المؤلفون: Marcelo Monteiro Pedroso, David W. Waite, Okke Melse, Liam Wilson, Nataša Mitić, Ross P. McGeary, Iris Antes, Luke W. Guddat, Philip Hugenholtz, Gerhard Schenk

المصدر: Protein & Cell, Vol 11, Iss 8, Pp 613-617 (2020)

مصطلحات موضوعية: Cytology, QH573-671, Animal biochemistry, QP501-801

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

URL الوصول: https://doaj.org/article/c5279e498577457280e0298b11ad0da2

المؤلفون: You Lv, Shan Zheng, Adi Goldenzweig, Fengjiang Liu, Yan Gao, Xiuna Yang, Ajit Kandale, Ross P. McGeary, Simon Williams, Bostjan Kobe, Mark A. Schembri, Michael J. Landsberg, Bin Wu, Thomas B. Brück, Volker Sieber, Mikael Boden, Zihe Rao, Sarel J. Fleishman, Gerhard Schenk, Luke W. Guddat

المصدر: Applied Biosciences; Volume 1; Issue 2; Pages: 163-178

مصطلحات موضوعية: cell-free enzyme cascades, biomanufacturing, enzyme stability, protein design, PROSS, branched chain amino acid biosynthesis, ketol-acid reductoisomerase

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/applbiosci1020011

الاتاحة: https://doi.org/10.3390/applbiosci1020011

المؤلفون: Ajit Kandale (10052453), Khushboo Patel (10052456), Waleed M. Hussein (552234), Shun Jie Wun (9553917), Shan Zheng (432999), Lendl Tan (3105966), Nicholas P. West (324121), Gerhard Schenk (1471624), Luke W. Guddat (288645), Ross P. McGeary (2391481)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, antimycobacterial activity, 19.7 nM, analogue, anti-TB drug discovery, plant KARI, MIC 90, compound, Promising Anti-TB Drug, Inhibit Mycobacterium tuberculosis ., anti-TB agent, second-line treatments, Mycobacterium tuberculosis, Prodrug, K i value, IpOHA, K i, New drugs, antimycobacterial agents, Mt KARI, tight-binding inhibitors

Relation: https://figshare.com/articles/journal_contribution/Analogues_of_the_Herbicide_i_N_i_Hydroxy_i_N_i_isopropyloxamate_Inhibit_Mycobacterium_tuberculosis_Ketol-Acid_Reductoisomerase_and_Their_Prodrugs_Are_Promising_Anti-TB_Drug_Leads/13664894

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01919.s002

المؤلفون: Nahid Alimoradi, Mohammad Reza Ashrafi-Kooshk, Mohsen Shahlaei, Shabnam Maghsoudi, Hadi Adibi, Ross P. McGeary, Reza Khodarahmi

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 20-28 (2017)

مصطلحات موضوعية: Acid phosphatase, enzyme inhibition, phosphonic acid, synthesis, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/67f6303ce0d847dcb096aeed9dc81c55

المؤلفون: Julia L Kurz, Marcelo M Pedroso, Emmanuelle Richard, Ross P McGeary, Gerhard Schenk

مصطلحات موضوعية: medicinal_chemistry_50

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae24c15f9646725cb2f623c7862a628

المؤلفون: Julia L. Kurz, Marcelo Monteiro Pedroso, Emmanuelle Richard, Ross P. McGeary, Gerhard Schenk

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::645aa071f8c844771b1feaac3824e3dc
https://doi.org/10.2139/ssrn.4428715

المؤلفون: Daniel Feder, Siti Hajar Mohd-Pahmi, Hadi Adibi, Luke W. Guddat, Gerhard Schenk, Ross P. McGeary, Waleed M. Hussein

المصدر: European Journal of Medicinal Chemistry. 254:115383

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9e12609493ddfdac2337a863b60a097a
https://doi.org/10.1016/j.ejmech.2023.115383

المؤلفون: Luke W. Guddat, Ajit Kandale, Lendl Tan, Gerhard Schenk, Nicholas P. West, Shun Jie Wun, Waleed M. Hussein, Ross P. McGeary, Khushboo M. Patel, Shan Zheng

المصدر: Journal of Medicinal Chemistry. 64:1670-1684

مصطلحات موضوعية: Drug, Tuberculosis, Stereochemistry, medicine.drug_class, media_common.quotation_subject, Virulence, medicine.disease_cause, Antimycobacterial, 01 natural sciences, Mycobacterium tuberculosis, 03 medical and health sciences, Drug Discovery, medicine, 030304 developmental biology, media_common, 0303 health sciences, biology, Drug discovery, Chemistry, Prodrug, biology.organism_classification, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Staphylococcus aureus, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::53c21cfcd7fd00c0fed17f2619927f5f
https://doi.org/10.1021/acs.jmedchem.0c01919

المؤلفون: Ross P. McGeary, Shun Jie Wun, Xin Lin, Gerhard Schenk, Julia L. Kurz, Nicholas P. West, Thierry G. A. Lonhienne, Luke W. Guddat, Waleed M. Hussein, Khushboo M. Patel

المصدر: Chemistry – A European Journal. 27:3130-3141

مصطلحات موضوعية: Staphylococcus aureus, Stereochemistry, Ketol-Acid Reductoisomerase, Branched-chain amino acid, Antitubercular Agents, Pyrimidinones, 010402 general chemistry, 01 natural sciences, Catalysis, Cell Line, Chemical library, Mycobacterium tuberculosis, chemistry.chemical_compound, Biosynthesis, Pyrimidinedione, Humans, Tuberculosis, chemistry.chemical_classification, biology, 010405 organic chemistry, Organic Chemistry, Isothermal titration calorimetry, General Chemistry, biology.organism_classification, 0104 chemical sciences, Enzyme, chemistry, Drug development, NADP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4733624013e906f200a3803b116bd7c4
https://doi.org/10.1002/chem.202004665

المؤلفون: James A. Fraser, Gerhard Schenk, Quan Wang, Michael J. Landsberg, Zihe Rao, Luke W. Guddat, Craig M. Williams, Yu shang Low, Thierry G. A. Lonhienne, Lou Brillault, Ross P. McGeary, Nicholas P. West, Tristan I. Croll, Mario D. Garcia, Yan Gao

المصدر: Nature. 586:317-321

مصطلحات موضوعية: 0301 basic medicine, Flavin adenine dinucleotide, chemistry.chemical_classification, Acetolactate synthase, Multidisciplinary, 030102 biochemistry & molecular biology, biology, Protein subunit, Saccharomyces cerevisiae, biology.organism_classification, Amino acid, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, 030104 developmental biology, Protein structure, Biosynthesis, chemistry, Biochemistry, biology.protein, health care economics and organizations

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9c145dd1cfac1a81095e69745f842ed0
https://doi.org/10.1038/s41586-020-2514-3

المؤلفون: Ross P. McGeary, Nataša Mitić, Philip Hugenholtz, Luke W. Guddat, Liam A. Wilson, David W. Waite, Gerhard Schenk, Iris Antes, Marcelo Monteiro Pedroso, Okke Melse

المصدر: Protein & Cell
Protein & Cell, Vol 11, Iss 8, Pp 613-617 (2020)

مصطلحات موضوعية: Genetics, Letter, QH573-671, Bacteria, QP501-801, Cell Biology, Microbial Sensitivity Tests, Biology, Biochemistry, Animal biochemistry, Metallo β lactamase, Human genetics, beta-Lactamases, Anti-Bacterial Agents, Evolution, Molecular, Broad spectrum, Drug Discovery, Stem cell, Cytology, Developmental biology, Clavulanic Acid, Phylogeny, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b9d5adf3a1f049dcf47b7d8882c66d
http://europepmc.org/articles/PMC7381538

المؤلفون: You Lv, Shan Zheng, Adi Goldenzweig, Fengjiang Liu, Yan Gao, Xiuna Yang, Ajit Kandale, Ross P. McGeary, Simon Williams, Bostjan Kobe, Mark A. Schembri, Michael J. Landsberg, Bin Wu, Thomas B. Brück, Volker Sieber, Mikael Boden, Zihe Rao, Sarel J. Fleishman, Gerhard Schenk, Luke W. Guddat

المصدر: Applied Biosciences; Volume 1; Issue 2; Pages: 163-178

مصطلحات موضوعية: cell-free enzyme cascades, biomanufacturing, enzyme stability, protein design, PROSS, branched chain amino acid biosynthesis, ketol-acid reductoisomerase, Article, ddc

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf0a7e7d6df0297b8f241237e34c9e
https://mediatum.ub.tum.de/doc/1689329/document.pdf

المؤلفون: Ross P. McGeary, Gerhard Schenk, Luke W. Guddat, Lawrence R. Gahan, Daniel Feder

المصدر: ChemBioChem. 20:1536-1540

مصطلحات موضوعية: Models, Molecular, Acid Phosphatase, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, 03 medical and health sciences, Catalytic Domain, medicine, Vanadate, Molecular Biology, Plant Proteins, 030304 developmental biology, Phaseolus, chemistry.chemical_classification, 0303 health sciences, Transition (genetics), Chemistry, Organic Chemistry, Substrate (chemistry), Purple acid phosphatases, Adenosine, Transition state, 3. Good health, 0104 chemical sciences, Red kidney beans, Kinetics, Enzyme, Molecular Medicine, Vanadates, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdc2a337f62d0335b05787278f562bf
https://doi.org/10.1002/cbic.201900077

المؤلفون: Gawain McColl, Stephen Chan, Marie-Odile Parat, Suresh Kumar Veliyath, Zeyad D. Nassar, Xavier Brazzolotto, Israel Silman, Joel L. Sussman, Eugenio de la Mora, Satish N. Dighe, Jared A. Miles, B. Yogi Sreenivas, Martin Weik, Ross P. McGeary, Benjamin P. Ross, Srinivas Kantham

المصدر: Communications Chemistry, Vol 2, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Drug, Rivastigmine, biology, Tertiary amine, Membrane permeability, Chemistry, Amyloid beta, media_common.quotation_subject, Metabolite, food and beverages, General Chemistry, Pharmacology, Druglikeness, Biochemistry, lcsh:Chemistry, chemistry.chemical_compound, lcsh:QD1-999, In vivo, Materials Chemistry, biology.protein, medicine, Environmental Chemistry, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd4ae5ed5b5bda78c7c14c1d7504d4
http://link.springer.com/article/10.1038/s42004-019-0133-4

المؤلفون: Waleed M. Hussein, Luke W. Guddat, Siti Hajar Mohd-Pahmi, Gerhard Schenk, Daniel Feder, Ross P. McGeary

المصدر: ChemMedChem. 16(21)

مصطلحات موضوعية: Models, Molecular, Swine, Glutamine, Acid Phosphatase, 010402 general chemistry, Ligands, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Animals, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Enzyme Inhibitors, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, HEPES, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, Fragment (computer graphics), Organic Chemistry, Rational design, Active site, Purple acid phosphatases, 3. Good health, 0104 chemical sciences, Amino acid, Enzyme, chemistry, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1d49e1af2db0e3d2451cea08ebb4ef
https://pubmed.ncbi.nlm.nih.gov/34331400

المؤلفون: Jared A. Miles, Jia Hui Ng, B. Yogi Sreenivas, Charlotte Courageux, Alexandre Igert, José Dias, Ross P. McGeary, Xavier Brazzolotto, Benjamin P. Ross

المصدر: Chemical Biology & Drug Design. 97

مصطلحات موضوعية: Pharmacology, Drug Discovery, Organic Chemistry, Molecular Medicine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ade5eb36bf372bbf8a88b1eb9267d304
https://doi.org/10.1111/cbdd.13717

المؤلفون: Ajit, Kandale, Khushboo, Patel, Waleed M, Hussein, Shun Jie, Wun, Shan, Zheng, Lendl, Tan, Nicholas P, West, Gerhard, Schenk, Luke W, Guddat, Ross P, McGeary

المصدر: Journal of medicinal chemistry. 64(3)

مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Cell Survival, Herbicides, Ketol-Acid Reductoisomerase, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Cell Line, Molecular Docking Simulation, Mice, Drug Discovery, Animals, Humans, Prodrugs, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::851f04823dcab4b2bcd2fd149663be3d
https://pubmed.ncbi.nlm.nih.gov/33512163

المؤلفون: Ross P. McGeary, Charlotte Courageux, José A. Dias, Jia Hui Ng, Alexandre Igert, Benjamin P. Ross, Jared A. Miles, Xavier Brazzolotto, B. Yogi Sreenivas

المصدر: Chemical biologydrug designREFERENCES. 97(5)

مصطلحات موضوعية: Drug, In silico, media_common.quotation_subject, Mixed inhibition, Molecular Dynamics Simulation, computer.software_genre, 01 natural sciences, Biochemistry, Permeability, chemistry.chemical_compound, Alzheimer Disease, Catalytic Domain, Drug Discovery, Animals, Donepezil, Horses, Cholinesterase, media_common, Pharmacology, Virtual screening, Binding Sites, biology, Database, 010405 organic chemistry, Organic Chemistry, Ligand (biochemistry), Acetylcholinesterase, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Kinetics, chemistry, Butyrylcholinesterase, Electrophorus, biology.protein, Molecular Medicine, Cholinesterase Inhibitors, computer, Databases, Chemical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a59cb21fe096d1aa8d76fa0dd74606
https://pubmed.ncbi.nlm.nih.gov/33455074

المؤلفون: Kenichi Akaji, Marwa M. Shaaban, Mona A. Mahran, Hanan M. Ragab, Bassma H. Elwakil, Waleed M. Hussein, Ross P. McGeary, Adnan A. Bekhit, Tamer M. Ibrahim, Julia L. Kurz, Alaa-Eldin A. Bekhit, Salma A. Bekhit

المصدر: Bioorganic chemistry. 105

مصطلحات موضوعية: Microbial Sensitivity Tests, Conjugated system, 01 natural sciences, Biochemistry, Meropenem, beta-Lactamases, chemistry.chemical_compound, Structure-Activity Relationship, Cefalexin, Drug Discovery, Drug Resistance, Bacterial, medicine, Molecular Biology, Sulfonyl, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Hydrazones, Combinatorial chemistry, In vitro, 0104 chemical sciences, Anti-Bacterial Agents, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Klebsiella pneumoniae, chemistry, Docking (molecular), Drug Design, Pyrazoles, Antibacterial activity, beta-Lactamase Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0595bb90bdc56639292be290b1adb31
https://pubmed.ncbi.nlm.nih.gov/33137556

المؤلفون: Ross P. McGeary, Daniel Feder, Waleed M. Hussein, Luke W. Guddat, Gerhard Schenk

المصدر: European Journal of Medicinal Chemistry. 157:462-479

مصطلحات موضوعية: Swine, Acid Phosphatase, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Structure-Activity Relationship, chemistry.chemical_compound, Hydrolysis, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Glycoproteins, Tartrate-resistant acid phosphatase, Phaseolus, Pharmacology, chemistry.chemical_classification, Kidney, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Active site, General Medicine, Purple acid phosphatases, Phosphate, 0104 chemical sciences, Molecular Docking Simulation, medicine.anatomical_structure, Enzyme, chemistry, Biochemistry, Docking (molecular), biology.protein, Osteoporosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9d876975ac78c1bf41e002c5220716
https://doi.org/10.1016/j.ejmech.2018.08.004