المؤلفون: Devin G. Roller, Stephen A. Hoang, Kristopher D. Rawls, Katherine A. Owen, Michael B. Simmers, Robert A. Figler, Julia D. Wulfkuhle, Emanuel F. Petricoin, Brian R. Wamhoff, Daniel Gioeli

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8

المؤلفون: Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor

المصدر: JHEP Reports, Vol 3, Iss 2, Pp 100217- (2021)

مصطلحات موضوعية: NAFLD, Metabolism, Fructose, Fibrosis, Treatment, NASH, Diseases of the digestive system. Gastroenterology, RC799-869

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555920301518; https://doaj.org/toc/2589-5559

URL الوصول: https://doaj.org/article/4340ddc01197436fbd613f61ff255144

المؤلفون: Maria S. Collado, Banumathi K. Cole, Robert A. Figler, Mark Lawson, David Manka, Michael B. Simmers, Steve Hoang, Felipe Serrano, Brett R. Blackman, Sanjay Sinha, Brian R. Wamhoff

المصدر: Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1673-1683 (2017)

مصطلحات موضوعية: Induced pluripotent stem cells, Endothelial cells, Smooth muscle cells, Hemodynamics, Vascular, Medicine (General), R5-920, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2157-6564; https://doaj.org/toc/2157-6580

URL الوصول: https://doaj.org/article/13ade552b30543e5bd3d6e5691a0dbeb

المؤلفون: Ryan E Feaver, M Scott Bowers, Banumathi K Cole, Steve Hoang, Mark J Lawson, Justin Taylor, Brian D LaMoreaux, Lin Zhao, Brad R Henke, Brian A Johns, Andrew C Nyborg, Brian R Wamhoff, Robert A Figler

المصدر: PLoS ONE, Vol 18, Iss 9, p e0291330 (2023)

مصطلحات موضوعية: Medicine, Science

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291330&type=printable; https://doaj.org/toc/1932-6203; https://doaj.org/article/73653be581c742099685677071b70e9b

الاتاحة: https://doi.org/10.1371/journal.pone.0291330
https://doaj.org/article/73653be581c742099685677071b70e9b

المؤلفون: Allison J. Armstrong (10639004), Brad R. Henke (1453429), Maria Sol Collado (10639007), Justin M. Taylor (10639010), Taylor D. Pourtaheri (10639013), John E. Dillberger (10639016), Thomas D. Roper (2718895), Brian R. Wamhoff (199470), Matthew W. Olson (10639019), Robert A. Figler (10639022), Stephen A. Hoang (10639025), John E. Reardon (6829922), Brian A. Johns (1833643)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, methylmalonic acidemia, Methylmalonic Acidemia Propionic ac., HST 5040, Propionic Acidemia, enzymes P-CoA carboxylase, organ dysfunction, metabolites results, short-chain carboxylic acids, intermediary metabolism, PA, identification, intramitochondrial accumulation, M-CoA, vivo absorption, excretion profile, disease-related metabolites, hepatocyte disease models, autosomal recessive disorders

Relation: https://figshare.com/articles/journal_contribution/Identification_of_2_2-Dimethylbutanoic_Acid_HST5040_a_Clinical_Development_Candidate_for_the_Treatment_of_Propionic_Acidemia_and_Methylmalonic_Acidemia/14410565

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00124.s002

المؤلفون: Charles J. Billington, Kimberly A. Chapman, Eyby Leon, Beatrix W. Meltzer, Seth I. Berger, Matthew Olson, Robert A. Figler, Steve A. Hoang, Cui Wanxing, Brian R. Wamhoff, M. Sol Collado, Kristina Cusmano‐Ozog

المصدر: American Journal of Medical Genetics Part A. 188:2738-2749

مصطلحات موضوعية: Genetics, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4b66d3c54f69fb3e39a611777e46bfaa
https://doi.org/10.1002/ajmg.a.62893

المؤلفون: Brian A. Johns, Christin A. Hamilton, Allison J. Armstrong, Robert A. Figler, Maria Sol Collado, Taylor D. Pourtaheri, Brad R. Henke, Marshall M. Summar, Stephen A. Hoang, Kimberly A. Chapman, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson

المصدر: Mol Genet Metab

مصطلحات موضوعية: 0301 basic medicine, Methylmalonyl-CoA Decarboxylase, Propionic Acidemia, Endocrinology, Diabetes and Metabolism, Methylmalonic acidemia, Methylmalonic acid, 030105 genetics & heredity, Biochemistry, Article, Cell Line, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Valine, Carnitine, Genetics, medicine, Humans, Citrates, Propionic acidemia, Amino Acid Metabolism, Inborn Errors, Molecular Biology, Methionine, Catabolism, Liver cell, Methylmalonyl-CoA Mutase, food and beverages, medicine.disease, chemistry, Hepatocytes, Acyl Coenzyme A, Isoleucine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d2bba59a2136c64aeca4cb4d67b68
https://doi.org/10.1016/j.ymgme.2021.03.001

المؤلفون: Brian R. Wamhoff, Daniel Gioeli, Devin G. Roller, Kristopher D. Rawls, Katherine A. Owen, Emanuel F. Petricoin, Julia Wulfkuhle, Stephen A. Hoang, Robert A. Figler, Michael B. Simmers

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

مصطلحات موضوعية: Cancer microenvironment, Lung Neoplasms, Science, Mice, Nude, Mice, SCID, Models, Biological, Article, Transcriptome, Mice, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Tumor Microenvironment, Animals, Humans, Medicine, Cancer models, Lung cancer, Cancer, EGFR inhibitors, Tumor microenvironment, Multidisciplinary, business.industry, Drug discovery, Endothelial Cells, Five-year survival rate, medicine.disease, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b6fb5abd08967fc19b35686028bfdb
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8

المؤلفون: Nathan Day, Brian R. Wamhoff, Matthew Olson, Marshall L. Summar, Allison J. Armstrong, Stephen A. Hoang, Robert A. Figler, M. Sol Collado, John E. Reardon, Kimberly A. Chapman

المصدر: Mol Genet Metab

مصطلحات موضوعية: 0301 basic medicine, Methylmalonyl-CoA Decarboxylase, Propionic Acidemia, Endocrinology, Diabetes and Metabolism, Citric Acid Cycle, Methylmalonic acid, Methylmalonic acidemia, In Vitro Techniques, 030105 genetics & heredity, Biochemistry, Citric Acid, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Valine, Genetics, medicine, Humans, Citrates, Amino Acids, Propionic acidemia, Amino Acid Metabolism, Inborn Errors, Molecular Biology, Cells, Cultured, Catabolism, Methylmalonyl-CoA Mutase, medicine.disease, chemistry, Case-Control Studies, Urea cycle, Organic acidemia, Hepatocytes, Propionates, Isoleucine, 030217 neurology & neurosurgery, Methylmalonic Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa105949df1c68bac4254f95a16f56af
https://doi.org/10.1016/j.ymgme.2020.05.003

المؤلفون: John E Dillberger, Thomas D Roper, Allison J. Armstrong, Brian R. Wamhoff, Stephen A. Hoang, Matthew W. Olson, Justin M. Taylor, Brad R. Henke, John E. Reardon, Maria Sol Collado, Brian A. Johns, Robert A. Figler, Taylor D. Pourtaheri

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: Propionic Acidemia, Methylmalonic acidemia, Drug Evaluation, Preclinical, Pharmacology, 01 natural sciences, Models, Biological, 03 medical and health sciences, Mice, Structure-Activity Relationship, Mutase, Dogs, Drug Discovery, medicine, Animals, Humans, Propionic acidemia, Amino Acid Metabolism, Inborn Errors, Cells, Cultured, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemistry, Catabolism, Organ dysfunction, Metabolism, medicine.disease, 0104 chemical sciences, Pyruvate carboxylase, Rats, 010404 medicinal & biomolecular chemistry, Butyrates, Enzyme, ROC Curve, Area Under Curve, Hepatocytes, Molecular Medicine, Acyl Coenzyme A, medicine.symptom, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254da545beecc6f429bfbe4bad4afc4f
https://pubmed.ncbi.nlm.nih.gov/33848153

المؤلفون: Ellie Northall, Banumathi K. Cole, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson, Stephen A. Hoang, Kae Matsuda, Ulrich L. Günther, Mark J. Lawson, Ryan E. Feaver, Jason Pickens, Patricia F. Lalor, Raquel Saborano, Robert A. Figler, Hiroaki Yashiro, Derek M. Erion, Hitomi Ogino, Emma L. Shepherd, Gideon M. Hirschfield, Nobuhiro Nishigaki

المصدر: JHEP Reports, Vol 3, Iss 2, Pp 100217-(2021)
JHEP Reports

مصطلحات موضوعية: ALD, alcohol-related cirrhosis, IGF, insulin-like growth factor, PDGF, platelet-derived growth factor, chemistry.chemical_compound, Fibrosis, AST, aspartate transaminase, Immunology and Allergy, Glycolysis, Liver injury, G/F, glucose/fructose, biology, TG, triglyceride, Fatty liver, Gastroenterology, NASH, HSQC, heteronuclear single quantum coherence, CT, computed tomography, aLMF, activated liver myofibroblasts, HSCs, hepatic stellate cells, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, FIB4, fibrosis-4, DNL, de novo lipogenesis, Fructose, Internal medicine, NAFLD, Internal Medicine, medicine, TGFB, transforming growth factor beta, lcsh:RC799-869, APRI, AST to Platelet Ratio Index, NPCs, non-parenchymal cells, KO, knockout, Hepatology, business.industry, medicine.disease, WT, wild-type, KHK, ketohexokinase, HSECs, hepatic sinusoidal endothelial cells, Treatment, Endocrinology, PSC, primary sclerosing cholangitis, Metabolism, chemistry, Alanine transaminase, Hepatic stellate cell, biology.protein, BSA, bovine serum albumin, TIMP-1, Tissue Inhibitor of Matrix metalloproteinase-1, lcsh:Diseases of the digestive system. Gastroenterology, PBC, primary biliary cholangitis, Steatosis, business, BEC, biliary epithelial cells, LGLI, low glucose and insulin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e901d5e74295d49cc1586ef5be254e
http://www.sciencedirect.com/science/article/pii/S2589555920301518

المؤلفون: Mark Hayes, Maria Sol Collado, Kimberly A. Chapman, Brian Johns, Mavis Waller, Brad Henke, Allison J. Armstrong, Marshall L. Summar, Gerald F. Cox, John E. Reardon, Robert A. Figler, Brian R. Wamhoff

المصدر: Molecular Genetics and Metabolism. 132:S162

مصطلحات موضوعية: Endocrinology, Chemistry, Endocrinology, Diabetes and Metabolism, Phase (matter), Genetics, Pharmacology, Molecular Biology, Biochemistry, Small molecule

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4fb6c27bf76bc1f60ef58ca451b985
https://doi.org/10.1016/s1096-7192(21)00340-1

المؤلفون: Michael J. Littlefield, Jayson M. Rieger, Robert A. Figler, Allison B. Reiss, Steven E. Carsons, Iryna Voloshyna

المصدر: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1831:407-416

مصطلحات موضوعية: medicine.medical_specialty, Receptor, Adenosine A2A, CD36, Blotting, Western, Adenosine A2A receptor, Polymerase Chain Reaction, Cell Line, Immune system, Downregulation and upregulation, Internal medicine, medicine, Humans, Scavenger receptor, Molecular Biology, DNA Primers, Foam cell, Microscopy, Confocal, Base Sequence, biology, Macrophages, Reverse cholesterol transport, Cell Biology, Cell biology, Cholesterol, Endocrinology, Microscopy, Fluorescence, ABCA1, biology.protein, lipids (amino acids, peptides, and proteins), Endothelium, Vascular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c903bd3152e3e8d2f12319ab06443cd
https://doi.org/10.1016/j.bbalip.2012.11.005

المؤلفون: Brian R. Wamhoff, Arun J. Sanyal, Banumathi K. Cole, Ajit Dash, Stephen A. Hoang, Brett R. Blackman, Ryan E. Feaver, Svetlana Marukian, Mark J. Lawson, Robert A. Figler

المصدر: JCI Insight. 1

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Apolipoprotein B, medicine.medical_treatment, Inflammation, Carbohydrate metabolism, Models, Biological, 03 medical and health sciences, chemistry.chemical_compound, Insulin resistance, Non-alcoholic Fatty Liver Disease, Internal medicine, Hepatic Stellate Cells, medicine, Animals, Humans, biology, Macrophages, Insulin, Obeticholic acid, General Medicine, medicine.disease, Lipids, Coculture Techniques, Mice, Inbred C57BL, Glucose, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Technical Advance, Liver, chemistry, Hepatocyte, Hepatocytes, Metabolome, biology.protein, Hepatic stellate cell, Cancer research, Insulin Resistance, medicine.symptom, Transcriptome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f79ab9cf50aded0d484894f7230336
https://doi.org/10.1172/jci.insight.90954

المؤلفون: David Manka, Brian R. Wamhoff, Arun J. Sanyal, Banumathi K. Cole, Robert A. Figler, Ryan E. Feaver, S. Marukian, Aaron J. Mackey, Brett R. Blackman, Ajit Dash, Mark J. Lawson, Maria Sol Collado, Stephen A. Hoang

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.medical_specialty, Pharmacotoxicology, medicine.drug_class, Cell Survival, medicine.medical_treatment, Biology, Toxicology, Chenodeoxycholic Acid, Article, 03 medical and health sciences, chemistry.chemical_compound, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Humans, Cells, Cultured, Cholesterol, Insulin, Obeticholic acid, FGF19, General Medicine, 030104 developmental biology, Endocrinology, chemistry, Hepatocytes, Farnesoid X receptor, Signal transduction, Transcriptome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662532fcafde1a77101476e7b6cad014
https://europepmc.org/articles/PMC5191970/

المؤلفون: Ajit Dash, Brian R. Wamhoff, Robert A. Figler, Arun J. Sanyal

المصدر: Expert Opin Drug Metab Toxicol

مصطلحات موضوعية: 0301 basic medicine, Drug, Pathology, medicine.medical_specialty, media_common.quotation_subject, Drug Evaluation, Preclinical, Context (language use), Disease, Toxicology, Bioinformatics, Models, Biological, Article, 03 medical and health sciences, medicine, Animals, Humans, media_common, Pharmacology, Liver injury, business.industry, Fatty liver, Non alcoholic, General Medicine, medicine.disease, Lipid Metabolism, Fatty Liver, 030104 developmental biology, Hepatocytes, Steatohepatitis, Chemical and Drug Induced Liver Injury, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c921985a4349da18c56c60a6653a94a4
https://pubmed.ncbi.nlm.nih.gov/27759439

المؤلفون: Joshua J. Field, Lanlin Chen, Joel Linden, Adrian R.L. Gear, Robert A. Figler, Kori L. Wallace, Renata Polanowska-Grabowska, Melissa A. Marshall

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 30:2392-2399

مصطلحات موضوعية: Blood Platelets, medicine.medical_specialty, Ticlopidine, P-selectin, Neutrophils, CD40 Ligand, Mice, Transgenic, Vascular permeability, Inflammation, Anemia, Sickle Cell, Platelet Glycoprotein GPIIb-IIIa Complex, Article, Antibodies, Neutrophil Activation, Flow cytometry, Capillary Permeability, Mice, Platelet Adhesiveness, Internal medicine, Animals, Humans, Medicine, Platelet, Platelet activation, Hypoxia, Lung, Respiratory Burst, CD11b Antigen, medicine.diagnostic_test, biology, business.industry, Flow Cytometry, Platelet Activation, Clopidogrel, Respiratory burst, Mice, Inbred C57BL, P-Selectin, Endocrinology, Hemoglobin Subunits, Integrin alpha M, Case-Control Studies, Immunology, biology.protein, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a54cf1939bf3d6fe5a61b7d84b62577
https://doi.org/10.1161/atvbaha.110.211615

المؤلفون: Tina C. Wan, John A. Auchampach, Garrett J. Gross, Jason E. Maas, Robert A. Figler

المصدر: Journal of Molecular and Cellular Cardiology. 49:886-893

مصطلحات موضوعية: Agonist, medicine.medical_specialty, medicine.drug_class, Myocardial Infarction, Ischemia, Aminopyridines, Blood Pressure, Myocardial Reperfusion Injury, In Vitro Techniques, Pharmacology, Receptor, Adenosine A2B, Article, Rats, Sprague-Dawley, Mice, Heart Rate, Internal medicine, parasitic diseases, Animals, Medicine, cardiovascular diseases, Receptor, Molecular Biology, Cardioprotection, business.industry, Antagonist, medicine.disease, Adenosine receptor, Adenosine, Rats, Mice, Inbred C57BL, Heart Function Tests, Ischemic Preconditioning, Myocardial, Cardiology, Ischemic preconditioning, Cardiology and Cardiovascular Medicine, business, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fdc311156da7bff7eafd827e9ccab6
https://doi.org/10.1016/j.yjmcc.2010.08.015

المؤلفون: Joel Linden, Oma N. Agbai, Jayson M. Rieger, Robert A. Figler, Jeffrey M. Wilson, William Ross, Renea Frazier, Peter B. Ernst

المصدر: The Journal of Immunology. 182:4616-4623

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Lipopolysaccharides, medicine.medical_specialty, T cell, Immunology, Bone Marrow Cells, Lymphocyte Activation, Receptor, Adenosine A2B, Article, Mice, Internal medicine, Cyclic AMP, medicine, Animals, Immunology and Allergy, CD86, MHC class II, biology, Cell Differentiation, Dendritic Cells, Purinergic signalling, Adenosine A3 receptor, Adenosine, Adenosine receptor, Coculture Techniques, Interleukin-10, Cell biology, Endocrinology, medicine.anatomical_structure, biology.protein, B7-2 Antigen, Nucleoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265538cb3b9a17f1b232631526cf2b68
https://doi.org/10.4049/jimmunol.0801279

المؤلفون: Joel Linden, Lixin Wang, Heidi Figler, Robert A. Figler, Andrew T. Gewirtz, Didier Merlin, Vasantha L. Kolachala, Simon M. Mwangi, Matam Vijay-Kumar, Shanthi Srinivasan, S Sitaraman, Brittani K. Ruble

المصدر: British Journal of Pharmacology. 155:127-137

مصطلحات موضوعية: Pharmacology, 0303 health sciences, medicine.medical_specialty, Chemokine, Interleukin, Biology, medicine.disease, Inflammatory bowel disease, Adenosine receptor, Adenosine, 3. Good health, 03 medical and health sciences, Interleukin 10, 0302 clinical medicine, Endocrinology, 030220 oncology & carcinogenesis, Internal medicine, medicine, biology.protein, Colitis, Receptor, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1e6990f5fd624ab623ee251c8ad622dd
https://doi.org/10.1038/bjp.2008.227