المؤلفون: Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 387-397 (2023)

مصطلحات موضوعية: Fragment-based drug discovery, hit triage, inhibitors, antibacterial agents, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/ed3c6b42930745d2a6bd5cc66b4d848a

المؤلفون: Rok Frlan, Martina Hrast, Stanislav Gobec

المصدر: ACS Omega, Vol 8, Iss 36, Pp 33006-33016 (2023)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/b66abc5b3bbe41ed94f949a1d5f84037

المؤلفون: Tjaša Žagar, Rok Frlan, Nina Kočevar Glavač

المصدر: Antibiotics, Vol 13, Iss 4, p 334 (2024)

مصطلحات موضوعية: subcritical water extraction, polyphenols, phenolic acids, flavonoids, antimicrobial activity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/13/4/334; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/2a41cb18a4e64bc985e0b7376f7773a0

المؤلفون: Vid Kuralt, Rok Frlan

المصدر: Antibiotics, Vol 13, Iss 3, p 252 (2024)

مصطلحات موضوعية: antibacterial drug development, enoyl-acyl carrier protein reductases, ENR inhibitors, antibiotic resistance, Fab, InhA, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/13/3/252; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/fcc1709c49ad48c6bc738a5d3a3b4045

المؤلفون: Samo Kuzmič, Martina Hrast, Rok Frlan

المصدر: Acta Chimica Slovenica, Vol 69, Iss 2, Pp 261-270 (2022)

مصطلحات موضوعية: dipeptides, aziridines, biomarkers, warheads, antibacterial agents, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://journals.matheo.si/index.php/ACSi/article/view/6673; https://doaj.org/toc/1318-0207; https://doaj.org/toc/1580-3155

URL الوصول: https://doaj.org/article/753edc1dac4e4d71a510fdf2f839de1a

المؤلفون: Matej Sova, Rok Frlan, Stanislav Gobec, Zdenko Časar

المصدر: ACS Omega, Vol 5, Iss 10, Pp 5356-5364 (2020)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/d521585f09f74880a5095afe44b1bb3e

المؤلفون: Rok Frlan

المصدر: Antibiotics, Vol 11, Iss 5, p 675 (2022)

مصطلحات موضوعية: shikimate pathway, druggability, ligandability, antibacterial, inhibitors, broad-spectrum, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/11/5/675; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/d11aa5b8f5ba41de9066dceda3ae3585

المؤلفون: Macarena Funes Chabán, Martina Hrast, Rok Frlan, Dafni G. Graikioti, Constantinos M. Athanassopoulos, María Cecilia Carpinella

المصدر: Antibiotics, Vol 10, Iss 12, p 1535 (2021)

مصطلحات موضوعية: dehydroabietane derivatives, diterpenes, MurA and MurF inhibitors, Staphylococcus aureus MurA, Escherichia coli MurA, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/10/12/1535; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/18afbccf4d6f4815869a4f68b183d5ae

المؤلفون: Rok Frlan, Martina Hrast, Stanislav Gobec

المصدر: Molecules, Vol 24, Iss 7, p 1261 (2019)

مصطلحات موضوعية: β-lactams, dibenzylamino, Mitsunobu reaction, nocardicin, pseudopeptides, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/7/1261; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/c5e4a4d763f94c2e995d30695536d52f

المؤلفون: AleÅ¡ Obreza, Slavko PeÄÂar, Stanislav Gobec, Didier Blanot, Andreja KovaÄÂ, Rok Frlan

المصدر: Molecules, Vol 13, Iss 1, Pp 11-30 (2008)

مصطلحات موضوعية: MurC, MurD, amidobenzaldehyde, inhibitors, antibacterial, hydrazide., Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/13/1/11/; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/988857da4db046daacec8dc29ac56b1a

المؤلفون: Matic Proj, Martina Hrast, Damijan Knez, Krištof Bozovičar, Katarina Grabrijan, Anže Meden, Stanislav Gobec, Rok Frlan

المصدر: ACS medicinal chemistry letters. 13(12)

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094b30a68a94ec61d5f50c5b3094f8d4
https://pubmed.ncbi.nlm.nih.gov/36518695

المؤلفون: Zdenko Časar, Stanislav Gobec, Matej Sova, Rok Frlan

المصدر: ACS Omega, Vol 5, Iss 10, Pp 5356-5364 (2020)
ACS Omega

مصطلحات موضوعية: chemistry.chemical_classification, Trifluoromethyl, Double bond, Pyrazine, Chemistry, General Chemical Engineering, General Chemistry, Medicinal chemistry, Article, Solvent, chemistry.chemical_compound, Hydrolysis, Reagent, Yield (chemistry), Peptide bond, QD1-999

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13888945168355ad1c84aa9ed25832c1
https://doaj.org/article/d521585f09f74880a5095afe44b1bb3e

المؤلفون: Matic Proj, Krištof Bozovičar, Martina Hrast, Rok Frlan, Stanislav Gobec

المصدر: Bioorganic & medicinal chemistry letters, vol. 73, no. 128915, 2022.
Bioorganic & Medicinal Chemistry Letters, 4 str. : Ilustr., Vol. 73, art. 128915, 2022
COBISS-ID: 34486272

مصطلحات موضوعية: udc:615.4.54, inhibitorji, Alanine, Alkyl and Aryl Transferases, screening, antibacterial agents, DNA-encoded library, screening, inhibitors, Organic Chemistry, Clinical Biochemistry, DNA-encoded library, Pharmaceutical Science, antibacterial agents, DNA, Peptidoglycan, Biochemistry, Biosynthetic Pathways, antibakterijska sredstva, inhibitors, Drug Discovery, Molecular Medicine, DNA-kodirana knjižnica, Enzyme Inhibitors, antibakterijska sredstva, DNA-kodirana knjižnica, inhibitorji, udc:615.4, Molecular Biology

وصف الملف: application/pdf; text/url

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17915ac93d1a3e63a6b81b81578b374c
https://doi.org/10.1016/j.bmcl.2022.128915

المؤلفون: Irena Zdovc, Rok Frlan, Hélène Barreteau, Stanislav Gobec, Martina Hrast, Damijan Knez

المصدر: Bioorganicmedicinal chemistry letters. 40

مصطلحات موضوعية: Scaffold, Staphylococcus aureus, Pyridines, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Benzylidene Compounds, Bacterial cell structure, chemistry.chemical_compound, Structure-Activity Relationship, Antibiotic resistance, Bacterial Proteins, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Peptide Synthases, Molecular Biology, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Antimicrobial, biology.organism_classification, 0104 chemical sciences, Anti-Bacterial Agents, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Peptidoglycan, Antibacterial activity, Bacteria, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02baba904bbb0c0ef9285eb340022374
https://pubmed.ncbi.nlm.nih.gov/33744441

المؤلفون: Duygu Senturk, Berna Sariyar Akbulut, Jean-Michel Jault, Fatma Ece Altinisik Kaya, Pemra Ozbek, Tihomir Tomašič, Rok Frlan, Onur Serçinoğlu, Fatma Gizem Avci, Cédric Orelle

المساهمون: Recep Tayyip Erdogan University, Marmara University [Kadıköy - İstanbul], Üsküdar university, University of Ljubljana, Microbiologie moléculaire et biochimie structurale / Molecular Microbiology and Structural Biochemistry (MMSB), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sercinoglu, Onur, Senturk, Duygu, Kaya, Fatma Ece Altinisik, Avci, Fatma Gizem, Frlan, Rok, Tomasic, Tihomir, Ozbek, Pemra, Orelle, Cedric, Jault, Jean-Michel, Akbulut, Berna Sariyar

المصدر: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2020, 105, pp.104452. ⟨10.1016/j.bioorg.2020.104452⟩

مصطلحات موضوعية: Protein Conformation, Antibiotic resistance, Drug Evaluation, Preclinical, ATP-binding cassette transporter, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Ligands, NUCLEOTIDE-BINDING, 01 natural sciences, Biochemistry, Ethidium, Drug Discovery, Efflux pump inhibitors, Chemistry, MULTIDRUG EFFLUX PUMP, P-GLYCOPROTEIN, Chemotheca, ACRB, Small molecule, 3. Good health, Molecular Docking Simulation, BmrA, Cyclic nucleotide-binding domain, Molecular docking, Lipinski's rule of five, Efflux, Bacillus subtilis, Virtual screening, BACILLUS-SUBTILIS, Small Molecule Libraries, Bacterial Proteins, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, ATP-BINDING, REVERSAL AGENTS, Molecular Biology, STAPHYLOCOCCUS-AUREUS, DRUG-RESISTANCE, 010405 organic chemistry, Organic Chemistry, Membrane Transport Proteins, Nucleotide-binding domain, IN-SILICO, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 0104 chemical sciences, Multiple drug resistance, 010404 medicinal & biomolecular chemistry, ATP-Binding Cassette Transporters, Protein Multimerization

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0d518ad17d435904cf27cc601b9e5a
https://hal.archives-ouvertes.fr/hal-03200521

المؤلفون: Marko Anderluh, Lucija Peterlin Mašič, Rok Frlan, Viviana Gatta, Päivi Tammela, Nace Zidar, Michaela Barančoková, Danijel Kikelj, Tihomir Tomašič, Janez Ilaš

المساهمون: Bioactivity Screening Group, Division of Pharmaceutical Biosciences, Drug Research Program, University Management

المصدر: ChemBioChem, str. 1918-1922 : Ilustr., Vol. 21, iss. 13, 2020
COBISS-ID: 519041305

مصطلحات موضوعية: 116 Chemical sciences, medicine.disease_cause, 01 natural sciences, Biochemistry, Lactones, chemistry.chemical_compound, Bakterije, antivirulence, DOCKING, bioreporters, Enzyme Inhibitors, udc:615.4, biology, Chemistry, Escherichia coli Proteins, AI-2, Quorum Sensing, Recombinant Proteins, Molecular Docking Simulation, Phosphotransferases (Alcohol Group Acceptor), Gram-negative bacteria, Molecular Medicine, Bioreporter, Plasmids, virulenca, spojine, zaviralci LsrK, Virulence, Farmacevtska kemija, Computational biology, 010402 general chemistry, SYSTEMS, Escherichia coli, Homoserine, medicine, DRUGS, Molecular Biology, Binding Sites, IDENTIFICATION, 010405 organic chemistry, BIOFILM FORMATION, Organic Chemistry, Biofilm, biology.organism_classification, 0104 chemical sciences, Autoinducer-2, AUTOINDUCER-2, Quorum sensing, Docking (molecular), 1182 Biochemistry, cell and molecular biology, LsrK

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6fe19fe562ba1c2984ea13ab4ff7f4
https://plus.cobiss.net/cobiss/si/en/bib/4879729

المؤلفون: Damijan Knez, Martina Hrast, Rok Frlan, Anja Pišlar, Simon Žakelj, Janko Kos, Stanislav Gobec

المصدر: Bioorganic Chemistry. 119:105581

مصطلحات موضوعية: Models, Molecular, Indoles, Monoamine Oxidase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Organic Chemistry, Drug Evaluation, Preclinical, Antineoplastic Agents, Biochemistry, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Drug Screening Assays, Antitumor, Monoamine Oxidase, Piperazine, Molecular Biology, Cells, Cultured, Nitrites, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7636ab892c7f919b3e7a25c1a466ee3
https://doi.org/10.1016/j.bioorg.2021.105581

المؤلفون: Rok Frlan, Andreja Kovač, Didier Blanot, Stanislav Gobec, Slavko Pečar

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.mdpi.com/1420-3049/13/1/11/pdf/.

مصطلحات موضوعية: MurC, MurD, amidobenzaldehyde, inhibitors, antibacterial, hydrazide

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.595.660; http://www.mdpi.com/1420-3049/13/1/11/pdf/

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.595.660
http://www.mdpi.com/1420-3049/13/1/11/pdf/

المؤلفون: Maud Gayral, Rok Frlan, Christine Gravier-Pelletier, Janez Mravljak

المصدر: Synlett. 27:1551-1556

مصطلحات موضوعية: chemistry.chemical_classification, Tandem, Stereochemistry, Organic Chemistry, Epoxide, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Amino acid, chemistry.chemical_compound, Enantiopure drug, Nucleophile, chemistry, Glycine, Organic chemistry, Amine gas treating, Glycosyl, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6bcae1b0550f3230806a3d3ff3de878c
https://doi.org/10.1055/s-0035-1561987

المؤلفون: Rok Frlan, Stanislav Gobec, Janko Kos, Abdelkarim El Qami, Badr Jismy, Damijan Knez, Mohamed Abarbri, Anja Pišlar

المصدر: European Journal of Medicinal Chemistry. 209:112911

مصطلحات موضوعية: Bromides, Indazoles, Monoamine Oxidase Inhibitors, Monoamine oxidase, Tyramine, 01 natural sciences, Coupling reaction, Antiparkinson Agents, Small Molecule Libraries, Neuroblastoma, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Coordination Complexes, Drug Discovery, medicine, Humans, Monoamine Oxidase, 030304 developmental biology, Pharmacology, 0303 health sciences, Indazole, 010405 organic chemistry, Aryl, Organic Chemistry, General Medicine, Antiparkinsonian Agent, medicine.disease, Combinatorial chemistry, 0104 chemical sciences, Molecular Docking Simulation, Neuroprotective Agents, chemistry, Metals, Docking (molecular), Monoamine oxidase B, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc673745989cc85c1dc7e33662978db4
https://doi.org/10.1016/j.ejmech.2020.112911