المؤلفون: Elisa Puigdomenech, Eugenia Riviere, Oscar Levalle, Soledad Paola Rossi, Monica Beatriz Frungieri, Roberto Ponzio, Ricardo S. Calandra, Mónica M. Muñoz de Toro, Maria Eugenia Matzkin, Gustavos Martinez, Claudio Terradas, Yamil Ezequiel Tavalieri

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, MELATONIN, CIENCIAS MÉDICAS Y DE LA SALUD, 030209 endocrinology & metabolism, Inflammation, medicine.disease_cause, Biochemistry, Antioxidants, Male infertility, Melatonin, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, INFLAMMATION, Fibrosis, Internal medicine, Testis, medicine, TBARS, Humans, OXIDATIVE STRESS, Spermatogenesis, Molecular Biology, MALE INFERTILITY, Unexplained infertility, Azoospermia, business.industry, TESTIS, Bioquímica y Biología Molecular, medicine.disease, Oxidative Stress, Medicina Básica, 030104 developmental biology, Dietary Supplements, medicine.symptom, business, Oxidative stress, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66073a6c8a15c39d0610e17a2536128
https://www.sciencedirect.com/science/article/abs/pii/S0303720720301891

المؤلفون: Soledad Paola Rossi, Artur Mayerhofer, Roberto Ponzio, Elisa Puigdomenech, Claudio Terradas, Eugenia Riviere, Oscar Levalle, Maria Eugenia Matzkin, Ricardo S. Calandra, Monica Beatriz Frungieri

مصطلحات موضوعية: 0301 basic medicine, Male, Biochemistry, Pathogenesis, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Testis, ADRENERGIC RECEPTORS, Testosterone, MACROPHAGES, Receptor, Cells, Cultured, Catecholaminergic, TESTIS, PROSTAGLANDIN, EPINEPHRINE, Bioquímica y Biología Molecular, Medicina Básica, NOREPINEPHRINE, medicine.symptom, COX2, CIENCIAS NATURALES Y EXACTAS, Infertility, Adult, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Adrenergic receptor, Prostaglandin, 030209 endocrinology & metabolism, Inflammation, Biology, Ciencias Biológicas, 03 medical and health sciences, Downregulation and upregulation, INFLAMMATION, Internal medicine, Receptors, Adrenergic, beta, medicine, IDIOPATHIC INFERTILITY, Animals, Humans, Molecular Biology, Infertility, Male, Mesocricetus, Macrophages, medicine.disease, 030104 developmental biology, chemistry, Cyclooxygenase 2, Prostaglandins

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62e93b567cd3114310ae6a069e64744
https://www.sciencedirect.com/science/article/abs/pii/S0303720719302473?via=ihub

المؤلفون: Adriana María Belén Abiuso, Marcos Alberto Besio Moreno, Roberto Ponzio, Alejandra Lucía Marcos, Luis A. Haro Durand, María Luisa Varela, Esperanza Berensztein, Alicia Belgorosky, Carolina Mondillo, Omar Pedro Pignataro, Marco A. Rivarola

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Angiogenesis, medicine.medical_treatment, Angiogenesis Inhibitors, Steroid Synthesis Inhibitors, Medicina Clínica, Guanidines, ANGIOGENESIS, Receptor, IGF Type 1, 0302 clinical medicine, OESTRADIOL, HISTAMINE, Endocrinología y Metabolismo, Medicine, Molecular Targeted Therapy, Aromatase, Neovascularization, Pathologic, biology, Leydig cell, Age Factors, Imidazoles, Thiourea, medicine.anatomical_structure, Oncology, Receptors, Androgen, 030220 oncology & carcinogenesis, Leydig Cell Tumor, Signal Transduction, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, STEROIDOGENESIS, Antineoplastic Agents, Coturnix, Leydig cell tumour, Histamine Agonists, 03 medical and health sciences, Testicular Neoplasms, Cell Line, Tumor, Internal medicine, Human Umbilical Vein Endothelial Cells, Animals, Estrogen Receptor beta, Humans, Endocrine system, Histamine H4 receptor, Cell Proliferation, Receptors, Histamine H4, business.industry, Growth factor, Estrogen Receptor alpha, Infant, Receptors, Somatomedin, medicine.disease, Rats, Androgen receptor, 030104 developmental biology, Endocrinology, biology.protein, CYP19 AROMATASE, business, LEYDIG-CELL TUMOUR, HISTAMINE RECEPTOR H4

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c346ebdd23312d724bad55b48c47b96
https://www.sciencedirect.com/science/article/pii/S0959804917314600

المؤلفون: E. Puigdomenech, Ricardo S. Calandra, Roberto Ponzio, Artur Mayerhofer, Claudio Terradas, Oscar Levalle, Monica Beatriz Frungieri, Maria Eugenia Matzkin, Soledad Paola Rossi, S. Windschuettl

المصدر: Andrology. 2:436-449

مصطلحات موضوعية: Male, Corticotropin-Releasing Hormone, Endocrinology, Diabetes and Metabolism, Interleukin-1beta, Anti-Inflammatory Agents, Receptors, Melatonin, Antioxidants, Superoxide Dismutase-1, Endocrinology, Cricetinae, Testis, Mast Cells, Receptor, Azoospermia, Melatonin, Sertoli Cell-Only Syndrome, Leydig Cells, Catalase, Mast cell, medicine.anatomical_structure, Androgens, Tumor necrosis factor alpha, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, medicine.drug, Adult, endocrine system, medicine.medical_specialty, Urology, Hamster, Biology, Cell Line, Sertoli cell-only syndrome, Internal medicine, medicine, Animals, Humans, Infertility, Male, Cell Proliferation, Superoxide Dismutase, Tumor Necrosis Factor-alpha, Macrophages, Oligospermia, Peroxiredoxins, medicine.disease, Melatonergic, Oxidative Stress, Reproductive Medicine, Cyclooxygenase 2, Cell culture, Reactive Oxygen Species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1704813dc6ef33435421efbeadb87aec
https://doi.org/10.1111/j.2047-2927.2014.00207.x

المؤلفون: Ailén Magalí Díaz, Roberto Ponzio, Andrea Canellada, María Belén Azpiroz, Marcela Manghi, Matías Alejandro Molina, Mónica Sparo, Marisa Silvia Castro

المصدر: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

مصطلحات موضوعية: 0301 basic medicine, Chemokine, immunomodulation, Applied Microbiology and Biotechnology, law.invention, Mice, Probiotic, law, Intestine, Small, Enterococcus faecalis, Intestinal Mucosa, Caco-2 cells, Mice, Inbred BALB C, probiotic activity, biology, General Medicine, Intestines, medicine.anatomical_structure, Cytokines, Tumor necrosis factor alpha, intestinal epithelial cells, CIENCIAS NATURALES Y EXACTAS, Biotechnology, adhesion to intestinal epithelial cells, Medicina, Otras Ciencias Biológicas, 030106 microbiology, Proinflammatory cytokine, Microbiology, Enterococcus faecalis CECT7121, Ciencias Biológicas, 03 medical and health sciences, Immune system, medicine, Animals, Humans, Immunity, Mucosal, Ciencias Exactas, Interleukin-6, Tumor Necrosis Factor-alpha, Probiotics, Interleukin-8, Epithelial Cells, mucosal immune response, biology.organism_classification, Small intestine, 030104 developmental biology, Caco-2, biology.protein, Caco-2 Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c9c30f9fadc9798acfd4697030a19f
http://sedici.unlp.edu.ar/handle/10915/101711

المؤلفون: Cristian Marcelo Sobarzo, Livia Lustig, Roberto Ponzio, María Olga Suescun, Berta Denduchis

المصدر: Microscopy Research and Technique. 72:868-877

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Histology, Biology, Occludin, Cell junction, Connexins, Tight Junctions, Rats, Sprague-Dawley, chemistry.chemical_compound, Diethylhexyl Phthalate, Internal medicine, Testis, medicine, Animals, Instrumentation, Blood–testis barrier, Sertoli Cells, Leydig cell, Tight junction, Phthalate, Gap Junctions, Leydig Cells, Seminiferous Tubules, Rats, Medical Laboratory Technology, medicine.anatomical_structure, Endocrinology, chemistry, Anatomy, Spermatogenesis, Germ cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dab725476909d8f629814cca36c56c2
https://doi.org/10.1002/jemt.20741

المؤلفون: Roberto Ponzio, O. Vilar, J. Hib

المصدر: Andrologia. 14:121-129

مصطلحات موضوعية: Male, Sertoli Cells, Chemistry, Macrophages, Urology, Rats, Inbred Strains, General Medicine, Seminiferous Tubules, Sertoli cell, Molecular biology, Carbon, Rats, Microscopy, Electron, Endocrinology, medicine.anatomical_structure, Phagocytosis, Testis, medicine, Animals, Thorium Dioxide, Colloids, Electron microscopic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8590317bde5798db2c9df223d51b256a
https://doi.org/10.1111/j.1439-0272.1982.tb03110.x

المؤلفون: Roberto Ponzio, J. Hib, O. Vilar

المصدر: Andrologia. 11:326-330

مصطلحات موضوعية: Male, Urology, medicine.medical_treatment, media_common.quotation_subject, Fertility, Biology, Andrology, Contractility, Endocrinology, medicine, Animals, Sex organ, Prostaglandin E2, media_common, Epididymis, Diminution, Prostaglandins E, General Medicine, Sperm, Rats, Sperm Maturation, medicine.anatomical_structure, medicine.drug, Prostaglandin E

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146ffb908fe26d03f10c724618463cd
https://doi.org/10.1111/j.1439-0272.1979.tb02215.x

المؤلفون: Roberto Ponzio, Mariana Costanzo, Alicia Belgorosky, María Sonia Baquedano, Carolina M. Pepe, Marco A. Rivarola, Nora Saraco, Esperanza Berensztein

المصدر: Pediatric Research. 63:662-666

مصطلحات موضوعية: Male, medicine.medical_specialty, 3-Hydroxysteroid Dehydrogenases, Cellular differentiation, medicine.medical_treatment, Apoptosis, Growth hormone receptor, Insulin-like growth factor, Insulin-Like Growth Factor II, Internal medicine, Testis, medicine, Humans, Insulin, Testosterone, Cholesterol Side-Chain Cleavage Enzyme, RNA, Messenger, Insulin-Like Growth Factor I, Cells, Cultured, Cell Proliferation, Insulin-like growth factor 1 receptor, biology, Leydig cell, Cell growth, Cholesterol side-chain cleavage enzyme, Age Factors, Infant, Newborn, Infant, Leydig Cells, Cell Differentiation, Receptors, Somatomedin, Receptor, Insulin, Recombinant Proteins, Insulin receptor, Endocrinology, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, biology.protein, Autopsy, Carrier Proteins, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05d409ce7987c95dc6ee268d4273abe
https://doi.org/10.1203/pdr.0b013e31816c8ffc

المؤلفون: J T Rodriguez, Alicia Belgorosky, Nora Saraco, Esperanza Berensztein, María Sonia Baquedano, Candela Rocio Gonzalez, Roberto Ponzio, Marco A. Rivarola

المصدر: Pediatric Research. 60:740-744

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, medicine.drug_class, Cellular differentiation, Testicle, Gene Expression Regulation, Enzymologic, Aromatase, Gonocyte, Internal medicine, Testis, medicine, Estrogen Receptor beta, Humans, Cholesterol Side-Chain Cleavage Enzyme, RNA, Messenger, Sertoli Cells, biology, Estrogen Receptor alpha, Infant, Newborn, Infant, Leydig Cells, Cell Differentiation, Sertoli cell, Androgen receptor, Germ Cells, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, Receptors, Androgen, Estrogen, Child, Preschool, Pediatrics, Perinatology and Child Health, biology.protein, Estrogen receptor alpha, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdf9338f02f0ba9b279a90ffbc910e0
https://doi.org/10.1203/01.pdr.0000246072.04663.bb

المؤلفون: Silvia I. Gonzalez-Calvar, Candela Rocio Gonzalez, Roberto Ponzio, Ricardo S. Calandra, Alfredo Daniel Vitullo, Oscar Levalle, Claudio Terradas, Elisa Puigdomenech, Pablo Ignacio Felipe Inserra

المصدر: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

مصطلحات موضوعية: endocrine system, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, medicine.drug_class, Leydig, Estrogen receptor, Biology, Sertoli cell-only syndrome, Paracrine signalling, Aromatase, Internal medicine, medicine, Autocrine signalling, Progesterone, Leydig cell, urogenital system, General Medicine, purl.org/becyt/ford/3.1 [https], Bioquímica y Biología Molecular, medicine.disease, Sertoli cell, Estrogen, Medicina Básica, Endocrinology, medicine.anatomical_structure, biology.protein, purl.org/becyt/ford/3 [https], hormones, hormone substitutes, and hormone antagonists

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7a6991a646a8d0694d07795b280ae3
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53101

المؤلفون: Roberto Ponzio, Gabriela Ruibal, Martha Suarez, Ana Maria Sequera, Jorge Giuseppucci, Patricia Sobrado, Andrea B. Pujol, Hugo L. Fideleff, Hugo R. Boquete, Miriam Azaretsky

المصدر: European Journal of Endocrinology. 143:775-781

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Adolescent, medicine.drug_class, Biopsy, Endocrinology, Diabetes and Metabolism, Varicocele, Testicular pain, Chorionic Gonadotropin, Gonadotropin-Releasing Hormone, Follicle-stimulating hormone, Basal (phylogenetics), Endocrinology, Reference Values, Internal medicine, Testis, medicine, Humans, Testosterone, Child, Spermatogenesis, Sertoli Cells, medicine.diagnostic_test, business.industry, Leydig Cells, General Medicine, Luteinizing Hormone, medicine.disease, Spermatids, Histopathology, Follicle Stimulating Hormone, medicine.symptom, Gonadotropin, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce8922416847974cb86b61d822cb6fa
https://doi.org/10.1530/eje.0.1430775

المؤلفون: Roberto Ponzio, R-Marc Pelletier, Livia Lustig, Michel Lauzon, Berta Denduchis

المصدر: Biology of Reproduction. 62:1505-1514

مصطلحات موضوعية: Basement membrane, medicine.medical_specialty, biology, Cell Biology, General Medicine, Testicle, Sertoli cell, Epithelium, Andrology, medicine.anatomical_structure, Endocrinology, Seminiferous tubule, Reproductive Medicine, Laminin, Internal medicine, medicine, biology.protein, Basal lamina, Spermatogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::510b7080c419c4367be87ada61004f24
https://doi.org/10.1095/biolreprod62.6.1505

المؤلفون: S. Spillner, Ricardo S. Calandra, Monica Beatriz Frungieri, Maria Eugenia Matzkin, J. U. Schwarzer, Claudio Terradas, Katrin Spinnler, Roberto Ponzio, Frank-Michael Köhn, Oscar Levalle, Artur Mayerhofer, C. Kampfer, E. Puigdomenech

المصدر: International journal of andrologyReferences. 35(6)

مصطلحات موضوعية: Male, medicine.medical_specialty, Urology, Endocrinology, Diabetes and Metabolism, Peroxiredoxin 1, medicine.disease_cause, Polymerase Chain Reaction, Male infertility, Immune system, Fibrosis, Internal medicine, Testis, medicine, Humans, Cells, Cultured, Infertility, Male, DNA Primers, chemistry.chemical_classification, Reactive oxygen species, biology, Base Sequence, Superoxide Dismutase, Free Radical Scavengers, Peroxiredoxins, medicine.disease, Catalase, Endocrinology, Reproductive Medicine, chemistry, biology.protein, Reactive Oxygen Species, Spermatogenesis, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d70e74a5ca6eded0b19a9576318c0a8
https://pubmed.ncbi.nlm.nih.gov/22640168

المؤلفون: Soledad Paola Rossi, Monica Beatriz Frungieri, Roberto Ponzio, Ricardo S. Calandra, Oscar Levalle, Elisa Puigdomenech, Maria Eugenia Matzkin, Claudio Terradas

المصدر: General and comparative endocrinology. 178(1)

مصطلحات موضوعية: MAPK/ERK pathway, Male, medicine.medical_specialty, endocrine system, MELATONIN, CIENCIAS MÉDICAS Y DE LA SALUD, Corticotropin-Releasing Hormone, Hamster, Melatonin receptor, Melatonin, Endocrinology, Internal medicine, TESTOSTERONE, Cricetinae, medicine, Animals, LEYDIG CELLS, biology, Leydig cell, Steroidogenic acute regulatory protein, Leydig Cells, Bioquímica y Biología Molecular, Medicina Básica, medicine.anatomical_structure, Mitogen-activated protein kinase, biology.protein, TYROSINE PHOSPHATASES, Animal Science and Zoology, Signal transduction, INTRACELLULAR SIGNALINGI, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2d9af7e46b466aaac684cbcdb3060b
https://pubmed.ncbi.nlm.nih.gov/22580327

المؤلفون: Roberto Ponzio, Cecilia Zylbersztein, Oscar Levalle, Sergio Aszpis, Virginia Mariani, Claudio Aranda, Abraham Guitelman, Hugo E. Scaglia

المصدر: Human Reproduction. 9:781-787

مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, medicine.drug_class, Follicle-stimulating hormone, Internal medicine, Testis, medicine, Humans, Testosterone, Spermatogenesis, Infertility, Male, Azoospermia, Estradiol, business.industry, Rehabilitation, Obstetrics and Gynecology, Luteinizing Hormone, Androgen, medicine.disease, Gonadotropin secretion, Endocrinology, Reproductive Medicine, Estrogen, Follicle Stimulating Hormone, Gonadotropin, business, Luteinizing hormone, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2cab47df302329f8ef6e2d7ff73698
https://doi.org/10.1093/oxfordjournals.humrep.a138596

المؤلفون: Anabella Della Gaspera, Esperanza Berensztein, Roberto Ponzio, Marco A Rivarola, Alicia Belgorosky

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0f20222d6af75ae85fc1ff5cbd658d58
https://doi.org/10.1210/endo-meetings.2011.part2.p28.p2-175

المؤلفون: Candela Rocio Gonzalez, Maria Eugenia Matzkin, Ricardo S. Calandra, Betina Gonzalez, Oscar Levalle, Claudio Terradas, Artur Mayerhofer, Elisa Puigdomenech, Silvia I. Gonzalez-Calvar, Soledad Paola Rossi, Monica Beatriz Frungieri, Roberto Ponzio

المصدر: Fertility and sterility. 94(5)

مصطلحات موضوعية: Gene isoform, Adult, Male, endocrine system, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Biopsy, Interleukin-1beta, Prostaglandin, Medicina Clínica, Testicle, Male infertility, Sertoli cell-only syndrome, chemistry.chemical_compound, Mice, Internal medicine, Testis, medicine, Animals, Humans, Cells, Cultured, Infertility, Male, biology, medicine.diagnostic_test, urogenital system, business.industry, Sertoli Cell-Only Syndrome, Macrophages, Interleukin 1beta, Obstetrics and Gynecology, Leydig Cells, medicine.disease, medicine.anatomical_structure, Endocrinology, Reproductive Medicine, chemistry, Cyclooxygenase 2, biology.protein, Prostaglandins, Cyclooxygenase, Medicina Critica y de Emergencia, business, Germ cell, COX2

وصف الملف: application/pdf; application/rar

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1db4f853aae4ce856135f5f4f307cea
https://pubmed.ncbi.nlm.nih.gov/20188355

المؤلفون: María del Carmen C. Vidal, Elisa Bal de Kier Joffé, Roberto Ponzio, Lydia Puricelli, Lucas L. Colombo, Daniel E. Gomez

المصدر: Journal of Surgical Oncology. 45:190-195

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Mammary gland, Biology, Chromosomes, Metastasis, Mice, In vivo, Cell Adhesion, Tumor Cells, Cultured, medicine, Animals, Lymph node, Mice, Inbred BALB C, Mammary tumor, Mammary Neoplasms, Experimental, General Medicine, medicine.disease, Microscopy, Electron, medicine.anatomical_structure, Lymphatic system, Oncology, Lymphatic Metastasis, Adenocarcinoma, Female, Surgery, Lymph

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5518b4625fd165dd1c5269f6dc36ff
https://doi.org/10.1002/jso.2930450312

المؤلفون: Roberto Ponzio, Cristian Marcelo Sobarzo, Livia Lustig, Berta Denduchis

المصدر: Reproductive toxicology (Elmsford, N.Y.). 22(1)

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Delta Catenin, Blotting, Western, Fluorescent Antibody Technique, Apoptosis, Biology, Testicle, Toxicology, Rats, Sprague-Dawley, chemistry.chemical_compound, Microscopy, Electron, Transmission, Plasticizers, Spermatocytes, Internal medicine, Diethylhexyl Phthalate, Testis, medicine, In Situ Nick-End Labeling, Animals, Spermatogenesis, Intubation, Gastrointestinal, Sertoli Cells, Body Weight, Phthalate, Catenins, Organ Size, Seminiferous Tubules, Sertoli cell, Cadherins, Phosphoproteins, Spermatogonia, Rats, Blot, Endocrinology, Seminiferous tubule, medicine.anatomical_structure, chemistry, Cell Adhesion Molecules, Corn oil, Germ cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb32d06292d1cf057ccde329b48598e
https://pubmed.ncbi.nlm.nih.gov/16678996