المؤلفون: Michael Walsh, Claudette Bethune, Andrew Smyth, Jessica Tyrwhitt, Shiangtung W. Jung, Rosie Z. Yu, Yanfeng Wang, Richard S. Geary, Jeffrey Weitz, Sanjay Bhanot

المصدر: Kidney International Reports, Vol 7, Iss 2, Pp 200-209 (2022)

مصطلحات موضوعية: anticoagulation, antisense oligonucleotide, FXI, hemodialysis, pharmacokinetics, randomized controlled trial, Diseases of the genitourinary system. Urology, RC870-923

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468024921015175; https://doaj.org/toc/2468-0249

URL الوصول: https://doaj.org/article/9d5c672fdff6474baf02354f5b056319

المؤلفون: Nicholas J. Viney, Shuling Guo, Li‐Jung Tai, Brenda F. Baker, Mariam Aghajan, Shiangtung W. Jung, Rosie Z. Yu, Sheri Booten, Heather Murray, Todd Machemer, Sebastien Burel, Sue Murray, Gustavo Buchele, Sotirios Tsimikas, Eugene Schneider, Richard S. Geary, Merrill D. Benson, Brett P. Monia

المصدر: ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)

مصطلحات موضوعية: Transthyretin, Amyloidosis, Cardiomyopathy, Polyneuropathy, Antisense, Ligand‐conjugated, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-5822

URL الوصول: https://doaj.org/article/3297462a8e6e4c1081fbb6040b37c72e

المؤلفون: Brenda F. Baker, Shuting Xia, Wesley Partridge, T. Jesse Kwoh, Sotirios Tsimikas, Sanjay Bhanot, Richard S. Geary

المصدر: Nucleic Acid Therapeutics. 33:72-80

مصطلحات موضوعية: Drug Discovery, Genetics, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::54dc571f4f0996da54a23f710d864e2f
https://doi.org/10.1089/nat.2022.0044

المؤلفون: Elif A. Oral, Abhimanyu Garg, Joseph Tami, Eric A. Huang, Louis St.L. O'Dea, Hartmut Schmidt, Anatoly Tiulpakov, Ann Mertens, Veronica J. Alexander, Lynnetta Watts, Eunju Hurh, Joseph L. Witztum, Richard S. Geary, Sotirios Tsimikas

المصدر: Journal of Clinical Lipidology. 16:833-849

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine, Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a511815ca92594eaecdb3be627b967ea
https://doi.org/10.1016/j.jacl.2022.08.008

المؤلفون: Brenda F. Baker, Shuting Xia, Wesley Partridge, Richard S. Geary, Sanjay Bhanot, T. Jesse Kwoh

المصدر: Nucleic Acid Therapeutics

مصطلحات موضوعية: Identification methods, Oncology, medicine.medical_specialty, Mipomersen, mipomersen, Biochemistry, Article, Internal medicine, Drug Discovery, Injection site, Genetics, medicine, Humans, tolerability, Adverse effect, Molecular Biology, business.industry, Incidence (epidemiology), 2′MOE, Oligonucleotides, Antisense, Discontinuation, integrated safety database, Tolerability, Antisense oligonucleotides, Molecular Medicine, randomized placebo-controlled trials, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a15be03ddcace5a4a9c8c879eb0520
https://doi.org/10.1089/nat.2020.0917

المؤلفون: Brenda F, Baker, Shuting, Xia, Wesley, Partridge, T Jesse, Kwoh, Sotirios, Tsimikas, Sanjay, Bhanot, Richard S, Geary

المصدر: Nucleic acid therapeutics.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1cac4ff6aa3549f8c0528a32a24803c8
https://pubmed.ncbi.nlm.nih.gov/36454263

المؤلفون: Sanjay Bhanot, Eleonora Marostica, Maximilian Lobmeyer, Nelleke Snelder, Erin E. Morgan, Anthonie W. A. Lensing, Richard S. Geary, Markus Jensen, Shiangtung W. Jung, Yanfeng Wang, Rosie Z. Yu, Stefan Willmann, Claudette Bethune, Alexander Solms

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 890-901 (2021)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: medicine.medical_treatment, Population, RM1-950, Pharmacology, Models, Biological, Article, End stage renal disease, Pharmacokinetics, Renal Dialysis, Humans, Medicine, Pharmacology (medical), education, Factor XI, PK/PD models, Randomized Controlled Trials as Topic, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Research, Articles, Oligonucleotides, Antisense, Pharmacometrics, Modeling and Simulation, Pharmacodynamics, Kidney Failure, Chronic, Asialoglycoprotein receptor, Hemodialysis, Therapeutics. Pharmacology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c833bb12274e461ae57144f261c44b4
https://doaj.org/article/a0f07a9e368749df85e58f6529f928d9

المؤلفون: Shiangtung W. Jung, Li Jung Tai, Márcia Waddington-Cruz, William J. Litchy, Sotirios Tsimikas, Peter J. Dyck, Cecilia Monteiro, Gustavo Buchele, Julian D. Gillmore, Michela Brambatti, John L. Berk, Eugene Schneider, Yukio Ando, Teresa Coelho, Morie A. Gertz, Merrill D. Benson, Nicholas J. Viney, Louis O'Dea, Richard S. Geary, Brett P. Monia, Sami Khella, Laura Obici

المصدر: Neurology and therapy, vol 10, iss 1
Neurology and Therapy

مصطلحات موضوعية: Oncology, endocrine system, medicine.medical_specialty, Neurology, Clinical Trials and Supportive Activities, Phases of clinical research, Neurodegenerative, Placebo, Study Protocol, 03 medical and health sciences, Rare Diseases, 0302 clinical medicine, Phase 3 clinical trial, Clinical Research, Internal medicine, medicine, Antisense oligonucleotide, 030212 general & internal medicine, Dosing, Peripheral Neuropathy, biology, business.industry, Amyloidosis, Clinical study design, Neurosciences, Evaluation of treatments and therapeutic interventions, nutritional and metabolic diseases, medicine.disease, Hereditary transthyretin-mediated amyloid polyneuropathy, AKCEA-TTR-L-rx, Clinical trial design, Transthyretin, Orphan Drug, AKCEA-TTR-Lrx, 6.1 Pharmaceuticals, biology.protein, Neurology (clinical), business, Polyneuropathy, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae92472f0364a8018070ff0215ebd0d
https://doi.org/10.1007/s40120-021-00235-6

المؤلفون: Yanfeng Wang, Padma Narayanan, Daniel A. Norris, Richard S. Geary, Scott P. Henry, Tae-Won Kim, Brett P. Monia, Rosie Z. Yu

المصدر: Nucleic Acid Therapeutics. 30:265-275

مصطلحات موضوعية: medicine.medical_specialty, Hematology, biology, business.industry, Immunogenicity, Cmax, Pharmacology, Biochemistry, Titer, Transthyretin, Pharmacokinetics, Internal medicine, Pharmacodynamics, Drug Discovery, Toxicity, Genetics, medicine, biology.protein, Molecular Medicine, business, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9bdd6fde5c778b60361c6e8fcb009283
https://doi.org/10.1089/nat.2020.0867

المؤلفون: Gwendolyn E. Kaeser, Richard S Geary, Danny M. Cohn, Brenda F. Baker, Shuting Xia, Marcel Levi, Nicholas J. Viney, Lauré M. Fijen, Erik S.G. Stroes, Charvi Nanavati, Joost C. M. Meijers, Eugene Schneider, Veronica J Alexander

المساهمون: Vascular Medicine, Experimental Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Amsterdam Cardiovascular Sciences, ACS - Atherosclerosis & ischemic syndromes

المصدر: New England journal of medicine, 383(13), 1242-1247. Massachussetts Medical Society

مصطلحات موضوعية: Adult, Compassionate Use Trials, medicine.medical_specialty, Injections, Subcutaneous, Pilot Projects, 030204 cardiovascular system & hematology, Bradykinin, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Mucosal swelling, Angioedema, business.industry, Angioedemas, Hereditary, Prekallikrein, General Medicine, Oligonucleotides, Antisense, medicine.disease, Hereditary angioedema, Antisense oligonucleotides, Female, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaabd31b958b313a998dbacd6b6902a
https://doi.org/10.1056/nejmoa1915035

المؤلفون: Louis O'Dea, Richard S. Geary, Eunju Hurh, Veronica J. Alexander, Kristin Balogh, Lynnetta Watts, Ewa Karwatowska-Prokopczuk, Sotirios Tsimikas

المصدر: Nucleic Acid Therapeutics. 30:198-206

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Messenger RNA, business.industry, Corrected qt, Affect (psychology), Biochemistry, QT interval, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Drug Discovery, Healthy volunteers, Antisense oligonucleotides, Genetics, Cardiology, Molecular Medicine, Medicine, business, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7d58d2ba6edce51833df1ea253692149
https://doi.org/10.1089/nat.2019.0837

المؤلفون: Jon W Collins, Scott P. Henry, Richard S. Geary, Brett P. Monia, Elizabeth J. Ackermann, Shannon Hall, Yanfeng Wang, Rosie Z. Yu

المصدر: Nucleic Acid Therapeutics

مصطلحات موضوعية: Male, 0301 basic medicine, Oligonucleotides, Gene Expression, inotersen, Biochemistry, Gastroenterology, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Prealbumin, Drug Dosage Calculations, hereditary TTR amyloidosis, Aged, 80 and over, education.field_of_study, biology, Alanine Transaminase, Middle Aged, Original Papers, Neuroprotective Agents, 030220 oncology & carcinogenesis, Molecular Medicine, Female, RNA Interference, pharmacokinetics, Glomerular Filtration Rate, Adult, oligonucleotide, medicine.medical_specialty, Bilirubin, antisense, Population, Renal function, 03 medical and health sciences, Pharmacokinetics, Internal medicine, pharmacodynamics, Genetics, medicine, Humans, education, Molecular Biology, Serum Albumin, Aged, Amyloid Neuropathies, Familial, Models, Statistical, business.industry, Confidence interval, Transthyretin, 030104 developmental biology, chemistry, Case-Control Studies, Pharmacodynamics, Mutation, Lean body mass, biology.protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7738a399c01da5a8eb9f6c5e8d9fd228
https://doi.org/10.1089/nat.2019.0822

المؤلفون: Jean-Claude Tardif, Ewa Karwatowska-Prokopczuk, Eric St Amour, Christie M Ballantyne, Michael D Shapiro, Patrick M Moriarty, Seth J Baum, Eunju Hurh, Victoria J Bartlett, Joyce Kingsbury, Amparo L Figueroa, Veronica J Alexander, Joseph Tami, Joseph L Witztum, Richard S Geary, Louis St L O’Dea, Sotirios Tsimikas, Daniel Gaudet

المصدر: European heart journal, vol 43, iss 14

مصطلحات موضوعية: Lipoproteins, Clinical Trials and Supportive Activities, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Cardiovascular, Risk Factors, Clinical Research, Hypertriglyceridaemia, Humans, Antisense, Triglycerides, Cardiovascular risk factors, Hypertriglyceridemia, Apolipoprotein C-III, apoC-III, Prevention, Evaluation of treatments and therapeutic interventions, Atherosclerosis, Cardiovascular disease, Cholesterol, Heart Disease, Good Health and Well Being, Cardiovascular System & Hematology, Cardiovascular Diseases, Heart Disease Risk Factors, 6.1 Pharmaceuticals, Cardiology and Cardiovascular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab435f70ddb9874ac3d5d38b0c089f7
https://escholarship.org/uc/item/52k3p81s

المؤلفون: Yanfeng Wang, John K. Diep, Rosie Z. Yu, Eunju Hurh, Ewa Karwatowska‐Prokopczuk, Eugene Schneider, Scott Henry, Sanjay Bhanot, Richard S. Geary

المصدر: Journal of clinical pharmacologyReferences.

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60c46dc27f55a183d4b9afa6f7b0ecf
https://pubmed.ncbi.nlm.nih.gov/35801818

المؤلفون: Rosie Z Yu, Mark J Graham, Noah Post, Stan Riney, Thomas Zanardi, Shannon Hall, Jennifer Burkey, Colby S Shemesh, Thazha P Prakash, Punit P Seth, Eric E Swayze, Richard S Geary, Yanfeng Wang, Scott Henry

المصدر: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

مصطلحات موضوعية: antisense oligonucleotide, disposition, mice, pharmacokinetics, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253117300409; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/2b26807b841244429f7ffc38c01b9c47

المؤلفون: Rosie Z Yu, John S Grundy, Scott P Henry, Tae-Won Kim, Daniel A Norris, Jennifer Burkey, Yanfeng Wang, Andrew Vick, Richard S Geary

المصدر: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253116300026; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/246f1041032e42dfa83f03452a855de3

المؤلفون: Yanfeng Wang, Rosie Z. Yu, Scott P. Henry, Richard S. Geary

المصدر: Expert Opinion on Drug Metabolism & Toxicology. 15:475-485

مصطلحات موضوعية: Pharmacology, Clinical pharmacology, business.industry, Oligonucleotide, General Medicine, Prodrug, Toxicology, Ligand (biochemistry), 030226 pharmacology & pharmacy, law.invention, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, law, 030220 oncology & carcinogenesis, Medicine, Distribution (pharmacology), Asialoglycoprotein receptor, business, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7222b2975d1d028e96a5f949d277b42e
https://doi.org/10.1080/17425255.2019.1621838

المؤلفون: Michael, Walsh, Claudette, Bethune, Andrew, Smyth, Jessica, Tyrwhitt, Shiangtung W, Jung, Rosie Z, Yu, Yanfeng, Wang, Richard S, Geary, Jeffrey, Weitz, Sanjay, Bhanot

المصدر: Kidney international reports. 7(2)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae4aa5ef679c132fcc18ff3e3bf48d6
https://pubmed.ncbi.nlm.nih.gov/35155859

المؤلفون: Catarina Nilsson, Rosanne M. Crooke, Nigel Davies, Birgitta Rosengren, Brett P. Monia, Eva Hurt-Camejo, Cristina S. J. Rocha, Tina Rydén-Bergsten, Stan Riney, Daniel Lindén, Rosie Z. Yu, Yanfeng Wang, Peter Gennemark, Anna Tivesten, Dorota Kakol-Palm, Ulf Andersson, Lloyd G. Tillman, Marie Elebring, Björn Carlsson, Mikko Hölttä, Jane Knöchel, Linda Wernevik, Rasmus Jansson-Löfmark, Niclas Clemmensen, Rikard Isaksson, Katrin Walter, Richard S. Geary, Dinko Rekić

المصدر: Science Translational Medicine. 13

مصطلحات موضوعية: 0301 basic medicine, 030204 cardiovascular system & hematology, Pharmacology, 03 medical and health sciences, Subcutaneous injection, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Oral administration, medicine, Animals, Potency, business.industry, Cholesterol, PCSK9, PCSK9 Inhibitors, Serine Endopeptidases, General Medicine, Oligonucleotides, Antisense, medicine.disease, Rats, Bioavailability, Macaca fascicularis, 030104 developmental biology, chemistry, business, Dyslipidemia, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197948bccc867454748627a58e0b6234
https://doi.org/10.1126/scitranslmed.abe9117

المؤلفون: Gina McMullen, Charvi Nanavati, Rosie Z. Yu, Yanfeng Wang, Scott P. Henry, Richard S. Geary

المصدر: Nucleic acid therapeutics. 31(4)

مصطلحات موضوعية: Body surface area, Chemistry, Conjugated system, Pharmacology, Oligonucleotides, Antisense, Biochemistry, chemistry.chemical_compound, Interspecies scaling, Single species, Pharmacokinetics, Galactosamine, Drug Discovery, Antisense oligonucleotides, Genetics, Retrospective analysis, Molecular Medicine, Humans, Molecular Biology, Retrospective Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358d598c863e745127456ab0533c214d
https://pubmed.ncbi.nlm.nih.gov/33891483