المؤلفون: John R. Apps, Jose Mario Gonzalez-Meljem, Romain Guiho, Jessica C. Pickles, Eric Prince, Edward Schwalbe, Nikhil Joshi, Thomas J. Stone, Olumide Ogunbiyi, Jane Chalker, Akang Bassey, Georg Otto, Rosalind Davies, Debbie Hughes, Sebastian Brandner, Enrica Tan, Victoria Lee, Caroline Hayhurst, Cassie Kline, Sergi Castellano, Todd Hankinson, Timo Deutschbein, Thomas S. Jacques, Juan Pedro Martinez-Barbera

المصدر: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)

مصطلحات موضوعية: Craniopharyngioma, MAPK signalling pathway, MEK inhibitor, Macrophage/microglia, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-5960

URL الوصول: https://doaj.org/article/0874ef81d5794b778ecf6f36f0dcbfe2

المؤلفون: Domhnall McHugh, Bin Sun, Carmen Gutierrez-Muñoz, Fernanda Hernández-González, Massimiliano Mellone, Romain Guiho, Imanol Duran, Joaquim Pombo, Federico Pietrocola, Jodie Birch, Wouter W Kallemeijn, Sanjay Khadayate, Gopuraja Dharmalingam, Santiago Vernia, Edward W Tate, Juan Pedro Martínez-Barbera, Dominic J Withers, Gareth J Thomas, Manuel Serrano, Jesús Gil

مصطلحات موضوعية: Model organisms, Biochemistry & Proteomics, Cell Biology, Infectious Disease, Tate - sat, 06 Biological Sciences, 11 Medical and Health Sciences, Developmental Biology, 3101 Biochemistry and cell biology

Relation: https://figshare.com/articles/journal_contribution/COPI_vesicle_formation_and_N-myristoylation_are_targetable_vulnerabilities_of_senescent_cells_/24806160

الاتاحة: https://doi.org/10.25418/crick.24806160.v1
https://figshare.com/articles/journal_contribution/COPI_vesicle_formation_and_N-myristoylation_are_targetable_vulnerabilities_of_senescent_cells_/24806160

المؤلفون: Régis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Bénédicte Brounais-Le Royer, Franck Verrecchia, Françoise Rédini, Romain Guiho

المصدر: Cancers; Volume 14; Issue 22; Pages: 5627

مصطلحات موضوعية: TNF-related apoptosis inducing ligand (TRAIL), TRAIL-based therapies, osteosarcoma, Ewing sarcoma, pediatric bone tumor, resistance, non-apoptotic pathways

وصف الملف: application/pdf

Relation: Cancer Pathophysiology; https://dx.doi.org/10.3390/cancers14225627

الاتاحة: https://doi.org/10.3390/cancers14225627

المؤلفون: Till Milde, Olaf Witt, David T.W. Jones, Stefan M. Pfister, Tilman Brummer, Andrey Korshunov, Christel Herold-Mende, Martin U. Schuhmann, Andreas von Deimling, David Capper, Daniela Kuhn, Marcel Kool, Cornelis M. van Tilburg, Ina Oehme, Jan Gronych, Stefan Pusch, Daniel Picard, Marc Remke, Annika K. Wefers, J.P. Martinez-Barbera, Alexander C. Sommerkamp, Britta Ismer, Diren Usta, Dennis Riehl, Johannes Ridinger, Felix Sahm, Jonas Ecker, Romain Guiho, Thomas Hielscher, Florian Selt, Juliane L. Buhl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933af723fb366c7c79902971bcc81edb
https://doi.org/10.1158/1078-0432.22474442.v1

المؤلفون: Till Milde, Olaf Witt, David T.W. Jones, Stefan M. Pfister, Tilman Brummer, Andrey Korshunov, Christel Herold-Mende, Martin U. Schuhmann, Andreas von Deimling, David Capper, Daniela Kuhn, Marcel Kool, Cornelis M. van Tilburg, Ina Oehme, Jan Gronych, Stefan Pusch, Daniel Picard, Marc Remke, Annika K. Wefers, J.P. Martinez-Barbera, Alexander C. Sommerkamp, Britta Ismer, Diren Usta, Dennis Riehl, Johannes Ridinger, Felix Sahm, Jonas Ecker, Romain Guiho, Thomas Hielscher, Florian Selt, Juliane L. Buhl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9a7a149a322124373279d6a19c00e7
https://doi.org/10.1158/1078-0432.22474457.v1

المؤلفون: Till Milde, Olaf Witt, David T.W. Jones, Stefan M. Pfister, Tilman Brummer, Andrey Korshunov, Christel Herold-Mende, Martin U. Schuhmann, Andreas von Deimling, David Capper, Daniela Kuhn, Marcel Kool, Cornelis M. van Tilburg, Ina Oehme, Jan Gronych, Stefan Pusch, Daniel Picard, Marc Remke, Annika K. Wefers, J.P. Martinez-Barbera, Alexander C. Sommerkamp, Britta Ismer, Diren Usta, Dennis Riehl, Johannes Ridinger, Felix Sahm, Jonas Ecker, Romain Guiho, Thomas Hielscher, Florian Selt, Juliane L. Buhl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc286084be3ba9a2e33425fa4ae89c0
https://doi.org/10.1158/1078-0432.22474460.v1

المؤلفون: Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Simone Schmid, Heike Peterziel, Jessica W Tsai, Romain Guiho, Juan Pedro Martínez-Barbera, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M van Tilburg, Martin U Schuhman, Ahmed El Damaty, Pratiti Bandopadhayay, Christel Herold-Mende, Andreas von Deimling, Stefan M Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David T W Jones, Olaf Witt, Till Milde

المصدر: Neuro-oncology.

مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c60acac149538ab86273c133c9683e5
https://pubmed.ncbi.nlm.nih.gov/35977048

المؤلفون: Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Heike Peterziel, Jessica W Tsai, Romain Guiho, Juan Pedro Martínez-Barbera, Stefan Pusch, Martin U Schuhmann, Ahmed El Damaty, Pratiti Bandopadhayay, Andreas von Deimling, Stefan M Pfister, Joan Montero, David Capper, Christel Herold-Mende, Ina Oehme, Felix Sahm, David T W Jones, Olaf Witt, Till Milde

المصدر: Neuro-Oncology. 24:i91-i92

مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a90f46599bea4f98f9f901fe39a1d2fa
https://doi.org/10.1093/neuonc/noac079.333

المؤلفون: Florian Selt, Daniela Kuhn, Diren Usta, Stefan M. Pfister, Marc Remke, Romain Guiho, Felix Sahm, Alexander C Sommerkamp, Andrey Korshunov, Annika K. Wefers, Johannes Ridinger, Thomas Hielscher, David Capper, David T.W. Jones, Britta Ismer, Andreas von Deimling, Ina Oehme, Tilman Brummer, Juan Pedro Martinez-Barbera, Juliane L. Buhl, Dennis Riehl, Olaf Witt, Jonas Ecker, Cornelis M. van Tilburg, Till Milde, Daniel Picard, Jan Gronych, Stefan Pusch, Christel Herold-Mende, Martin U. Schuhmann, Marcel Kool

المصدر: Clinical Cancer Research. 25:1851-1866

مصطلحات موضوعية: Male, 0301 basic medicine, Senescence, Cancer Research, Interleukin-1beta, Primary Cell Culture, Datasets as Topic, Astrocytoma, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Tumor Cells, Cultured, medicine, Animals, Humans, Viability assay, Child, Senolytic, neoplasms, Cellular Senescence, Cell Proliferation, Pilocytic astrocytoma, Brain Neoplasms, Cell growth, Gene Expression Profiling, fungi, Prognosis, medicine.disease, Progression-Free Survival, nervous system diseases, Gene expression profiling, Disease Models, Animal, 030104 developmental biology, nervous system, Oncology, Cell culture, Culture Media, Conditioned, 030220 oncology & carcinogenesis, Cancer research, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbfc54dd5b153e356c3dcec398c78c0
https://doi.org/10.1158/1078-0432.ccr-18-1965

المؤلفون: Daniela Kocher, Florian Selt, Gintvile Valinciute, Julia Zaman, David Vonhören, Stefan Pusch, Romain Guiho, Juan Pedro Martinez-Barbera, Andreas von Deimling, Stefan M Pfister, David T W Jones, Tilman Brummer, Olaf Witt, Till Milde, Romain Sigaud

المصدر: Neuro-Oncology. 24:i91-i91

مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::459cddf0c72e2a822baaf275628a3979
https://doi.org/10.1093/neuonc/noac079.332

المؤلفون: Ashley Vardon, Romain Guiho, Diana Carvalho, Jessica Boult, Rebecca Carter, Yura Grabovska, Alan Mackay, Guangrong Zheng, Daohong Zhou, Crispin Hiley, Mark Lythgoe, Chris Jones, Darren Hargrave, Juan-Pedro Martinez

المصدر: Neuro-Oncology. 24:i29-i29

مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::14aeafe405cb64e05e847c8217589421
https://doi.org/10.1093/neuonc/noac079.103

المؤلفون: Than‐Thuy Nham, Romain Guiho, Régis Brion, Jérôme Amiaud, Bénédicte Brounais Le Royer, Anne Gomez‐Brouchet, Françoise Rédini, Hélios Bertin

الاتاحة: http://dx.doi.org/10.1111/odi.14897/v2/response1

المؤلفون: Romain Guiho, Juan Pedro Martinez-Barbera, Gabriela Carreno

المصدر: Neuropathology and Applied Neurobiology

مصطلحات موضوعية: 0301 basic medicine, Senescence, Histology, Carcinogenesis, Parkinson's disease, Cell, Neuropathology, low‐grade glioma, medulloblastoma, multiple sclerosis, SASP, Pathology and Forensic Medicine, senolytic, 03 medical and health sciences, glioblastoma multiforme, 0302 clinical medicine, Physiology (medical), medicine, Animals, Humans, Secretion, Senolytic, Tissue homeostasis, Cellular Senescence, Invited Review, business.industry, Brain Neoplasms, Neurodegeneration, Alzheimer's disease, medicine.disease, Phenotype, diffuse midline glioma, 030104 developmental biology, medicine.anatomical_structure, Neurology, cell senescence, Nerve Degeneration, Cancer research, Neurology (clinical), business, craniopharyngioma, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee442c02cac955d74af23c6a1b0c412
https://pubmed.ncbi.nlm.nih.gov/33378554

المؤلفون: Juan Pedro Martinez-Barbera, Lutz F. Tietze, Anthony G. Uren, Ana Guerrero, Nicolás Herranz, Romain Guiho, Dominic J. Withers, Jesús Gil

المساهمون: Wellcome Trust, Medical Research Council

المصدر: Aging Cell

مصطلحات موضوعية: 0301 basic medicine, Aging, Geriatrics & Gerontology, CLEARANCE, senescence, Apoptosis, Craniopharyngioma, Mice, chemistry.chemical_compound, 0302 clinical medicine, PROGRAM, Bystander effect, senescence-associated β-galactosidase, Cytotoxic T cell, Prodrugs, 11 Medical and Health Sciences, Cellular Senescence, Tissue homeostasis, 0303 health sciences, Antibiotics, Antineoplastic, CHEMOTHERAPY, Prodrug, 3. Good health, Cell biology, 030220 oncology & carcinogenesis, senescence‐associated β‐galactosidase, prodrug, Life Sciences & Biomedicine, medicine.drug, Senescence, duocarmycin, Senescence-associated beta-galactosidase, Biology, CONTRIBUTES, Cell Line, GLYCOSIDIC PRODRUGS, Duocarmycins, 03 medical and health sciences, medicine, senescence-associated beta-galactosidase, Animals, Humans, Doxorubicin, Duocarmycin, 030304 developmental biology, Original Paper, Science & Technology, Galactose, Neoplasms, Experimental, Cell Biology, 06 Biological Sciences, beta-Galactosidase, Coculture Techniques, Mice, Inbred C57BL, SENESCENT CELLS, 030104 developmental biology, chemistry, senolytics, SECRETOME, 030217 neurology & neurosurgery, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef81e2f81aa7258cdfb00431a328e7f3
https://doi.org/10.1111/acel.13133

المؤلفون: Florian Selt, Olaf Witt, Jessica W Tsai, Julia Zaman, Pratiti Bandopadhayay, Martin U. Schuhmann, Stefan Pusch, Heike Peterziel, Juan Pedro Martinez-Barbera, Till Milde, Philipp Sievers, Romain Guiho, Stefan M. Pfister, David T.W. Jones, Ina Oehme, Romain Sigaud, Ahmed El Damaty, Felix Sahm

المصدر: Neuro-Oncology

مصطلحات موضوعية: Cancer Research, Bh3 mimetics, biology, Pilocytic astrocytoma, Chemistry, Bcl-xL, Compartment (chemistry), medicine.disease, Low Grade Gliomas, Oncology, biology.protein, Cancer research, medicine, AcademicSubjects/MED00300, AcademicSubjects/MED00310, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df22666a67945b0fccaba5f8011cf390
https://doi.org/10.1093/neuonc/noab090.135

المؤلفون: Juan Pedro Martinez Barbera, Thomas S. Jacques, Olaf Witt, Thomas J Stone, Jesús Gil, Romain Guiho, Till Milde, Florian Selt, Darren Hargrave

المصدر: Neuro-Oncology

مصطلحات موضوعية: Cancer Research, Navitoclax, business.industry, Vinblastine, chemistry.chemical_compound, Text mining, Oncology, chemistry, MAPK Inhibitors, Low Grade Gliomas, medicine, Cancer research, AcademicSubjects/MED00300, AcademicSubjects/MED00310, Neurology (clinical), Senolytic, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc41512533e5ad23ff51f72ccc2d8d6
http://europepmc.org/articles/PMC8168216

المؤلفون: Juan Pedro Martinez-Barbera, Chris Jones, Darren Hargrave, Romain Guiho, Ashley Vardon, Diana Carvalho

المصدر: Neuro-Oncology

مصطلحات موضوعية: Senescence, Cancer Research, Palliative care, biology, Chemistry, DNA damage, medicine.medical_treatment, Radiation induced, Bcl-xL, Radiation therapy, Oncology, Cell culture, Selective vulnerability, medicine, biology.protein, Cancer research, AcademicSubjects/MED00300, AcademicSubjects/MED00310, High Grade Gliomas, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edfc7a15df06aeef5ba0376d4c8aa8f
https://doi.org/10.1093/neuonc/noab090.073

المؤلفون: Romain Guiho, Julien Taurelle, Kevin Biteau, Giulia Grisendi, Dominique Heymann, Massimo Dominici, Françoise Rédini, Malika Gantier, Mathias Chatelais

المصدر: International Journal of Cancer. 139:2802-2811

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Stromal cell, business.industry, medicine.medical_treatment, Cell, Mesenchymal stem cell, medicine.disease, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Cytokine, Oncology, Apoptosis, Tumor progression, 030220 oncology & carcinogenesis, Immunology, Cancer research, medicine, Sarcoma, Stem cell, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61d51b81e36813845c67725d298da6ed
https://doi.org/10.1002/ijc.30402

المؤلفون: Elaine E. Irvine, Danijela Heide, Juan Pedro Martinez-Barbera, Antoni Olona, Dominic J. Withers, Joaquim Pombo, Saba Manshaei, Suchira Gallage, Daniel Dauch, Nicolás Herranz, Gopuraja Dharmalingam, Romain Guiho, Bin Sun, Lars Zender, Justyna A. Glegola, Katharina Wolter, Santiago Vernia, Ana Guerrero, Wagner, Mathias Heikenwalder, Andrew J. Innes, Jesús Gil, Anthony G. Uren, Jule Harbig, Jacques Behmoaras, Jodie Birch

المساهمون: Medical Research Council (MRC), Wellcome Trust, Medical Research Council

المصدر: Nature Metabolism
Nature metabolism

مصطلحات موضوعية: Senescence, PHARMACOKINETICS, CLEARANCE, Endocrinology, Diabetes and Metabolism, SECRETORY PHENOTYPE, Antineoplastic Agents, Apoptosis, medicine.disease_cause, Ouabain, Article, MECHANISMS, CONTRIBUTES, Cardiac Glycosides, 03 medical and health sciences, Endocrinology & Metabolism, Mice, 0302 clinical medicine, Physiology (medical), Cellular stress response, Internal Medicine, medicine, PROGRAM, Animals, Humans, Secretion, Senolytic, 030304 developmental biology, Cardiac glycoside, 0303 health sciences, Science & Technology, Chemistry, CELLULAR SENESCENCE, Cell Biology, CHEMOTHERAPY, 3. Good health, Rats, 030220 oncology & carcinogenesis, CELLS, Cancer research, Quercetin, Carcinogenesis, Life Sciences & Biomedicine, RESISTANCE, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c144b497f59e0a322c031b14ede15824

المؤلفون: Ying Hong, Robert J. Beynon, Saba Manshaei, Darren Hargrave, Paul A. Brogan, Benedetta Pettorini, Jesús Gil, Alex Virasami, Todd C. Hankinson, Márta Korbonits, Juan Pedro Martinez-Barbera, Lisa C.D. Storer, Kristian Aquilina, Shirleen Hallang, Julie E. Cooper, Jose Mario Gonzalez-Meljem, Thomas S. Jacques, Mark A. Ungless, Rolf Buslei, Helen Christina Fraser, Deborah M. Simpson, David A Hilton, Abhijit Joshi, Hywel Williams, David T.W. Jones, Selvam Thavaraj, Cynthia L. Andoniadou, Kyoko Tossell, Romain Guiho, Andrew M. Donson, Helen Spoudeas, Gabriela Carreno, Scott Haston, Nital Jani, Colin R. Goding, John R. Apps, Richard Grundy, Annett Hölsken, Thomas J Stone

المصدر: Apps, J R, Carreno, G, Gonzalez-meljem, J M, Haston, S, Guiho, R, Cooper, J E, Manshaei, S, Jani, N, Hölsken, A, Pettorini, B, Beynon, R J, Simpson, D M, Fraser, H C, Hong, Y, Hallang, S, Stone, T J, Virasami, A, Donson, A M, Jones, D, Aquilina, K, Spoudeas, H, Joshi, A R, Grundy, R, Storer, L C D, Korbonits, M, Hilton, D A, Tossell, K, Thavaraj, S, Ungless, M A, Gil, J, Buslei, R, Hankinson, T, Hargrave, D, Goding, C, Andoniadou, C L, Brogan, P, Jacques, T S, Williams, H J & Martinez-Barbera, J P 2018, ' Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target ', Acta Neuropathologica, vol. 135, no. 5, pp. 757-777 . https://doi.org/10.1007/s00401-018-1830-2
Acta Neuropathologica

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, medicine.medical_treatment, PATHOGENESIS, Stem cell marker, BETA-CATENIN, Inflammasome, Tissue Culture Techniques, Mice, Craniopharyngioma, 0302 clinical medicine, MOUSE MODELS, Tumor Microenvironment, Pathology, INTERLEUKIN-1, TOOTH FORMATION, Laser capture microdissection, MEK inhibitor, 3. Good health, Cytokine, DIFFERENTIATION, Pituitary Gland, Paracrine signalling, Cytokines, Odontogenesis, IL1-β, Neuroglia, Life Sciences & Biomedicine, EXPRESSION, Cell type, MAP Kinase Signaling System, Clinical Neurology, Laser Capture Microdissection, Biology, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, stomatognathic system, Trametinib, medicine, Animals, Humans, Pituitary Neoplasms, Inflammation, Original Paper, Science & Technology, Neurology & Neurosurgery, Sequence Analysis, RNA, Neurosciences, Computational Biology, 1103 Clinical Sciences, Disease Models, Animal, 030104 developmental biology, PAPILLARY CRANIOPHARYNGIOMAS, CELLS, MORPHOGENESIS, Cancer research, Neurology (clinical), Neurosciences & Neurology, Transcriptome, 1109 Neurosciences, 030217 neurology & neurosurgery, Immunostaining, IL1-beta

وصف الملف: PDF; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b1a23189555ff40faf66ac67d96c46
https://orca.cardiff.ac.uk/id/eprint/128285/1/Apps2018_Article_TumourCompartmentTranscriptomi.pdf