المؤلفون: Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I. Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/8cb734f3e6db454ca663dbe7df2cc0bb

المؤلفون: Jeffrey H. Kogan, Samer Chmait, Chun Li, Essa Hu, Michelle Lindstrom, Jiandong Zhang, Kristin L. Andrews, Roland Burli, Roxanne Kunz, Stephen Hitchcock, James J. S. Treanor, Ning Chen, Shannon Rumfelt

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2262-2265

مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Coumarins, In vivo, Drug Discovery, Avoidance Learning, Animals, Humans, Potency, Molecular Biology, chemistry.chemical_classification, Psychotropic Drugs, Binding Sites, Behavior, Animal, Phosphoric Diester Hydrolases, Organic Chemistry, Phosphodiesterase, Metabolism, Rats, Enzyme, chemistry, Molecular Medicine, PDE10A, Selectivity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865cbcb6f0a332d88ba4d4befabc0a9d
https://doi.org/10.1016/j.bmcl.2012.01.086

المؤلفون: Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu

المصدر: ACS Medicinal Chemistry Letters. 2:107-112

مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Lymphocyte, Sphingosine-1-phosphate receptor, Organic Chemistry, Experimental autoimmune encephalomyelitis, Inflammation, Pharmacology, medicine.disease, Biochemistry, Blood lymphocyte, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Drug Discovery, Pyridine, Medicine, medicine.symptom, Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469aac7dbf0531b12b4eec83f252b55d
https://doi.org/10.1021/ml100306h

المؤلفون: Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag

المصدر: ACS Medicinal Chemistry Letters. 2:97-101

مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Sphingosine-1-phosphate receptor, Organic Chemistry, Pharmacology, Biochemistry, In vitro, Bioavailability, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Potency, Benzofuran, business, Selectivity, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8291efcc95ecdaf3a6ce8e57343599
https://doi.org/10.1021/ml100227q

المؤلفون: Jennifer E. Golden, Randall W. Hungate, Alexander J. Pickrell, Gloria Biddlecome, Roland Burli, Mike Frohn, Jennifer Dao, Norma Rogers, Vellarkad N. Viswanadhan, Jennifer R. Allen, Kristine M. Muller, Sean Yoder

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5023-5026

مصطلحات موضوعية: Models, Molecular, Molecular model, Clinical Biochemistry, Procollagen-Proline Dioxygenase, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Hypoxia-Inducible Factor-Proline Dioxygenases, Structure-Activity Relationship, Drug Discovery, Basic Helix-Loop-Helix Transcription Factors, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Aza Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Hypoxia-Inducible Factor 1, alpha Subunit, In vitro, Enzyme, Hypoxia-inducible factors, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Procollagen-proline dioxygenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe8ee6a4b24c934b0f90897c408cc8
https://doi.org/10.1016/j.bmcl.2008.08.012

المؤلفون: Randall W. Hungate, Jennifer Dao, Christopher M. Tegley, Sean Yoder, Catherine H. Chang, Tanya Peterkin, Roland Burli, Henrike Veith, Jennifer R. Allen, Philip Tagari, Norma Rogers, Kaustav Biswas, Vellarkad N. Viswanadhan, Michael J. Frohn, Gloria Biddlecome

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3925-3928

مصطلحات موضوعية: Models, Molecular, Erythrocytes, Chemistry, Pharmaceutical, Clinical Biochemistry, Drug Evaluation, Preclinical, Myocardial Infarction, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Prolyl-Hydroxylase Inhibitors, Drug Discovery, Diabetes Mellitus, medicine, Humans, Molecular Biology, Peripheral Vascular Diseases, chemistry.chemical_classification, Chemistry, Organic Chemistry, Hypoxia-Inducible Factor 1, alpha Subunit, Stroke, Thiazoles, Red blood cell, medicine.anatomical_structure, Enzyme, Models, Chemical, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b45d47469e72a7c165facd5f7029bbb
https://doi.org/10.1016/j.bmcl.2008.06.031

المؤلفون: Ning Chen, Andrea Itano, Randall W. Hungate, Ryan White, Yang Xu, Matthew H. Plant, Yanyan Tudor, Yen Nguyen, Roxanne Kunz, Perry M. Novak, Kristin Meagher, Essa Hu, Jason Brooks Human, Shaun Flynn, Gordon Ng, Xuxia Zhang, Violeta Yu, Roland Burli, Douglas A. Whittington, Andrew Tasker

المصدر: Journal of Medicinal Chemistry. 51:3065-3068

مصطلحات موضوعية: Models, Molecular, Pyridones, Administration, Oral, Pharmacology, Crystallography, X-Ray, Histamine Release, Receptor tyrosine kinase, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Mast Cells, Tyrosine, Protein Kinase Inhibitors, Molecular Structure, biology, Chemistry, Mast cell, Rats, Proto-Oncogene Proteins c-kit, medicine.anatomical_structure, Enzyme inhibitor, Quinazolines, biology.protein, Molecular Medicine, Signal transduction, Histamine, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81447f11bfae7a4d16eb01799010756e
https://doi.org/10.1021/jm800188g

المؤلفون: Aaron C. Siegmund, Celia Dominguez, Daniel Retz, Roland Burli, Ning Xi, Longbin Liu

المصدر: Synlett. 2008:1005-1008

مصطلحات موضوعية: Organic Chemistry, Pyrazolone, Epoxide, Regioselectivity, Pyrazole, Medicinal chemistry, chemistry.chemical_compound, Stereospecificity, chemistry, medicine, Organic chemistry, Pyrazolones, Carboxylate, Magnesium perchlorate, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dad9fe261ec74d9a661a6714c0e1cb8f
https://doi.org/10.1055/s-2008-1042923

المؤلفون: Kristine M. Muller, Roland Burli, Jennifer E. Golden, Shanina D. Sanders

المصدر: Tetrahedron Letters. 49:794-798

مصطلحات موضوعية: Coupling, chemistry.chemical_classification, Chemistry, Aryl halide, Organic Chemistry, Pyrazolone, Regioselectivity, Pyrazole, Biochemistry, Medicinal chemistry, Tautomer, chemistry.chemical_compound, Drug Discovery, medicine, Organic chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::20de58f596f180be7b399be54df34465
https://doi.org/10.1016/j.tetlet.2007.11.185

المؤلفون: Kelly Regal, Randall W. Hungate, Mike Frohn, Vellarkad N. Viswanadhan, Matthew Adlam, Han Xu, Philip Tagari, Min Wong, Kristine M. Muller, Roland Burli, Jennifer E. Golden, Xiaoming Zou, Matthew H. Plant, Michele McElvain

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3713-3718

مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Anti-Inflammatory Agents, Administration, Oral, Pharmaceutical Science, Inflammation, Pharmacology, Biochemistry, Anti-inflammatory, Mice, In vivo, Drug Discovery, medicine, Animals, Humans, Receptors, Lipoxin, Receptor, Molecular Biology, G protein-coupled receptor, Formyl peptide receptor, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Receptors, Formyl Peptide, In vitro, Disease Models, Animal, Immunology, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19e4048cb68caaf96dd2c0a6c5b8b6a
https://doi.org/10.1016/j.bmcl.2006.04.068

المؤلفون: Heinz E. Moser, Roland Burli, Kiet Truong, Yigong Ge, Alfred Chen, Timothy Friend Stanton, Wenhao Hu, Matthew I. Gross, Jacob Kaizerman, Sofia M. Touami, Vernon Jiang, Peter G. Jones, Mari Iwamoto, Kirk W. Johnson, Jian-Xin Duan

المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2067-2072

مصطلحات موضوعية: Lung Diseases, Staphylococcus aureus, Clinical Biochemistry, Pharmaceutical Science, Peritonitis, Ligands, medicine.disease_cause, Biochemistry, Microbiology, Amino Acids, Aromatic, Mice, chemistry.chemical_compound, In vivo, Streptococcal Infections, Drug Discovery, Aromatic amino acids, medicine, Animals, Molecular Biology, Antibacterial agent, chemistry.chemical_classification, biology, Organic Chemistry, DNA, Staphylococcal Infections, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Amino acid, Disease Models, Animal, Streptococcus pneumoniae, chemistry, Molecular Medicine, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c0c07e0f36e16473735524315dc3a9
https://doi.org/10.1016/j.bmcl.2004.02.047

المؤلفون: M. Gross, J. Kaizerman, Vernon Jiang, Heinz E. Moser, B. Batiste, Kirk W. Johnson, R. Tanaka, Roland Burli, J.-X. Duan, M. Garcia, P. Jones, U. Hoch

المصدر: Antimicrobial Agents and Chemotherapy. 47:3448-3457

مصطلحات موضوعية: Male, Neutropenia, Potassium Channels, medicine.drug_class, Antibiotics, Peritonitis, Biology, Pharmacology, medicine.disease_cause, Rats, Sprague-Dawley, Mice, Dogs, Pharmacokinetics, Heterocyclic Compounds, Vancomycin, In vivo, Acetamides, medicine, Animals, Tissue Distribution, Pharmacology (medical), Muscle, Skeletal, Cation Transport Proteins, Oxazolidinones, Antibacterial agent, Mice, Inbred ICR, Behavior, Animal, Linezolid, Biological activity, Bacterial Infections, DNA, Pneumonia, Pneumococcal, Ether-A-Go-Go Potassium Channels, In vitro, Anti-Bacterial Agents, Rats, Infectious Diseases, Mechanism of action, Potassium Channels, Voltage-Gated, Staphylococcus aureus, Area Under Curve, Calibration, Female, medicine.symptom, Mutagens, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc9dd37f8af1d8454adae2b202438bd
https://doi.org/10.1128/aac.47.11.3448-3457.2003

المؤلفون: Yigong Ge, Heinz E. Moser, Sarah White, Matthew I. Gross, Kirk W. Johnson, Jacob Kaizerman, Richard D Tanaka, Wenhao Hu, Eldon E. Baird, Roland Burli, Jian-Xin Duan

المصدر: Journal of Medicinal Chemistry. 46:3914-3929

مصطلحات موضوعية: Staphylococcus aureus, Morpholines, Microbial Sensitivity Tests, Peritonitis, Gram-Positive Bacteria, Ligands, medicine.disease_cause, Enterococcus faecalis, Microbiology, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Resistance, Bacterial, Drug Discovery, Streptococcus pneumoniae, Toxicity Tests, Acute, medicine, Animals, Potency, Pyrroles, Antibacterial agent, Mice, Inbred ICR, biology, Distamycins, DNA replication, DNA, Staphylococcal Infections, biology.organism_classification, Anti-Bacterial Agents, Biochemistry, chemistry, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95747a0d02237790107e7e75224f770c
https://doi.org/10.1021/jm030097a

المؤلفون: Andrea Vasella, Roland Burli, Barbara Hoffmann, Diana Zanini, Isabelle Ripoche

المصدر: Helvetica Chimica Acta. 84:1862-1888

مصطلحات موضوعية: chemistry.chemical_classification, Anomer, Cyclodextrin, Chemistry, Stereochemistry, Organic Chemistry, Butane, Glycosidic bond, Oligosaccharide, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Yield (chemistry), Drug Discovery, Moiety, Glycosyl, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d75db9d38afd419bfc939b750890fe3d
https://doi.org/10.1002/1522-2675(20010613)84:6<1862::aid-hlca1862>3.0.co;2-z

المؤلفون: Roland Burli, Andrea Vasella

المصدر: Helvetica Chimica Acta. 82:485-493

مصطلحات موضوعية: chemistry.chemical_classification, Oxidative cyclization, Metal ions in aqueous solution, Organic Chemistry, Oligosaccharide, Polysaccharide, Biochemistry, Combinatorial chemistry, Catalysis, 2,2'-Bipyridine, Inorganic Chemistry, chemistry.chemical_compound, Uv spectra, chemistry, Drug Discovery, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::40e85fa47d29df458c571c5443d788e4
https://doi.org/10.1002/(sici)1522-2675(19990407)82:4<485::aid-hlca485>3.0.co;2-a

المؤلفون: Roland Burli, Matthew H. Plant, Randall W. Hungate, Roxanne Kunz, Douglas A. Whittington, Yang Xu, Shannon Rumfelt, Gordon Ng, Violeta Yu, Michael Schrag, Ning Chen, Yen Nguyen, Yanyan Tudor, Andrew Tasker, Kristin Meagher, Essa Hu, Dawei Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5115-5117

مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Biochemistry, Receptor tyrosine kinase, Targeted therapy, Structure-Activity Relationship, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Tyrosine, Molecular Biology, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Isoxazoles, Mast cell, Amides, Proto-Oncogene Proteins c-kit, medicine.anatomical_structure, Enzyme inhibitor, biology.protein, Cancer research, Molecular Medicine, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2f15cb2f6855f01eb5d331d0b8302
https://doi.org/10.1016/j.bmcl.2008.07.111

المؤلفون: Bobby Riahi, Randall W. Hungate, Mike Frohn, Roland Burli

المصدر: Tetrahedron Letters. 48:487-489

مصطلحات موضوعية: Template, Ideal (set theory), Chemistry, Organic Chemistry, Drug Discovery, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6428f8b0410b31771c9b58694ab1b3f5
https://doi.org/10.1016/j.tetlet.2006.11.035

المؤلفون: Roland Burli, Andrea Vasella

المصدر: Helvetica Chimica Acta. 80:2215-2237

مصطلحات موضوعية: chemistry.chemical_classification, Cyclodextrin, Stereochemistry, Dimer, Organic Chemistry, Intermolecular force, Oligosaccharide, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Monomer, chemistry, Tetramer, Acetylation, Intramolecular force, Drug Discovery, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0dbf368026ad7d7e0178c83d5eec66c1
https://doi.org/10.1002/hlca.19970800720

المؤلفون: Andrea Vasella, Roland Burli

المصدر: Helvetica Chimica Acta. 80:1027-1052

مصطلحات موضوعية: chemistry.chemical_classification, Cyclodextrin, Concentration dependence, Stereochemistry, Organic Chemistry, Trimer, Oligosaccharide, Polysaccharide, Biochemistry, Catalysis, Inorganic Chemistry, chemistry, Tetramer, Drug Discovery, Physical and Theoretical Chemistry, Optical rotation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::66611a77fce6de9f58a6dbdf397706ca
https://doi.org/10.1002/hlca.19970800403

المؤلفون: Liz Stones, Omar Aziz, Maria Beconi, Ignacio Munoz-Sanjuan, Hannah McNeil, John E. Mangette, Philip Leonard, Julie Vann, Andrew J. Stott, Alan Findlay Haughan, Kim L. Matthews, Ilka Müller, Michel Maillard, Catherine M. O'Connell, Vahri Beaumont, Dawn Yates, Marieke Lamers, Tania Mead, Stephen D. Penrose, Richardson Christine Mary, Christopher A. Luckhurst, Grant Wishart, Roland Burli, Michael Wall, Celia Dominguez, Rebecca E. Jarvis, Samantha Hughes, George McAllister, Kathy Lyons, Perla Breccia

المصدر: Journal of medicinal chemistry. 56(24)

مصطلحات موضوعية: Male, Models, Molecular, Disease, Histone Deacetylases, Mice, Structure-Activity Relationship, Huntington's disease, Drug Discovery, medicine, Animals, Humans, Therapeutic strategy, Biological evaluation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, medicine.disease, Small molecule, Histone Deacetylase Inhibitors, Isoenzymes, Mice, Inbred C57BL, Enzyme, Huntington Disease, chemistry, Design synthesis, Biochemistry, Drug Design, Cancer research, Microsomes, Liver, Molecular Medicine, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e9f5c003f61255472576a839680e89
https://pubmed.ncbi.nlm.nih.gov/24261862