المؤلفون: Robert A. Zimmermann, Tim R. Fischer, Marvin Schwickert, Zarina Nidoieva, Tanja Schirmeister, Christian Kersten

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6109

مصطلحات موضوعية: RNA methyltransferases, DNMT2, NSUN6, virtual screening, ultra-large molecular libraries, molecular docking, chemical spaces

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Informatics; https://dx.doi.org/10.3390/ijms24076109

الاتاحة: https://doi.org/10.3390/ijms24076109

المؤلفون: Turkhan Mehdiyev, MD, Davide Maffei, MA, Verena Müller, BSc, Waltraud Mair, BSc, Robert F. Zimmermann, MD, Eva-Maria Baur, MD

المصدر: Plastic and Reconstructive Surgery, Global Open, Vol 10, Iss 10, p e4604 (2022)

مصطلحات موضوعية: Surgery, RD1-811

وصف الملف: electronic resource

Relation: http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004604; https://doaj.org/toc/2169-7574

URL الوصول: https://doaj.org/article/fd8493b653304b72a29c365136ab25f4

المؤلفون: Sascha Jung (556123), Natalie Fuchs (11260767), Patrick Johe (10304854), Annika Wagner (4350595), Erika Diehl (11260770), Tri Yuliani (11260773), Collin Zimmer (10304857), Fabian Barthels (8123720), Robert A. Zimmermann (10499199), Philipp Klein (8232639), Waldemar Waigel (3082392), Jessica Meyr (11260776), Till Opatz (1395832), Stefan Tenzer (115768), Ute Distler (115774), Hans-Joachim Räder (5829056), Christian Kersten (9215), Bernd Engels (1293771), Ute A. Hellmich (2097241), Jochen Klein (818777), Tanja Schirmeister (634370)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, MS experiments, Trypanosoma brucei rhodesiense, modeling approaches, Enzymatic dilution assays, P 2, nanomolar affinity, cysteine protease inhibitors, 3 nM, slow-tight binder, Vivo Studies Rhodesain, cathepsins B, cysteine protease, EC, Potent Covalent Reversible Inhibitors, K i, 4- Me-Phe residue, drug target, MD simulations, antitrypanosomal activity, nonfluorinated 2, Trypanosomal Cysteine Protease Rhod., Inhibition Mechanism, α- halovinylsulfones, mice brain tissue

Relation: https://figshare.com/articles/journal_contribution/Fluorovinylsulfones_and_-Sulfonates_as_Potent_Covalent_Reversible_Inhibitors_of_the_Trypanosomal_Cysteine_Protease_Rhodesain_Structure_Activity_Relationship_Inhibition_Mechanism_Metabolism_and_In_Vivo_Studies/15148830

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01002.s001

المؤلفون: Robert Alexander Zimmermann, Marvin Schwickert, J. Laurenz Meidner, Zarina Nidoieva, Mark Helm, Tanja Schirmeister

المصدر: ACS Pharmacology & Translational Science. 5:1079-1085

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5471752aa57cb7f5512e2519533f7310
https://doi.org/10.1021/acsptsci.2c00175

المؤلفون: Marvin Schwickert, Robert A. Zimmermann, Tanja Habeck, Sabrina N. Hoba, Zarina Nidoieva, Tim R. Fischer, Martin M. Stark, Christian Kersten, Frederik Lermyte, Mark Helm, Tanja Schirmeister

المصدر: ACS Medicinal Chemistry Letters.

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b132e77095c506f9bd587fab837a9e2
https://doi.org/10.1021/acsmedchemlett.3c00062

المؤلفون: Annika Wagner, Sascha Jung, Natalie Fuchs, Philipp Klein, Ute Distler, Jochen Klein, Bernd Engels, Ute A. Hellmich, Stefan Tenzer, Fabian Barthels, Hans Joachim Räder, Patrick Johe, Waldemar Waigel, Tri Yuliani, Erika Diehl, Till Opatz, Collin Zimmer, Robert A. Zimmermann, Christian Kersten, Tanja Schirmeister, Jessica Meyr

المصدر: Journal of Medicinal Chemistry. 64:12322-12358

مصطلحات موضوعية: Male, Biodistribution, Vinyl Compounds, Molecular model, Trypanosoma brucei brucei, Cysteine Proteinase Inhibitors, Mice, Structure-Activity Relationship, Parasitic Sensitivity Tests, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Sulfones, Enzyme Assays, chemistry.chemical_classification, Molecular Structure, Chemistry, Trypanosoma brucei rhodesiense, Trypanocidal Agents, Cysteine protease, Molecular Docking Simulation, Cysteine Endopeptidases, Kinetics, Enzyme, Biochemistry, Covalent bond, Molecular Medicine, Female, Sulfonic Acids, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77d1b8e0a10409b4d2df95e00d985a0
https://doi.org/10.1021/acs.jmedchem.1c01002

المؤلفون: Marvin Schwickert, Tim R. Fischer, Robert A. Zimmermann, Sabrina N. Hoba, J. Laurenz Meidner, Marlies Weber, Moritz Weber, Martin M. Stark, Jonas Koch, Nathalie Jung, Christian Kersten, Maike Windbergs, Frank Lyko, Mark Helm, Tanja Schirmeister

المصدر: Journal of medicinal chemistry. 65(14)

مصطلحات موضوعية: S-Adenosylmethionine, Archaeal Proteins, Neoplasms, Drug Discovery, Molecular Medicine, Humans, DNA, Methyltransferases, Caco-2 Cells, S-Adenosylhomocysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c85f35e600e7884a7db46b7f212e69e
https://pubmed.ncbi.nlm.nih.gov/35849534

المؤلفون: Peter Fischer, Robert K. Zimmermann, Benedict Maisano

المصدر: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 1040:167033

مصطلحات موضوعية: Nuclear and High Energy Physics, Instrumentation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68861185db941becb620e95d5e831134
https://doi.org/10.1016/j.nima.2022.167033

المؤلفون: Tanja Schirmeister, Robert A. Zimmermann, Carla Di Chio, Collin Zimmer, Giorgio Amendola, Santo Previti, Anna Messere, Roberta Ettari, Stefan Hammerschmidt, Sandro Cosconati, Salvatore Di Maro, Maria Zappalà

المساهمون: Amendola, G., Ettari, R., Previti, S., Di Chio, C., Messere, A., Di Maro, S., Hammerschmidt, S. J., Zimmer, C., Zimmermann, R. A., Schirmeister, T., Zappala, M., Cosconati, S.

المصدر: Journal of Chemical Information and Modeling

مصطلحات موضوعية: Coronavirus disease 2019 (COVID-19), General Chemical Engineering, medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), In silico, Computational biology, Library and Information Sciences, 01 natural sciences, Molecular Docking Simulation, Antiviral Agents, Article, Docking (dog), 0103 physical sciences, medicine, Humans, Protease Inhibitors, Pandemics, Virtual screening, Protease, 010304 chemical physics, business.industry, SARS-CoV-2, COVID-19, General Chemistry, 0104 chemical sciences, Computer Science Applications, 010404 medicinal & biomolecular chemistry, Target protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2608d5acb0c1f2e4b9c8c8226726294c
http://europepmc.org/articles/PMC8029447

المؤلفون: Giorgio Amendola, Roberta Ettari, Santo Previti, Carla Di Chio, Anna Messere, Salvatore Di Maro, Stefan J. Hammerschmidt, Collin Zimmer, Robert A. Zimmermann, Tanja Schirmeister, Maria Zappalà, and Sandro Cosconati

المساهمون: Amendola, Giorgio, Ettari, Roberta, Previti, Santo, DI CHIO, Carla, Messere, Anna, Di Maro, Salvatore, Hammerschmidt, Stefan J., Zimmer, Collin, Zimmermann, Robert A., Schirmeister, Tanja, Zappala', Maria, Sandro Cosconati, And

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/33784094; info:eu-repo/semantics/altIdentifier/wos/WOS:000644728600048; volume:61; issue:4; firstpage:2062; lastpage:2073; numberofpages:12; journal:JOURNAL OF CHEMICAL INFORMATION AND MODELING; https://hdl.handle.net/11570/3203480; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104922022

الاتاحة: https://hdl.handle.net/11570/3203480
https://doi.org/10.1021/acs.jcim.1c00184
https://pubs.acs.org/doi/abs/10.1021/acs.jcim.1c00184

المؤلفون: Fabienne Aujard, Robert A. Zimmermann, Alessandra Angelucci, Juan Daniel Flórez Weidinger, Daniel Huber, Koji Ikezoe, Mario Prsa, Tsuyoshi Okamoto, Fabien Pifferi, Fred Wolf, Sam Merlin, Chun Lum Andy Ho, Manuel Schottdorf

المساهمون: Mécanismes adaptatifs : des organismes aux communautés, Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Mécanismes Adaptatifs et Evolution (MECADEV)

المصدر: Current Biology-CB
Current Biology-CB, Elsevier, 2021, 31 (4), pp.733-741.e7. ⟨10.1016/j.cub.2020.11.027⟩
Current Biology-CB, Elsevier, 2020, 31 (4), pp.733-741.e7. ⟨10.1016/j.cub.2020.11.027⟩

مصطلحات موضوعية: 0301 basic medicine, Male, Microcebus murinus, Models, Neurological, Lemur, Prosimian, Macaque, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, biology.animal, Orientation, Primary Visual Cortex, medicine, Animals, Primate, ComputingMilieux_MISCELLANEOUS, Neurons, Orientation column, biology, Mouse lemur, [SCCO.NEUR]Cognitive science/Neuroscience, biology.organism_classification, 030104 developmental biology, Visual cortex, medicine.anatomical_structure, Evolutionary biology, Female, General Agricultural and Biological Sciences, Cheirogaleidae, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96143287fa1397e5c44393ce1c96fde
https://hal.archives-ouvertes.fr/hal-03417169

المؤلفون: Christoph A. Sotriffer, Ramakanth Madhugiri, Collin Zimmer, John Ziebuhr, Stefan Hammerschmidt, Armin Welker, Patrick Müller, Hannah Maus, Robert A. Zimmermann, Christian Kersten, Tanja Schirmeister, Christin Müller

المصدر: ChemMedChem
Chemmedchem

مصطلحات موضوعية: Computational chemistry, Proteases, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Structure-activity relationships, Cysteine Proteinase Inhibitors, Isoindoles, Crystallography, X-Ray, Virus Replication, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Biochemistry, Drug design, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Chlorocebus aethiops, Drug Discovery, medicine, Animals, ddc:610, General Pharmacology, Toxicology and Pharmaceutics, Benzamide, Vero Cells, Coronavirus 3C Proteases, Coronavirus, Pharmacology, Protease, Molecular Structure, Full Paper, SARS-CoV-2, 010405 organic chemistry, Organic Chemistry, Full Papers, Protease inhibitors, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Benzamides, ddc:540, Molecular Medicine, Protein Binding, Cysteine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627c491608d91a712d1a845443b3f44e
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22570

المؤلفون: Giorgio Amendola (4350601), Roberta Ettari (1664104), Santo Previti (4350607), Carla Di Chio (8320887), Anna Messere (2004889), Salvatore Di Maro (8519730), Stefan J. Hammerschmidt (10499196), Collin Zimmer (10304857), Robert A. Zimmermann (10499199), Tanja Schirmeister (634370), Maria Zappalà (2381623), Sandro Cosconati (561195)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, silico screening, syndrome coronavirus 2, Covalent Docking-Based Virtual Scre., screening campaign, FDA, EMA, chemical libraries, AutoDock 4, AutoDock 4 docking software, inhibition properties, Michael acceptors, Lead Discovery, COVID -19 patients, SARS-CoV -2 M, American Food, non-peptide ligands, effort, chymotrypsin-like cysteine protease, covalent binders

Relation: https://figshare.com/articles/dataset/Lead_Discovery_of_SARS-CoV_2_Main_Protease_Inhibitors_through_Covalent_Docking-Based_Virtual_Screening/14340378

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00184.s002

المؤلفون: Bruce A. Maguire, Artemy D. Beniaminov, Haripriya Ramu, Er S. Mankin, Robert A. Zimmermann

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mankinlab.cpb.uic.edu/publications/2005-MolCell-20-427-435.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.551.3361; http://mankinlab.cpb.uic.edu/publications/2005-MolCell-20-427-435.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.551.3361
http://mankinlab.cpb.uic.edu/publications/2005-MolCell-20-427-435.pdf

المؤلفون: Clément Prévost-Solié, Yannick Ormen, Sebastien Pellat, Anthony Herrel, Fabienne Aujard, Daniel Huber, Ali Nourizonoz, Robert A. Zimmermann, Gilles Reymond, Chun Lum Andy Ho, Fabien Pifferi

المساهمون: Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Nature Methods
Nature Methods, Nature Publishing Group, 2020, 17, pp.1052-1059. ⟨10.1038/s41592-020-0961-2⟩

مصطلحات موضوعية: Computer science, [SDV]Life Sciences [q-bio], Neurophysiology, Optogenetics, Biochemistry, 03 medical and health sciences, Automation, Mice, Human–computer interaction, 3d tracking, Animals, Molecular Biology, 030304 developmental biology, Monitoring, Physiologic, Systems neuroscience, 0303 health sciences, Neuroethology, Behavior, Animal, Lemuridae, Brain, Cell Biology, Optical tracking, Conditioning, Operant, Roaming, Closed loop, Wireless Technology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0691c745ec395e1cc982ccf0db37a
https://pubmed.ncbi.nlm.nih.gov/32994566

المؤلفون: Bruce A. Maguire, Anton V. Manuilov, Robert A, Robert A. Zimmermann

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jb.asm.org/content/183/22/6565.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.509.9685; http://jb.asm.org/content/183/22/6565.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.509.9685
http://jb.asm.org/content/183/22/6565.full.pdf

المؤلفون: Christoph A. Sotriffer, Hannah Maus, John Ziebuhr, Ramakanth Madhugiri, Collin Zimmer, Christin Müller, Robert A. Zimmermann, Stefan Hammerschmidt, Armin Welker, Patrick Müller, Christian Kersten, Tanja Schirmeister

المصدر: ChemMedChem. 16:301-301

مصطلحات موضوعية: Pharmacology, Front cover, Protease, Chemistry, medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Organic Chemistry, Drug Discovery, medicine, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Virology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ada7073de77f2500ed4590e1ab0f1f6
https://doi.org/10.1002/cmdc.202000987

المؤلفون: Robert A. Zimmermann

المصدر: RNA (New York, N.Y.). 21(4)

مصطلحات موضوعية: Genetics, Peptidyl transferase, biology, Crystallography, X-Ray, Ribosome, Ribosome assembly, Anniversaries and Special Events, Ribosomal protein, 23S ribosomal RNA, Transfer RNA, biology.protein, Humans, Nucleic Acid Conformation, RNA, Eukaryotic Ribosome, Molecular Biology, Personal Reflections, 50S, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfab2a5bebf0d47f2240a0b63f2b7ad
https://pubmed.ncbi.nlm.nih.gov/25780133

المؤلفون: Robert A. Zimmermann, Alexei Nikulin, S. Volchkov, Oleg Nikonov, N. Nevskaya, Caroline Köhrer, Stanislav Nikonov, Ekaterina Nikonova, Maria Garber, Peter G. Stockley, Vladislav Kljashtorny, Svetlana Tishchenko, Wolfgang Piendl

المصدر: Journal of Molecular Biology. 355:747-759

مصطلحات موضوعية: Ribosomal Proteins, Methanococcus, Molecular Sequence Data, 5.8S ribosomal RNA, Biology, 5S ribosomal RNA, Structural Biology, Ribosomal protein, 30S, Amino Acid Sequence, RNA, Messenger, Molecular Biology, 50S, Thermus thermophilus, Hydrogen Bonding, Surface Plasmon Resonance, Ribosomal RNA, Molecular biology, Protein Structure, Tertiary, Kinetics, RNA, Bacterial, A-site, Biochemistry, RNA, Ribosomal, Nucleic Acid Conformation, Eukaryotic Ribosome, Sequence Alignment, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d1a9868e4a8199d8a88bece433b3b0
https://doi.org/10.1016/j.jmb.2005.10.084

المؤلفون: Robert A. Zimmermann, Alexei A. Bogdanov, Petr V. Sergiev, Inna N. Lavrik, Olga A. Dontsova

المصدر: Molecular Biology. 38:799-805

مصطلحات موضوعية: biology, Biophysics, medicine.disease_cause, Ribosome, chemistry.chemical_compound, chemistry, Biochemistry, Structural Biology, Transcription (biology), Diazirine, Transfer RNA, medicine, biology.protein, T7 RNA polymerase, P-site, RNase H, Escherichia coli, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e61008a6f44f8a656986ce255037d842
https://doi.org/10.1023/b:mbil.0000043949.56555.03