المؤلفون: Yongzhi Gao (6949313), Matthijs J. van Haren (7314779), Ned Buijs (7148459), Paolo Innocenti (228808), Yurui Zhang (11057230), Davide Sartini (353765), Roberto Campagna (11321400), Monica Emanuelli (353762), Richard B. Parsons (3108744), Willem Jespers (3138927), Hugo Gutiérrez-de-Terán (1373487), Gerard J. P. van Westen (8115707), Nathaniel I. Martin (847378)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Hematology, Chemical Sciences not elsewhere classified, SAM, 3.7 nM, 1- methylnicotinamide, nicotinamide substrate, nicotinamide moiety, MNA, binding mode, Alkene-Linked Bisubstrate Mimics Be., alkene linker, NNMT overexpression, bisubstrate inhibitors, small-molecule NNMT inhibitors, methylates nicotinamide, NNMT inhibitor, modeling studies, cell-based assays, cofactor mimics, Potent Inhibition, NNMT inhibitors, IC 50 value

Relation: https://figshare.com/articles/journal_contribution/Potent_Inhibition_of_Nicotinamide_i_N_i_Methyltransferase_by_Alkene-Linked_Bisubstrate_Mimics_Bearing_Electron_Deficient_Aromatics/16416627

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01094.s001

المؤلفون: Yongzhi Gao (6949313), Matthijs J. van Haren (7314779), Ned Buijs (7148459), Paolo Innocenti (228808), Yurui Zhang (11057230), Davide Sartini (353765), Roberto Campagna (11321400), Monica Emanuelli (353762), Richard B. Parsons (3108744), Willem Jespers (3138927), Hugo Gutiérrez-de-Terán (1373487), Gerard J. P. van Westen (8115707), Nathaniel I. Martin (847378)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Hematology, Chemical Sciences not elsewhere classified, SAM, 3.7 nM, 1- methylnicotinamide, nicotinamide substrate, nicotinamide moiety, MNA, binding mode, Alkene-Linked Bisubstrate Mimics Be., alkene linker, NNMT overexpression, bisubstrate inhibitors, small-molecule NNMT inhibitors, methylates nicotinamide, NNMT inhibitor, modeling studies, cell-based assays, cofactor mimics, Potent Inhibition, NNMT inhibitors, IC 50 value

Relation: https://figshare.com/articles/dataset/Potent_Inhibition_of_Nicotinamide_i_N_i_Methyltransferase_by_Alkene-Linked_Bisubstrate_Mimics_Bearing_Electron_Deficient_Aromatics/16416636

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01094.s004

المؤلفون: Yongzhi Gao (6949313), Matthijs J. van Haren (7314779), Ned Buijs (7148459), Paolo Innocenti (228808), Yurui Zhang (11057230), Davide Sartini (353765), Roberto Campagna (11321400), Monica Emanuelli (353762), Richard B. Parsons (3108744), Willem Jespers (3138927), Hugo Gutiérrez-de-Terán (1373487), Gerard J. P. van Westen (8115707), Nathaniel I. Martin (847378)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Hematology, Chemical Sciences not elsewhere classified, SAM, 3.7 nM, 1- methylnicotinamide, nicotinamide substrate, nicotinamide moiety, MNA, binding mode, Alkene-Linked Bisubstrate Mimics Be., alkene linker, NNMT overexpression, bisubstrate inhibitors, small-molecule NNMT inhibitors, methylates nicotinamide, NNMT inhibitor, modeling studies, cell-based assays, cofactor mimics, Potent Inhibition, NNMT inhibitors, IC 50 value

Relation: https://figshare.com/articles/dataset/Potent_Inhibition_of_Nicotinamide_i_N_i_Methyltransferase_by_Alkene-Linked_Bisubstrate_Mimics_Bearing_Electron_Deficient_Aromatics/16416639

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01094.s005

المؤلفون: Yongzhi Gao (6949313), Matthijs J. van Haren (7314779), Ned Buijs (7148459), Paolo Innocenti (228808), Yurui Zhang (11057230), Davide Sartini (353765), Roberto Campagna (11321400), Monica Emanuelli (353762), Richard B. Parsons (3108744), Willem Jespers (3138927), Hugo Gutiérrez-de-Terán (1373487), Gerard J. P. van Westen (8115707), Nathaniel I. Martin (847378)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Hematology, Chemical Sciences not elsewhere classified, SAM, 3.7 nM, 1- methylnicotinamide, nicotinamide substrate, nicotinamide moiety, MNA, binding mode, Alkene-Linked Bisubstrate Mimics Be., alkene linker, NNMT overexpression, bisubstrate inhibitors, small-molecule NNMT inhibitors, methylates nicotinamide, NNMT inhibitor, modeling studies, cell-based assays, cofactor mimics, Potent Inhibition, NNMT inhibitors, IC 50 value

Relation: https://figshare.com/articles/dataset/Potent_Inhibition_of_Nicotinamide_i_N_i_Methyltransferase_by_Alkene-Linked_Bisubstrate_Mimics_Bearing_Electron_Deficient_Aromatics/16416630

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01094.s002

المؤلفون: Yongzhi Gao (6949313), Matthijs J. van Haren (7314779), Ned Buijs (7148459), Paolo Innocenti (228808), Yurui Zhang (11057230), Davide Sartini (353765), Roberto Campagna (11321400), Monica Emanuelli (353762), Richard B. Parsons (3108744), Willem Jespers (3138927), Hugo Gutiérrez-de-Terán (1373487), Gerard J. P. van Westen (8115707), Nathaniel I. Martin (847378)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Hematology, Chemical Sciences not elsewhere classified, SAM, 3.7 nM, 1- methylnicotinamide, nicotinamide substrate, nicotinamide moiety, MNA, binding mode, Alkene-Linked Bisubstrate Mimics Be., alkene linker, NNMT overexpression, bisubstrate inhibitors, small-molecule NNMT inhibitors, methylates nicotinamide, NNMT inhibitor, modeling studies, cell-based assays, cofactor mimics, Potent Inhibition, NNMT inhibitors, IC 50 value

Relation: https://figshare.com/articles/dataset/Potent_Inhibition_of_Nicotinamide_i_N_i_Methyltransferase_by_Alkene-Linked_Bisubstrate_Mimics_Bearing_Electron_Deficient_Aromatics/16416642

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01094.s006