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1
المؤلفون: Barbara Pio, Ravi P. Nargund, Yan Guo, Daniel Kosinski, Josien Hubert B, Michael Wright, Michele Pachanski, Harry R. Chobanian, Xiaoping Zhang, Richard Tschirret-Guth, Melissa Kirkland, Andrew D. Howard, Sarah Souza, Eric R. Ashley, Robert K. Orr, Steven L. Colletti, Joel Mane, Jerry Di Salvo, Michael W. Miller, Boonlert Cheewatrakoolpong, Koppara Samuel, William K. Hagmann, James Lamca, Juliann Ehrhart, Maria E. Trujillo, Jackie Shang, Qing Chen, Adam B. Weinglass, Randal M. Bugianesi
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1842-1848
مصطلحات موضوعية: Agonist, endocrine system, medicine.drug_class, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Enteroendocrine cell, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Receptor, Mode of action, Molecular Biology, geography, geography.geographical_feature_category, 010405 organic chemistry, Chemistry, Organic Chemistry, Islet, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Drug Design, Indans, Molecular Medicine, medicine.symptom
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2
المؤلفون: Richard Tschirret-Guth, Caroline McGregor, Mark Cartwright, Michael D. Altman, Suman Mukherjee, Iain Martin, Alan B. Northrup, Pierre Daublain, Kung-I Feng, Rebecca Nofsinger
المصدر: Molecular Pharmaceutics. 14:1634-1645
مصطلحات موضوعية: Swine, In silico, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Drug molecule, 030226 pharmacology & pharmacy, Permeability, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, Oral route, Animals, Humans, Chemistry, Hydrogen-Ion Concentration, Body Fluids, Rats, Intestinal Absorption, Pharmaceutical Preparations, Area Under Curve, 030220 oncology & carcinogenesis, Plasma concentration, LLC-PK1 Cells, Molecular Medicine, Exposure data
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3
المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan
المصدر: ACS Medicinal Chemistry Letters. 8:221-226
مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business
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4
المؤلفون: Harold B. Wood, Kunal Desai, Daming Feng, Jamie McCabe-Dunn, Yi-Heng Chen, Edward C. Sherer, Jane Y. Wu, Marc Poirier, Hong Li, Dongfang Meng, Ting Zhang, Kenneth P. Ellsworth, Liangqin Guo, Teruyuki Nishimura, Jiayi Xu, Tomokazu Hirabayashi, Sunita V. Dewnani, Patrick Andre, Louis-Charles Campeau, Richard Tschirret-Guth, Isao Sakurada, Paul Reichert, Cameron J. Smith, Robert K. Orr, Lisa M. Sonatore, Wayne M. Geissler, Thomas Bateman, Kazuto Araki, Joe Metzger, Alan Hruza, Richard A. Berger, Dann L. Parker, Tianying Jian
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5437-5443
مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, High selectivity, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Thrombin generation, Factor IXa, Pharmacokinetics, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Rats, Enzyme Activation, Human plasma, Drug Design, Pharmacodynamics, Molecular Medicine, Coagulation factor IXa, Heterocyclic Compounds, 3-Ring, Tricyclic
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5
المؤلفون: David Wilson, Bindhu V. Karanam, Mona Purcell, Maria Madeira, Gary G. Chicchi, Jianming Bao, Liza Gantert, Robert J. DeVita, Huagang Lu, Wai-Si Eng, Sander G. Mills, Richard G. Ball, Andrew J. Kassick, Peter Lin, Sanjeev Kumar, Jaime Lynn Bunda, George A. Doss, Kwei-Lan C. Tsao, Jacquelyn J. Cook, Xinchun Tong, Richard Tschirret-Guth, Jinlong Jiang, Koppara Samuel, Richard Hargreaves, Hong Wang, Donald F. Hora
المصدر: Journal of Medicinal Chemistry. 56:5940-5948
مصطلحات موضوعية: Trifluoromethyl, CYP3A4, Chemistry, Stereochemistry, Glucuronidation, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, Potency, NK1 receptor antagonist, Once daily dosing, Short duration, Aprepitant, medicine.drug
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6
المؤلفون: Yan Zou, Vincent Tong, Richard Tschirret-Guth, Jocelyn Yabut, Jackie Shang, Herve A. Aloysius, Scott A. Bradley
المصدر: Chemical Research in Toxicology. 25:1412-1422
مصطلحات موضوعية: Male, Lysine, Administration, Oral, Thiophenes, Kidney, Toxicology, Mass Spectrometry, Serine, In vivo, Animals, Humans, Biotransformation, Cells, Cultured, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Proteolytic enzymes, Proteins, Kidney metabolism, General Medicine, Metabolism, Rats, Amino acid, Receptors, Lysosphingolipid, Liver, Biochemistry, chemistry, Isotope Labeling, Hepatocytes, Microsomes, Liver, Azetidines, Peptides, Cysteine
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7
المؤلفون: Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5547-5551
مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Cell Membrane Permeability, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, ATP-binding cassette transporter, Absorption (skin), Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Piperidines, Renin, Drug Discovery, Renin–angiotensin system, Animals, Structure–activity relationship, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Biological Transport, Stereoisomerism, Transporter, Rats, Bioavailability, Permeability (electromagnetism), Molecular Medicine, Efflux
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8
المؤلفون: Wai-Si Eng, Xinchun Tong, Richard Tschirret-Guth, Song Zheng, Gary G. Chicchi, Geoge A. Doss, Koppara Samuel, Richard Hargreaves, Terence G. Hamill, Marc M. Kurtz, Robert J. DeVita, Sanjeev Kumar, Alan Wheeldon, Emma J. Carlson, Alana Upthagrove, Jaime Lynn Bunda, Stephen Krause, Jinlong Jiang, Christine Ryan, Sander G. Mills, Donald Burns, Kwei-Lan C. Tsao
المصدر: Journal of Medicinal Chemistry. 52:3039-3046
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Morpholines, Administration, Oral, Stereoisomerism, CHO Cells, Isoindoles, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Cricetulus, Neurokinin-1 Receptor Antagonists, Cricetinae, Drug Discovery, medicine, Animals, Humans, Antiemetic, Drug Interactions, Enzyme Inhibitors, Aprepitant, Trifluoromethyl, Antagonist, Brain, Receptor antagonist, Macaca mulatta, chemistry, Molecular Medicine, NK1 receptor antagonist, medicine.drug
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9
المؤلفون: Jan N. M. Commandeur, Chris Oostenbrink, Peter H. J. Keizers, Nico P. E. Vermeulen, Richard Tschirret-Guth, Robert A.B. van Waterschoot, Barbara M A van Vugt-Lussenburg, Chris de Graaf
المساهمون: Molecular and Computational Toxicology
المصدر: de Graaf, C, Oostenbrink, C, Keizers, P H J, van Vugt-Lussenburg, B M A, van Waterschoot, R A B, Tschirret-Guth, R A, Commandeur, J N M & Vermeulen, N P E 2007, ' Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6 ', Current Drug Metabolism, vol. 8, no. 1, pp. 59-77 . https://doi.org/10.2174/138920007779315062
Current Drug Metabolism, 8(1), 59-77. Bentham Science Publishers B.V.مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Molecular Sequence Data, Mutagenesis (molecular biology technique), Sequence alignment, digestive system, Models, Journal Article, Site-Directed, Homology modeling, Amino Acid Sequence, Validation Studies, Site-directed mutagenesis, skin and connective tissue diseases, Structural Homology, Pharmacology, Virtual screening, biology, Drug discovery, Protein, Active site, Molecular, Cytochrome P-450 CYP2D6, Structural Homology, Protein, Mutagenesis, biology.protein, Mutagenesis, Site-Directed, Sequence Alignment
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10
المؤلفون: Edward C. Sherer, Robert K. Orr, Wayne M. Geissler, Kazuto Araki, Thomas Bateman, Ting Zhang, Xiaoxia Qian, Kenneth P. Ellsworth, Teruyuki Nishimura, Andrew Nolting, Patrick Andre, Yi-Heng Chen, Paul Reichert, Kunal Desai, Harold B. Wood, Liangqin Guo, Dann L. Parker, Dongfang Meng, Cameron J. Smith, Lisa M. Sonatore, Tianying Jian, Richard Tschirret-Guth, Alan Hruza, Min Shu, Louis-Charles Campeau, Isao Sakurada
المصدر: Bioorganicmedicinal chemistry letters. 25(21)
مصطلحات موضوعية: Drug, Models, Molecular, media_common.quotation_subject, Clinical Biochemistry, High selectivity, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, Crystallography, X-Ray, Biochemistry, Thrombin generation, Factor IXa, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Animals, Humans, Amines, Enzyme Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Bioavailability, Rats, Human plasma, Pharmacodynamics, Drug Design, Molecular Medicine, Coagulation factor IXa
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11
المؤلفون: George A. Doss, Nathan X. Yu, Yohannes Teffera, Suzanne L. Ciccotto, Stella H. Vincent, Wei Tang, Mellissa Creighton, M. Reza Anari, Richard Tschirret-Guth, Donald F. Hobra, John B. Coleman, Jason S. Ngui, David C. Evans
المصدر: Drug Metabolism and Disposition. 34:1367-1375
مصطلحات موضوعية: Male, Agonist, Taurine, medicine.drug_class, Metabolite, Administration, Oral, Pharmaceutical Science, Thiophenes, Adduct, Rats, Sprague-Dawley, Feces, chemistry.chemical_compound, Dogs, Species Specificity, medicine, Animals, Bile, Intestinal Mucosa, Biotransformation, Pharmacology, Chemistry, Metabolism, Glutathione, Rats, Receptors, Lysosphingolipid, Biochemistry, Injections, Intravenous, Microsome, Azetidines, Glucuronide, Protein Binding
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12
المؤلفون: Andrew J, Kassick, Jinlong, Jiang, Jaime, Bunda, David, Wilson, Jianming, Bao, Huagang, Lu, Peter, Lin, Richard G, Ball, George A, Doss, Xinchun, Tong, Kwei-Lan C, Tsao, Hong, Wang, Gary, Chicchi, Bindhu, Karanam, Richard, Tschirret-Guth, Koppara, Samuel, Donald F, Hora, Sanjeev, Kumar, Maria, Madeira, Waisi, Eng, Richard, Hargreaves, Mona, Purcell, Liza, Gantert, Jacquelyn, Cook, Robert J, DeVita, Sander G, Mills
المصدر: Journal of medicinal chemistry. 56(14)
مصطلحات موضوعية: Glucuronides, Neurokinin-1 Receptor Antagonists, Metabolic Clearance Rate, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Humans, Drug Interactions, Isoindoles, Substance P, Oxazoles, Peptide Fragments
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13
المصدر: Journal of the American Association for Laboratory Animal Science : JAALAS. 49(6)
مصطلحات موضوعية: Male, Injections, Subcutaneous, Skin Diseases, Bacterial, Macaca mulatta, Anti-Bacterial Agents, Cephalosporins, Macaca fascicularis, Dogs, Species Specificity, Area Under Curve, Animals, Dog Diseases, Saimiri, Biology, Half-Life
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14
المؤلفون: Richard Tschirret-Guth, Byron H. Arison, Maria Victoria Silva Elipe, B.F. Michael, Donald Thompson, Terry Faidley, Herve A. Aloysius, Timothy A. Blizzard, Wesley L. Shoop
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 36(8)
مصطلحات موضوعية: medicine.medical_specialty, Pharmaceutical Science, Administration, Oral, Biology, Tritium, behavioral disciplines and activities, Cecum, Feces, Dogs, Pharmacokinetics, In vivo, Oral administration, Internal medicine, mental disorders, medicine, Animals, Spiro Compounds, Pharmacology, Gastrointestinal tract, Sheep, Fissipedia, Indolizines, Metabolism, biology.organism_classification, humanities, medicine.anatomical_structure, Endocrinology, Gerbillinae, Half-Life
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15
المؤلفون: Clare London, Catherine Abbadie, Xiaohua Li, Joseph L. Duffy, Erin McGowan, Gregory J. Kaczorowski, Maria L. Garcia, McHardy M. Smith, Richard Tschirret-Guth, Vivien A. Warren, Brande S. Williams, Brian Dean, William H. Parsons, Bindhu V. Karanam, Kathryn A. Lyons, Scott B. Hoyt, John P. Felix, Nina Jochnowitz, William J. Martin, Birgit T. Priest
المصدر: Bioorganicmedicinal chemistry letters. 18(5)
مصطلحات موضوعية: Stereochemistry, Pyridines, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Pain, Pharmacology, Biochemistry, Sodium Channels, Structure-Activity Relationship, Sodium channel blocker, Oral administration, Drug Discovery, medicine, Potency, Animals, Channel blocker, Molecular Biology, Inflammation, Analgesics, Molecular Structure, Chemistry, Sodium channel, Organic Chemistry, NAV1.7 Voltage-Gated Sodium Channel, Rats, Allodynia, Neuropathic pain, Molecular Medicine, medicine.symptom, Sodium Channel Blockers
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16
المؤلفون: Peter H. J. Keizers, Chris de Graaf, Richard Tschirret-Guth, Nico P. E. Vermeulen, Robert A.B. van Waterschoot
المساهمون: Molecular and Computational Toxicology, Medicinal chemistry
المصدر: Archives of Biochemistry and Biophysics, 447(1), 53-8. Academic Press Inc.
van Waterschoot, R A B, Keizers, P H J, de Graaf, C, Vermeulen, N P E & Tschirret-Guth, R A 2006, ' Topological role of cytochrome P450 2D6 active site residues ', Archives of Biochemistry and Biophysics, vol. 447, no. 1, pp. 53-8 . https://doi.org/10.1016/j.abb.2006.01.002مصطلحات موضوعية: Models, Molecular, Molecular model, Protein Conformation, Stereochemistry, Mutant, Biophysics, Topology, Biochemistry, chemistry.chemical_compound, Escherichia coli, Humans, Computer Simulation, Molecular Biology, Alanine, chemistry.chemical_classification, biology, Chemistry, Mutagenesis, Active site, Substrate (chemistry), Recombinant Proteins, Amino acid, Enzyme Activation, Amino Acid Substitution, Cytochrome P-450 CYP2D6, Models, Chemical, biology.protein, Homology (chemistry)
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17
المؤلفون: A. Brian Jones, Kun Liu, Black Regina M, Cherrie Liu, Ralph T. Mosley, Richard Tschirret-Guth, Margaret E. McCann, John J. Acton, Joel P. Berger, Peter T. Meinke, Meng Yang, Lawrence F. Colwell, Sheryl D. Debenham, Harold B. Wood, Chuanlin F. Wang, Ramon Abola, Margaret Wu, David E. Moller, Karen L. MacNaul
المصدر: Bioorganicmedicinal chemistry letters. 15(10)
مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Indoles, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Adipose tissue, Biochemistry, Partial agonist, chemistry.chemical_compound, Mice, In vivo, Internal medicine, Adipocyte, Drug Discovery, Brown adipose tissue, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Biological activity, Rats, PPAR gamma, medicine.anatomical_structure, Endocrinology, Adipogenesis, Area Under Curve, Molecular Medicine
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18
المؤلفون: Richard Tschirret-Guth, Harold B. Wood
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 31(8)
مصطلحات موضوعية: Indoles, Stereochemistry, Substituent, Amidines, Pharmaceutical Science, Electrons, Chemistry Techniques, Analytical, Amidine, chemistry.chemical_compound, Structure-Activity Relationship, Cytochrome P-450 Enzyme System, Moiety, Animals, Oxazoles, Bond cleavage, Pharmacology, Indole test, Carbon Monoxide, Molecular Structure, Chemistry, Air, Benzisoxazole, Substrate (chemistry), Isoxazoles, Rats, Ketoconazole, Microsome, Microsomes, Liver, Oxidation-Reduction, NADP
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19
المصدر: Archives of biochemistry and biophysics. 397(2)
مصطلحات موضوعية: Programmed cell death, Metalloporphyrins, Biophysics, Antineoplastic Agents, Apoptosis, Biology, medicine.disease_cause, Biochemistry, Antioxidants, Cyclic N-Oxides, Methionine, Lipid oxidation, medicine, Humans, Molecular Biology, Etoposide, chemistry.chemical_classification, Cisplatin, Reactive oxygen species, F2-Isoprostanes, Hydrogen Peroxide, Oxidants, Molecular biology, Burkitt Lymphoma, Acetylcysteine, Cytosol, chemistry, Spin Labels, Reactive Oxygen Species, Oxidative stress, Intracellular, medicine.drug