المؤلفون: García-Souto, Daniel, Bruzos, Alicia, Pequeño-Valtierra, Ana, Román-Lewis, Camila F, Rodrñiguez-Castro, Jorge, Villanueva, Antonio, Silva, Luis, Tubio, Jose MC

المساهمون: Metzger, M.J. (Michael J)

مصطلحات موضوعية: Clam. genome, cancer, mitochondrial, Centro Oceanográfico de Cádiz, Pesquerías, medicine, zoology, genetics, diseases, research

جغرافية الموضوع: Vigo (España)

Relation: Centro Oceanográfico de Cádiz; AM; https://elifesciences.org/articles/66946; eLife, 10. 2022: Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe Daniel Garcia-Souto1,2,3*†, Alicia L Bruzos1,2†, Seila Diaz1†, Sara Rocha4, Ana Pequeño-Valtierra1, Camila F Roman-Lewis5, Juana Alonso5,6, Rosana Rodriguez7, Damian Costas7, Jorge Rodriguez-Castro1, Antonio Villanueva7, Luis Silva8, Jose Maria Valencia9,10, Giovanni Annona11, Andrea Tarallo11, Fernando Ricardo12, Ana Bratoš Cetinić13, David Posada5,6,14, Juan Jose Pasantes14,15, Jose MC Tubio1,2* 1Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain; 2Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; 3Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, United Kingdom; 4Phylogenomics Lab, Universidade de Vigo, Vigo, Spain; 5CINBIO, Universidade de Vigo, Vigo, Spain; 6Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain; 7Centro de Investigación Mariña, Universidade de Vigo, ECIMAT, Vigo, Spain; 8Instituto Español de Oceanografía (IEO), Centro Oceanográfico de Cádiz, Cádiz, Spain; 9Laboratori d’Investigacions Marines i Aqüicultura, (LIMIA) - Govern de les Illes Balears, Port d'Andratx, Balearic Islands, Spain; 10Instituto de Investigaciones Agroambientales y de Economía del Agua (INAGEA) (INIA-CAIB- UIB), Palma de Mallorca, Balearic Islands, Spain; 11Stazione Zoologica Anton Dohrn, Napoli, Italy; 12ECOMARE, Centre for Environmental and Marine Studies (CESAM), Department of Biology, University of Aveiro, Santiago University Campus, Aveiro, Portugal; 13Department of Aquaculture, University of Dubrovnik, Dubrovnik, Croatia; 14Department of Biochemistry, Genetics and Immunology, Universidade de Vigo, Vigo, Spain; 15Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain Abstract Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe.-Yonemitsu MA, Giersch RM, Polo-Prieto M, Hammel M, Simon A, Cremonte F, Avilés FT, Merino-Véliz N, Burioli EA, Muttray AF, Sherry J, Reinisch C, Baldwin SA, Goff SP, Houssin M, Arriagada G, Vázquez N, Bierne N, Metzger MJ. 2019. A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe. eLife 8:e47788. DOI: https://doi.org/10.7554/eLife.47788, PMID: 31686650; http://hdl.handle.net/10508/15701; http://hdl.handle.net/10261/324433; 50036

الاتاحة: http://hdl.handle.net/10508/15701
http://hdl.handle.net/10261/324433
https://doi.org/10.7554/eLife.66946

المؤلفون: Metzger, M.J. (Michael J), García-Souto, Daniel, Bruzos, Alicia, Pequeño-Valtierra, Ana, Román-Lewis, Camila F, Rodrñiguez-Castro, Jorge, Villanueva, Antonio, Silva, Luis, Tubio, Jose MC

مصطلحات الفهرس: Clam. genome, cancer, mitochondrial, Centro Oceanográfico de Cádiz, Pesquerías, artículo

URL: http://hdl.handle.net/10261/324433
https://elifesciences.org/articles/66946
Centro Oceanográfico de Cádiz
Postprint
https://elifesciences.org/articles/66946