ray, Drug Design, Humans, Hydrophobic and Hydrophilic Interactions, Kinetics, Ligands, Models, Molecular, Mutant Proteins, Mutation, Receptors, Dopamine D2, Receptors, Dopamine D3, Receptors, Dopamine D4, Risperidone, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8r93v5k6
https://escholarship.org/content/qt8r93v5k6/qt8r93v5k6.pdf

المؤلفون: Lee, Yi-Yuan, Guler, Mustafa, Chigumba, Desnor N., Wang, Shen, Mittal, Neel, Miller, Cameron, Krummenacher, Benjamin, Liu, Haodong, Cao, Liu, Kannan, Aditya, Narayan, Keshav, Slocum, Samuel T., Roth, Bryan L., Gurevich, Alexey, Behsaz, Bahar, Kersten, Roland D., Mohimani, Hosein

مصطلحات موضوعية: ddc:004, Computational platforms and environments, Drug discovery and development, Natural products, Peptides

Relation: https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-023-39905-4/MediaObjects/41467_2023_39905_MOESM1_ESM.pdf; https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-023-39905-4/MediaObjects/41467_2023_39905_MOESM2_ESM.pdf; hdl:20.500.11880/36974

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-412231
https://doi.org/10.22028/D291-41223
https://doi.org/10.1038/s41467-023-39905-4