المؤلفون: Jason E Cummings, Christopher S Lunde, M R K Alley, Richard A Slayden

المصدر: PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011795 (2023)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011795&type=printable; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/507864f1f55e4eee9340ff09864717bb

المؤلفون: Collin M Bantle, C Tenley French, Jason E Cummings, Shankar Sadasivan, Kevin Tran, Richard A Slayden, Richard J Smeyne, Ronald B Tjalkens

المصدر: PLoS ONE, Vol 16, Iss 1, p e0245171 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/c6f1ecacc541473c9b389152ae23b0da

المؤلفون: Jason E Cummings, Richard A Slayden

المصدر: PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005209 (2017)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5230754?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/b2616ee54a944088842aa2e1282b8606

المؤلفون: William J Wilson, Maryam F Afzali, Jason E Cummings, Marie E Legare, Ronald B Tjalkens, Christopher P Allen, Richard A Slayden, William H Hanneman

المصدر: PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005065 (2016)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5085046?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/66edc4060af546d18cef03821edc386c

المؤلفون: Susan E Knudson, Divya Awasthi, Kunal Kumar, Alexandra Carreau, Laurent Goullieux, Sophie Lagrange, Hélèn Vermet, Iwao Ojima, Richard A Slayden

المصدر: PLoS ONE, Vol 9, Iss 4, p e93953 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3988029?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/07b55a1f9972459fb958b169883595ff

المؤلفون: Helen P. Bartlett, Clinton C. Dawson, Cody M. Glickman, David W. Osborn, Christopher R. Evans, Benjamin J. Garcia, Lauren C. Frost, Jason E. Cummings, Nicholas Whittel, Richard A. Slayden, Jason W. Holder

المصدر: Microbiology Spectrum, Vol 12, Iss 5 (2024)

مصطلحات موضوعية: NTM, AMR, enzybiotic, liposome, macrophage, capsule, Microbiology, QR1-502

Relation: https://doaj.org/toc/2165-0497; https://doaj.org/article/75c0c1c5c1174a9db6bee2933f0b4e4f

الاتاحة: https://doi.org/10.1128/spectrum.03534-23
https://doaj.org/article/75c0c1c5c1174a9db6bee2933f0b4e4f

المؤلفون: Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan, Devin A. Aldaz, Casey P. McDermott, Katriana A. Popichak, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens

المصدر: Frontiers in Immunology, Vol 13 (2022)

مصطلحات موضوعية: COVID-19, SARS – CoV – 2, glucocorticoid receptor, androgen receptor, innate immunity, inflammation, Immunologic diseases. Allergy, RC581-607

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.811430/full; https://doaj.org/toc/1664-3224; https://doaj.org/article/042ff2a87d9a449d818ce9b18173369f

الاتاحة: https://doi.org/10.3389/fimmu.2022.811430
https://doaj.org/article/042ff2a87d9a449d818ce9b18173369f

المؤلفون: Yanran Lu (6686399), Sandip Vibhute (2563972), Linsen Li (548722), Antony Okumu (11530664), Steven C. Ratigan (9279098), Sheri Nolan (6686393), Jonathan L. Papa (9537544), Chelsea A. Mann (11530667), Anthony English (6686396), Anna Chen (424723), Justin T. Seffernick (5030693), Bryan Koci (11530670), Leonard R. Duncan (11530673), Brieanna Roth (11530676), Jason E. Cummings (2803606), Richard A. Slayden (552399), Steffen Lindert (115057), Craig A. McElroy (2355709), Daniel J. Wozniak (8968187), Jack Yalowich (9537553), Mark J. Mitton-Fry (1936516)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new antibiotics, potent antistaphylococcal activity, microsomal metabolic stability, key safety liability, cardiovascular safety profile, 5 ‑ amino, previously reported dioxane, focused optimization enabled, reduced herg inhibition, herg inhibition, vivo <, vitro <, topoiv potency, topoisomerase iv, positive pathogens, murine model, low frequency, dna gyrase

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_TopoIV_Potency_ADMET_Properties_and_hERG_Inhibition_of_5_Amino-1_3-dioxane-Linked_Novel_Bacterial_Topoisomerase_Inhibitors_Identification_of_a_Lead_with_i_In_Vivo_i_Efficacy_against_MRSA/16755332

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01250.s007

المؤلفون: Oxana Kazakova, Roxana Racoviceanu, Anastasiya Petrova, Marius Mioc, Adrian Militaru, Lucreția Udrescu, Mihai Udrescu, Adrian Voicu, Jason Cummings, Gregory Robertson, Diane J. Ordway, Richard A. Slayden, Codruța Șoica

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 22; Pages: 12542

مصطلحات موضوعية: triterpenoids, lupane, betulin, azepane, M. tuberculosis, resistant MTB strains, M. abscessus, M. avium, cytotoxicity

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biophysics; https://dx.doi.org/10.3390/ijms222212542

الاتاحة: https://doi.org/10.3390/ijms222212542

المؤلفون: Linsen Li, Steffen Lindert, Yanran Lu, Anna Chen, Jason E. Cummings, Chelsea A Mann, Sandip Vibhute, Brieanna Roth, Anthony English, Sheri Nolan, Mark J. Mitton-Fry, Daniel J. Wozniak, Steven C Ratigan, Richard A. Slayden, Jack C. Yalowich, Bryan Koci, Antony A. Okumu, Jonathan L. Papa, Craig A. McElroy, Justin T Seffernick, Leonard R Duncan

المصدر: Journal of Medicinal Chemistry. 64:15214-15249

مصطلحات موضوعية: biology, medicine.drug_class, Chemistry, Topoisomerase IV, Antibiotics, hERG, Pharmacology, DNA gyrase, In vitro, In vivo, Drug Discovery, medicine, biology.protein, Molecular Medicine, Potency, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3892c880ddb3b3758eba4c921a02b47
https://doi.org/10.1021/acs.jmedchem.1c01250

المؤلفون: Jason E. Cummings, Christopher S. Lunde, M. R. K. Alley, Richard A. Slayden

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies using thp, clinical patient outcomes, assess clinical relevance, 13 clinically derived, 1 macrophages confirmed, reduce treatment duration, improve treatment outcomes, trna synthetase inhibitor, ex vivo <, burkholderia pseudomallei <, demonstrates murine efficacy, care drug ceftazidime, trna synthetase, vivo <, pseudomallei <, possible treatment, murine model, vitro <, b <, work warrants, transfer rna, three reference

Relation: https://figshare.com/articles/figure/Efficacy_of_epetraborole_in_the_acute_i_B_i_/24644566

الاتاحة: https://doi.org/10.1371/journal.pntd.0011795.g002
https://figshare.com/articles/figure/Efficacy_of_epetraborole_in_the_acute_i_B_i_/24644566

المؤلفون: Jason E. Cummings, Christopher S. Lunde, M. R. K. Alley, Richard A. Slayden

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies using thp, clinical patient outcomes, assess clinical relevance, 13 clinically derived, 1 macrophages confirmed, reduce treatment duration, improve treatment outcomes, trna synthetase inhibitor, ex vivo <, burkholderia pseudomallei <, demonstrates murine efficacy, care drug ceftazidime, trna synthetase, vivo <, pseudomallei <, possible treatment, murine model, vitro <, b <, work warrants, transfer rna, three reference

Relation: https://figshare.com/articles/figure/Epetroborale_activity_in_i_ex_vivo_i_model_of_infection_/24644563

الاتاحة: https://doi.org/10.1371/journal.pntd.0011795.g001
https://figshare.com/articles/figure/Epetroborale_activity_in_i_ex_vivo_i_model_of_infection_/24644563

المؤلفون: Jason E. Cummings, Christopher S. Lunde, M. R. K. Alley, Richard A. Slayden

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies using thp, clinical patient outcomes, assess clinical relevance, 13 clinically derived, 1 macrophages confirmed, reduce treatment duration, improve treatment outcomes, trna synthetase inhibitor, ex vivo <, burkholderia pseudomallei <, demonstrates murine efficacy, care drug ceftazidime, trna synthetase, vivo <, pseudomallei <, possible treatment, murine model, vitro <, b <, work warrants, transfer rna, three reference

Relation: https://figshare.com/articles/figure/Delayed_dosing_with_epetraborole_against_clinically_derived_i_B_i_i_pseudomallei_i_strain_/24644569

الاتاحة: https://doi.org/10.1371/journal.pntd.0011795.g003
https://figshare.com/articles/figure/Delayed_dosing_with_epetraborole_against_clinically_derived_i_B_i_i_pseudomallei_i_strain_/24644569

المؤلفون: Jason E. Cummings, Christopher S. Lunde, M. R. K. Alley, Richard A. Slayden

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies using thp, clinical patient outcomes, assess clinical relevance, 13 clinically derived, 1 macrophages confirmed, reduce treatment duration, improve treatment outcomes, trna synthetase inhibitor, ex vivo <, burkholderia pseudomallei <, demonstrates murine efficacy, care drug ceftazidime, trna synthetase, vivo <, pseudomallei <, possible treatment, murine model, vitro <, b <, work warrants, transfer rna, three reference

Relation: https://figshare.com/articles/dataset/The_inhibitory_concentration_of_Epetraborole_against_i_Burkholderia_pseudomallei_i_/24644572

الاتاحة: https://doi.org/10.1371/journal.pntd.0011795.t001
https://figshare.com/articles/dataset/The_inhibitory_concentration_of_Epetraborole_against_i_Burkholderia_pseudomallei_i_/24644572

المؤلفون: Jason E. Cummings, Christopher S. Lunde, M. R. K. Alley, Richard A. Slayden

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies using thp, clinical patient outcomes, assess clinical relevance, 13 clinically derived, 1 macrophages confirmed, reduce treatment duration, improve treatment outcomes, trna synthetase inhibitor, ex vivo <, burkholderia pseudomallei <, demonstrates murine efficacy, care drug ceftazidime, trna synthetase, vivo <, pseudomallei <, possible treatment, murine model, vitro <, b <, work warrants, transfer rna, three reference

Relation: https://figshare.com/articles/dataset/Epetraborole_murine_pharmacokinetic_parameters_/24644575

الاتاحة: https://doi.org/10.1371/journal.pntd.0011795.t002
https://figshare.com/articles/dataset/Epetraborole_murine_pharmacokinetic_parameters_/24644575

المؤلفون: Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan, Devin A. Aldaz, Casey P. McDermott, Katriana A. Popichak, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, COVID-19, SARS – CoV – 2, glucocorticoid receptor, androgen receptor, inflammation, therapeutic, treatment

Relation: https://figshare.com/articles/dataset/DataSheet_1_A_Novel_Glucocorticoid_and_Androgen_Receptor_Modulator_Reduces_Viral_Entry_and_Innate_Immune_Inflammatory_Responses_in_the_Syrian_Hamster_Model_of_SARS-CoV-2_Infection_docx/19180382

الاتاحة: https://doi.org/10.3389/fimmu.2022.811430.s001
https://figshare.com/articles/dataset/DataSheet_1_A_Novel_Glucocorticoid_and_Androgen_Receptor_Modulator_Reduces_Viral_Entry_and_Innate_Immune_Inflammatory_Responses_in_the_Syrian_Hamster_Model_of_SARS-CoV-2_Infection_docx/19180382

المؤلفون: Jason E. Cummings, Zaid Abdo, Richard A. Slayden

المصدر: JAC-antimicrobial resistance. 4(2)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dbcdf06625939da27364ac92e9c7e0
https://pubmed.ncbi.nlm.nih.gov/35350133

المؤلفون: Yanran, Lu, Sandip, Vibhute, Linsen, Li, Antony, Okumu, Steven C, Ratigan, Sheri, Nolan, Jonathan L, Papa, Chelsea A, Mann, Anthony, English, Anna, Chen, Justin T, Seffernick, Bryan, Koci, Leonard R, Duncan, Brieanna, Roth, Jason E, Cummings, Richard A, Slayden, Steffen, Lindert, Craig A, McElroy, Daniel J, Wozniak, Jack, Yalowich, Mark J, Mitton-Fry

المصدر: Journal of medicinal chemistry. 64(20)

مصطلحات موضوعية: DNA Topoisomerase IV, Dioxanes, Methicillin-Resistant Staphylococcus aureus, Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, DNA Gyrase, Humans, Microbial Sensitivity Tests, Enzyme Inhibitors, Ether-A-Go-Go Potassium Channels, Anti-Bacterial Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::dc8f7442e2cb53241c3d17ad1ee5eb4c
https://pubmed.ncbi.nlm.nih.gov/34614347

المؤلفون: Jason E. Cummings, Keaton W. Slayden, Richard A. Slayden

المصدر: JAC-Antimicrobial Resistance

مصطلحات موضوعية: Doxycycline, 0303 health sciences, biology, 030306 microbiology, business.industry, Brief Report, Spleen, medicine.disease, biology.organism_classification, Microbiology, Tularemia, 03 medical and health sciences, AcademicSubjects/MED00290, medicine.anatomical_structure, AcademicSubjects/MED00740, Medicine, Potency, AcademicSubjects/MED00230, business, Survival rate, Pathogen, Francisella tularensis, Rifampicin, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdbee67ef6ee6970eb0d4645790ee1c
https://doi.org/10.1093/jacamr/dlab058

المؤلفون: Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Katriana A. Popichak, Casey P. McDermott, Clinton C. Dawson, Jason E. Cummings, Juliette Lewis, Philip Reigan, Tawfik A. Aboellail, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens

مصطلحات موضوعية: Androgen receptor, Innate immune system, Viral entry, Immunology, medicine, Hamster, Lung injury, Biology, Receptor, TMPRSS2, Glucocorticoid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad93a5416c6c7abf235bc615ce2d3f9
https://doi.org/10.1101/2021.02.20.432110