المؤلفون: Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Heng-Hong Li, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk

المصدر: Frontiers in Toxicology, Vol 4 (2022)

مصطلحات موضوعية: genetic toxicology, TGx-28.65 genomic biomarker, toxicogenomics, nitrofurantoin, metronidazole, novobiocin, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2022.991590/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/e639082783d548ec8aa9253661029295

المؤلفون: Robin Ruepp, Roland Frötschl, Robert Bream, Maria Filancia, Thomas Girard, Andrei Spinei, Martina Weise, Rhys Whomsley

المصدر: Frontiers in Medicine, Vol 8 (2021)

مصطلحات موضوعية: nitrosamines, human medicines, sartans, ranitidine, metformin, nitrite (NaNO2), Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.782536/full; https://doaj.org/toc/2296-858X

URL الوصول: https://doaj.org/article/6cbe2a2b5d95426d9f6833a958105120

المؤلفون: Bodo Haas, Veronika Klinger, Christina Keksel, Verena Bonigut, Daniela Kiefer, Julia Caspers, Julia Walther, Maria Wos-Maganga, Sandra Weickhardt, Gabriele Röhn, Marco Timmer, Roland Frötschl, Niels Eckstein

المصدر: Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: Glioblastoma, Drug resistance, PI3K, Temozolomide, Cisplatin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12935-018-0565-4; https://doaj.org/toc/1475-2867

URL الوصول: https://doaj.org/article/cbc74fa257cc4e36b6334340db9acf0c

المؤلفون: Navin Sarin, Florian Engel, Ganna V Kalayda, Mareike Mannewitz, Jindrich Cinatl, Florian Rothweiler, Martin Michaelis, Hisham Saafan, Christoph A Ritter, Ulrich Jaehde, Roland Frötschl

المصدر: PLoS ONE, Vol 12, Iss 7, p e0181081 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5528889?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/29faa58f678e40c0a520742228b169f6

المؤلفون: Navin Sarin, Florian Engel, Florian Rothweiler, Jindrich Cinatl, Martin Michaelis, Roland Frötschl, Holger Fröhlich, Ganna Kalayda

المصدر: International Journal of Molecular Sciences; Volume 19; Issue 3; Pages: 767

مصطلحات موضوعية: cisplatin resistance, cellular signalling, HRas, p38, CCL2, DOK1, PTK2B, JNK3

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Bioinorganic Chemistry; https://dx.doi.org/10.3390/ijms19030767

الاتاحة: https://doi.org/10.3390/ijms19030767

المؤلفون: Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Heng-Hong Li, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, genetic toxicology, TGx-28.65 genomic biomarker, toxicogenomics, nitrofurantoin, metronidazole, novobiocin

Relation: https://figshare.com/articles/dataset/DataSheet1_Integrated_Genotoxicity_Testing_of_three_anti-infective_drugs_using_the_TGx-DDI_transcriptomic_biomarker_and_high-throughput_CometChip_assay_in_TK6_cells_PDF/21196354

الاتاحة: https://doi.org/10.3389/ftox.2022.991590.s001
https://figshare.com/articles/dataset/DataSheet1_Integrated_Genotoxicity_Testing_of_three_anti-infective_drugs_using_the_TGx-DDI_transcriptomic_biomarker_and_high-throughput_CometChip_assay_in_TK6_cells_PDF/21196354

المؤلفون: Andrei Spinei, Thomas Girard, Roland Frötschl, Robert Bream, Rhys Whomsley, Robin Ruepp, Maria Filancia, Martina Weise

المصدر: Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2021)
Frontiers in medicine, 8:782536

مصطلحات موضوعية: Medicine (General), business.industry, sartans, human medicines, nitrosamines, linear extrapolation, ranitidine, metformin, carcinogenicity, nitrite (NaNO2), General Medicine, chemistry.chemical_compound, R5-920, chemistry, Nitrosamine, Environmental health, Perspective, Medicine, business, Carcinogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e4cd1b0e25861b2dae2f5b632fdd92
http://europepmc.org/articles/PMC8641785

المؤلفون: Roland Frötschl, Karl Broich, Britta Haenisch, Willy Gomm, Katrin Schüssel, Christoph Röthlein, Helmut Schröder, Steffen Hess, Gabriela Brückner

المصدر: Deutsches Ärzteblatt international 118(21), 357-362 (2021). doi:10.3238/arztebl.m2021.0129

مصطلحات موضوعية: medicine.medical_specialty, epidemiology [Neoplasms], Proportional hazards model, business.industry, Hazard ratio, Confounding, Cancer, General Medicine, medicine.disease, adverse effects [Valsartan], Confidence interval, Dimethylnitrosamine, Cohort Studies, Valsartan, chemically induced [Neoplasms], Internal medicine, Cohort, medicine, Humans, ddc:610, Drug Contamination, business, medicine.drug, Cohort study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5eb59d67fcfb0bb5b7ebbaa2963fc9
https://doi.org/10.3238/arztebl.m2021.0129

المؤلفون: Bernd Kaina, Hartwig Visser, Adam D. Thomas, Roland Frötschl, Jan G. Hengstler

المصدر: Regulatory Toxicology
Regulatory Toxicology ISBN: 9783642362064

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Threshold dose, Internal medicine, cons, medicine, Biology, Carcinogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0551841ff728e463e3a7c915098f0340
https://doi.org/10.1007/978-3-030-57499-4_55

المؤلفون: Willy, Gomm, Christoph, Röthlein, Katrin, Schüssel, Gabriela, Brückner, Helmut, Schröder, Steffen, Heß, Roland, Frötschl, Karl, Broich, Britta, Haenisch

المصدر: Dtsch Arztebl Int

مصطلحات موضوعية: Cohort Studies, Neoplasms, Humans, Valsartan, Original Article, Drug Contamination, Dimethylnitrosamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3f8c6d6e9879372f718eca8c566fcd05
https://pubmed.ncbi.nlm.nih.gov/34247699

المؤلفون: Daniel R. Hyduke, Heidrun Ellinger-Ziegelbauer, Heng-Hong Li, Andrew Williams, Renxiang Chen, Albert J. Fornace, Carole L. Yauk, Jiri Aubrecht, Syril D Pettit, Roland Frötschl

المصدر: Frontiers in Big Data

مصطلحات موضوعية: Big Data, Drug, business.industry, media_common.quotation_subject, genotoxicity, Review, Computational biology, medicine.disease_cause, TGx-DDI, Transcriptome, Biomarker, Drug development, Artificial Intelligence, In vivo, toxicogenomics, Computer Science (miscellaneous), medicine, biomarker, Animal testing, Toxicogenomics, business, high-throughput (HT) approaches, Genotoxicity, Information Systems, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32969ef537e5367e252fa881364a380b
https://doi.org/10.3389/fdata.2019.00036

المؤلفون: Heng-Hong Li, Carole L. Yauk, Renxiang Chen, Daniel R. Hyduke, Andrew Williams, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril Pettit, Jiri Aubrecht, Albert J. Fornace

مصطلحات موضوعية: Computer Engineering, Applied Computer Science, Artificial Intelligence and Image Processing, Pattern Recognition and Data Mining, Data Structures, TGx-DDI, toxicogenomics, genotoxicity, biomarker, high-throughput (HT) approaches

Relation: https://figshare.com/articles/dataset/fdata-02-00036-g0001_TGx-DDI_a_Transcriptomic_Biomarker_for_Genotoxicity_Hazard_Assessment_of_Pharmaceuticals_and_Environmental_Chemicals_tif/11947356

الاتاحة: https://doi.org/10.3389/fdata.2019.00036.s003
https://figshare.com/articles/dataset/fdata-02-00036-g0001_TGx-DDI_a_Transcriptomic_Biomarker_for_Genotoxicity_Hazard_Assessment_of_Pharmaceuticals_and_Environmental_Chemicals_tif/11947356

المؤلفون: Heng-Hong Li, Carole L. Yauk, Renxiang Chen, Daniel R. Hyduke, Andrew Williams, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril Pettit, Jiri Aubrecht, Albert J. Fornace

مصطلحات موضوعية: Computer Engineering, Applied Computer Science, Artificial Intelligence and Image Processing, Pattern Recognition and Data Mining, Data Structures, TGx-DDI, toxicogenomics, genotoxicity, biomarker, high-throughput (HT) approaches

Relation: https://figshare.com/articles/dataset/fdata-02-00036_TGx-DDI_a_Transcriptomic_Biomarker_for_Genotoxicity_Hazard_Assessment_of_Pharmaceuticals_and_Environmental_Chemicals_xml/11947347

الاتاحة: https://doi.org/10.3389/fdata.2019.00036.s002
https://figshare.com/articles/dataset/fdata-02-00036_TGx-DDI_a_Transcriptomic_Biomarker_for_Genotoxicity_Hazard_Assessment_of_Pharmaceuticals_and_Environmental_Chemicals_xml/11947347

المؤلفون: Niels Eckstein, Bodo Haas, Konstantin Weber-Lassalle, Roland Frötschl

المصدر: Regulatory Toxicology and Pharmacology. 77:25-34

مصطلحات موضوعية: 0301 basic medicine, Drug, Indoles, Cell Survival, medicine.drug_class, media_common.quotation_subject, Antineoplastic Agents, Apoptosis, Pharmacology, Toxicology, Risk Assessment, Tyrosine-kinase inhibitor, Inhibitory Concentration 50, 03 medical and health sciences, 0302 clinical medicine, Therapeutic index, Cell Line, Tumor, Neoplasms, Toxicity Tests, Sunitinib, medicine, Animals, Drugs, Generic, Humans, Pyrroles, Viability assay, Phosphorylation, Protein Kinase Inhibitors, media_common, Dose-Response Relationship, Drug, business.industry, In vitro toxicology, Cancer, Imatinib, General Medicine, medicine.disease, 030104 developmental biology, Organ Specificity, 030220 oncology & carcinogenesis, Imatinib Mesylate, Cancer research, Drug and Narcotic Control, Apoptosis Regulatory Proteins, business, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3653d62a14039c885cb7fc059661965f
https://doi.org/10.1016/j.yrtph.2016.02.010

المؤلفون: Steffi Chang, Martina Dammann, Christina Ziemann, Nina Queisser, Annette Bitsch, Lea A. I. Vaas, Marlies Nern, Roland Frötschl, Richardus Vonk, Stefan Pfuhler, Dietmar Zellner, Volker Krzykalla, Bernd-Wolfgang Igl, Volker Harm, Frank Bringezu, Markus Schulz, Jasmin Lott, Andreas Sutter, Rupert Kellner

المساهمون: Publica

المصدر: Regulatory toxicology and pharmacology : RTP. 102

مصطلحات موضوعية: Male, Computer science, 010501 environmental sciences, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, Stability (probability), 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, Reference Values, Statistics, Animals, Rats, Wistar, 0105 earth and related environmental sciences, Parametric statistics, Micronucleus Tests, General Medicine, Control Groups, Test (assessment), Data set, Reference data, Micronucleus test, Female, Analysis of variance, Tolerance interval

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01db78c067da127a724c301269da73
https://pubmed.ncbi.nlm.nih.gov/30572081

المؤلفون: Julia Walther, Verena Bonigut, Christina Keksel, Marco Timmer, Gabriele Röhn, Julia Caspers, Maria Wos-Maganga, Niels Eckstein, Daniela Kiefer, Bodo Haas, Roland Frötschl, Sandra Weickhardt, Veronika Klinger

المصدر: Cancer Cell International
Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)
Cancer cell international, 18:69

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, lcsh:RC254-282, PI3K, Receptor tyrosine kinase, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Temozolomide, lcsh:QH573-671, Protein kinase B, PI3K/AKT/mTOR pathway, Cisplatin, biology, Chemistry, lcsh:Cytology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Glioblastoma, Drug resistance, 030104 developmental biology, Oncology, Cell culture, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Primary Research, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b529afc4d1e9d4bcddd73049344ff4
http://europepmc.org/articles/PMC5935937

المؤلفون: Lutz Müller, Makoto Hayashi, Dan D. Levy, Lya G. Soeteman-Hernández, Maik Schuler, James T. MacGregor, George E. Johnson, Shoji Fukushima, David A. Eastmond, Roland Frötschl, Kenny S. Crump, Melanie Guérard, Véronique Thybaud, Paul D. White, Toshio Kasamatsu, Takeshi Morita, Rita Schoeny

المصدر: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:55-65

مصطلحات موضوعية: Models, Genetic, Mutagenicity Tests, Health, Toxicology and Mutagenesis, Extrapolation, DNA, Exposure response relationships, Exponential models, medicine.disease_cause, Risk Assessment, Upper and lower bounds, Toxicology, Neoplasms, Benchmark (surveying), Mutation, Statistics, Genetics, medicine, Humans, Risk assessment, Genotoxicity, Mutagens, Genetic Toxicology, Mathematics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d3094a046ca35b4ab488fb4febc7d6
https://doi.org/10.1016/j.mrgentox.2014.09.011

المؤلفون: Roland Frötschl, Jiri Aubrecht, Heidrun Ellinger-Ziegelbauer, Andrew Williams, Heng-Hong Li, Renxiang Chen, Albert J. Fornace, Raegan O’Lone, Carole L. Yauk, Daniel R. Hyduke

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Genetic Markers, 0301 basic medicine, DNA damage, Cell Culture Techniques, Computational biology, Biology, DNA damage response, medicine.disease_cause, high-throughput screening, Risk Assessment, TGx-DDI, transcriptomic biomarker, Transcriptome, 03 medical and health sciences, Cell Line, Tumor, High-Throughput Screening Assays, medicine, Humans, Cells, Cultured, Chromosome Aberrations, Multidisciplinary, Mutagenicity Tests, Gene Expression Profiling, genotoxicity, Reproducibility of Results, Biological Sciences, 3. Good health, Gene expression profiling, 030104 developmental biology, PNAS Plus, Genetic marker, Biomarker (medicine), Applied Biological Sciences, Biomarkers, Genotoxicity, DNA Damage, Genetic Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ec003d8ac5c6cd165ef3207b1b8249
https://doi.org/10.1073/pnas.1714109114

المؤلفون: Roland Frötschl

المصدر: Mutagenesis. 30:51-57

مصطلحات موضوعية: In Vitro Techniques, Health, Toxicology and Mutagenesis, Pharmacology, Gene mutation, Toxicology, Ames test, In vivo, Genetics, medicine, Animals, Genetics (clinical), Micronucleus Tests, Mutagenicity Tests, business.industry, Reproducibility of Results, In vitro, Rats, Comet assay, medicine.anatomical_structure, Liver, Micronucleus test, Drug Evaluation, Comet Assay, Bone marrow, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e902744c6c33c50ff9a40d422eb872
https://doi.org/10.1093/mutage/geu069

المؤلفون: Heidrun Ellinger-Ziegelbauer, Roland Frötschl, Dominik Lutter, Norbert Benda, Heinke Bastek, James A. Swenberg, Leonard B. Collins, Katja Damme, Daniel R. Dietrich, Valentina Klaus, Kerstin Stemmer

المصدر: Arch. Toxicol. 91, 3427–3438 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, Guanine, Methylazoxymethanol Acetate, Time Factors, Tumor suppressor gene, DNA repair, Health, Toxicology and Mutagenesis, Biology, Toxicology, medicine.disease_cause, Kidney, Rats, Mutant Strains, Article, 03 medical and health sciences, chemistry.chemical_compound, DNA Adducts, 0302 clinical medicine, Biomarkers Of Effect, Biomarkers Of Exposure, Dna Adducts, Eker Rat, Kidney Cancer, ddc:570, Gene expression, medicine, Transcriptional regulation, Animals, Gene, Carcinogen, Cell Proliferation, Methylazoxymethanol acetate, Dose-Response Relationship, Drug, General Medicine, Molecular biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cell Transformation, Neoplastic, chemistry, 030220 oncology & carcinogenesis, Female, Carcinogenesis, DNA Damage

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1312883ab8c7096361d24dd6568ff5f8
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/89875