المؤلفون: Mark E. Layton (1443547), Jeffrey C. Kern (2399026), Timothy J. Hartingh (1503232), William D. Shipe (1514749), Izzat Raheem (14370322), Monika Kandebo (10947802), Robert P. Hayes (9220508), Sarah Huszar (14370325), Donnie Eddins (14370328), Bennett Ma (14370331), Joy Fuerst (5175641), Gordon K. Wollenberg (14370334), Jing Li (10611), Jeff Fritzen (7491188), Georgia B. McGaughey (1270989), Jason M. Uslaner (1514734), Sean M. Smith (1514728), Paul J. Coleman (1834798), Christopher D. Cox (1514737)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Mental Health, Hematology, Chemical Sciences not elsewhere classified, rational design led, potentially novel means, normalize dysfunctional activity, selective pde10a inhibitor, pde10a inhibition represents, developing pde10a inhibitors, dysfunctional striatal activity, isomeric pyrimidine series, 18 , striatal signaling, schizophrenia pde10a, target activities, physicochemical properties, liabilities seen, important regulator, highly potent, fragment hit, early optimization, earlier compounds

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_MK-8189_a_Highly_Potent_and_Selective_PDE10A_Inhibitor_for_the_Treatment_of_Schizophrenia/21856102

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01521.s001

المؤلفون: Robert P. Hayes, Mee Ra Heo, Mark Mason, John Reid, Christine Burlein, Kira A. Armacost, David M. Tellers, Izzat Raheem, Anthony W. Shaw, Edward Murray, Philip M. McKenna, Pravien Abeywickrema, Sujata Sharma, Stephen M. Soisson, Daniel Klein

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/4bd96a2415b244b397a96da4a23966c4

المؤلفون: Ryan V. Quiroz (10359236), Michael H. Reutershan (2470597), Sebastian E. Schneider (2198083), David Sloman (10359430), Brian M. Lacey (2135143), Brooke M. Swalm (10359433), Charles S. Yeung (2302963), Craig Gibeau (1586212), Daniel S. Spellman (2649097), Danica A. Rankic (1858132), Dapeng Chen (528941), David Witter (10359239), Doug Linn (10359436), Erik Munsell (10359439), Guo Feng (413683), Haiyan Xu (148626), Jonathan M. E. Hughes (6912470), Jongwon Lim (163671), Josep Saurí (1523239), Kristin Geddes (10359442), Murray Wan (10359445), My Sam Mansueto (3384113), Nicole E. Follmer (10359448), Patrick S. Fier (1333728), Phieng Siliphaivanh (1822588), Pierre Daublain (1625986), Rachel L. Palte (8299626), Robert P. Hayes (9220508), Sandra Lee (273007), Shuhei Kawamura (1407448), Steven Silverman (10359451), Sulagna Sanyal (2918147), Timothy J. Henderson (2397364), Yingchun Ye (2032282), Yuanwei Gao (3951080), Benjamin Nicholson (2035678), Michelle R. Machacek (2639716)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel designs, Novel Classes, balancing bioavailability, structure-based drug designs, DNA repair, type II arginine methyltransferase, Additional efforts, optimization strategies, bicyclic nucleoside-derived classes, protein substrates, identification, dose projections, PRMT 5 activity, Cancer Protein arginine methyltrans., RNA, CYP 3A inhibition, strain energy calculations, compound docking, vivo activity, PRMT 5, PRMT 5 inhibitors

Relation: https://figshare.com/articles/journal_contribution/The_Discovery_of_Two_Novel_Classes_of_5_5-Bicyclic_Nucleoside-Derived_PRMT5_Inhibitors_for_the_Treatment_of_Cancer/14272906

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02083.s001

المؤلفون: Mark E. Layton, Jeffrey C. Kern, Timothy J. Hartingh, William D. Shipe, Izzat Raheem, Monika Kandebo, Robert P. Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K. Wollenberg, Jing Li, Jeff Fritzen, Georgia B. McGaughey, Jason M. Uslaner, Sean M. Smith, Paul J. Coleman, Christopher D. Cox

المصدر: Journal of Medicinal Chemistry. 66:1157-1171

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b34d1b1b6ca3f79f9d512404321891d5
https://doi.org/10.1021/acs.jmedchem.2c01521

المؤلفون: My Sam Mansueto, Brooke M Swalm, Patrick S. Fier, Rachel L. Palte, Sandra Lee, Kristin Geddes, Josep Saurí, Michael H. Reutershan, Charles S. Yeung, Benjamin Nicholson, David J. Witter, Murray Wan, Robert P Hayes, Haiyan Xu, David L. Sloman, Nicole Follmer, Daniel S. Spellman, Danica A. Rankic, Pierre Daublain, Timothy J. Henderson, Jongwon Lim, Dapeng Chen, Erik Munsell, Guo Feng, Steven M. Silverman, Ryan V Quiroz, Doug Linn, Sulagna Sanyal, Michelle R. Machacek, Craig R. Gibeau, Shuhei Kawamura, Yuanwei Gao, Jonathan M E Hughes, Sebastian Schneider, Phieng Siliphaivanh, Yingchun Ye, Brian M. Lacey

المصدر: Journal of medicinal chemistry. 64(7)

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, DNA repair, Antineoplastic Agents, Plasma protein binding, Computational biology, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Transcription (biology), Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Bicyclic molecule, Molecular Structure, Chemistry, Protein arginine methyltransferase 5, Nucleosides, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Docking (molecular), Drug Design, RNA splicing, Aminoquinolines, Molecular Medicine, Female, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9cca5e958fa221091b3803ef442cf
https://pubmed.ncbi.nlm.nih.gov/33755451

المؤلفون: Robert P. Hayes, Timothy W. Moural, Kevin M. Lewis, David Onofrei, Luying Xun, ChulHee Kang

المصدر: International Journal of Molecular Sciences, Vol 15, Iss 11, Pp 20736-20752 (2014)

مصطلحات موضوعية: LysR-family, transcription factor, bioremediation, pentachlorophenol, 2,4,6-trichlorophenol, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: http://www.mdpi.com/1422-0067/15/11/20736; https://doaj.org/toc/1422-0067; https://doaj.org/article/27e9a0a03c5149fdb3d8d33d5fc54e2e

الاتاحة: https://doi.org/10.3390/ijms151120736
https://doaj.org/article/27e9a0a03c5149fdb3d8d33d5fc54e2e

المؤلفون: Robert P. Hayes, Brian N. Webb, Arun Kumar Subramanian, Mark Nissen, Andrew Popchock, Luying Xun, ChulHee Kang

المصدر: International Journal of Molecular Sciences; Volume 13; Issue 8; Pages: 9769-9784

مصطلحات موضوعية: TCP, flavin, bioremediation, monooxygenase, TcpA, TftD, crystal structure

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms13089769

الاتاحة: https://doi.org/10.3390/ijms13089769

المؤلفون: Cupriavidus Necator Jmp, Robert P. Hayes, Brian N. Webb, Arun Kumar Subramanian, Mark Nissen, Andrew Popchock, Luying Xun, Chulhee Kang

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.mdpi.com/1422-0067/13/8/9769/pdf/.

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.361.9095; http://www.mdpi.com/1422-0067/13/8/9769/pdf/

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.361.9095
http://www.mdpi.com/1422-0067/13/8/9769/pdf/

المؤلفون: Christopher Sondey, Michael D. Altman, Sebastian Schneider, Michelle R. Machacek, Yingchun Ye, Robert P Hayes, Zangwei Xu, Phieng Siliphaivanh, Brian M. Lacey, Shuhei Kawamura, Haiyan Xu, Michael H. Reutershan, Rachel L. Palte, My Sam Mansueto

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Methyltransferase, biology, Arginine, 010405 organic chemistry, Chemistry, Protein arginine methyltransferase 5, Organic Chemistry, Allosteric regulation, Methylation, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Histone, Drug Discovery, Histone methylation, biology.protein, Binding site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3126f87f0a4fc31062a3550868e0e6
https://pubmed.ncbi.nlm.nih.gov/32944135

المؤلفون: Fran Ding, Blake Wiedenheft, Scott Bailey, Ailong Ke, Robert P. Hayes, Yibei Xiao, Kanagalaghatta R. Rajashankar, Paul B. G. van Erp

المصدر: Nature. 530:499-503

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Base pair, CRISPR-Associated Proteins, Molecular Sequence Data, Molecular Conformation, Crystallography, X-Ray, Article, 03 medical and health sciences, chemistry.chemical_compound, D-loop, Escherichia coli, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Nucleotide Motifs, Base Pairing, Genetics, Trans-activating crRNA, Multidisciplinary, Base Sequence, biology, Escherichia coli Proteins, DNA Helicases, Helicase, DNA, Cell biology, Protein Subunits, RNA, Bacterial, Protospacer adjacent motif, 030104 developmental biology, chemistry, Multiprotein Complexes, Coding strand, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198a1b40fd905ff7def1291234f2fb72
https://doi.org/10.1038/nature16995

المؤلفون: Kevin M. Lewis, Robert P. Hayes, ChulHee Kang, Luying Xun

المصدر: Journal of Biological Chemistry. 288:28447-28456

مصطلحات موضوعية: Models, Molecular, Burkholderia, Stereochemistry, Molecular Sequence Data, Lyases, Sequence alignment, Biology, Crystallography, X-Ray, Ligands, medicine.disease_cause, Biochemistry, Substrate Specificity, Enzyme catalysis, Catalytic Domain, medicine, Amino Acid Sequence, Protein Structure, Quaternary, Molecular Biology, Peptide sequence, Mutation, Circular Dichroism, Mutagenesis, Cell Biology, Lyase, Hydroquinones, Solutions, Multigene Family, Enzymology, Biocatalysis, Quantum Theory, Mutant Proteins, Oxyanion hole, Sequence Alignment, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c7c8607d9d87178b866e42ca9f2225
https://doi.org/10.1074/jbc.m113.499368

المؤلفون: ChulHee Kang, Kevin M. Lewis, Luying Xun, Robert P. Hayes, Mark S. Nissen, Abigail R. Green

المصدر: Molecular Microbiology. 88:523-536

مصطلحات موضوعية: Stereochemistry, Mutagenesis, Biology, Ring (chemistry), biology.organism_classification, Cleavage (embryo), Microbiology, Sphingomonadaceae, Protein structure, Biochemistry, Dioxygenase, Binding site, Molecular Biology, Sphingobium chlorophenolicum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3ef1159b5af6ac91b2eda7d7e15f2deb
https://doi.org/10.1111/mmi.12204

المؤلفون: Ailong Ke, Robert P. Hayes

المصدر: Journal of Molecular Biology. 427(2):228-230

مصطلحات موضوعية: Trans-activating crRNA, Operon, Cas9, CRISPR-Associated Proteins, RNA, Computational biology, chemistry.chemical_compound, chemistry, Bacterial Proteins, Structural Biology, Methanocaldococcus, Nucleic acid, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Molecular Biology, DNA, Ribonucleoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ceb534602018ff383f17210bd846729

المؤلفون: Travis Hooper, Robert P. Hayes, Mark S. Nissen, ChulHee Kang, Qunrui Li, Luying Xun, Emiliano J. Sanchez, Brian N. Webb

المصدر: Molecular Microbiology. 83:85-95

مصطلحات موضوعية: chemistry.chemical_classification, Ethanol, integumentary system, biology, Stereochemistry, Cupriavidus necator, Furfural, biology.organism_classification, Microbiology, Cofactor, chemistry.chemical_compound, Glycerol-3-phosphate dehydrogenase, chemistry, Biochemistry, Oxidoreductase, biology.protein, NAD+ kinase, Molecular Biology, Alcohol dehydrogenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c917fc5d165933fb352c822e477ae7de
https://doi.org/10.1111/j.1365-2958.2011.07914.x

المؤلفون: Yibei Xiao, Min Luo, Maofu Liao, Robert P. Hayes, Fang Ding, Jonathan Kim, Ailong Ke, Sherwin Ng

المصدر: Cell. 170:48-60.e11

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, R-loop, CRISPR-Associated Proteins, Biology, Cleavage (embryo), General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Nucleic acid thermodynamics, 0302 clinical medicine, Bacterial Proteins, CRISPR, Genetics, Trans-activating crRNA, Base Sequence, Cryoelectron Microscopy, Nucleic Acid Hybridization, Helicase, Actinobacteria, RNA, Bacterial, 030104 developmental biology, chemistry, Cascade, biology.protein, Biophysics, RNA, Small Untranslated, CRISPR-Cas Systems, 030217 neurology & neurosurgery, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c389c62df051a2ea7e9614775a3c925
https://doi.org/10.1016/j.cell.2017.06.012

المؤلفون: Arun Kumar Subramanian, Michael Fill, Brian N. Webb, Kevin M. Lewis, ChulHee Kang, Mark S. Nissen, Jeffrey P. Jones, James O. Schenk, Robert P. Hayes, Emiliano J. Sanchez, John T. Barr, Eric A. Shelden, Barbara A. Sorg

المصدر: Drug and alcohol dependence. 133(2)

مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, Light, Protein Conformation, Calorimetry, Toxicology, Calsequestrin, Rats sprague dawley, Article, Cell Line, Rats, Sprague-Dawley, Mice, Cocaine, Internal medicine, Scattering radiation, medicine, Animals, Scattering, Radiation, Pharmacology (medical), Pharmacology, Ryanodine receptor, business.industry, Myocardium, Spectrophotometry, Atomic, Arrhythmias, Cardiac, Heart, Methamphetamine, Rats, Molecular Weight, Psychiatry and Mental health, Sarcoplasmic Reticulum, Anesthesia, Cardiology, Calcium Channels, business, Dialysis, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d528e9053863d43c2853897edcff142
https://pubmed.ncbi.nlm.nih.gov/23876860

المؤلفون: ChulHee Kang, Abigail R. Green, Robert P. Hayes, Luying Xun

المصدر: The Journal of biological chemistry. 287(43)

مصطلحات موضوعية: Stereochemistry, Mutation, Missense, Biology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Oxidoreductase, medicine, Escherichia coli, Molecular Biology, Sphingobium chlorophenolicum, chemistry.chemical_classification, Hydroquinone, Escherichia coli Proteins, Vitamin K 3, Cell Biology, Glutathione, biology.organism_classification, Protein Structure, Tertiary, Sphingomonadaceae, Enzyme, Glutathione S-transferase, chemistry, Protein Structure and Folding, biology.protein, Oxidoreductases, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b97a735b75b343bc2aa696cf963b354
https://pubmed.ncbi.nlm.nih.gov/22955277

المؤلفون: Luying Xun, Robert P. Hayes, Brian N. Webb, ChulHee Kang, Mark S. Nissen, Arun Kumar Subramanian, Andrew Popchock

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 13; Issue 8; Pages: 9769-9784

مصطلحات موضوعية: Models, Molecular, crystal structure, Stereochemistry, Protein Conformation, Cupriavidus necator, Molecular Sequence Data, Flavin group, Burkholderia cepacia, Crystallography, X-Ray, Article, Catalysis, Mixed Function Oxygenases, Substrate Specificity, Inorganic Chemistry, TcpA, 03 medical and health sciences, chemistry.chemical_compound, TftD, Oxidoreductase, bioremediation, Amino Acid Sequence, Physical and Theoretical Chemistry, monooxygenase, Molecular Biology, Spectroscopy, 030304 developmental biology, chemistry.chemical_classification, Flavin adenine dinucleotide, 0303 health sciences, biology, Sequence Homology, Amino Acid, 030306 microbiology, Organic Chemistry, General Medicine, Monooxygenase, biology.organism_classification, flavin, Computer Science Applications, Enzyme, Burkholderia, chemistry, Biochemistry, Docking (molecular), Flavin-Adenine Dinucleotide, TCP, crystal structure , Chlorophenols

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495c123f66fa226a9c11c0397279fd20
http://europepmc.org/articles/PMC3431827

المؤلفون: ChulHee Kang, Luying Xun, Andrew Popchock, Arun Kumar Subramanian, Brian N. Webb, Robert P. Hayes, Mark Nissen

المصدر: International Journal of Molecular Sciences, Vol 13, Iss 8, Pp 9769-9784 (2012)

مصطلحات موضوعية: TcpA, lcsh:Chemistry, TftD, lcsh:Biology (General), lcsh:QD1-999, bioremediation, crystal structure , monooxygenase, TCP, flavin, lcsh:QH301-705.5

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doajarticles::3b50857bed462314aed6a37d8d097bba
http://www.mdpi.com/1422-0067/13/8/9769

المؤلفون: Robert P. Hayes, Eliot L. Berson, Thomas H. Roderick, Clareann H. Bunker, William C. Bromley

المصدر: American journal of ophthalmology. 97(3)

مصطلحات موضوعية: Adult, Male, Pediatrics, medicine.medical_specialty, X Chromosome, Adolescent, Eye disease, Population, Pedigree chart, Physical examination, Genes, Recessive, Gene Frequency, Ophthalmology, Retinitis pigmentosa, Epidemiology, medicine, Electroretinography, Humans, Maine, education, Child, Aged, Genes, Dominant, education.field_of_study, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Medical record, Infant, Middle Aged, medicine.disease, Child, Preschool, Female, business, Retinitis Pigmentosa

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c6a1b6321e2cb1a504de0e7511e2b8
https://pubmed.ncbi.nlm.nih.gov/6702974