المؤلفون: Michele Cianci, Nicola Giacchè, Lucia Cialabrini, Andrea Carotti, Paride Liscio, Emiliano Rosatelli, Francesca De Franco, Massimiliano Gasparrini, Janet Robertson, Adolfo Amici, Nadia Raffaelli, Roberto Pellicciari

المصدر: Frontiers in Molecular Biosciences, Vol 9 (2022)

مصطلحات موضوعية: ACMSD, X-ray crystallography, TES-1025, decarboxylase, drug discovery, de novo NAD+ synthesis, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.834700/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/939b4944020c4a4f9cf2c164cbbc4724

المؤلفون: Noortje Ijssennagger, Kristel S. van Rooijen, Stefanía Magnúsdóttir, José M. Ramos Pittol, Ellen C.L. Willemsen, Marcel R. de Zoete, Matthijs J.D. Baars, Paul B. Stege, Carolina Colliva, Roberto Pellicciari, Sameh A. Youssef, Alain de Bruin, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. van Mil

المصدر: JHEP Reports, Vol 3, Iss 5, Pp 100344- (2021)

مصطلحات موضوعية: Farnesoid X receptor, Liver-specific Fxr-KO mouse, Intestine-specific Fxr-KO mouse, Colon, Gut microbiome, Mucus layer, Diseases of the digestive system. Gastroenterology, RC799-869

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555921001208; https://doaj.org/toc/2589-5559

URL الوصول: https://doaj.org/article/d6f47344bb9a4166b5afc39b37bff9cd

المؤلفون: Antimo Gioiello, Antonio Macchiarulo, Roberto Pellicciari, Roberto Nuti, Roccaldo Sardella, Benedetto Natalini, Paola Sabbatini, Paolo Filipponi

المصدر: Molecules, Vol 18, Iss 9, Pp 10497-10513 (2013)

مصطلحات موضوعية: bile acids, structure-property relationships, critical micellization concentration, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/18/9/10497; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/8e4133ca8e6640ba9b50e69e84beee9c

المؤلفون: John M. Kauffman, Roberto Pellicciari, Martin C. Carey

المصدر: Journal of Lipid Research, Vol 46, Iss 3, Pp 571-581 (2005)

مصطلحات موضوعية: phosphatidylcholine, condensation, pressure-area isotherm, orientation, bulk solubility, farnesoid X receptor, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520340414; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/97eab2897a0944c6b6df3b55120464bd

المؤلفون: Giada Ceccarelli, Laura Goracci, Andrea Carotti, Federico Paccoia, Daniela Passeri, Marco Cipolloni, Stefano Di Bona, Gabriele Cruciani, Roberto Pellicciari, Antimo Gioiello

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, switch modulating infection, biological results led, alternative therapeutic approaches, 12 agonist endowed, high receptor selectivity, novel chemical tools, 12 ligands permit, 3 , 12 receptor modulators, therapeutic intervention, steroidal ligands, ss <, 12 receptor, 12 antagonists, receptor binding, nuclear receptor, treating parasitism, molecular shape, life cycle, improved properties

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Structure_Activity_Relationshsips_of_Novel_i_ss_i_DAF-12_Receptor_Modulators/25308658

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02421.s001

المؤلفون: Felipe Luis Pérez-Gordillo, Natalia Serrano-Morillas, Luz Marina Acosta-García, María Teresa Aranda, Daniela Passeri, Roberto Pellicciari, María Jesús Pérez de Vega, Rosario González-Muñiz, Diego Alvarez de la Rosa, Mercedes Martín-Martínez

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 2439

مصطلحات موضوعية: MR, nuclear receptor, NR3C2, aldosterone, DHP, antagonist, docking, molecular dynamics

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms24032439

الاتاحة: https://doi.org/10.3390/ijms24032439

المؤلفون: Samuel Harry Myers, Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli

المساهمون: Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli

مصطلحات موضوعية: BRCA2, RAD51, synthetic lethality

وصف الملف: ELETTRONICO

Relation: ispartofbook:ACS Spring 2022; ACS Spring 2022; firstpage:1; lastpage:1; numberofpages:1; https://hdl.handle.net/11585/929676; https://www.morressier.com/o/event/623377e0b300ee00119b311f/article/6234a19a818a915252b803a2

الاتاحة: https://hdl.handle.net/11585/929676
https://www.morressier.com/o/event/623377e0b300ee00119b311f/article/6234a19a818a915252b803a2

المؤلفون: Fabiola Moretti, Antonio Macchiarulo, Jean Christophe Marine, Alfredo Pontecorvi, Roberto Pellicciari, Giulia Piaggio, Mara D'Onofrio, Maurizio Fanciulli, Tiziana Bruno, Rossella Brandi, Laura Fici, Marianna Buttarelli, Emanuela Teveroni, Fulvio Florenzano, Ivan Arisi, Isabella Manni, Nicola Giacchè, Alice Coletti, Rossella Lucà, Francesca Mancini, Marsha Pellegrino

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f412cf386837aee8ea282366fd89e0
https://doi.org/10.1158/0008-5472.22405989.v1

المؤلفون: Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, Andrea Cavalli

مصطلحات موضوعية: Synthetic lethality Homologous recombination Protein-protein small molecule inhibitors Anticancer drugs PARP inhibitors

Relation: https://doi.org/10.1016/j.ejmech.2019.01.008; oai:zenodo.org:6425602

الاتاحة: https://doi.org/10.1016/j.ejmech.2019.01.008

المؤلفون: Eline Hendrix, Anthony Tumber, Klemensas Simelis, Mathew L. Coleman, Nicola Mautone, Akane Kawamura, Catrine Johansson, Alessia Ciogli, Udo Oppermann, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Daniela Passeri, Antonello Mai, Mohammad Salik Zeya Ansari, Regina Andrijes, Daniela Trisciuoglio, Eidarus Salah, Donatella Del Bufalo, Francesca Romana Pellegrini, Radosław P Nowak, Roberto Pellicciari, Rino Ragno, Christopher J. Schofield

المصدر: Journal of Medicinal Chemistry
Journal of medicinal chemistry 64 (2021): 17031–17050. doi:10.1021/acs.jmedchem.1c00605
info:cnr-pdr/source/autori:Nowak R.P.; Tumber A.; Hendrix E.; Ansari M.S.Z.; Sabatino M.; Antonini L.; Andrijes R.; Salah E.; Mautone N.; Pellegrini F.R.; Simelis K.; Kawamura A.; Johansson C.; Passeri D.; Pellicciari R.; Ciogli A.; Del Bufalo D.; Ragno R.; Coleman M.L.; Trisciuoglio D.; Mai A.; Oppermann U.; Schofield C.J.; Rotili D./titolo:First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53/doi:10.1021%2Facs.jmedchem.1c00605/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:17031/pagina_a:17050/intervallo_pagine:17031–17050/volume:64

مصطلحات موضوعية: Models, Molecular, Oxygenase, Protein Conformation, medical chemistry, Article, Cofactor, Dioxygenases, Substrate Specificity, Hydroxylation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, solid cancer, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Transcription factor, MINA53 inhibitors, oncology, Cell Proliferation, 030304 developmental biology, Histone Demethylases, 0303 health sciences, epigenetics, biology, Chemistry, Nuclear Proteins, Active site, Ribosomal RNA, 3. Good health, Biochemistry, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Molecular Medicine, Demethylase, Crystallization, Ribosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a2018a4fda17782bb28cfc487a6ff
https://doi.org/10.1021/acs.jmedchem.1c00605

المؤلفون: Vittoria Massafra, Roberto Pellicciari, Antimo Gioiello, Saskia W.C. van Mil

مصطلحات موضوعية: European Commission, EC, SP3-People, Marie-Curie Actions, FP7, Pharmacology (medical), Pharmacology

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/38140

الاتاحة: https://www.openaccessrepository.it/record/38140
https://doi.org/10.1016/j.pharmthera.2018.06.009

المؤلفون: Francesco Venturoni, Bruno Cerra, Maura Marinozzi, Emidio Camaioni, Antimo Gioiello, Roberto Pellicciari

المصدر: Catalysts; Volume 8; Issue 12; Pages: 600

مصطلحات موضوعية: α-diazo-β-hydroxy ketones, decomposition, vinyl cation cascade, diazoacetone, borontrifluoride

وصف الملف: application/pdf

Relation: Catalysis in Organic and Polymer Chemistry; https://dx.doi.org/10.3390/catal8120600

الاتاحة: https://doi.org/10.3390/catal8120600

المؤلفون: Sabrina Diano, Sungho Jin, Bernard L. Schneider, Antimo Gioiello, Nadia Bresciani, Laura A. Velázquez-Villegas, Yu Sun, Qingyao Huang, Philippe Zizzari, Aiste Baleisyte, Valérie S. Fénelon, Julijana Ivanisevic, Giuseppe Bruschetta, Kristina Schoonjans, Daniela Cota, Roberto Pellicciari, Ashley Castellanos-Jankiewicz, Alessia Perino

المصدر: Nature metabolism, vol. 3, no. 5, pp. 595-603

مصطلحات موضوعية: Male, receptor, Endocrinology, Diabetes and Metabolism, Receptors, G-Protein-Coupled, Bile Acids, Eating, Mice, 0302 clinical medicine, Receptors, rat, Receptor, gaba, Mice, Knockout, Neurons, 2. Zero hunger, 0303 health sciences, Drug discovery, Chemistry, Neuropeptide Y receptor, G protein-coupled bile acid receptor, Anorexia, cortex, medicine.anatomical_structure, medicine.drug, medicine.medical_specialty, Central nervous system, Hypothalamus, Neuropeptide, Mice, Transgenic, leptin, Cell Line, Neuropeptides, Bile Acids and Salts, G-Protein-Coupled, 03 medical and health sciences, Physiology (medical), Orexigenic, Internal medicine, Internal Medicine, medicine, Animals, Secretion, 030304 developmental biology, G protein-coupled receptor, Cell Biology, agrp neurons, Endocrinology, glucagon-like peptide-1, Gene Expression Regulation, area postrema, activation, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2281574709bc9ea4131aabfc156b9f6c
https://doi.org/10.1038/s42255-021-00398-4

المؤلفون: Bruno Cerra, Francesco Venturoni, Maria Souma, Giada Ceccarelli, Anna Maria Lozza, Daniela Passeri, Francesca De Franco, Ian R Baxendale, Roberto Pellicciari, Antonio Macchiarulo, Antimo Gioiello

المساهمون: Cerra, Bruno, Venturoni, Francesco, Souma, Maria, Ceccarelli, Giada, Maria Lozza, Anna, Passeri, Daniela, De Franco, Francesca, R Baxendale, Ian, Pellicciari, Roberto, Macchiarulo, Antonio, Gioiello, Antimo

مصطلحات موضوعية: Bile acid, Flow chemistry, FXR, Metabolite, Ozonolysi, Process chemistry, Scale-up, Sulfates

Relation: info:eu-repo/semantics/altIdentifier/pmid/36049273; info:eu-repo/semantics/altIdentifier/wos/WOS:000854107400002; volume:242; firstpage:114652; numberofpages:15; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11391/1540336; https://www.sciencedirect.com/science/article/pii/S0223523422005542

الاتاحة: https://hdl.handle.net/11391/1540336
https://doi.org/10.1016/j.ejmech.2022.114652
https://www.sciencedirect.com/science/article/pii/S0223523422005542

المؤلفون: Marco Gargaro, Giulia Scalisi, Giorgia Manni, Carlos G. Briseño, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marilena Castelli, Chenling A. Xu, Gerd Meyer zu Hörste, Giuseppe Servillo, Maria A. Della Fazia, Giulia Mencarelli, Doriana Ricciuti, Eleonora Padiglioni, Nicola Giacchè, Carolina Colliva, Roberto Pellicciari, Mario Calvitti, Teresa Zelante, Dietmar Fuchs, Ciriana Orabona, Louis Boon, Alban Bessede, Marco Colonna, Paolo Puccetti, Theresa L. Murphy, Kenneth M. Murphy, Francesca Fallarino

المساهمون: Gargaro, Marco, Scalisi, Giulia, Manni, Giorgia, Briseño, Carlos G., Bagadia, Prachi, Durai, Vivek, Theisen, Derek J., Kim, Sunkyung, Castelli, Marilena, Xu, Chenling A., Meyer zu Hörste, Gerd, Servillo, Giuseppe, Della Fazia, Maria A., Mencarelli, Giulia, Ricciuti, Doriana, Padiglioni, Eleonora, Giacchè, Nicola, Colliva, Carolina, Pellicciari, Roberto, Calvitti, Mario, Zelante, Teresa, Fuchs, Dietmar, Orabona, Ciriana, Boon, Loui, Bessede, Alban, Colonna, Marco, Puccetti, Paolo, Murphy, Theresa L., Murphy, Kenneth M., Fallarino, Francesca

مصطلحات موضوعية: AhR, IDO1, IL-6, RelB, dendritic cells, immunotolerance, kynurenine, metabolites, neuroinflammation, tryptophan metabolism, Animals, Humans, Mice, Signal Transduction, Tryptophan, Indoleamine-Pyrrole 2,3,-Dioxygenase

Relation: info:eu-repo/semantics/altIdentifier/pmid/35704993; info:eu-repo/semantics/altIdentifier/wos/WOS:000823293900012; volume:55; issue:6; firstpage:1032; lastpage:1050; numberofpages:19; journal:IMMUNITY; https://hdl.handle.net/11391/1535413

الاتاحة: https://hdl.handle.net/11391/1535413
https://doi.org/10.1016/j.immuni.2022.05.013
https://www.cell.com/immunity/fulltext/S1074-7613(22)00233-3?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S1074761322002333?showall=true

المؤلفون: Carlos L. Manrique-Caballero, Francesca De Franco, Hernando Gomez, Roberto Pellicciari, John A. Kellum, Nicola Giacchè

المصدر: Antioxid Redox Signal

مصطلحات موضوعية: medicine.medical_specialty, Physiology, Clinical Biochemistry, Drug target, Urology, Renal function, urologic and male genital diseases, Kidney, Biochemistry, chemistry.chemical_compound, medicine, Humans, Sirtuins, Molecular Biology, Cell damage, General Environmental Science, Nicotinamide, urogenital system, Critically ill, business.industry, Acute kidney injury, Epithelial Cells, Cell Biology, medicine.disease, Forum Review Articles, NAD, chemistry, General Earth and Planetary Sciences, NAD+ kinase, Complication, business, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9bee5427ef7fa52c74ab011c040bdc
https://europepmc.org/articles/PMC8905249/

المؤلفون: Isabella Pallavicini, Greta Bagnolini, Andrea Balboni, Marinella Roberti, Janet Robertson, Giuseppina Di Stefano, Fulvia Farabegoli, Sebastiano Peri, Jose Antonio Ortega, Saverio Minucci, D. Gioia, Federico Falchi, Domenico Milano, Francesca De Franco, Fabrizio Schipani, Roberto Pellicciari, Andrea Cavalli, Marcella Manerba, Stefania Girotto

المساهمون: Bagnolini G., Milano D., Manerba M., Schipani F., Ortega J.A., Gioia D., Falchi F., Balboni A., Farabegoli F., De Franco F., Robertson J., Pellicciari R., Pallavicini I., Peri S., Minucci S., Girotto S., Di Stefano G., Roberti M., Cavalli A.

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, RAD51, Antineoplastic Agents, Synthetic lethality, Adenocarcinoma, Poly(ADP-ribose) Polymerase Inhibitors, 01 natural sciences, Poly (ADP-Ribose) Polymerase Inhibitor, Piperazines, Article, Poly(ADP-ribose) Polymerase Inhibitor, Olaparib, Antineoplastic Agent, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Small Molecule Librarie, Cell Line, Tumor, Pancreatic cancer, Drug Discovery, medicine, Humans, Protein Interaction Maps, Homologous Recombination, Piperazine, Phthalazine, 030304 developmental biology, BRCA2 Protein, 0303 health sciences, Drug discovery, Pancreatic Neoplasm, Drug Synergism, medicine.disease, 0104 chemical sciences, Pancreatic Neoplasms, 010404 medicinal & biomolecular chemistry, chemistry, Cancer research, Phthalazines, Molecular Medicine, Rad51 Recombinase, Synthetic Lethal Mutations, Homologous recombination, Protein Interaction Map, Human, DNA Damage

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9ce8f1a24b0337c5b7b86be9e4f0a
https://doi.org/10.1021/acs.jmedchem.9b01526

المؤلفون: Valentina Mancino, Andrea Carotti, Daniela Passeri, Roccaldo Sardella, Antimo Gioiello, Giada Ceccarelli, Roberto Pellicciari, Laura Goracci

المصدر: Organicbiomolecular chemistry. 19(24)

مصطلحات موضوعية: Double bond, Cyclopropanation, Stereochemistry, nuclear receptors, Hyodeoxycholic acid, 01 natural sciences, Biochemistry, law.invention, 03 medical and health sciences, chemistry.chemical_compound, law, Side chain, Parasitism, nuclear receptors, natural steroids, structure-activity relationship, Physical and Theoretical Chemistry, Walden inversion, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, 010405 organic chemistry, Chemistry, structure-activity relationship, Organic Chemistry, Biological activity, 0104 chemical sciences, Parasitism, natural steroids, Wittig reaction, Stereoselectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32236092ca6dcde30a73c55264fb4fc
https://pubmed.ncbi.nlm.nih.gov/34056641

المؤلفون: Alessandro Di Michele, Roccaldo Sardella, Bruno Cerra, Daniela Passeri, Andrea Carotti, Roberto Pellicciari, Giada Moroni, Antimo Gioiello, Antonio Macchiarulo

المساهمون: Cerra B., Carotti A., Passeri D., Sardella R., Moroni G., Di Michele A., MacChiarulo A., Pellicciari R., Gioiello A.

المصدر: ACS Medicinal Chemistry Letters. 10:677-681

مصطلحات موضوعية: Class (computer programming), Pregnane X receptor, integrated flow system, 010405 organic chemistry, Computer science, Organic Chemistry, electronic circular dichroism, flow technologies, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, enantioresolution, Automation, 010404 medicinal & biomolecular chemistry, flow technologie, Drug Discovery, lead discovery, Biological evaluation

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a3c6ed84d58f4d7899664e215f90e2
https://doi.org/10.1021/acsmedchemlett.8b00459

المؤلفون: Marika Zietak, Roberto Pellicciari, Nicola Giacchè, Lucia Cialabrini, Adrienne Mottis, Vera van der Velpen, Elena Katsyuba, Nadia Raffaelli, Paride Liscio, Nadine Stokar-Regenscheit, Johan Auwerx, Julijana Ivanisevic, David Legouis, Kristina Schoonjans, Karim Gariani, Francesca De Franco, Sophie de Seigneux, Olli Matilainen, Dongryeol Ryu

المصدر: Nature
Nature, vol. 563, no. 7731, pp. 354-359
Nature, Vol. 563, No 7731 (2018) pp. 354-359

مصطلحات موضوعية: 0301 basic medicine, α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, Nicotinamide adenine dinucleotide, Article, 03 medical and health sciences, chemistry.chemical_compound, longevity, Biosynthesis, NAD+, NAFLD, Gene expression, Kynurenine, life-span, ddc:616, chemistry.chemical_classification, Multidisciplinary, biology, Sirtuin 1, c. elegans, Tryptophan, NASH, Metabolism, transcutaneous measurement, Acute Kidney Injury, gene-expression, key enzyme, Cell biology, ACMSD, 030104 developmental biology, Enzyme, semialdehyde decarboxylase acmsd, chemistry, Sirtuin, biology.protein, NAD+ kinase, biosynthesis, metabolism

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67ac5e7b82b1e25a16fa2bb1827b630
https://doi.org/10.1038/s41586-018-0645-6